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  • Publication . Preprint . Research . Other literature type . Article . 2021
    Open Access English
    Authors: 
    Sven Heinemeyer; Stanislaw Jadach; Jürgen Reuter;
    Publisher: Springer Nature
    Countries: Spain, Germany
    Project: EC | FCCIS (951754)

    High-precision experimental measurements of the properties of the Higgs boson at ∼125 GeV as well as electroweak precision observables such as the W-boson mass or the effective weak leptonic mixing angle are expected at future e+e− colliders such as the FCC-ee. This high anticipated precision has to be matched with theory predictions for the measured quantities at the same level of accuracy. We briefly summarize the status of these predictions within the standard model and of the tools that are used for their determination. We outline how the theory predictions will have to be improved in order to reach the required accuracy, and also comment on the simulation frameworks for the Higgs and EW precision program. The work of S.H. is supported in part by the MEINCOP Spain under contract PID2019-110058GB-C21 and in part by the AEI through the Grant IFT Centro de Excelencia Severo Ochoa SEV-2016-0597. S.J. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No. 951754 and support of the National Science Centre, Poland, Grant No. 2019/34/E/ST2/00457. JRR acknowledges the support by the Deutsche Forschungsgemeinschaft (DFG, German Research Association) under Germany’s Excellence Strategy-EXC 2121 “Quantum Universe”-39083330. Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. Peer reviewed

  • Open Access English
    Authors: 
    Tumasyan, Armen; Adam, Wolfgang; Andrejkovic, Janik Walter; Bergauer, Thomas; Chatterjee, Suman; Dragicevic, Marko; Escalante Del Valle, Alberto; Fruehwirth, Rudolf; Jeitler, Manfred; Krammer, Natascha; +532 more
    Publisher: HAL CCSD
    Countries: Spain, Germany, Turkey, Croatia, Belgium, Spain, Turkey, United Kingdom, Croatia, Germany ...
    Project: EC | STRONG-2020 (824093), EC | AMVA4NewPhysics (675440), EC | PSI-FELLOW-III-3i (884104), EC | MajorNet (758316), EC | LHCTOPVLQ (752730), EC | HIGCC (724704), EC | INSIGHTS (765710)

    A measurement of the top quark mass is performed using a data sample enriched with single top quark events produced in the t channel. The study is based on proton- proton collision data, corresponding to an integrated luminosity of 35.9 fb−1, recorded at s√ = 13 TeV by the CMS experiment at the LHC in 2016. Candidate events are selected by requiring an isolated high-momentum lepton (muon or electron) and exactly two jets, of which one is identified as originating from a bottom quark. Multivariate discriminants are designed to separate the signal from the background. Optimized thresholds are placed on the discriminant outputs to obtain an event sample with high signal purity. The top quark mass is found to be 172.13+0.76−0.77 GeV, where the uncertainty includes both the statistical and systematic components, reaching sub-GeV precision for the first time in this event topology. The masses of the top quark and antiquark are also determined separately using the lepton charge in the final state, from which the mass ratio and difference are determined to be 0.9952+0.0079−0.0104 and 0.83+1.79−1.35 GeV, respectively. The results are consistent with CPT invariance. Individuals have received support from the Marie-Curie program and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 724704, 752730, 758316, 765710, 824093, 884104, and COST Action CA16108 (European Union); CERN; the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2015-0509 and the Programa Severo Ochoa del Principado de Asturias. CMS Collaboration: et al. Peer reviewed

  • Publication . Other literature type . Research . 2019
    Open Access English
    Authors: 
    Toshkov, D.D.; Mazepus, H.; Chulitskaya, T.; Ramasheuskaya, I.; Rabava, N.;
    Countries: Germany, Netherlands, Italy
    Project: EC | EU-STRAT (693382)

    The European Union (EU) and the countries in the Eastern Partnership (EaP) framework have developed ambitious and comprehensive programmes for scientific cooperation that provide a major source of funding for science institutes and crucial support for science policies in the region. However, science policies and scientific cooperation are embedded in broader political and governance institutional structures. This paper explores the idea that in limited access orders (LAOs), institutions and powerful actors can constrain the design and implementation of scientific cooperation projects in a way that limits their broader transformative potential and societal effects. Empirically, the paper is focused on three EaP countries – Belarus, Moldova, and Ukraine – that differ in the forms and intensity of their scientific cooperation with the EU, but also in the types of regimes they have. The paper develops theoretically the possible and likely effects of LAOs on science policies and scientific cooperation and seeks evidence for such effects using sets of interviews with policy experts and scientists. Our empirical analysis shows that the results of scientific cooperation projects rarely spillover to broader society. It is unclear, however, to what extent this is a result of the generally limited capacity of EaP governments for strategic policy making and policy implementation, and to what extent it stems from features characteristic of LAOs. Overall, we find that, in line with our theoretical reasoning, the less open the regime, the more stringent the constraints on science and scientific cooperation it imposes. This project has received funding from the European Union’s Horizon 2020 research and innovative programme under grant agreement no. 693382.

  • Publication . Article . Other literature type . Preprint . Research . 2021 . Embargo End Date: 01 Jan 2020
    Open Access English
    Authors: 
    Erika Covi; Elisa Donati; Xiangpeng Liang; David Kappel; Hadi Heidari; Melika Payvand; Wei Wang;
    Publisher: ETH Zurich
    Countries: Switzerland, United Kingdom
    Project: EC | BeFerroSynaptic (871737)

    Wearable devices are a fast-growing technology with impact on personal healthcare for both society and economy. Due to the widespread of sensors in pervasive and distributed networks, power consumption, processing speed, and system adaptation are vital in future smart wearable devices. The visioning and forecasting of how to bring computation to the edge in smart sensors have already begun, with an aspiration to provide adaptive extreme edge computing. Here, we provide a holistic view of hardware and theoretical solutions toward smart wearable devices that can provide guidance to research in this pervasive computing era. We propose various solutions for biologically plausible models for continual learning in neuromorphic computing technologies for wearable sensors. To envision this concept, we provide a systematic outline in which prospective low power and low latency scenarios of wearable sensors in neuromorphic platforms are expected. We successively describe vital potential landscapes of neuromorphic processors exploiting complementary metal-oxide semiconductors (CMOS) and emerging memory technologies (e.g., memristive devices). Furthermore, we evaluate the requirements for edge computing within wearable devices in terms of footprint, power consumption, latency, and data size. We additionally investigate the challenges beyond neuromorphic computing hardware, algorithms and devices that could impede enhancement of adaptive edge computing in smart wearable devices. Frontiers in Neuroscience, 15 ISSN:1662-4548 ISSN:1662-453X

  • Publication . Preprint . Other literature type . Article . Research . 2022
    Open Access English
    Authors: 
    O. Grocholski; B. Pire; P. Sznajder; L. Szymanowski; J. Wagner;
    Publisher: APS
    Country: Germany
    Project: EC | STRONG-2020 (824093)

    We develop the analysis of diphoton exclusive photoproduction in the kinematics where a collinear QCD factorization framework applies, namely nearly forward large invariant mass diphoton production. We work at the leading twist level and at the next-to-leading order (NLO) in the strong coupling constant $\alpha_S$. We compare our predictions for cross sections with Born order calculations for the experimental conditions accessible to JLab experiments and show the interesting sensitivity of our results to various models of generalized parton distributions (GPDs). The NLO corrections are rather large and negative but do not prevent the studied reaction from being a promising tool for the extraction of C–odd GPDs, which do not contribute to either spacelike or timelike deeply virtual Compton scattering amplitudes. Physical review / D 105(9), 094025 (2022). doi:10.1103/PhysRevD.105.094025 Published by Inst., Melville, NY

  • Publication . Article . Preprint . Other literature type . Research . 2021
    Open Access English
    Authors: 
    Thomas Bergauer; Marko Dragicevic; Jochen Schieck; Wolfgang Waltenberger; Tahys Janssen; Freya Blekman; Emil Sørensen Bols; Martin Delcourt; H. El Faham; Abanti Ranadhir Sahasransu; +445 more
    Countries: Turkey, Turkey, Finland, Spain, France, Belgium, Croatia, Germany, United States, Italy ...
    Project: EC | AMVA4NewPhysics (675440), EC | LHCTOPVLQ (752730), EC | STRONG-2020 (824093), EC | INSIGHTS (765710), EC | HIGCC (724704)

    A search for a heavy Higgs boson H decaying into the observed Higgs boson h with a mass of 125 GeV and another Higgs boson hS is presented. The h and hS bosons are required to decay into a pair of tau leptons and a pair of b quarks, respectively. The search uses a sample of proton-proton collisions collected with the CMS detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 137 fb−1. Mass ranges of 240–3000 GeV for mH and 60–2800 GeV for mhS are explored in the search. No signal has been observed. Model independent 95% confidence level upper limits on the product of the production cross section and the branching fractions of the signal process are set with a sensitivity ranging from 125 fb (for mH = 240 GeV) to 2.7 fb (for mH = 1000 GeV). These limits are compared to maximally allowed products of the production cross section and the branching fractions of the signal process in the next-to-minimal supersymmetric extension of the standard model. [Figure not available: see fulltext.] Journal of High Energy Physics, 2021 (11) ISSN:1029-8479 ISSN:1126-6708

  • Open Access English
    Authors: 
    Saverio Lombardi; Ciro Bigongiari; Stefano Gallozzi; Louis Antonelli; Denis Bastieri; I. Donnarumma; Fabrizio Lucarelli; M. Mastropietro; Pere Munar; M. Perri; +4 more
    Countries: Italy, Germany
    Project: EC | ASTERICS (653477)

    The Cherenkov Telescope Array (CTA) is a worldwide project aimed at building the next-generation ground-based gamma-ray observatory. Within the CTA project, the Italian National Institute for Astrophysics (INAF) is developing an end-to-end prototype of the CTA Small-Size Telescopes with a dual-mirror (SST-2M) Schwarzschild-Couder configuration. The prototype, named ASTRI SST-2M, is located at the INAF "M.C. Fracastoro" observing station in Serra La Nave (Mt. Etna, Sicily) and is currently in the scientific and performance validation phase. A mini-array of (at least) nine ASTRI telescopes has been then proposed to be deployed at the Southern CTA site, by means of a collaborative effort carried out by institutes from Italy, Brazil, and South-Africa. The CTA/ASTRI team is developing an end-to-end software package for the reduction of the raw data acquired with both ASTRI SST-2M prototype and mini-array, with the aim of actively contributing to the global ongoing activities for the official data handling system of the CTA observatory. The group is also undertaking a massive Monte Carlo simulation data production using the detector Monte Carlo software adopted by the CTA consortium. Simulated data are being used to validate the simulation chain and evaluate the ASTRI SST-2M prototype and mini-array performance. Both activities are also carried out in the framework of the European H2020-ASTERICS (Astronomy ESFRI and Research Infrastructure Cluster) project. A data archiving system, for both ASTRI SST-2M prototype and mini-array, has been also developed by the CTA/ASTRI team, as a testbed for the scientific archive of CTA. In this contribution, we present the main components of the ASTRI data handling systems and report the status of their development. Proceedings of the 35th International Cosmic Ray Conference (ICRC 2017), Bexco, Busan, Korea. All CTA contributions at arXiv:1709.03483

  • Publication . Research . Article . Book . Other literature type . 2021
    Open Access English
    Authors: 
    Jürgen Gerhards; Holger Lengfeld; Clara Dilger;
    Publisher: Freie Universität Berlin
    Country: Germany
    Project: EC | SOLIDUS (649489)

    European citizenship consisting of equal economic, social, and political rights for all EU citizens has come under pressure in recent years due to the different crisis the EU had to face. Based on a survey conducted in 13 EU member states we examined to what extent EU-citizens support the notion that citizens from other European countries should enjoy the same rights as nationals. Overall, only 56 % of EU citizens support the idea that EU foreigners and national citizens should be treated equally. In addition, we find remarkable variations between the countries. Multivariate analysis indicates that cultural factors on the individual and the country level have a strong impact on attitudes towards Europeanised equality, whereas structural factors that are related to individuals’ and a countries’ socioeconomic position are only of minor importance. One can conclude from our findings that the EU is not only situated in an institutional but also in a legitimacy crisis.

  • Publication . Research . Preprint . 2017
    Open Access English
    Authors: 
    Calabrese, Claudia; Lehmann, Kjong-Van; Urban, Lara; Liu, Fenglin; Erkek, Serap; Fonseca, Nuno; Kahles, Andre; Kilpinen-Barrett, Leena Helena; Markowski, Julia; PCAWG-3; +7 more
    Publisher: Cold Spring Harbor Laboratory
    Country: Switzerland
    Project: EC | PanCanRisk (635290), EC | CAGEKID (241669), EC | EUROCANPLATFORM (260791)

    Cancer is characterised by somatic genetic variation, but the effect of the majority of non-coding somatic variants and the interface with the germline genome are still unknown. We analysed the whole genome and RNA-seq data from 1,188 human cancer patients as provided by the Pan-cancer Analysis of Whole Genomes (PCAWG) project to map cis expression quantitative trait loci of somatic and germline variation and to uncover the causes of allele-specific expression patterns in human cancers. The availability of the first large-scale dataset with both whole genome and gene expression data enabled us to uncover the effects of the non-coding variation on cancer. In addition to confirming known regulatory effects, we identified novel associations between somatic variation and expression dysregulation, in particular in distal regulatory elements. Finally, we uncovered links between somatic mutational signatures and gene expression changes, including TERT and LMO2, and we explained the inherited risk factors in APOBEC-related mutational processes. This work represents the first large-scale assessment of the effects of both germline and somatic genetic variation on gene expression in cancer and creates a valuable resource cataloguing these effects. bioRxiv

  • Publication . Research . Other literature type . Article . Preprint . 2017
    Open Access English
    Authors: 
    M. S. Bloom; M. J. V. Streeter; Stefan Kneip; R. A. Bendoyro; O. Cheklov; Jason Cole; A. Döpp; C. J. Hooker; J. Holloway; J. Jiang; +10 more
    Publisher: American Physical Society
    Country: United Kingdom
    Project: UKRI | Bright table-top x-ray so... (EP/I014462/1), EC | EuPRAXIA (653782), EC | TeX-MEx (682399)

    We show that the properties of the electron beam and bright x-rays produced by a laser wakefield accelerator can be predicted if the distance over which the laser self-focuses and compresses prior to self-injection is taken into account. A model based on oscillations of the beam inside a plasma bubble shows that performance is optimised when the plasma length is matched to the laser depletion length. With a 200~TW laser pulse this results in an x-ray beam with median photon energy of \unit[20]{keV}, $> 6\times 10^{8}$ photons above \unit[1]{keV} per shot and a peak brightness of $\unit[3 \times 10^{22}]{photons~s^{-1}mrad^{-2}mm^{-2} (0.1\% BW)^{-1}}$. 5 pages, 4 figures

Advanced search in
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Include:
60 Research products, page 1 of 6
  • Publication . Preprint . Research . Other literature type . Article . 2021
    Open Access English
    Authors: 
    Sven Heinemeyer; Stanislaw Jadach; Jürgen Reuter;
    Publisher: Springer Nature
    Countries: Spain, Germany
    Project: EC | FCCIS (951754)

    High-precision experimental measurements of the properties of the Higgs boson at ∼125 GeV as well as electroweak precision observables such as the W-boson mass or the effective weak leptonic mixing angle are expected at future e+e− colliders such as the FCC-ee. This high anticipated precision has to be matched with theory predictions for the measured quantities at the same level of accuracy. We briefly summarize the status of these predictions within the standard model and of the tools that are used for their determination. We outline how the theory predictions will have to be improved in order to reach the required accuracy, and also comment on the simulation frameworks for the Higgs and EW precision program. The work of S.H. is supported in part by the MEINCOP Spain under contract PID2019-110058GB-C21 and in part by the AEI through the Grant IFT Centro de Excelencia Severo Ochoa SEV-2016-0597. S.J. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No. 951754 and support of the National Science Centre, Poland, Grant No. 2019/34/E/ST2/00457. JRR acknowledges the support by the Deutsche Forschungsgemeinschaft (DFG, German Research Association) under Germany’s Excellence Strategy-EXC 2121 “Quantum Universe”-39083330. Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. Peer reviewed

  • Open Access English
    Authors: 
    Tumasyan, Armen; Adam, Wolfgang; Andrejkovic, Janik Walter; Bergauer, Thomas; Chatterjee, Suman; Dragicevic, Marko; Escalante Del Valle, Alberto; Fruehwirth, Rudolf; Jeitler, Manfred; Krammer, Natascha; +532 more
    Publisher: HAL CCSD
    Countries: Spain, Germany, Turkey, Croatia, Belgium, Spain, Turkey, United Kingdom, Croatia, Germany ...
    Project: EC | STRONG-2020 (824093), EC | AMVA4NewPhysics (675440), EC | PSI-FELLOW-III-3i (884104), EC | MajorNet (758316), EC | LHCTOPVLQ (752730), EC | HIGCC (724704), EC | INSIGHTS (765710)

    A measurement of the top quark mass is performed using a data sample enriched with single top quark events produced in the t channel. The study is based on proton- proton collision data, corresponding to an integrated luminosity of 35.9 fb−1, recorded at s√ = 13 TeV by the CMS experiment at the LHC in 2016. Candidate events are selected by requiring an isolated high-momentum lepton (muon or electron) and exactly two jets, of which one is identified as originating from a bottom quark. Multivariate discriminants are designed to separate the signal from the background. Optimized thresholds are placed on the discriminant outputs to obtain an event sample with high signal purity. The top quark mass is found to be 172.13+0.76−0.77 GeV, where the uncertainty includes both the statistical and systematic components, reaching sub-GeV precision for the first time in this event topology. The masses of the top quark and antiquark are also determined separately using the lepton charge in the final state, from which the mass ratio and difference are determined to be 0.9952+0.0079−0.0104 and 0.83+1.79−1.35 GeV, respectively. The results are consistent with CPT invariance. Individuals have received support from the Marie-Curie program and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 724704, 752730, 758316, 765710, 824093, 884104, and COST Action CA16108 (European Union); CERN; the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2015-0509 and the Programa Severo Ochoa del Principado de Asturias. CMS Collaboration: et al. Peer reviewed

  • Publication . Other literature type . Research . 2019
    Open Access English
    Authors: 
    Toshkov, D.D.; Mazepus, H.; Chulitskaya, T.; Ramasheuskaya, I.; Rabava, N.;
    Countries: Germany, Netherlands, Italy
    Project: EC | EU-STRAT (693382)

    The European Union (EU) and the countries in the Eastern Partnership (EaP) framework have developed ambitious and comprehensive programmes for scientific cooperation that provide a major source of funding for science institutes and crucial support for science policies in the region. However, science policies and scientific cooperation are embedded in broader political and governance institutional structures. This paper explores the idea that in limited access orders (LAOs), institutions and powerful actors can constrain the design and implementation of scientific cooperation projects in a way that limits their broader transformative potential and societal effects. Empirically, the paper is focused on three EaP countries – Belarus, Moldova, and Ukraine – that differ in the forms and intensity of their scientific cooperation with the EU, but also in the types of regimes they have. The paper develops theoretically the possible and likely effects of LAOs on science policies and scientific cooperation and seeks evidence for such effects using sets of interviews with policy experts and scientists. Our empirical analysis shows that the results of scientific cooperation projects rarely spillover to broader society. It is unclear, however, to what extent this is a result of the generally limited capacity of EaP governments for strategic policy making and policy implementation, and to what extent it stems from features characteristic of LAOs. Overall, we find that, in line with our theoretical reasoning, the less open the regime, the more stringent the constraints on science and scientific cooperation it imposes. This project has received funding from the European Union’s Horizon 2020 research and innovative programme under grant agreement no. 693382.

  • Publication . Article . Other literature type . Preprint . Research . 2021 . Embargo End Date: 01 Jan 2020
    Open Access English
    Authors: 
    Erika Covi; Elisa Donati; Xiangpeng Liang; David Kappel; Hadi Heidari; Melika Payvand; Wei Wang;
    Publisher: ETH Zurich
    Countries: Switzerland, United Kingdom
    Project: EC | BeFerroSynaptic (871737)

    Wearable devices are a fast-growing technology with impact on personal healthcare for both society and economy. Due to the widespread of sensors in pervasive and distributed networks, power consumption, processing speed, and system adaptation are vital in future smart wearable devices. The visioning and forecasting of how to bring computation to the edge in smart sensors have already begun, with an aspiration to provide adaptive extreme edge computing. Here, we provide a holistic view of hardware and theoretical solutions toward smart wearable devices that can provide guidance to research in this pervasive computing era. We propose various solutions for biologically plausible models for continual learning in neuromorphic computing technologies for wearable sensors. To envision this concept, we provide a systematic outline in which prospective low power and low latency scenarios of wearable sensors in neuromorphic platforms are expected. We successively describe vital potential landscapes of neuromorphic processors exploiting complementary metal-oxide semiconductors (CMOS) and emerging memory technologies (e.g., memristive devices). Furthermore, we evaluate the requirements for edge computing within wearable devices in terms of footprint, power consumption, latency, and data size. We additionally investigate the challenges beyond neuromorphic computing hardware, algorithms and devices that could impede enhancement of adaptive edge computing in smart wearable devices. Frontiers in Neuroscience, 15 ISSN:1662-4548 ISSN:1662-453X

  • Publication . Preprint . Other literature type . Article . Research . 2022
    Open Access English
    Authors: 
    O. Grocholski; B. Pire; P. Sznajder; L. Szymanowski; J. Wagner;
    Publisher: APS
    Country: Germany
    Project: EC | STRONG-2020 (824093)

    We develop the analysis of diphoton exclusive photoproduction in the kinematics where a collinear QCD factorization framework applies, namely nearly forward large invariant mass diphoton production. We work at the leading twist level and at the next-to-leading order (NLO) in the strong coupling constant $\alpha_S$. We compare our predictions for cross sections with Born order calculations for the experimental conditions accessible to JLab experiments and show the interesting sensitivity of our results to various models of generalized parton distributions (GPDs). The NLO corrections are rather large and negative but do not prevent the studied reaction from being a promising tool for the extraction of C–odd GPDs, which do not contribute to either spacelike or timelike deeply virtual Compton scattering amplitudes. Physical review / D 105(9), 094025 (2022). doi:10.1103/PhysRevD.105.094025 Published by Inst., Melville, NY

  • Publication . Article . Preprint . Other literature type . Research . 2021
    Open Access English
    Authors: 
    Thomas Bergauer; Marko Dragicevic; Jochen Schieck; Wolfgang Waltenberger; Tahys Janssen; Freya Blekman; Emil Sørensen Bols; Martin Delcourt; H. El Faham; Abanti Ranadhir Sahasransu; +445 more
    Countries: Turkey, Turkey, Finland, Spain, France, Belgium, Croatia, Germany, United States, Italy ...
    Project: EC | AMVA4NewPhysics (675440), EC | LHCTOPVLQ (752730), EC | STRONG-2020 (824093), EC | INSIGHTS (765710), EC | HIGCC (724704)

    A search for a heavy Higgs boson H decaying into the observed Higgs boson h with a mass of 125 GeV and another Higgs boson hS is presented. The h and hS bosons are required to decay into a pair of tau leptons and a pair of b quarks, respectively. The search uses a sample of proton-proton collisions collected with the CMS detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 137 fb−1. Mass ranges of 240–3000 GeV for mH and 60–2800 GeV for mhS are explored in the search. No signal has been observed. Model independent 95% confidence level upper limits on the product of the production cross section and the branching fractions of the signal process are set with a sensitivity ranging from 125 fb (for mH = 240 GeV) to 2.7 fb (for mH = 1000 GeV). These limits are compared to maximally allowed products of the production cross section and the branching fractions of the signal process in the next-to-minimal supersymmetric extension of the standard model. [Figure not available: see fulltext.] Journal of High Energy Physics, 2021 (11) ISSN:1029-8479 ISSN:1126-6708

  • Open Access English
    Authors: 
    Saverio Lombardi; Ciro Bigongiari; Stefano Gallozzi; Louis Antonelli; Denis Bastieri; I. Donnarumma; Fabrizio Lucarelli; M. Mastropietro; Pere Munar; M. Perri; +4 more
    Countries: Italy, Germany
    Project: EC | ASTERICS (653477)

    The Cherenkov Telescope Array (CTA) is a worldwide project aimed at building the next-generation ground-based gamma-ray observatory. Within the CTA project, the Italian National Institute for Astrophysics (INAF) is developing an end-to-end prototype of the CTA Small-Size Telescopes with a dual-mirror (SST-2M) Schwarzschild-Couder configuration. The prototype, named ASTRI SST-2M, is located at the INAF "M.C. Fracastoro" observing station in Serra La Nave (Mt. Etna, Sicily) and is currently in the scientific and performance validation phase. A mini-array of (at least) nine ASTRI telescopes has been then proposed to be deployed at the Southern CTA site, by means of a collaborative effort carried out by institutes from Italy, Brazil, and South-Africa. The CTA/ASTRI team is developing an end-to-end software package for the reduction of the raw data acquired with both ASTRI SST-2M prototype and mini-array, with the aim of actively contributing to the global ongoing activities for the official data handling system of the CTA observatory. The group is also undertaking a massive Monte Carlo simulation data production using the detector Monte Carlo software adopted by the CTA consortium. Simulated data are being used to validate the simulation chain and evaluate the ASTRI SST-2M prototype and mini-array performance. Both activities are also carried out in the framework of the European H2020-ASTERICS (Astronomy ESFRI and Research Infrastructure Cluster) project. A data archiving system, for both ASTRI SST-2M prototype and mini-array, has been also developed by the CTA/ASTRI team, as a testbed for the scientific archive of CTA. In this contribution, we present the main components of the ASTRI data handling systems and report the status of their development. Proceedings of the 35th International Cosmic Ray Conference (ICRC 2017), Bexco, Busan, Korea. All CTA contributions at arXiv:1709.03483

  • Publication . Research . Article . Book . Other literature type . 2021
    Open Access English
    Authors: 
    Jürgen Gerhards; Holger Lengfeld; Clara Dilger;
    Publisher: Freie Universität Berlin
    Country: Germany
    Project: EC | SOLIDUS (649489)

    European citizenship consisting of equal economic, social, and political rights for all EU citizens has come under pressure in recent years due to the different crisis the EU had to face. Based on a survey conducted in 13 EU member states we examined to what extent EU-citizens support the notion that citizens from other European countries should enjoy the same rights as nationals. Overall, only 56 % of EU citizens support the idea that EU foreigners and national citizens should be treated equally. In addition, we find remarkable variations between the countries. Multivariate analysis indicates that cultural factors on the individual and the country level have a strong impact on attitudes towards Europeanised equality, whereas structural factors that are related to individuals’ and a countries’ socioeconomic position are only of minor importance. One can conclude from our findings that the EU is not only situated in an institutional but also in a legitimacy crisis.

  • Publication . Research . Preprint . 2017
    Open Access English
    Authors: 
    Calabrese, Claudia; Lehmann, Kjong-Van; Urban, Lara; Liu, Fenglin; Erkek, Serap; Fonseca, Nuno; Kahles, Andre; Kilpinen-Barrett, Leena Helena; Markowski, Julia; PCAWG-3; +7 more
    Publisher: Cold Spring Harbor Laboratory
    Country: Switzerland
    Project: EC | PanCanRisk (635290), EC | CAGEKID (241669), EC | EUROCANPLATFORM (260791)

    Cancer is characterised by somatic genetic variation, but the effect of the majority of non-coding somatic variants and the interface with the germline genome are still unknown. We analysed the whole genome and RNA-seq data from 1,188 human cancer patients as provided by the Pan-cancer Analysis of Whole Genomes (PCAWG) project to map cis expression quantitative trait loci of somatic and germline variation and to uncover the causes of allele-specific expression patterns in human cancers. The availability of the first large-scale dataset with both whole genome and gene expression data enabled us to uncover the effects of the non-coding variation on cancer. In addition to confirming known regulatory effects, we identified novel associations between somatic variation and expression dysregulation, in particular in distal regulatory elements. Finally, we uncovered links between somatic mutational signatures and gene expression changes, including TERT and LMO2, and we explained the inherited risk factors in APOBEC-related mutational processes. This work represents the first large-scale assessment of the effects of both germline and somatic genetic variation on gene expression in cancer and creates a valuable resource cataloguing these effects. bioRxiv

  • Publication . Research . Other literature type . Article . Preprint . 2017
    Open Access English
    Authors: 
    M. S. Bloom; M. J. V. Streeter; Stefan Kneip; R. A. Bendoyro; O. Cheklov; Jason Cole; A. Döpp; C. J. Hooker; J. Holloway; J. Jiang; +10 more
    Publisher: American Physical Society
    Country: United Kingdom
    Project: UKRI | Bright table-top x-ray so... (EP/I014462/1), EC | EuPRAXIA (653782), EC | TeX-MEx (682399)

    We show that the properties of the electron beam and bright x-rays produced by a laser wakefield accelerator can be predicted if the distance over which the laser self-focuses and compresses prior to self-injection is taken into account. A model based on oscillations of the beam inside a plasma bubble shows that performance is optimised when the plasma length is matched to the laser depletion length. With a 200~TW laser pulse this results in an x-ray beam with median photon energy of \unit[20]{keV}, $> 6\times 10^{8}$ photons above \unit[1]{keV} per shot and a peak brightness of $\unit[3 \times 10^{22}]{photons~s^{-1}mrad^{-2}mm^{-2} (0.1\% BW)^{-1}}$. 5 pages, 4 figures

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