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464 research outcomes, page 1 of 47
  • publication . Review . Article . 2012
    Open Access English
    Authors:
    Lih-Fen Lue; Cassandra Andrade; Marwan N. Sabbagh; Douglas G. Walker;
    Persistent Identifiers
    Publisher: Hindawi Publishing Corporation

    <jats:p>Metabolic dysregulation, including abnormal glucose utilization and insulin resistance or deficiency, occurs at an early stage of AD independent of type II diabetes mellitus (T2DM). Thus, AD has been considered as type 3 diabetes. T2DM is a risk factor for AD; t...

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  • publication . Other literature type . Article . Review . 2010
    Open Access
    Authors:
    Mattsson, Niklas; Brax, David; Zetterberg, Henrik;
    Persistent Identifiers
    Publisher: Hindawi Limited

    <jats:p>In Alzheimer's disease (AD), pathological processes start in the brain long before clinical dementia. Biomarkers reflecting brain alterations may therefore indicate disease at an early stage, enabling early diagnosis. This raises several ethical questions and th...

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  • publication . Article . Other literature type . 2011
    Open Access
    Authors:
    Anthony R. White; Peter Faller; Craig S. Atwood; Paolo Zatta;
    Persistent Identifiers
    Publisher: Hindawi Limited

    Research into the role of metals in Alzheimer's disease (AD) has rapidly advanced over the past two decades. Early studies described controversial links between trace metals and dementia. More recently, this concept has developed further with the understanding that a ra...

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  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Fukui, H.; Arai, A.; Toyoshima, K.;
    Persistent Identifiers
    Publisher: Hindawi Limited

    We report that music therapy is effective in the treatment of Alzheimer's disease. We found that the secretion of 17β-estradiol and testosterone, hormones that are supposed to have preventive effects on Alzheimer's disease, is significantly increased by music therapy. D...

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  • publication . Article . 2010
    Open Access
    Authors:
    Philipp Spitzer; Hans Klafki; Kaj Blennow; Luc Buée; Hermann Esselmann; Sanna Kaisa Herruka; Connie R. Jimenez; Péter Klivényi; Piotr Lewczuk; Juan Manuel Maler; ...
    Persistent Identifiers
    Publisher: Hindawi Limited

    <jats:p>“clinical NEUroPROteomics of neurodegenerative diseases” (cNEUPRO) is a Specific Targeted Research Project (STREP) within the sixth framework program of the European Commission dedicated to the search for novel biomarker candidates for Alzheimer's disease and ot...

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  • publication . Review . Article . Other literature type . 2013
    Open Access English
    Authors:
    Choo, Xin Yi; Alukaidey, Lobna; White, Anthony R.; Grubman, Alexandra;
    Persistent Identifiers
    Publisher: Hindawi Publishing Corporation

    <jats:p>Inflammation is the innate immune response to infection or tissue damage. Initiation of proinflammatory cascades in the central nervous system (CNS) occurs through recognition of danger associated molecular patterns by cognate immune receptors expressed on infla...

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  • publication . Review . Article . 2010
    Open Access English
    Authors:
    Jin Wu; Masatomo Ishikawa; Jichun Zhang; Kenji Hashimoto;
    Persistent Identifiers
    Publisher: SAGE-Hindawi Access to Research

    Receptors have a prominent role in brain function, as they are the effector sites of neurotransmission at the postsynaptic membrane, have a regulatory role on presynaptic sites for transmitter reuptake and feedback, and are modulating various functions on the cell membr...

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  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Shinagawa, Shunichiro; Nakamura, Shiori; Iwamoto, Makoto; Tsuno, Norifumi; Shigeta, Masahiro; Nakayama, Kazuhiko;
    Persistent Identifiers
    Publisher: Hindawi Publishing Corporation

    <jats:p><jats:italic>Background</jats:italic>. A new public long-term care (LTC) insurance was launched in 2000 in Japan. However, there have been few studies involving factors that increase LTC costs of demented subjects; no follow-up studies involving the Government-C...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Alessandra Mocali; Nunzia Della Malva; Claudia Abete; Vito Antonio Mitidieri Costanza; A. Bavazzano; Vieri Boddi; Luis Sanchez; Sandra Dessì; Alessandra Pani; Francesco Paoletti;
    Persistent Identifiers
    Publisher: Hindawi Limited

    <jats:p>There is great interest in developing reliable biomarkers to support antemortem diagnosis of late-onset Alzheimer’s disease (AD). Early prediction and diagnosis of AD might be improved by the detection of a proteolytic dysfunction in extracts from cultured AD fi...

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  • publication . Article . 2011
    Open Access English
    Authors:
    Mithu Raychaudhuri; Debashis Mukhopadhyay;
    Persistent Identifiers
    Publisher: SAGE-Hindawi Access to Research

    <jats:p>Amyloid precursor protein (APP), implicated in Alzheimer's disease, is a transmembrane protein of undetermined function. APP is cleaved by gamma-secretase that releases the APP intracellular domain (AICD) in the cytoplasm.<jats:italic>In vitro</jats:italic>and<j...

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464 research outcomes, page 1 of 47