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  • Authors: Linford J. B. Briant, Quan Zhang, Elisa Vergari, Joely A. Kellard, Blanca Rodriguez, Frances M. Ashcroft, Patrik Rorsman;
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: van Drooge, Barend L.; Sicard, Michaël; Stohl, Andreas; Fontal, Marta; +5 Authors

    The combined use of chemical analysis of organic molecules in atmospheric aerosols (PM1) collected in situ in Barcelona and optical measurements with a light detection and ranging (LIDAR) instrument allowed the characterization of the smoke plume from a wildfire that reached the city in July 2012. Analysis of the chemical composition of the aerosols collected on 23 July 2012 confirmed the large effect of biomass burning on urban air quality during a period of several hours. Typical biomass burning tracers, such as levoglucosan, dehydroabietic acid and polycyclic aromatic hydrocarbons (PAH) were enhanced at the same time as the aerosol concentrations in the boundary layer increased. According to air-mass trajectory modeling, the biomass burning particles originated from a severe wildfire burning 120 km northeast of the city. On the following days, no significant contribution of wildfire smoke was found in the urban air, although the lidar detected particles aloft. A Lagrangian particle dispersion model (FLEXPART) was used to simulate the transport of aerosols (PM2.5) and carbon monoxide (CO), and the simulated concentrations in Barcelona were compared to in-situ measurements. FLEXPART simulated the onset of the wildfire smoke plume event in the urban center in the early morning of 23 July successfully; by contrast, the fast passage of the plume at the surface and the decoupling of the cleaner boundary layer from the persistent smoke plume aloft was not well captured. This was attributed to the fact that the model did not capture the local sea-breeze circulation well enough. Peer Reviewed

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    Atmospheric Pollution Research
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      Atmospheric Pollution Research
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      License: CC BY NC ND
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  • Authors: Elisabeth Maritschnegg; Nicole Heinzl; Stuart Wilson; Simon Deycmar; +6 Authors

    A growing number of diseases are being linked to protein misfolding and amyloid formation. Recently, p53 was also shown to associate into amyloid aggregates, raising the question of whether cancer development is associated with protein aggregation as well. However, a lack of suitable tools has hampered the evaluation of their clinical relevance. Herein, we report an enzyme-linked-immunosorbent-assay (ELISA) system based on a polyionic, high-molecular-weight ligand that specifically captures aggregated oligomers and amyloid proteins. We proved that naturally occurring tetramers of p53 are not bound, but high-molecular-weight aggregates are bound and subsequently detected. For the first time, this assay allows the quantitative detection of p53 aggregates from cell lysates, which was demonstrated using 22 ovarian-cancer cell lines as well as 7 patient-derived tumor tissues. The levels of p53 aggregates within the missense-mutated tissue samples varied more than 12-fold. This simple, robust method allows studying the abundance and clinical relevance of protein aggregates. This could help our understanding of the role of protein misfolding in cancer or even in predicting therapy responses to aggregation-targeting drugs.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Aaboud, M.; ATLAS Collaboration; Barreiro Alonso, Fernando; Calvente López, S.; +5 Authors

    We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, the Canada Council, CANARIE, CRC, Compute Canada, FQRNT, and the Ontario Innovation Trust, Canada; EPLANET, ERC, FP7, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d’Avenir Labex and Idex, ANR, Région Auvergne and Fondation Partager le Savoir, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF; BSF, GIF and Minerva, Israel; BRF, Norway; Generalitat de Catalunya, Generalitat Valenciana, Spain; the Royal Society and Leverhulme Trust, United Kingdom Measurements of the jet activity in tt¯ events produced in proton-proton collisions at √ s = 8 TeV are presented, using 20.3 fb−1 of data collected by the ATLAS experiment at the Large Hadron Collider. The events were selected in the dilepton eµ decay channel with two identified b-jets. The numbers of additional jets for various jet transverse momentum (pT) thresholds, and the normalised differential cross-sections as a function of pT for the five highest-pT additional jets, were measured in the jet pseudorapidity range |η| < 4.5. The gap fraction, the fraction of events which do not contain an additional jet in a central rapidity region, was measured for several rapidity intervals as a function of the minimum pT of a single jet or the scalar sum of pT of all additional jets. These fractions were also measured in different intervals of the invariant mass of the eµb¯b system. All measurements were corrected for detector effects, and found to be mostly well-described by predictions from next-to-leading-order and leading-order tt¯ event generators with appropriate parameter choices. The results can be used to further optimise the parameters used in such generators Artículo escrito por muchos autores, sólo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración y los autores que firman como pertenecientes a la UAM Journal of High Energy Physics 2016.9 (2016): 074 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)

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    Biblos-e Archivo
    Other literature type . 2016
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      Biblos-e Archivo
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  • Authors: F. Calegari, A. Trabattoni, E. Månsson, J. B. Greenwood, P. Decleva, F. Martìn, M. Nisoli;
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    Authors: Ivo Feussner; KRZYSZTOF ZIENKIEWICZ;

    Oleaginous microalgae are promising sources of energy-rich triacylglycerols (TAGs) for direct use for food, feed and industrial applications. Lobosphaera incisa is a fresh water unicellular alga, which in response to nutrient stress accumulates a high amount of TAGs with a high proportion of arachidonic acid (ARA). The final committed step of de novo TAG biosynthesis is catalyzed by acyl-CoA:diacylglycerol acyltransferases (DGATs), which add a fatty acid (FA) to the final sn-3 position of diacylglycerol (DAG). Genome analysis revealed the presence of five putative DGAT isoforms in L. incisa, including one DGAT of type 1, three DGATs of type 2 and a single isoform of a type 3 DGAT. For LiDGAT1, LiDGAT2.1, LiDGAT2.2 and LiDGAT2.3 enzyme activity was confirmed by expressing them in the TAG-deficient yeast strain H1246. Feeding experiments of yeast transformants with fatty acids suggest a broad substrate specificity spectrum for LiDGAT1. A significant TAG production in response to exogenous ARA was found for LiDGAT2.2. Cellular localization of the four type 1 and type 2 DGATs expressed in yeast revealed that they all localize to distinct ER domains. A prominent association of LiDGAT1 with ER domains in close proximity to forming lipid droplets (LDs) was also observed. The data revealed a distinct molecular, functional and cellular nature of type 1 and type 2 DGATs from L. incisa, with LiDGAT1 being a major contributor to the TAG pool. LiDGATs of type 2 might be in turn involved in the incorporation of unusual fatty acids into TAG and thus regulate the composition of TAG. This report provides a valuable resource for the further research of microalgae DGATs oriented towards production of fresh-water strains with higher oil content of valuable composition, not only for oil industry but also for human and animal nutrition.

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    OpenAPC Global Initiative; BMC Plant Biology
    Article . Conference object . 2018
    License: CC BY
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    BMC Plant Biology
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    License: CC BY
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ OpenAPC Global Initi...arrow_drop_down
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      OpenAPC Global Initiative; BMC Plant Biology
      Article . Conference object . 2018
      License: CC BY
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      BMC Plant Biology
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Magalhães, Renan B.; Masó-Ferrando, Andreu; Bombacigno, Flavio; Olmo, Gonzalo J.; +1 Authors

    We construct a general class of modified Ellis wormholes, where one asymptotic Minkowski region is replaced by a bounded 2-sphere core, characterized by asymptotic finite areal radius. We pursue an in-depth analysis of the resulting geometry, outlining that geodesic completeness is guaranteed also when the radial function asymptotically shrinks to zero. Then, we study the evolution of scalar perturbations, bringing out how these geometric configurations can in principle affect the time-domain profiles of quasinormal modes, pointing out the distinctive features with respect to other black holes or wormholes geometries.

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    https://doi.org/10.48550/arxiv...
    Article . 2023
    License: CC BY
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      https://doi.org/10.48550/arxiv...
      Article . 2023
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    Authors: Stephen D. Lawn; Andrew D. Kerkhoff; Rosie Burton; Charlotte Schutz; +5 Authors

    Abstract Background Autopsy studies of HIV/AIDS-related hospital deaths in sub-Saharan Africa reveal frequent failure of pre-mortem diagnosis of tuberculosis (TB), which is found in 34–64 % of adult cadavers. We determined the overall prevalence and predictors of TB among consecutive unselected HIV-positive adults requiring acute hospital admission and the comparative diagnostic yield obtained by screening urine and sputum samples obtained on day 1 of admission with Xpert MTB/RIF (Xpert). Methods To determine overall TB prevalence accurately, comprehensive clinical sampling (sputum, urine, blood plus other relevant samples) was done and TB was defined by detection of Mycobacterium tuberculosis in any sample using Xpert and/or mycobacterial liquid culture. To evaluate a rapid screening strategy, we compared the diagnostic yield of Xpert testing sputum samples and urine samples obtained with assistance from a respiratory study nurse in the first 24 h of admission. Results Unselected HIV-positive acute adult new medical admissions (n = 427) who were not receiving TB treatment were enrolled irrespective of clinical presentation or symptom profile. From 2,391 cultures and Xpert tests done (mean, 5.6 tests/patient) on 1,745 samples (mean, 4.1 samples/patient), TB was diagnosed in 139 patients (median CD4 cell count, 80 cells/μL). TB prevalence was very high (32.6 %; 95 % CI, 28.1–37.2 %; 139/427). However, patient symptoms and risk factors were poorly predictive for TB. Overall, ≥1 non-respiratory sample(s) tested positive in 115/139 (83 %) of all TB cases, including positive blood cultures in 41/139 (29.5 %) of TB cases. In the first 24 h of admission, sputum (spot and/or induced samples) and urine were obtainable from 37.0 % and 99.5 % of patients, respectively (P <0.001). From these, the proportions of total TB cases (n = 139) that were diagnosed by Xpert testing sputum, urine or both sputum and urine combined within the first 24 h were 39/139 (28.1 %), 89/139 (64.0 %) and 108/139 (77.7 %) cases, respectively (P <0.001). Conclusions The very high prevalence of active TB and its non-specific presentation strongly suggest the need for routine microbiological screening for TB in all HIV-positive medical admissions in high-burden settings. The incremental diagnostic yield from Xpert testing urine was very high and this strategy might be used to rapidly screen new admissions, especially if sputum is difficult to obtain.

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    Europe PubMed Central
    Article . 2015
    Data sources: PubMed Central
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    CORE (RIOXX-UK Aggregator)
    Article . 2015
    License: CC BY
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    OpenUCT; BMC Medicine
    Other literature type . Article . 2015
    License: Springer TDM
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      Other literature type . Article . 2015
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    Authors: Marcello Graziano; Maurizio Fiaschetti; Carol Atkinson-Palombo;

    Abstract Building upon recent literature, we combine a novel spatiotemporal variable with spatial methods to investigate and quantify the influence of the built environment and jurisdictional boundaries on spatial peer-effects (SPEs) in inner-city areas. We focus on the Hartford Capital region, using detailed data at block-group and PV system levels for the years 2005-2013. This region is part of a state, Connecticut, actively engaged in supporting PV system at residential level. Adoption of PV systems varies substantially, and state policies are mediated by town-level regulations. We initially employ typology analysis to investigate the heterogeneity of the block groups with higher adoption rates. We then use panel FE and spatial estimations to determine the existence of spill-overs of SPEs beyond town boundaries. Our estimations suggest that new PV systems have a more limited spatiotemporal influence in inner-cities. We identify spatial spill-overs from neighboring block groups even between towns, suggesting that SPEs transcend municipal barriers. We do not find significant results for built-environment, although we identify several data limitations. Our results suggest that centralized, non-voluntary support policies may have larger effects if implemented beyond town-level, and that SPEs change their determination power depending on the underlying built environment.

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    Energy Research & Social Science
    Article . 2019
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    Authors: Harrison G. Zhang; Arianna Dagliati; Zahra Shakeri Hossein Abad; Xin Xiong; +54 Authors

    AbstractThe risk profiles of post-acute sequelae of COVID-19 (PASC) have not been well characterized in multi-national settings with appropriate controls. We leveraged electronic health record (EHR) data from 277 international hospitals representing 414,602 patients with COVID-19, 2.3 million control patients without COVID-19 in the inpatient and outpatient settings, and over 221 million diagnosis codes to systematically identify new-onset conditions enriched among patients with COVID-19 during the post-acute period. Compared to inpatient controls, inpatient COVID-19 cases were at significant risk for angina pectoris (RR 1.30, 95% CI 1.09–1.55), heart failure (RR 1.22, 95% CI 1.10–1.35), cognitive dysfunctions (RR 1.18, 95% CI 1.07–1.31), and fatigue (RR 1.18, 95% CI 1.07–1.30). Relative to outpatient controls, outpatient COVID-19 cases were at risk for pulmonary embolism (RR 2.10, 95% CI 1.58–2.76), venous embolism (RR 1.34, 95% CI 1.17–1.54), atrial fibrillation (RR 1.30, 95% CI 1.13–1.50), type 2 diabetes (RR 1.26, 95% CI 1.16–1.36) and vitamin D deficiency (RR 1.19, 95% CI 1.09–1.30). Outpatient COVID-19 cases were also at risk for loss of smell and taste (RR 2.42, 95% CI 1.90–3.06), inflammatory neuropathy (RR 1.66, 95% CI 1.21–2.27), and cognitive dysfunction (RR 1.18, 95% CI 1.04–1.33). The incidence of post-acute cardiovascular and pulmonary conditions decreased across time among inpatient cases while the incidence of cardiovascular, digestive, and metabolic conditions increased among outpatient cases. Our study, based on a federated international network, systematically identified robust conditions associated with PASC compared to control groups, underscoring the multifaceted cardiovascular and neurological phenotype profiles of PASC.

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    npj Digital Medicine
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  • Authors: Linford J. B. Briant, Quan Zhang, Elisa Vergari, Joely A. Kellard, Blanca Rodriguez, Frances M. Ashcroft, Patrik Rorsman;
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    Authors: van Drooge, Barend L.; Sicard, Michaël; Stohl, Andreas; Fontal, Marta; +5 Authors

    The combined use of chemical analysis of organic molecules in atmospheric aerosols (PM1) collected in situ in Barcelona and optical measurements with a light detection and ranging (LIDAR) instrument allowed the characterization of the smoke plume from a wildfire that reached the city in July 2012. Analysis of the chemical composition of the aerosols collected on 23 July 2012 confirmed the large effect of biomass burning on urban air quality during a period of several hours. Typical biomass burning tracers, such as levoglucosan, dehydroabietic acid and polycyclic aromatic hydrocarbons (PAH) were enhanced at the same time as the aerosol concentrations in the boundary layer increased. According to air-mass trajectory modeling, the biomass burning particles originated from a severe wildfire burning 120 km northeast of the city. On the following days, no significant contribution of wildfire smoke was found in the urban air, although the lidar detected particles aloft. A Lagrangian particle dispersion model (FLEXPART) was used to simulate the transport of aerosols (PM2.5) and carbon monoxide (CO), and the simulated concentrations in Barcelona were compared to in-situ measurements. FLEXPART simulated the onset of the wildfire smoke plume event in the urban center in the early morning of 23 July successfully; by contrast, the fast passage of the plume at the surface and the decoupling of the cleaner boundary layer from the persistent smoke plume aloft was not well captured. This was attributed to the fact that the model did not capture the local sea-breeze circulation well enough. Peer Reviewed

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    Atmospheric Pollution Research
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      Atmospheric Pollution Research
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  • Authors: Elisabeth Maritschnegg; Nicole Heinzl; Stuart Wilson; Simon Deycmar; +6 Authors

    A growing number of diseases are being linked to protein misfolding and amyloid formation. Recently, p53 was also shown to associate into amyloid aggregates, raising the question of whether cancer development is associated with protein aggregation as well. However, a lack of suitable tools has hampered the evaluation of their clinical relevance. Herein, we report an enzyme-linked-immunosorbent-assay (ELISA) system based on a polyionic, high-molecular-weight ligand that specifically captures aggregated oligomers and amyloid proteins. We proved that naturally occurring tetramers of p53 are not bound, but high-molecular-weight aggregates are bound and subsequently detected. For the first time, this assay allows the quantitative detection of p53 aggregates from cell lysates, which was demonstrated using 22 ovarian-cancer cell lines as well as 7 patient-derived tumor tissues. The levels of p53 aggregates within the missense-mutated tissue samples varied more than 12-fold. This simple, robust method allows studying the abundance and clinical relevance of protein aggregates. This could help our understanding of the role of protein misfolding in cancer or even in predicting therapy responses to aggregation-targeting drugs.

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    Authors: Aaboud, M.; ATLAS Collaboration; Barreiro Alonso, Fernando; Calvente López, S.; +5 Authors

    We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, the Canada Council, CANARIE, CRC, Compute Canada, FQRNT, and the Ontario Innovation Trust, Canada; EPLANET, ERC, FP7, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d’Avenir Labex and Idex, ANR, Région Auvergne and Fondation Partager le Savoir, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF; BSF, GIF and Minerva, Israel; BRF, Norway; Generalitat de Catalunya, Generalitat Valenciana, Spain; the Royal Society and Leverhulme Trust, United Kingdom Measurements of the jet activity in tt¯ events produced in proton-proton collisions at √ s = 8 TeV are presented, using 20.3 fb−1 of data collected by the ATLAS experiment at the Large Hadron Collider. The events were selected in the dilepton eµ decay channel with two identified b-jets. The numbers of additional jets for various jet transverse momentum (pT) thresholds, and the normalised differential cross-sections as a function of pT for the five highest-pT additional jets, were measured in the jet pseudorapidity range |η| < 4.5. The gap fraction, the fraction of events which do not contain an additional jet in a central rapidity region, was measured for several rapidity intervals as a function of the minimum pT of a single jet or the scalar sum of pT of all additional jets. These fractions were also measured in different intervals of the invariant mass of the eµb¯b system. All measurements were corrected for detector effects, and found to be mostly well-described by predictions from next-to-leading-order and leading-order tt¯ event generators with appropriate parameter choices. The results can be used to further optimise the parameters used in such generators Artículo escrito por muchos autores, sólo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración y los autores que firman como pertenecientes a la UAM Journal of High Energy Physics 2016.9 (2016): 074 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Biblos-e Archivo
      Other literature type . 2016
      Data sources: Biblos-e Archivo