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1,549 research outcomes, page 1 of 155
  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Masaya Yamaguchi; Shanshan Yu; Renping Qiao; Florian Weissmann; Darcie J. Miller; Ryan T. Vanderlinden; Nicholas G. Brown; Jeremiah J. Frye; Jan-Michael Peters; Brenda A. Schulman;
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: EC | PCUBE (227764)

    Abstract The anaphase-promoting complex/cyclosome (APC/C) is a massive E3 ligase that controls mitosis by catalyzing ubiquitination of key cell cycle regulatory proteins. The APC/C assembly contains two subcomplexes: the “Platform” centers around a cullin-RING-like E3 l...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Linda Cerofolini; Stefano Giuntini; Letizia Barbieri; Matteo Pennestri; Anna Codina; Marco Fragai; Lucia Banci; Enrico Luchinat; Enrico Ravera;
    Persistent Identifiers
    Project: EC | West-Life (675858), EC | iNEXT (653706), EC | INSTRUCT-ULTRA (731005)

    Abstract FlowNMR has the aim of continuously monitoring processes that occur in conditions that are not compatible with being carried out within a closed tube. However, it is sample intensive and not suitable for samples, such as proteins or living cells, that are often...

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  • publication . Article . 2017
    Open Access
    Authors:
    Janine Bowring; Maan M Neamah; Jorge Donderis; Ignacio Mir-Sanchis; Christian Alite; J. Rafael Ciges-Tomas; Elisa Maiques; Iltyar Medmedov; Alberto Marina; José R. Penadés;
    Project: EC | DUT-signal (670932), EC | BIOSTRUCT-X (283570), UKRI | Understanding a novel mec... (BB/N002873/1), WT | Understanding bacterial h... (201531), UKRI | Molecular biology of the ... (MR/M003876/1)

    Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, the clinically important Staphylococcus aureus pathogenicity islands (SaPIs) use this tactic to spread in nature. SaPIs reside passively in the host chromosome, under the...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Grigory Sharov; Karine Voltz; Alexandre Durand; Olga Kolesnikova; Gabor Papai; Alexander G. Myasnikov; Annick Dejaegere; Adam Ben Shem; Patrick Schultz;
    Publisher: Nature Publishing Group
    Project: ANR | UNISTRA (ANR-10-IDEX-0002), ANR | INRT (ANR-10-LABX-0030), ANR | Bip:Bip (ANR-10-BINF-0003)

    The transcription co-activator complex SAGA is recruited to gene promoters by sequence-specific transcriptional activators and by chromatin modifications to promote pre-initiation complex formation. The yeast Tra1 subunit is the major target of acidic activators such as...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Guillaume Tetreau; Anne-Sophie Banneville; Elena A. Andreeva; Aaron S. Brewster; Mark S. Hunter; Raymond G. Sierra; Jean-Marie Teulon; I.D. Young; Niamh Burke; Tilman A. Grünewald; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | X-in-vivo (ANR-17-CE11-0018), NIH | DIALS: New Computational ... (5R01GM117126-02), NIH | Pacific Southwest Regiona... (1U01CK000516-01), NIH | A SYNCHROTRON RADIATION B... (5P41RR001209-14), NIH | Molecular Improvement of ... (5R01AI045817-04), NIH | A Synchroton Radiation St... (8P41GM103393-33), ANR | CBH-EUR-GS (ANR-17-EURE-0003), NIH | Highly Improved Bacterial... (1U01AI054778-01), ANR | DynOCP (ANR-18-CE11-0005)

    Cyt1Aa is the one of four crystalline protoxins produced by mosquitocidal bacterium Bacillus thuringiensis israelensis (Bti) that has been shown to delay the evolution of insect resistance in the field. Limiting our understanding of Bti efficacy and the path to improved...

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  • publication . Article . 2020
    Open Access
    Authors:
    Gabriele Stevanato; Gilles Casano; Dominik J. Kubicki; Yu Rao; Laura Esteban Hofer; Georges Menzildjian; Hakim Karoui; Didier Siri; Manuel Cordova; Maxim Yulikov; ...
    Persistent Identifiers
    Publisher: American Chemical Society (ACS)
    Project: SNSF | Extending NMR crystallogr... (200020_178860), EC | Oligo-DNP (796904)

    The development of magic-angle spinning dynamic nuclear polarization (MAS DNP) has allowed atomic-level characterization of materials for which conventional solid-state NMR is impractical due to the lack of sensitivity. The rapid progress of MAS DNP has been largely ena...

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  • publication . Article . 2017
    Open Access
    Authors:
    Michal Pellach; Sudipta Mondal; Karl Harlos; Deni Mance; Marc Baldus; Ehud Gazit; Linda J. W. Shimon;
    Publisher: Wiley
    Project: WT | Understanding the genetic... (090532), NWO | Infrastructure for high-r... (2300154217), EC | BISON (694426)

    Abstract The crystal structure of a designed phospholipid‐inspired amphiphilic phosphopeptide at 0.8 Å resolution is presented. The phosphorylated β‐hairpin peptide crystallizes to form a lamellar structure that is stabilized by intra‐ and intermolecular hydrogen bondin...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Ai Woon Yee; Martine Moulin; Nina Breteau; Michael Haertlein; Edward P. Mitchell; Jonathan B. Cooper; Elisabetta Boeri Erba; V. Trevor Forsyth;
    Project: UKRI | Deuteration Initiative fo... (EP/C015452/1)

    Abstract It is well established that the formation of transthyretin (TTR) amyloid fibrils is linked to the destabilization and dissociation of its tetrameric structure into insoluble aggregates. Isotope labeling is used for the study of TTR by NMR, neutron diffraction, ...

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  • publication . Article . 2015
    Open Access
    Authors:
    Yana Valasatava; Claudia Andreini; Antonio Rosato;
    Persistent Identifiers
    Publisher: Springer Nature
    Project: EC | BIOMEDBRIDGES (284209), EC | EGI-Engage (654142)

    Metalloproteins account for a substantial fraction of all proteins. They incorporate metal atoms, which are required for their structure and/or function. Here we describe a new computational protocol to systematically compare and classify metal-binding sites on the basi...

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  • publication . Article . 2010
    Open Access
    Authors:
    Alexander Krah; Denys Pogoryelov; Julian D. Langer; Peter J. Bond; Thomas Meier; José D. Faraldo-Gómez;
    Persistent Identifiers
    Publisher: Elsevier BV

    AbstractThe functional mechanism of the F1Fo ATP synthase, like many membrane transporters and pumps, entails a conformational cycle that is coupled to the movement of H+ or Na+ ions across its transmembrane domain, down an electrochemical gradient. This coupling is an ...

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1,549 research outcomes, page 1 of 155