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1,713 research outcomes, page 1 of 172
  • publication . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Galilee, Meytal; Alian, Akram;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | iNEXT (653706)

    ABSTRACTNew anti-AIDS treatments must be continually developed in order to overcome resistance mutations including those emerging in the newest therapeutic target, the viral integrase (IN). Multimerization of IN is functionally imperative and provides a forthcoming ther...

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  • publication . Article . 2020
    Open Access
    Authors:
    Gabriele Stevanato; Gilles Casano; Dominik J. Kubicki; Yu Rao; Laura Esteban Hofer; Georges Menzildjian; Hakim Karoui; Didier Siri; Manuel Cordova; Maxim Yulikov; ...
    Persistent Identifiers
    Project: SNSF | Extending NMR crystallogr... (200020_178860), EC | Oligo-DNP (796904)

    The development of magic-angle spinning dynamic nuclear polarization (MAS DNP) has allowed atomic-level characterization of materials for which conventional solid-state NMR is impractical due to the lack of sensitivity. The rapid progress of MAS DNP has been largely ena...

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  • publication . Article . 2018
    Open Access
    Authors:
    Spyridon Gourdoupis; Veronica Nasta; Vito Calderone; Simone Ciofi-Baffoni; Lucia Banci;
    Persistent Identifiers
    Publisher: American Chemical Society (ACS)
    Project: EC | iNEXT (653706)

    The maturation of mitochondrial iron-sulfur proteins requires a complex protein machinery. Human IBA57 protein was proposed to act in a late phase of this machinery, along with GLRX5, ISCA1, and ISCA2. However, a molecular picture on how these proteins cooperate is not ...

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  • publication . Article . 2014
    Open Access
    Authors:
    Masaya Yamaguchi; Shanshan Yu; Renping Qiao; Florian Weissmann; Darcie J. Miller; Ryan T. Vanderlinden; Nicholas G. Brown; Jeremiah J. Frye; Jan-Michael Peters; Brenda A. Schulman;
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: EC | PCUBE (227764)

    Abstract The anaphase-promoting complex/cyclosome (APC/C) is a massive E3 ligase that controls mitosis by catalyzing ubiquitination of key cell cycle regulatory proteins. The APC/C assembly contains two subcomplexes: the “Platform” centers around a cullin-RING-like E3 l...

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  • publication . Doctoral thesis . 2014
    Open Access English
    Authors:
    Joana Abreu Luís da Silva Santos;
    Project: FCT | PTDC/BBB-BEP/2127/2012 (127722), EC | BIOSTRUCT-X (283570)
  • publication . Article . 2016
    Open Access
    Authors:
    Ai Woon Yee; Martine Moulin; Nina Breteau; Michael Haertlein; Edward P. Mitchell; Jonathan B. Cooper; Elisabetta Boeri Erba; V. Trevor Forsyth;
    Publisher: Wiley
    Project: UKRI | Deuteration Initiative fo... (EP/C015452/1)

    Abstract It is well established that the formation of transthyretin (TTR) amyloid fibrils is linked to the destabilization and dissociation of its tetrameric structure into insoluble aggregates. Isotope labeling is used for the study of TTR by NMR, neutron diffraction, ...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Linda Cerofolini; Stefano Giuntini; Letizia Barbieri; Matteo Pennestri; Anna Codina; Marco Fragai; Lucia Banci; Enrico Luchinat; Enrico Ravera;
    Persistent Identifiers
    Project: EC | INSTRUCT-ULTRA (731005), EC | West-Life (675858), EC | iNEXT (653706)

    Abstract FlowNMR has the aim of continuously monitoring processes that occur in conditions that are not compatible with being carried out within a closed tube. However, it is sample intensive and not suitable for samples, such as proteins or living cells, that are often...

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  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Maira Diaz; María José Sánchez-Barrena; Juana María González-Rubio; Lesia Rodriguez; Daniel Fernández; Regina Antoni; Cristina Yunta; Borja Belda-Palazón; Miguel González-Guzmán; Marta Peirats-Llobet; ...
    Project: EC | PCUBE (227764)

    Regulation of ion transport in plants is essential for cell function. Abiotic stress unbalances cell ion homeostasis, and plants tend to readjust it, regulating membrane transporters and channels. The plant hormone abscisic acid (ABA) and the second messenger Ca are cen...

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  • publication . Project deliverable . Report . Article . 2020
    Open Access
    Authors:
    Glöckner, Frank Oliver; Kostadinov, Ivaylo; Cochrane, Guy;
    Publisher: Zenodo
    Project: EC | CORBEL (654248)

    This work addresses the establishment of cross-domain data sets as exemplified by the Ocean Sampling Day. To fulfil this goal a workflow based on the broker service of GFBio to concurrently submit molecular (sequence) data and environmental data to ENA and PANGAEA, by c...

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  • publication . Article . 2017
    Open Access
    Authors:
    Nicola L Harman; Rebecca James; John P.H. Wilding; Paula R Williamson;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: EC | CORBEL (654248)

    Background Outcomes measured in clinical trials should be meaningful to patients, healthcare professionals and researchers, yet there is heterogeneity in the outcomes used across trials. This inconsistency impacts on the ability to compare findings and may mean that the...

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1,713 research outcomes, page 1 of 172