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416 research outcomes, page 1 of 42
  • publication . Article . 2019
    Open Access
    Authors:
    Henrik Leffers; Theis Lange; Christopher E Collins; Constance J. Ulff-Møller; Søren Jacobsen;
    Persistent Identifiers
    Publisher: Elsevier BV

    Abstract Systemic lupus erythematosus (SLE) is a systemic inflammatory autoimmune disease characterized by a broad spectrum of clinical and serological manifestations. This may reflect a complex and multifactorial etiology involving several identified genetic and enviro...

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  • publication . Article . Other literature type . 2009
    Open Access
    Authors:
    J. A. Solís Herruzo; P. Solís Muñoz; T. Muñoz Yagüe;

    Primary biliary cirrhosis (PBC) would develop when the immune system comes across a microorganism with proteins similar to those in the piruvate dehydrogenase complex E2 (PDC-E2), or a neoantigen resulting from a xenobiotic-modified autoantigen. This would lead to an in...

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  • publication . Article . Other literature type . 2011
    Open Access
    Authors:
    Christopher J. Lessard; John A. Ice; Indra Adrianto; Graham B. Wiley; Jennifer A. Kelly; Patrick M. Gaffney; Courtney G. Montgomery; Kathy L. Moser;
    Persistent Identifiers
    Publisher: Elsevier BV

    Recent advances in the field of genetics have dramatically changed our understanding of autoimmune disease. Candidate gene and, more recently, genome-wide association (GWA) studies have led to an explosion in the number of loci and pathways known to contribute to autoim...

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  • publication . Article . 2013
    Open Access
    Authors:
    Yihong Yao; Zheng Liu; Bahija Jallal; Nan Shen; Lars Rönnblom;
    Persistent Identifiers
    Publisher: Elsevier BV

    AbstractSjögren's syndrome is a chronic autoimmune disease characterized by lymphocytic infiltration of the salivary and lachrymal glands resulting in dry eyes and mouth. Genetic predisposition, pathogenic infections and hormones have been implicated in the pathogenesis...

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  • publication . Article . 2009
    Open Access English
    Authors:
    Olga Lucía Rojas; Adriana Rojas-Villarraga; Paola Cruz-Tapias; Jorge Luis Sánchez; Juan Camilo Suárez-Escudero; Manuel A. Patarroyo; Juan Manuel Anaya;
    Persistent Identifiers

    "Objective: To identify HLA-DRB1 alleles contributing to susceptibility to multiple sclerosis (MS) in a Colombian population and to estimate the common effect size of HLA class II on MS susceptibility in Latin American populations through a meta-analysis. Methods: A tot...

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  • publication . Article . 2017
    Open Access
    Authors:
    Ali Maisam Afzali; Tobias Ruck; Heinz Wiendl; Sven G. Meuth;
    Persistent Identifiers
    Publisher: Elsevier BV

    Idiopathic inflammatory myopathies (IIMs) encompass a heterogenic group of rare muscle diseases with common symptoms including muscle weakness and the presence of certain histological features. Since the pathogenesis remains unclear, therapeutic approaches in general co...

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  • publication . Other literature type . Article . 2008
    Open Access English
    Authors:
    Patrizio Caturegli; Isabella Lupi; Melissa A. Landek-Salgado; Hiroaki Kimura; Noel R. Rose;
    Persistent Identifiers

    Pituitary autoimmunity encompasses a spectrum of conditions ranging from histologically proven forms of lymphocytic hypophysitis to the presence of pituitary antibodies in apparently healthy subjects. Hypophysitis is a rare but increasingly recognized disorder that typi...

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  • publication . Article . 2017
    Open Access
    Authors:
    Yehuda Shoenfeld; Roberto Giacomelli; Shir Azrielant; Onorina Berardicurti; John A. Reynolds; Ian N. Bruce;
    Persistent Identifiers
    Publisher: Elsevier BV

    Over the past 20years, much has been written about the potential role of vitamin D in on adverse health outcomes. In recent years, evidence has accumulated regarding the effect of vitamin D on the immune system, and its different cells. Some studies have noted lower vit...

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  • publication . Article . Other literature type . 2009
    Open Access
    Authors:
    Krzysztof Michalek; Syed A. Morshed; Rauf Latif; Terry F. Davies;
    Persistent Identifiers
    Publisher: Elsevier BV

    Thyrotropin receptor autoantibodies (TSHR-Abs) of the stimulating variety are the hallmark of Graves’ disease. The presence of immune defects leading to synthesis of TSHR-Abs causes hyperthyroidism and is associated with other extrathyroidal manifestations. Further char...

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  • publication . Article . 2014
    Open Access
    Authors:
    Jaume Alijotas-Reig; Raquel Ferrer-Oliveras; Amelia Ruffatti; Angela Tincani; Elmina Lefkou; Ma Tiziana Bertero; Emmanuel Coloma-Bazan; Sara De Carolis; Gerard Espinosa; Patrizia Rovere-Querini; ...
    Persistent Identifiers
    Publisher: Elsevier BV

    Abstract Aim To analyse the clinical features, laboratory data, foetal–maternal outcomes, and follow-up in a cohort of 247 women with obstetric antiphospholipid syndrome (OAPS). Methods The European Registry on APS became a Registry within the framework of the European ...

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416 research outcomes, page 1 of 42