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EVs count and characterization by NTA and Flow cytometry. Variables are expressed as minimum, first quartile, median, third quartile, maximum. (PDF 343Â kb)

Transcriptional expression of DUX4 target genes and the PCDHγ cluster in SMCHD1 KD 4qB cell lines. RNA expression analysis of (A) the DUX4 target genes ZSCAN4 and LEUTX in primary myotubes and the PCDHγ cluster isoform members in primary (B) myoblast and (C) myotube cells after SMCHD1 shRNA KD or control shRNA KD targeting luciferase and GFP. Results represent qRT-PCR analysis of the indicated gene after normalization to the internal control gene GUS1. For each gene, the value of expression in control shRNA samples was then arbitrarily set to 1. *Bonferroni adjusted P 

We study the type-I seesaw model with three right-handed neutrinos and Majorana masses below the pion mass. In this mass range, the model parameter space is not only strongly constrained by the requirement to explain the light neutrino masses, but also by experimental searches and cosmological considerations. In the existing literature, three disjoint regions of potentially viable parameter space have been identified. In one of them, all heavy neutrinos decay shortly before big bang nucleosynthesis. In the other two regions, one of the heavy neutrinos either decays between BBN and the CMB decoupling or is quasi-stable. We show that previously unaccounted constraints from photodisintegration of nuclei practically rule out all relevant decays that happen between BBN and the CMB decoupling. Quite remarkably, if all heavy neutrinos decay before BBN, the baryon asymmetry of the universe can be quite generically explained by low-scale leptogenesis, i.e. without further tuning in addition to what is needed to avoid experimental and cosmological constraints. This motivates searches for heavy neutrinos in pion decay experiments. Journal of high energy physics 01(1), 200 (2021). doi:10.1007/JHEP01(2021)200 Published by SISSA, [Trieste]

IN03185 Tammannǟgala Moonstone Inscription - Transcript and Translation Source: Paranavitana, S. (1934–41). ‘No. 17. Seven Sinhalese Inscriptions of the Seventh and Eighth Centuries,’ Epigraphia Zeylanica 4, pp. 148–149, no. 17, VI.

The air source heat pump (ASHP) systems assisted by solar energy have drawn great attentions, owing to their great feasibility in buildings for space heating/cooling and hot water purposes. However, there are a variety of configurations, parameters and performance criteria of solar assisted ASHP systems, leading to a major inconsistency that increase the degree of complexity to compare and implement different systems. A comparative literature review is lacking, with the aim to evaluate the performance of various ASHP systems from three main solar sources, such as solar thermal (ST), photovoltaic (PV) and hybrid photovoltaic/thermal (PV/T). This paper thus conducts a systematic review of the prevailing solar assisted ASHP systems, including their boundary conditions, system configurations, performance indicators, research methodologies and system performance. The comparison result indicates that PV-ASHP system has the best techno-economic performance, which performs best in average with coefficient of performance (COP) of around 3.75, but with moderate cost and payback time. While ST-ASHP and PV/T-ASHP systems have lower performance with mean COP of 2.90 and 3.03, respectively. Moreover, PV/T-ASHP system has the highest cost and longest payback time, while ST-ASHP has the lowest ones. Future research are discussed from aspects of methodologies, system optimization and standard evaluation.

We consider the problem of computing optimal linear control policies for linear systems in finite-horizon. The states and the inputs are required to remain inside pre-specified safety sets at all times despite unknown disturbances. In this technical note, we focus on the requirement that the control policy is distributed, in the sense that it can only be based on partial information about the history of the outputs. It is well-known that when a condition denoted as Quadratic Invariance (QI) holds, the optimal distributed control policy can be computed in a tractable way. Our goal is to unify and generalize the class of information structures over which quadratic invariance is equivalent to a test over finitely many binary matrices. The test we propose certifies convexity of the output-feedback distributed control problem in finite-horizon given any arbitrarily defined information structure, including the cases of time varying communication networks and forgetting mechanisms. Furthermore, the framework we consider allows for including polytopic constraints on the states and the inputs in a natural way, without affecting convexity. IEEE Transactions on Automatic Control, 64 (12) ISSN:1558-2523 ISSN:0018-9286

Measurements of the second Fourier harmonic coefficient (v2) of the azimuthal distributions of prompt and nonprompt D0 mesons produced in pp and pPb collisions are presented. Nonprompt D0 mesons come from beauty hadron decays. The data samples are collected by the CMS experiment at nucleon-nucleon center-of-mass energies of 13 and 8.16 TeV, respectively. In high multiplicity pp collisions, v2 signals for prompt charm hadrons are reported for the first time, and are found to be comparable to those for light-flavor hadron species over a transverse momentum (pT) range of 2–6 GeV. Compared at similar event multiplicities, the prompt D0 meson v2 values in pp and pPb collisions are similar in magnitude. The v2 values for open beauty hadrons are extracted for the first time via nonprompt D0 mesons in pPb collisions. For pT in the range of 2–5 GeV, the results suggest that v2 for nonprompt D0 mesons is smaller than that for prompt D0 mesons. These new measurements indicate a positive charm hadron v2 in pp collisions and suggest a mass dependence in v2 between charm and beauty hadrons in the pPb system. These results provide insights into the origin of heavy-flavor quark collectivity in small systems. Individuals have received support from the Marie-Curie program and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 752730, and 765710 (European Union); CERN; the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2015-0509 and the Programa Severo Ochoa del Principado de Asturias. CMS Collaboration: et al. Funded by SCOAP3. Peer reviewed

Additional file 7: Figure S3. Schematic representation of the construction of the vector pool.

A search in an all-jet final state for new massive resonances decaying to $\text{ W }{}{}\text{ W }{}{}$, $\text{ W }{}{}\text{ Z }{}{}$, or $\text{ Z }{}{}\text{ Z }{}{}$ boson pairs using a novel analysis method is presented. The analysis is performed on data corresponding to an integrated luminosity of 77.3 $\,\text {fb}^{-1}$ recorded with the CMS experiment at the LHC at a centre-of-mass energy of 13 $\text {Te}\text {V}$. The search is focussed on potential narrow-width resonances with masses above 1.2 $\text {Te}\text {V}$, where the decay products of each $\text{ W }{}{}$ or $\text{ Z }{}{}$ boson are expected to be collimated into a single, large-radius jet. The signal is extracted using a three-dimensional maximum likelihood fit of the two jet masses and the dijet invariant mass, yielding an improvement in sensitivity of up to 30% relative to previous search methods. No excess is observed above the estimated standard model background. In a heavy vector triplet model, spin-1 ${\text {Z}}^{\prime }$ and ${\text {W}}^{\prime }$ resonances with masses below 3.5 and 3.8 $\text {Te}\text {V}$, respectively, are excluded at 95% confidence level. In a bulk graviton model, upper limits on cross sections are set between 27 and 0.2 $\,\text {fb}$ for resonance masses between 1.2 and 5.2 $\text {Te}\text {V}$, respectively. The limits presented in this paper are the best to date in the dijet final state. The European physical journal / C Particles and fields C 80(3), 237 (2020). doi:10.1140/epjc/s10052-020-7773-5 Published by Springer, Heidelberg

Simulation of the distribution. (PDF 452Â kb)