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Additional file 7: Figure S3. Schematic representation of the construction of the vector pool.

Evidence for Higgs boson decay to a pair of muons is presented. This result combines searches in four exclusive categories targeting the production of the Higgs boson via gluon fusion, via vector boson fusion, in association with a vector boson, and in association with a top quark-antiquark pair. The analysis is performed using proton-proton collision data at s√ = 13 TeV, corresponding to an integrated luminosity of 137 fb−1, recorded by the CMS experiment at the CERN LHC. An excess of events over the back- ground expectation is observed in data with a significance of 3.0 standard deviations, where the expectation for the standard model (SM) Higgs boson with mass of 125.38 GeV is 2.5. The combination of this result with that from data recorded at s√ = 7 and 8 TeV, corresponding to integrated luminosities of 5.1 and 19.7 fb−1, respectively, increases both the expected and observed significances by 1%. The measured signal strength, relative to the SM prediction, is 1.19+0.40−0.39(stat)+0.15−0.14(syst). This result constitutes the first evidence for the decay of the Higgs boson to second generation fermions and is the most precise measurement of the Higgs boson coupling to muons reported to date. Individuals have received support from the Marie-Curie programme and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 752730, and 765710 (European Union); the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2015-0509 and the Programa Severo Ochoa del Principado de Asturias. CMS collaboration: et al. Peer reviewed

We study the type-I seesaw model with three right-handed neutrinos and Majorana masses below the pion mass. In this mass range, the model parameter space is not only strongly constrained by the requirement to explain the light neutrino masses, but also by experimental searches and cosmological considerations. In the existing literature, three disjoint regions of potentially viable parameter space have been identified. In one of them, all heavy neutrinos decay shortly before big bang nucleosynthesis. In the other two regions, one of the heavy neutrinos either decays between BBN and the CMB decoupling or is quasi-stable. We show that previously unaccounted constraints from photodisintegration of nuclei practically rule out all relevant decays that happen between BBN and the CMB decoupling. Quite remarkably, if all heavy neutrinos decay before BBN, the baryon asymmetry of the universe can be quite generically explained by low-scale leptogenesis, i.e. without further tuning in addition to what is needed to avoid experimental and cosmological constraints. This motivates searches for heavy neutrinos in pion decay experiments. Journal of high energy physics 01(1), 200 (2021). doi:10.1007/JHEP01(2021)200 Published by SISSA, [Trieste]

Supplementary Figures 1â 8, Supplementary Table 2. (PDF 760 kb)

A search for charged Higgs boson decaying to a charm and a bottom quark ( $ {\mathrm{H}}^{+}\to \mathrm{c}\overline{\mathrm{b}} $ ) is performed using 19.7 fb$^{−1}$ of pp collision data at $ \sqrt{s}=8 $ TeV. The production mechanism investigated in this search is $ \mathrm{t}\overline{\mathrm{t}} $ pair production in which one top quark decays to a charged Higgs boson and a bottom quark and the other decays to a charged lepton, a neutrino, and a bottom quark. Charged Higgs boson decays to $ \mathrm{c}\overline{\mathrm{b}} $ are searched for, resulting in a final state containing at least four jets, a charged lepton (muon or electron), and missing transverse momentum. A kinematic fit is performed to identify the pair of jets least likely to be the bottom quarks originating from direct top quark decays and the invariant mass of this pair is used as the final observable in the search. No evidence for the presence of a charged Higgs boson is observed and upper limits at 95% confidence level of 0.8–0.5% are set on the branching fraction ℬ(t → H$^{+}$b), assuming ℬ(H$^{+}$ → $ \mathrm{c}\overline{\mathrm{b}} $ ) = 1.0 and ℬ(t → H$^{+}$b) + ℬ(t → Wb) = 1.0, for the charged Higgs boson mass range 90–150 GeV. Journal of high energy physics 1811(11), 115 (2018). doi:10.1007/JHEP11(2018)115 Published by Springer Nature, Cham

Measurements of the second Fourier harmonic coefficient (v2) of the azimuthal distributions of prompt and nonprompt D0 mesons produced in pp and pPb collisions are presented. Nonprompt D0 mesons come from beauty hadron decays. The data samples are collected by the CMS experiment at nucleon-nucleon center-of-mass energies of 13 and 8.16 TeV, respectively. In high multiplicity pp collisions, v2 signals for prompt charm hadrons are reported for the first time, and are found to be comparable to those for light-flavor hadron species over a transverse momentum (pT) range of 2–6 GeV. Compared at similar event multiplicities, the prompt D0 meson v2 values in pp and pPb collisions are similar in magnitude. The v2 values for open beauty hadrons are extracted for the first time via nonprompt D0 mesons in pPb collisions. For pT in the range of 2–5 GeV, the results suggest that v2 for nonprompt D0 mesons is smaller than that for prompt D0 mesons. These new measurements indicate a positive charm hadron v2 in pp collisions and suggest a mass dependence in v2 between charm and beauty hadrons in the pPb system. These results provide insights into the origin of heavy-flavor quark collectivity in small systems. Individuals have received support from the Marie-Curie program and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 752730, and 765710 (European Union); CERN; the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2015-0509 and the Programa Severo Ochoa del Principado de Asturias. CMS Collaboration: et al. Funded by SCOAP3. Peer reviewed

Thyroid hormone parameters and components of the metabolic syndrome â men. Thyroid hormone parameters and components of the metabolic syndrome for TSH, FT4, TF3 and FT3FT4 quartiles, respectively, separately for men only. (DOCX 11Â kb)

A search for the standard model Higgs boson produced in association with a W or a Z boson and decaying to a pair of τ leptons is performed. A data sample of proton-proton collisions collected at s√ = 13 TeV by the CMS experiment at the CERN LHC is used, corresponding to an integrated luminosity of 35.9 fb−1. The signal strength is measured relative to the expectation for the standard model Higgs boson, yielding μ = 2.5 − 1.3 + 1.4 . These results are combined with earlier CMS measurements targeting Higgs boson decays to a pair of τ leptons, performed with the same data set in the gluon fusion and vector boson fusion production modes. The combined signal strength is μ = 1.24 − 0.27 + 0.29 (1.00 − 0.23 + 0.24 expected), and the observed significance is 5.5 standard deviations (4.8 expected) for a Higgs boson mass of 125 GeV. Journal of High Energy Physics, 2019 (6) ISSN:1029-8479 ISSN:1126-6708

Transcriptional expression of DUX4 target genes and the PCDHγ cluster in SMCHD1 KD 4qB cell lines. RNA expression analysis of (A) the DUX4 target genes ZSCAN4 and LEUTX in primary myotubes and the PCDHγ cluster isoform members in primary (B) myoblast and (C) myotube cells after SMCHD1 shRNA KD or control shRNA KD targeting luciferase and GFP. Results represent qRT-PCR analysis of the indicated gene after normalization to the internal control gene GUS1. For each gene, the value of expression in control shRNA samples was then arbitrarily set to 1. *Bonferroni adjusted P 

EVs count and characterization by NTA and Flow cytometry. Variables are expressed as minimum, first quartile, median, third quartile, maximum. (PDF 343Â kb)