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52 research outcomes, page 1 of 6
  • publication . Article . 2012
    Open Access
    Authors:
    Cyrus Cooper; Jean-Yves Reginster; Roland Chapurlat; Claus Christiansen; Harry K. Genant; Nicholas Bellamy; William G. Bensen; Federico Navarro; J. Badurski; Nasonov El; ...
    Persistent Identifiers
    Publisher: (:unav)

    Abstract Objective: The osteoporosis drug strontium ranelate dissociates bone remodelling processes. It also inhibits subchondral bone resorption and stimulates cartilage matrix formation in vitro. Exploratory studies in the osteoporosis trials report that strontium ran...

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  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Andrew Lloyd; Katy Gallop; Shehzad Ali; Derralynn Hughes; Alasdair MacCulloch;
    Publisher: TAYLOR & FRANCIS LTD

    Objective: Fabry disease is a rare inherited lysosomal storage disorder caused by deficiency of α-galactosidase A. Effective enzyme replacement therapies are available that are administered intravenously. However, a new oral treatment is being developed as an alternativ...

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  • publication . Article . 2012
    Restricted
    Authors:
    Ross D. Feldman; John M. Flack; L Howes; Trond Jenssen; R Reeves; Harry Shi; M Westergaard; F.D.R. Hobbs; Capable investigators;
    Persistent Identifiers
    Publisher: Informa Healthcare

    OBJECTIVES: To compare the simultaneous reduction of blood pressure (BP) to below 150 mmHg and low-density lipoprotein cholesterol (LDL-C) after treatment with single-pill amlodipine/atorvastatin (SPAA) among younger (<65 years), older (≥65 years) and elderly (≥75 years...

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  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Nadia Lascar; Quratul-ain Altaf; Neil T Raymond; James Brown; Helen M Pattison; Anthony H. Barnett; Clifford J. Bailey; Srikanth Bellary;
    Publisher: Taylor & Francis

    Background: Early onset of type 2 diabetes (T2DM) is associated with prolonged exposure to hyperglycaemia and increased propensity to chronic complications. The aim of this study was to characterize and compare the phenotypic characteristics and risk factors in a multi-...

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  • publication . Article . Review . 2012
    Restricted English
    Authors:
    Cyrus Cooper; Jean-Yves Reginster; Bernard Cortet; M. Diaz-Curiel; Roman Lorenc; John A. Kanis; René Rizzoli;
    Persistent Identifiers
    Publisher: LibraPharm Ltd (GB)

    Introduction: Postmenopausal osteoporosis is a chronic disease requiring treatment that balances long-term fracture efficacy against risk. Methods: We reviewed the efficacy and safety of calcium and vitamin D, the selective estrogen receptor modulators (SERMs), the bisp...

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  • publication . Article . 2018
    Open Access
    Authors:
    Sharmin S. Bala; Hamish A. Jamieson; Prasad S. Nishtala;
    Persistent Identifiers
    Publisher: Informa UK Limited

    Aim To identify factors associated with prescribing potentially inappropriate medications (PIMs) in older adults (≥ 65 years) with complex care needs, who have undertaken a comprehensive geriatric risk assessment.METHODS: A nationwide cross-sectional (retrospective, obs...

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  • publication . Article . 2011
    Open Access
    Authors:
    Linda M. Luxon;
    Publisher: Informa Healthcare

    SummaryAn essential prerequisite to the adequate management of patients with vertigo or dizziness is as full an understanding as possible of the aetiology of the symptom, which is often multi-factorial in origin. Time spent initally on taking a good patient history and ...

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  • publication . Article . Other literature type . 2009
    Open Access English
    Authors:
    Michelle Orme; S. Collins; Helen Dakin; Steven Kelly; Jane Loftus;

    OBJECTIVES: Primary open-angle glaucoma (POAG) is a chronic condition characterised by optic neuropathy and vision loss. Elevated intraocular pressure (IOP) can damage the optic nerve and is a risk factor for glaucoma, thus treatment usually comprises topical hypotensiv...

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  • publication . Article . 2006
    Restricted
    Authors:
    Benjamin J. Ansell; FD Richard Hobbs;
    Persistent Identifiers
    Publisher: Informa Healthcare

    BACKGROUND: Although reductions in cardiovascular risk can be achieved by lowering low-density lipoprotein cholesterol, treated patients remain at substantial risk. Epidemiological studies have established that higher levels of high-density lipoprotein cholesterol (HDL-...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Christian J. Hendriksz; Mathieu Anheim; Peter Bauer; Olivier Bonnot; Anupam Chakrapani; Jean-Christophe Corvol; Tomas J. De Koning; Anna Degtyareva; Carlo Dionisi-Vici; Sarah Doss; ...
    Persistent Identifiers
    Publisher: TAYLOR & FRANCIS LTD

    Background: Niemann-Pick disease type C (NP-C) is a rare, inherited neurodegenerative disease of impaired intracellular lipid trafficking. Clinical symptoms are highly heterogeneous, including neurological, visceral, or psychiatric manifestations. The incidence of NP-C ...

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52 research outcomes, page 1 of 6