handle: 11562/1125564 , 10278/3727121 , 11384/104844
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handle: 11562/1021961
Schedatura e metadatazione dei contenuti delle carte inerenti il corso del torrente Parma nel fondo archivistico Amministrazione Fabbriche, Acque e Strade dell'Archivio di Stato di Parma
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The Covid-19 pandemic caused by the novel coronavirus SARS-CoV-2 has completely reshaped the lives of people around the world, including higher education students. Beyond serious health consequences for a proportion of those directly affected by the virus, the pandemic holds important implications for the life and work of higher education students, considerably affecting their physical and mental well-being. To capture how students perceived the first wave of the pandemic���s impact, one of the most comprehensive and large-scale online surveys across the world was conducted. Carried out between 5 May 2020 and 15 June 2020, the survey came at a time when most countries were experiencing the arduous lockdown restrictions. The online questionnaire was prepared in seven different languages (English, Italian, North Macedonian, Portuguese, Romanian, Spanish, Turkish) and covered various aspects of higher education students��� life, including socio-demographic and academic characteristics, academic life, infrastructure and skills for studying from home, social life, emotional life and life circumstances. Using the convenience sampling method, the online questionnaire was distributed to higher education students (aged 18 and over) and enrolled in a higher education institution. The final dataset consisted of 31,212 responses from 133 countries and 6 continents. The data may prove useful for researchers studying the pandemic���s impacts on various aspects of student life. Policymakers can utilize the data to determine the best solutions as they formulate policy recommendations and strategies to support students during this and any future pandemic. Acknowledgments: The extensive dataset could not be collected without the numerous international partners who provided the exceptional assistance with questionnaire translation and/or data collection. This work also acknowledges the international partners, who may have been unintentionally omitted from authorship due to the snowball recruitment technique. Special thanks go also to anonymous global survey participants for their valuable insights into the lives of students, which they shared selflessly. The authors also acknowledge the CovidSocLab project (http://www.covidsoclab.org/) as a working platform for international collaboration. Funding: The authors acknowledge the financial support from the Slovenian Research Agency (research core funding No. P5-0093).
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citations | 1 | |
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handle: 11562/1025999
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handle: 11562/1012128 , 11572/285733 , 11577/3254618 , 11382/535804
In the context of finite elasticity, we propose plate models describing the spontaneous bending of nematic elastomer thin films due to variations along the thickness of the nematic order parameters. Reduced energy functionals are deduced from a three-dimensional description of the system using rigorous dimension reduction techniques, based on the theory of Γ-convergence. The two-dimensional models are non-linear plate theories, in which deviations from a characteristic target curvature tensor cost elastic energy. Moreover, the stored energy functional cannot be minimised to zero, thus revealing the presence of residual stresses, as observed in numerical simulations. Three nematic textures are considered: splay-bend and twisted orientations of the nematic director, and a uniform director perpendicular to the mid-plane of the film, with variable degree of nematic order along the thickness. These three textures realise three very different structural models: one with only one stable spontaneously bent configuration, a bistable model with two oppositely curved configurations of minimal energy, and a shell with zero stiffness to twisting.
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citations | 32 | |
popularity | Top 10% | |
influence | Top 10% | |
impulse | Top 10% |
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The TCMP-1 and TCMP-2 genes of tomato code for metallocarboxypeptidase inhibitors and show sequential, tightly regulated expression patterns during flower and fruit development. In particular, TCMP-1 is highly expressed in flower buds before anthesis, while TCMP-2 in ripe fruits. Their expression pattern suggests that they might play a role in fruit development. Here, to investigate their function, we altered their endogenous levels by generating transgenic plants harbouring a chimeric gene expressing the TCMP-1 coding sequence under the control of the TCMP-2 promoter. The expression of the transgene caused an earlier fruit setting with no visible phenotypic effects on plant and fruit growth. The altered TCMP-1 regulation determines an increased level of TCMP-1 in the fruit and unexpected changes in the levels of both TCMPs in flower buds before anthesis, suggesting a mechanism of transcriptional cross-regulation. We in silico analysed TCMPs promoter regions for the presence of common cis acting elements related to ovary/fruit development and we found that both promoters contain putative binding sites for INNER NO OUTER (INO), a transcription factor implicated in ovule development. By chromatin immunoprecipitation, we proved that INO binds to TCMP-1 and TCMP-2 promoters, thereby representing a candidate regulatory factor for coordinated control of TCMPs.
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citations | 11 | |
popularity | Average | |
influence | Average | |
impulse | Top 10% |
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handle: 11562/333047
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handle: 11562/309470 , 11585/964985
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pmid: 24882262
handle: 10281/205545 , 11562/914986 , 10807/230039 , 11573/912795
The toxicity and efficacy of intrathecal liposomal cytarabine (LC) were evaluated in children with central nervous system (CNS) relapsed/refractory acute leukemia/lymphoma. Thirty patients (male:female ratio 21:9; median age 9.4 years) with CNS relapsed/resistant disease were treated with intrathecal LC at dosages adjusted for age. Twenty-seven (90%) patients simultaneously received systemic chemotherapy, including concurrent high-dose cytarabine or methotrexate in 21 (70%) cases. Of 28 patients evaluable for response, 25 patients (89%) achieved CNS complete remission and three (11%) partial remission. The median number of intrathecal LC administrations per patient was 4. The cerebrospinal fluid was cleared after a median of 3 intrathecal LC administrations. Neurological toxicity ≥ grade 3 occurred in four (13%) patients. No permanent sequelae were observed. The median overall survival was 20.9 months and the 5-year probability of survival was 46%. These encouraging data suggest that intrathecal LC is well tolerated and effective in children with relapsed/refractory CNS leukemia/lymphoma.
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citations | 8 | |
popularity | Top 10% | |
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doi: 10.3233/sji-200644
handle: 11562/1106586 , 11585/821700
Big Data and the ‘Internet of Things’ are transforming the processes of data collection, storage and use. The relationship between data collected first hand (primary data) and data collected by someone else (secondary data) is becoming more fluid. New possibilities for data collection are envisaged. Data integration is emerging as a reliable strategy to overcome data shortage and other challenges such as data coverage, quality, time dis-alignment and representativeness. When we have two (or more) data sources where the units are not (at least partially) overlapping and/or the units’ unique identifiers are unavailable, the different information collected can be integrated by using Micro Statistical Matching (MiSM). MiSM has been used in the social sciences, politics and economics, but there are very few applications that use agricultural and farm data. We present an example of MiSM data integration between primary and secondary farm data on agricultural holdings in the Emilia-Romagna region (Italy). The novelty of the work lies in the fact that integration is carried out with non-parametric MiSM, which is compared to predictive mean matching and Bayesian linear regression. Moreover, the matching validity is assessed with a new strategy. The main issues addressed, the lessons learned and the use in a research field characterised by critical data shortage are discussed.
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handle: 11562/1125564 , 10278/3727121 , 11384/104844
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handle: 11562/1021961
Schedatura e metadatazione dei contenuti delle carte inerenti il corso del torrente Parma nel fondo archivistico Amministrazione Fabbriche, Acque e Strade dell'Archivio di Stato di Parma
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citations | 0 | |
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