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1,863 research outcomes, page 1 of 187
  • publication . Article . 2017
    Open Access English
    Authors:
    Toyama Sumika; Okada Naoko; Matsuda Akio; Morita Hideaki; Saito Hirohisa; Fujisawa Takao; Nakae Susumu; Karasuyama Hajime; Matsumoto Kenji;
    Publisher: Elsevier

    Background: Eosinophils play important roles in asthma, especially airway remodeling, by producing various granule proteins, chemical mediators, cytokines, chemokines and proteases. However, protease production by eosinophils is not fully understood. In the present stud...

  • publication . Article . 2011
    Open Access
    Authors:
    C. Warren Bierman;
    Persistent Identifiers
    Publisher: Japanese Society of Allergology

    ABSTRACT Urticaria occurs commonly in children and young adults. In general, a younger and atopic population is usually involved and the lesions are acute, usually less than 6 weeks in duration and it is relatively easy to show a cause and effect, usually by history. Th...

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  • publication . Article . 2004
    Open Access English
    Authors:
    Toshiyuki Takai;
    Persistent Identifiers
    Publisher: Elsevier

    ABSTRACTThe Ig-like receptors provide positive and negative regulation of immune cells upon recognition of various ligands, thus enabling those cells to respond adequately to extrinsic stimuli. Murine paired Ig-like receptor (PIR)-A and PIR-B, a typical receptor pair of...

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  • publication . Article . 2005
    Open Access English
    Authors:
    Takahiko Horiguchi; Rieko Kondo; Junichi Miyazaki; Mamoru Shiga; Masahiro Hirose; Tomohiro Ito; Koji Fukumoto; Hiroshi Torigoe; Soichi Tachikawa;
    Persistent Identifiers
    Publisher: Elsevier

    ABSTRACT Background Suplatast tosilate is a type 2 (Th2) cytokine inhibitor that blocks the production of IgE antibodies and the invasion of tissues by eosinophils during an allergic reaction. Suplatast tosilate ameliorates asthma symptoms and airway hypersensitivity by...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Mitsuhiro Okano; Tazuko Fujiwara; Shin Kariya; Takaya Higaki; Takenori Haruna; Osamu Matsushita; Yohei Noda; Seiichiro Makihara; Kengo Kanai; Yasuyuki Noyama; ...
    Persistent Identifiers
    Publisher: Elsevier

    ABSTRACT Background In contrast to Staphylococcus aureus-derived superantigenic exotoxins, the role of nonsuperantigenic exotoxins in the pathogenesis of eosinophilic airway diseases remains obscure. We sought to characterize S. aureus alpha-toxin-induced cellular respo...

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  • publication . Article . 2007
    Open Access English
    Authors:
    Kohei Yamauchi; Hiroshi Inoue;
    Persistent Identifiers
    Publisher: Elsevier

    ABSTRACTAirway remodeling in asthma is characterized by goblet cell hyperplasia, subepithelial fibrosis, and hyperplasia and hypertrophy of airway smooth muscle cells. The airway wall thickness increases because of subepithelial fibrosis, and hyperplasia and hypertrophy...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Masanari Watanabe; Hisashi Noma; Jun Kurai; Kazuhiro Kato; Hiroyuki Sano; Toshiyuki Tatsukawa; Hirofumi Nakazaki; Akira Yamasaki; Eiji Shimizu;
    Persistent Identifiers
    Publisher: Elsevier

    Abstract Background An important aspect of sand dust emissions in association with respiratory disorders is the quantity of particulate matter. This is usually expressed as particulate matter less than 10 μm (PM 10 ) and 2.5 μm (PM 2.5 ). However, the composition of PM ...

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  • publication . Article . 2011
    Open Access English
    Authors:
    Kyoichiro Toyoshima; Ikuo Imamura; Satoru Doi; Toshishige Inoue; Isamu Takamatsu; Norihide Murayama; Makoto Kameda; Michiaki Hayashida; Hiroyuki Fukui;
    Persistent Identifiers
    Publisher: Japanese Society of Allergology. Production and hosting by Elsevier B.V.
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  • publication . Article . 2014
    Open Access English
    Authors:
    Kenji Matsumoto;
    Publisher: Elsevier
  • publication . Article . 2020
    Open Access English
    Authors:
    Naomi Nakamura; Risa Tamagawa-Mineoka; Ayano Maruyama; Mari Nakanishi; Risa Yasuike; Koji Masuda; Hiroshi Matsunaka; Yumi Murakami; Emiko Yokosawa; Norito Katoh;
    Persistent Identifiers
    Publisher: Elsevier
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1,863 research outcomes, page 1 of 187