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Laboratories from 14 countries (with different levels of expertise in radionuclide measurements and 210Pb dating) participated in an interlaboratory comparison exercise (ILC) related to the application of 210Pb sediment dating technique within the framework of the IAEA Coordinated Research Project. The laboratories were provided with samples from a composite sediment core and were required to provide massic activities of several radionuclides and an age versus depth model from the obtained results, using the most suitable 210Pb dating model. Massic concentrations of Zn and Cu were also determined to be used for chronology validation. The ILC results indicated good analytical performances while the dating results didn't demonstrate the same degree of competence in part due to the different experience in dating of the participant laboratories. The ILC exercise enabled evaluation of the difficulties faced by laboratories implementing 210Pb dating methods and identified some limitations in providing reliable chronologies. This work was supported by the International Atomic Energy Agency (IAEA) Coordinated Research project “Study of Global Temporal Trends of Pollution in Selected Coastal Areas by the Application of Isotopic and Nuclear Tools” (CRP K41016). Peer reviewed

We describe a case of severe hypervitaminosis D and mild hypercalcaemia in a 68-year-old woman who presented with fatigue and weight loss. Her 25-hydroxy vitamin D (25OHD) was > 400 nmol/L (50-150) and corrected serum calcium was 2.83 mmol/L (2.1-2.6). Her intact parathyroid hormone (PTH) was 4.9 pmol/L (2.0-9.5). Further investigation revealed an IgM kappa paraprotein, and a bone marrow aspirate confirmed a diagnosis of lymphoplasmacytic lymphoma/Waldenstrom’s macroglobulinemia (LPL/WM). As the vitamin D level was discordant with the patient’s other results and presentation, the presence of an assay interferent was suspected. A 1-in-2 dilution of the sample returned a 25OHD result of 84 nmol/L in keeping with the presence of an interferent. Testing for rheumatoid factor was negative. The sample was treated with an antibody blocking reagent (Scantibodies) and results were not consistent with heterophile antibody interference. The sample was then analysed using liquid chromatography tandem mass spectrometry (LC-MS/MS), which returned a 25OHD result of 82 nmol/L. Testing on an alternative immunoassay platform produced a 25OHD result of 75 nmol/L. Reapeted testing on the original platform following reduction of the monoclonal paraprotein with chemotherapy, returned a result of 64 nmol/L. The patient’s mild hypercalcaemia persisted following resolution of the monoclonal paraprotein, in keeping with a diagnosis of primary hyperparathyroidism. This case highlights the potential for paraproteins to cause assay interference, and the importance of considering interference when results are incongruous with the clinical presentation.

The European Radiation Dosimetry Group (EURADOS) is a network of organizations and scientists promoting research and development in the dosimetry of ionizing radiation, contributing to harmonization in dosimetry practice across Europe, and offering education and training in areas relevant for dosimetry. As a registered non-profit association under German law, EURADOS is currently running eight active working groups (WGs): WG2 on “Harmonization of Individual Monitoring”, WG3 on “Environmental Dosimetry”, WG6 on “Computational Dosimetry”, WG7 on “Internal Dosimetry”, WG9 on “Dosimetry in Radiotherapy”, WG10 on “Retrospective Dosimetry”, WG11 on “Dosimetry in High-Energy Radiation Fields”, and WG12 on “Dosimetry in Medical Imaging”. This paper presents recent scientific results obtained within these working groups, and additionally highlights the role of EURADOS as an organization which contributes to the development of a systematic strategy of radiation protection research in Europe.

This volume contains a selection of papers presented at LFMTP 2020, the 15th International Workshop on Logical Frameworks and Meta-Languages: Theory and Practice (LFMTP), held the 29-30th of June, 2019, using the Zoom video conferencing tool due to COVID restrictions. Officially the workshop was held in Paris, France, and it was affiliated with IJCAR 2020, FSCD 2020 and many other satellite events. Logical frameworks and meta-languages form a common substrate for representing, implementing and reasoning about a wide variety of deductive systems of interest in logic and computer science. Their design, implementation and their use in reasoning tasks, ranging from the correctness of software to the properties of formal systems, have been the focus of considerable research over the last two decades. This workshop will bring together designers, implementors and practitioners to discuss various aspects impinging on the structure and utility of logical frameworks, including the treatment of variable binding, inductive and co-inductive reasoning techniques and the expressiveness and lucidity of the reasoning process.

Supplementary Information Online for the Manuscript, "Impact of diabetes on clinical and safety outcomes in acute ischemic stroke patients receiving reperfusion therapy: a meta-analysis" published in the Journal, Advances in Clinical and Experimental Medicine.

Coastline reveals profoundly different perceptions of the liminal space where land meets sea. Over centuries, artists have represented its changing appearance and meaning – sometimes as part of a journey, sometimes as a site of contact or work, sometimes just for contemplation. In Australia, the only nation that is an island continent, the coastline plays a highly symbolic cultural role defining identity, while demarcating the border as an exclusion zone. Today, with global warming causing rising sea levels and eroding shorelines, the coast has become a highly-charged space demarcating potential zones of conflict and loss. This collection-based exhibition offers an art historical overview of the role of maritime representations across more than three centuries.