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  • Open Access English
    Authors: 
    Maria Teresa Valenti; Luca Dalle Carbonare; Donato Zipeto; Monica Mottes;
    Country: Italy

    Autophagy is involved in different degenerative diseases and it may control epigenetic modifications, metabolic processes, stem cells differentiation as well as apoptosis. Autophagy plays a key role in maintaining the homeostasis of cartilage, the tissue produced by chondrocytes; its impairment has been associated to cartilage dysfunctions such as osteoarthritis (OA). Due to their location in a reduced oxygen context, both differentiating and mature chondrocytes are at risk of premature apoptosis, which can be prevented by autophagy. AutophagomiRNAs, which regulate the autophagic process, have been found differentially expressed in OA. AutophagomiRNAs, as well as other regulatory molecules, may also be useful as therapeutic targets. In this review, we describe and discuss the role of autophagy in OA, focusing mainly on the control of autophagomiRNAs in OA pathogenesis and their potential therapeutic applications.

  • Open Access Italian
    Authors: 
    Residori, Sonia;
    Country: Italy
  • Open Access English
    Authors: 
    Laura Bertolasi; Alessandra Danese; Salvatore Monaco; Mara Turri; K. Borg; L. Werhagen;
    Publisher: Bentham Open
    Country: Italy

    Background:Poliomyelitis was before the immunization an important medical problem. Nowadays polio prior patients (PP) suffer from polio sequelae or have developed post-polio-syndrome (PPS) with increasing paresis, pain and fatigue.Objectives:To analyze the medical situation 50 years after acute polio. The degree of paresis was compared between the recovery 1952-1961 and 2012.The prevalence of patients fulfilling the criteria for PPS was estimatedMethod:The study was performed in Italy. Included were PP with rehabilitation after acute polio 1952-1961 and in 2012. During the years PP underwent yearly evaluation. A thorough neurological examination was performed in 2012. A telephone interview with questions concerning pain, paresis, fatigue, walking aids and concomitant diseases was performed in 2012. The patients were divided in two groups, if they fulfilled the criteria for PPS or not.Results:Included were 67(94%) patients receiving rehabilitation after acute poliomyelitis and 2012. 78% were walkers, half of the PPS used wheelchair. Eight out of ten suffered from pain. Four out of ten fulfilled the PPS criteria. Pain was slightly more common in PPS.Conclusion:Female gender, fatigue and wheelchair dependency were significantly more common in PPS while pain was common in both groups.

  • Open Access English
    Authors: 
    Serena De Lucia; Ioannis Tsamesidis; Maria Carmina Pau; Kristina R. Kesely; Antonella Pantaleo; Francesco Michelangelo Turrini;
    Publisher: Public Library of Science (PLoS)
    Country: Italy

    Artemisinin resistance is a major threat to malaria control efforts. Resistance is characterized by an increase in the Plasmodium falciparum parasite clearance half-life following treatment with artemisinin-based combination therapies (ACTs) and an increase in the percentage of surviving parasites. The remarkably short blood half-life of artemisinin derivatives may contribute to drug-resistance, possibly through factors including sub-lethal plasma concentrations and inadequate exposure. Here we selected for a new strain of artemisinin resistant parasites, termed the artemisinin resistant strain 1 (ARS1), by treating P. falciparum Palo Alto (PA) cultures with sub-lethal concentrations of dihydroartemisinin (DHA). The resistance phenotype was maintained for over 1 year through monthly maintenance treatments with low doses of 2.5 nM DHA. There was a moderate increase in the DHA IC50 in ARS1 when compared with parental strain PA after 72 h of drug exposure (from 0.68 nM to 2 nM DHA). In addition, ARS1 survived treatment physiologically relevant DHA concentrations (700 nM) observed in patients. Furthermore, we confirmed a lack of cross-resistance against a panel of antimalarials commonly used as partner drugs in ACTs. Finally, ARS1 did not contain Pfk13 propeller domain mutations associated with ART resistance in the Greater Mekong Region. With a stable growth rate, ARS1 represents a valuable tool for the development of new antimalarial compounds and studies to further elucidate the mechanisms of ART resistance.

  • Open Access English
    Authors: 
    Pietro Ariani; Alice Regaiolo; Arianna Lovato; Alejandro Giorgetti; Andrea Porceddu; Salvatore Camiolo; Darren Wong; Simone D. Castellarin; Elodie Vandelle; Annalisa Polverari;
    Publisher: Nature Publishing Group
    Country: Italy

    The Arabidopsis Toxicos en Levadura (ATL) protein family is a class of E3 ubiquitin ligases with a characteristic RING-H2 Zn-finger structure that mediates diverse physiological processes and stress responses in plants. We carried out a genome-wide survey of grapevine (Vitis vinifera L.) ATL genes and retrieved 96 sequences containing the canonical ATL RING-H2 domain. We analysed their genomic organisation, gene structure and evolution, protein domains and phylogenetic relationships. Clustering revealed several clades, as already reported in Arabidopsis thaliana and rice (Oryza sativa), with an expanded subgroup of grapevine-specific genes. Most of the grapevine ATL genes lacked introns and were scattered among the 19 chromosomes, with a high level of duplication retention. Expression profiling revealed that some ATL genes are expressed specifically during early or late development and may participate in the juvenile to mature plant transition, whereas others may play a role in pathogen and/or abiotic stress responses, making them key candidates for further functional analysis. Our data offer the first genome-wide overview and annotation of the grapevine ATL family, and provide a basis for investigating the roles of specific family members in grapevine physiology and stress responses, as well as potential biotechnological applications.

  • Publication . Conference object . 2017
    Open Access Italian
    Authors: 
    Ceglie, Sara.; Ferreri, Corrado.; Forlani, Olga.; Morandini, Pierpaolo; Pasquali, Silvano.; Vicentini, Diego.;
    Publisher: Media Touch 2000 srl
    Country: Italy
  • Publication . Conference object . Part of book or chapter of book . 2018
    Open Access English
    Authors: 
    Florian Daniel; Maristella Matera; Elisa Quintarelli; Letizia Tanca; Vittorio Zaccaria;
    Publisher: Springer Verlag
    Country: Italy
    Project: EC | IT2RAIL (636078)

    Current scenarios for app development are characterized by rich resources that often overwhelm the final users, especially in mobile app usage situations. It is therefore important to define design methods that enable dynamic filtering of the pertinent resources and appropriate tailoring of the retrieved content. This paper presents a design framework based on the specification of the possible contexts deemed relevant to a given application domain and on their mapping onto an integrated schema of the resources underlying the app. The context and the integrated schema enable the instantiation at runtime of templates of app pages in function of the context characterizing the user’s current situation of use.

  • Open Access
    Authors: 
    Jennifer Kube; Nicole Ebner; Ewa A. Jankowska; Piotr Rozentryt; Mariantonietta Cicoira; Gerasimos Filippatos; Piotr Ponikowski; Wolfram Doehner; Stefan D. Anker; Stephan von Haehling;
    Publisher: Elsevier BV
    Country: Italy

    Abstract Background Natriuretic peptides play an important role in the diagnosis and risk stratification of patients with acute and chronic heart failure. Multiple studies have shown that these peptides are liable to the influence of individual factors. For N-terminal-pro-B-type natriuretic peptide (NT-proBNP) some of these confounding factors have been evaluated over the years such as age, gender, New York Heart Association (NYHA) class and body mass index (BMI). The aim of this study was to establish confounding factors of mid-regional pro-atrial natriuretic peptide (MR-proANP) assessment. Methods and results We studied 684 patients (94% male, age 61.2±11.2, left ventricular ejection fraction [LVEF] 2 , mean MR-proANP 296.0±281.0pmol/L, mean NT-proBNP 2792.0±5328.6pg/mL, mean creatinine level 110.2±38.0μmol/L and mean haemoglobin 13.9±1.5g/dL) with clinically stable chronic heart failure. MR-proANP levels increased with increasing NYHA class (p Conclusion MR-proANP is subject to the almost identical influencing factors like NT-proBNP. The effects of anaemia warrant further study.

  • Open Access English
    Authors: 
    DE MARCHI, Sergio; Dima, Francesco; Rigoni, Annamaria; Prior, Manlio; Rulfo, F.; Saracino, Laura; Arosio, Enrico;
    Country: Italy
  • Publication . Part of book or chapter of book . 2017
    Open Access English
    Authors: 
    Berloffa, Gabriella; Matteazzi, Eleonora; Mazzolini, Gabriele; Şandor, Alina; Villa, Paola;
    Country: Italy
Advanced search in
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6,596 Research products, page 1 of 660
  • Open Access English
    Authors: 
    Maria Teresa Valenti; Luca Dalle Carbonare; Donato Zipeto; Monica Mottes;
    Country: Italy

    Autophagy is involved in different degenerative diseases and it may control epigenetic modifications, metabolic processes, stem cells differentiation as well as apoptosis. Autophagy plays a key role in maintaining the homeostasis of cartilage, the tissue produced by chondrocytes; its impairment has been associated to cartilage dysfunctions such as osteoarthritis (OA). Due to their location in a reduced oxygen context, both differentiating and mature chondrocytes are at risk of premature apoptosis, which can be prevented by autophagy. AutophagomiRNAs, which regulate the autophagic process, have been found differentially expressed in OA. AutophagomiRNAs, as well as other regulatory molecules, may also be useful as therapeutic targets. In this review, we describe and discuss the role of autophagy in OA, focusing mainly on the control of autophagomiRNAs in OA pathogenesis and their potential therapeutic applications.

  • Open Access Italian
    Authors: 
    Residori, Sonia;
    Country: Italy
  • Open Access English
    Authors: 
    Laura Bertolasi; Alessandra Danese; Salvatore Monaco; Mara Turri; K. Borg; L. Werhagen;
    Publisher: Bentham Open
    Country: Italy

    Background:Poliomyelitis was before the immunization an important medical problem. Nowadays polio prior patients (PP) suffer from polio sequelae or have developed post-polio-syndrome (PPS) with increasing paresis, pain and fatigue.Objectives:To analyze the medical situation 50 years after acute polio. The degree of paresis was compared between the recovery 1952-1961 and 2012.The prevalence of patients fulfilling the criteria for PPS was estimatedMethod:The study was performed in Italy. Included were PP with rehabilitation after acute polio 1952-1961 and in 2012. During the years PP underwent yearly evaluation. A thorough neurological examination was performed in 2012. A telephone interview with questions concerning pain, paresis, fatigue, walking aids and concomitant diseases was performed in 2012. The patients were divided in two groups, if they fulfilled the criteria for PPS or not.Results:Included were 67(94%) patients receiving rehabilitation after acute poliomyelitis and 2012. 78% were walkers, half of the PPS used wheelchair. Eight out of ten suffered from pain. Four out of ten fulfilled the PPS criteria. Pain was slightly more common in PPS.Conclusion:Female gender, fatigue and wheelchair dependency were significantly more common in PPS while pain was common in both groups.

  • Open Access English
    Authors: 
    Serena De Lucia; Ioannis Tsamesidis; Maria Carmina Pau; Kristina R. Kesely; Antonella Pantaleo; Francesco Michelangelo Turrini;
    Publisher: Public Library of Science (PLoS)
    Country: Italy

    Artemisinin resistance is a major threat to malaria control efforts. Resistance is characterized by an increase in the Plasmodium falciparum parasite clearance half-life following treatment with artemisinin-based combination therapies (ACTs) and an increase in the percentage of surviving parasites. The remarkably short blood half-life of artemisinin derivatives may contribute to drug-resistance, possibly through factors including sub-lethal plasma concentrations and inadequate exposure. Here we selected for a new strain of artemisinin resistant parasites, termed the artemisinin resistant strain 1 (ARS1), by treating P. falciparum Palo Alto (PA) cultures with sub-lethal concentrations of dihydroartemisinin (DHA). The resistance phenotype was maintained for over 1 year through monthly maintenance treatments with low doses of 2.5 nM DHA. There was a moderate increase in the DHA IC50 in ARS1 when compared with parental strain PA after 72 h of drug exposure (from 0.68 nM to 2 nM DHA). In addition, ARS1 survived treatment physiologically relevant DHA concentrations (700 nM) observed in patients. Furthermore, we confirmed a lack of cross-resistance against a panel of antimalarials commonly used as partner drugs in ACTs. Finally, ARS1 did not contain Pfk13 propeller domain mutations associated with ART resistance in the Greater Mekong Region. With a stable growth rate, ARS1 represents a valuable tool for the development of new antimalarial compounds and studies to further elucidate the mechanisms of ART resistance.

  • Open Access English
    Authors: 
    Pietro Ariani; Alice Regaiolo; Arianna Lovato; Alejandro Giorgetti; Andrea Porceddu; Salvatore Camiolo; Darren Wong; Simone D. Castellarin; Elodie Vandelle; Annalisa Polverari;
    Publisher: Nature Publishing Group
    Country: Italy

    The Arabidopsis Toxicos en Levadura (ATL) protein family is a class of E3 ubiquitin ligases with a characteristic RING-H2 Zn-finger structure that mediates diverse physiological processes and stress responses in plants. We carried out a genome-wide survey of grapevine (Vitis vinifera L.) ATL genes and retrieved 96 sequences containing the canonical ATL RING-H2 domain. We analysed their genomic organisation, gene structure and evolution, protein domains and phylogenetic relationships. Clustering revealed several clades, as already reported in Arabidopsis thaliana and rice (Oryza sativa), with an expanded subgroup of grapevine-specific genes. Most of the grapevine ATL genes lacked introns and were scattered among the 19 chromosomes, with a high level of duplication retention. Expression profiling revealed that some ATL genes are expressed specifically during early or late development and may participate in the juvenile to mature plant transition, whereas others may play a role in pathogen and/or abiotic stress responses, making them key candidates for further functional analysis. Our data offer the first genome-wide overview and annotation of the grapevine ATL family, and provide a basis for investigating the roles of specific family members in grapevine physiology and stress responses, as well as potential biotechnological applications.

  • Publication . Conference object . 2017
    Open Access Italian
    Authors: 
    Ceglie, Sara.; Ferreri, Corrado.; Forlani, Olga.; Morandini, Pierpaolo; Pasquali, Silvano.; Vicentini, Diego.;
    Publisher: Media Touch 2000 srl
    Country: Italy
  • Publication . Conference object . Part of book or chapter of book . 2018
    Open Access English
    Authors: 
    Florian Daniel; Maristella Matera; Elisa Quintarelli; Letizia Tanca; Vittorio Zaccaria;
    Publisher: Springer Verlag
    Country: Italy
    Project: EC | IT2RAIL (636078)

    Current scenarios for app development are characterized by rich resources that often overwhelm the final users, especially in mobile app usage situations. It is therefore important to define design methods that enable dynamic filtering of the pertinent resources and appropriate tailoring of the retrieved content. This paper presents a design framework based on the specification of the possible contexts deemed relevant to a given application domain and on their mapping onto an integrated schema of the resources underlying the app. The context and the integrated schema enable the instantiation at runtime of templates of app pages in function of the context characterizing the user’s current situation of use.

  • Open Access
    Authors: 
    Jennifer Kube; Nicole Ebner; Ewa A. Jankowska; Piotr Rozentryt; Mariantonietta Cicoira; Gerasimos Filippatos; Piotr Ponikowski; Wolfram Doehner; Stefan D. Anker; Stephan von Haehling;
    Publisher: Elsevier BV
    Country: Italy

    Abstract Background Natriuretic peptides play an important role in the diagnosis and risk stratification of patients with acute and chronic heart failure. Multiple studies have shown that these peptides are liable to the influence of individual factors. For N-terminal-pro-B-type natriuretic peptide (NT-proBNP) some of these confounding factors have been evaluated over the years such as age, gender, New York Heart Association (NYHA) class and body mass index (BMI). The aim of this study was to establish confounding factors of mid-regional pro-atrial natriuretic peptide (MR-proANP) assessment. Methods and results We studied 684 patients (94% male, age 61.2±11.2, left ventricular ejection fraction [LVEF] 2 , mean MR-proANP 296.0±281.0pmol/L, mean NT-proBNP 2792.0±5328.6pg/mL, mean creatinine level 110.2±38.0μmol/L and mean haemoglobin 13.9±1.5g/dL) with clinically stable chronic heart failure. MR-proANP levels increased with increasing NYHA class (p Conclusion MR-proANP is subject to the almost identical influencing factors like NT-proBNP. The effects of anaemia warrant further study.

  • Open Access English
    Authors: 
    DE MARCHI, Sergio; Dima, Francesco; Rigoni, Annamaria; Prior, Manlio; Rulfo, F.; Saracino, Laura; Arosio, Enrico;
    Country: Italy
  • Publication . Part of book or chapter of book . 2017
    Open Access English
    Authors: 
    Berloffa, Gabriella; Matteazzi, Eleonora; Mazzolini, Gabriele; Şandor, Alina; Villa, Paola;
    Country: Italy
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