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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Jinguji, Megumi;

    鹿児島大学 博士(医学) Doctor of Philosophy in Medical Science 学位論文の要旨 thesis

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Kagoshima University...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: OYAMA, Kazuhiro; SHINOHARA, Katsuji;

    departmental bulletin paper

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Sui, Shuyan;

    鹿児島大学 博士(農学) Doctor of Philosophy in Agricultural Science 学位論文の要旨 thesis

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Kagoshima University...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: MIYAWAKI, Shouichi;

    歯学部における特徴ある研究、診療活動 departmental bulletin paper

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    The possibility of peptide vaccine targeting WT1 protein has been investigated. as a novel treatment strategy for spontaneous tumors in dogs. To establish an effective peptide vaccine, we cloned and sequenced the canine WT1 cDNA. Two canine WT1 cDNA clones were isolated and seemed to correspond to isoforms reported in human WT1 gene. Based on its deduced amino acid sequences, five peptides were made and used. Moreover, expression of WT1 protein in normal and tumor tissues in dogs were investigated using immunohistochemistry. In normal tissues, only weak expression of WT1 protein were detected in kidney, spleen, lung and ovary and no positive signal were detected in other normal tissues. On the other hand, strong signals were detected ubiquitously in cytoplasm and/or nucleus of tumor cells. 犬の自然発生腫瘍に対する免疫療法の開発としてWT1蛋白を標的としたペプチドワクチンによる免疫療法の可能性を探索した。ペプチドワクチン作成にあたり、犬WT1遺伝子を単離し、その塩基配列を決定した。2つのcDNAクローンが得られたが、いずれも人で報告のあるアイソフォームと同等の構造を有し、うち1つは腫瘍において高発現しているアイソフォームであったことから、このクローンの予測されるアミノ酸配列に基づきペプチドを作成した。一方、犬の正常組織および自然発生腫瘍組織におけるWT1蛋白の発現について免疫組織化学を用いて検討したところ、正常組織では腎臓、脾臓、肺、卵巣といった限られた組織においてわずかに発現が認められるのみであったのに対し、腫瘍組織においては様々な組織で強い発現が認められた。 2010-2011年度科学研究費助成事業(科学研究費補助金(若手研究(B)))研究成果報告書 課題番号:22780282 研究代表者:木之下明日香 (鹿児島大学農学部准教授)

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ JAIROarrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ JAIROarrow_drop_down
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    Diabetes is one of the major public health problem. Dysfunction of endothelial cells are involved in formation of the pathogenesis of this vascular diseases associated with diabetes. Our hypothesis is that cell to cell communication between endothelial cells and platelets would play a pivotal role in diabetic vascular complications. microRNAs (miRNAs) is a non-coding miRNAs that regulates protein synthesis post-transcriptionally. We used miRNAs as key players to organize a series of vascular events un der hyperglycemia. We have discovered that miR-503 was induced by hypoxia in cultured endothelial cells and that miR-503 regulates phosphorylation of Akt as well as cyclin D. We also observed that miR-503 is released by wrapping in exosomes under hypoxic condition. In the future studies, we will focus on the downstream target of Akt regulated by miR-503 in endothelial cells and clarify the mechanisms by which endothelial cells transfer the information to platelets. 「糖尿病性の血管病変形成に血小板と血管内皮細胞のクロストークが必要である」という仮説の第一段階を検証した。マイクロRNA(microRNA)は蛋白合成を制御して細胞の機能を制御する。今回の新しい知見は、血管内皮細胞においてmiR-503が低酸素刺激で誘導され、cyclinDの発現のみならずAktの活性化を制御していることと、血管内皮細胞はmiR-503を放出と取り込みをすることである。血管内皮細胞のmiR-503がどのようにPI3K-Aktシグナルの下流を制御しているか、miR-503を介した血小板と血管内皮細胞の細胞間情報伝達がどのように行われるか、などが、今後の検討課題である。 2013-2013年度科学研究費助成事業(研究活動スタート支援)研究成果報告書 課題番号:25893192 研究代表者:山口宗一(鹿児島大学・医歯(薬)学総合研究科・准教授)

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: KAWABATA, Sanae; YAMASHITA, Masashi;

    The results obtained from the field tests on the ventilation of air in a tunnel caused by the piston-action of a train running through it are reported in this paper. In the tests the wind-velocity at the exit of a blow-hole as well as at the exit of the tunnel was measured and the ventilation efficiency of air was calculated. According to the results of the tests, the ventilation efficiency does not depend on the velocity of the train. Rather, it was found that the larger the number of cars becomes, the larger the ventilation efficiency becomes. On the other hand, it also increases slightly by the presence of a blow-hole. Finally, it is expected that less than forty percent of the air in a tunnel is ventilated while a train is running through the tunnel. departmental bulletin paper

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    Authors: Kibe, Toshiro;

    鹿児島大学 博士(歯学) Doctor of Philosophy in Dental Science 学位論文の要旨 thesis

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    Authors: HATATE, Yasuo; UEMURA, Yoshimitsu; CHUREI, Seiya; MIYAUCHI, Masahiko; +3 Authors

    A semi-cylindrical spouted bed (0.099 m I.D.) with a semi-cylindrical draft tube (0.021 m I.D.) was employed to obtain fundamental data for the design of a spouted bed coal gasifier. Air was used as the carrier gas. Three kinds of glass particles were used as the circulating medium. The effects of gas feed rate, tube-cone clearance, cone angle, particle diameter, and particles loading on the behavior of the semi-cylindrical spouted bed were investigated. The gas velocity in draft tube only depended on the gas feed rate. The gas velocity in the annulus increased with increasing the tube-cone clearance, with increasing the cone angle, with increasing particle diameter, and with decreasing the particles loading. The solids circulation rate increased with increasing the tube-cone clearance. Correlations to describe the annulus gas velocity and solids circulation rate were proposed. departmental bulletin paper

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    This study aimed to reveal the short- and long-term changes in nutrient cycling after whole tree clearcutting of forested watershed developed on volcanic immature soil where soil organic matter contents is quite low. There were no clear differences in the parameters concerning nitrogen cycling such as net primary production, soil nitrogen mineralization and nitrogen uptake by plant between this study site and other regions. In contrast, nitrate discharge was significantly lower than other regions probably due to the unique soil properties and hydrological process of this study site. 本研究は、土壌中の有機物含量が非常に小さい火山灰性未熟土壌に成立する森林の皆伐後の短期的・長期的な養分循環の変化を明らかにすることを目的として行った。樹木の一次生産量、土壌窒素無機化速度、樹木の窒素吸収量など窒素循環に関わるパラメーターは、人工林と常緑広葉樹林ともに未熟土以外の同一気候帯の森林と大差ないことが明らかとなった。一方で伐採に伴う硝酸流出量は、他の同一気候帯での結果に比べて小さく、このことは本調査地の特徴的な土壌特性や水文特性などを反映しているものと考えられた。 2008-2010年度科学研究費補助金(若手研究(B))研究成果報告書 課題番号:20780120 研究代表者:舘野隆之輔 (鹿児島大学農学部准教授)

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Jinguji, Megumi;

    鹿児島大学 博士(医学) Doctor of Philosophy in Medical Science 学位論文の要旨 thesis

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    Authors: OYAMA, Kazuhiro; SHINOHARA, Katsuji;

    departmental bulletin paper

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    Authors: Sui, Shuyan;

    鹿児島大学 博士(農学) Doctor of Philosophy in Agricultural Science 学位論文の要旨 thesis

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    Authors: MIYAWAKI, Shouichi;

    歯学部における特徴ある研究、診療活動 departmental bulletin paper

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    The possibility of peptide vaccine targeting WT1 protein has been investigated. as a novel treatment strategy for spontaneous tumors in dogs. To establish an effective peptide vaccine, we cloned and sequenced the canine WT1 cDNA. Two canine WT1 cDNA clones were isolated and seemed to correspond to isoforms reported in human WT1 gene. Based on its deduced amino acid sequences, five peptides were made and used. Moreover, expression of WT1 protein in normal and tumor tissues in dogs were investigated using immunohistochemistry. In normal tissues, only weak expression of WT1 protein were detected in kidney, spleen, lung and ovary and no positive signal were detected in other normal tissues. On the other hand, strong signals were detected ubiquitously in cytoplasm and/or nucleus of tumor cells. 犬の自然発生腫瘍に対する免疫療法の開発としてWT1蛋白を標的としたペプチドワクチンによる免疫療法の可能性を探索した。ペプチドワクチン作成にあたり、犬WT1遺伝子を単離し、その塩基配列を決定した。2つのcDNAクローンが得られたが、いずれも人で報告のあるアイソフォームと同等の構造を有し、うち1つは腫瘍において高発現しているアイソフォームであったことから、このクローンの予測されるアミノ酸配列に基づきペプチドを作成した。一方、犬の正常組織および自然発生腫瘍組織におけるWT1蛋白の発現について免疫組織化学を用いて検討したところ、正常組織では腎臓、脾臓、肺、卵巣といった限られた組織においてわずかに発現が認められるのみであったのに対し、腫瘍組織においては様々な組織で強い発現が認められた。 2010-2011年度科学研究費助成事業(科学研究費補助金(若手研究(B)))研究成果報告書 課題番号:22780282 研究代表者:木之下明日香 (鹿児島大学農学部准教授)

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    Diabetes is one of the major public health problem. Dysfunction of endothelial cells are involved in formation of the pathogenesis of this vascular diseases associated with diabetes. Our hypothesis is that cell to cell communication between endothelial cells and platelets would play a pivotal role in diabetic vascular complications. microRNAs (miRNAs) is a non-coding miRNAs that regulates protein synthesis post-transcriptionally. We used miRNAs as key players to organize a series of vascular events un der hyperglycemia. We have discovered that miR-503 was induced by hypoxia in cultured endothelial cells and that miR-503 regulates phosphorylation of Akt as well as cyclin D. We also observed that miR-503 is released by wrapping in exosomes under hypoxic condition. In the future studies, we will focus on the downstream target of Akt regulated by miR-503 in endothelial cells and clarify the mechanisms by which endothelial cells transfer the information to platelets. 「糖尿病性の血管病変形成に血小板と血管内皮細胞のクロストークが必要である」という仮説の第一段階を検証した。マイクロRNA(microRNA)は蛋白合成を制御して細胞の機能を制御する。今回の新しい知見は、血管内皮細胞においてmiR-503が低酸素刺激で誘導され、cyclinDの発現のみならずAktの活性化を制御していることと、血管内皮細胞はmiR-503を放出と取り込みをすることである。血管内皮細胞のmiR-503がどのようにPI3K-Aktシグナルの下流を制御しているか、miR-503を介した血小板と血管内皮細胞の細胞間情報伝達がどのように行われるか、などが、今後の検討課題である。 2013-2013年度科学研究費助成事業(研究活動スタート支援)研究成果報告書 課題番号:25893192 研究代表者:山口宗一(鹿児島大学・医歯(薬)学総合研究科・准教授)

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    Authors: KAWABATA, Sanae; YAMASHITA, Masashi;

    The results obtained from the field tests on the ventilation of air in a tunnel caused by the piston-action of a train running through it are reported in this paper. In the tests the wind-velocity at the exit of a blow-hole as well as at the exit of the tunnel was measured and the ventilation efficiency of air was calculated. According to the results of the tests, the ventilation efficiency does not depend on the velocity of the train. Rather, it was found that the larger the number of cars becomes, the larger the ventilation efficiency becomes. On the other hand, it also increases slightly by the presence of a blow-hole. Finally, it is expected that less than forty percent of the air in a tunnel is ventilated while a train is running through the tunnel. departmental bulletin paper

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    Authors: Kibe, Toshiro;

    鹿児島大学 博士(歯学) Doctor of Philosophy in Dental Science 学位論文の要旨 thesis

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    Authors: HATATE, Yasuo; UEMURA, Yoshimitsu; CHUREI, Seiya; MIYAUCHI, Masahiko; +3 Authors

    A semi-cylindrical spouted bed (0.099 m I.D.) with a semi-cylindrical draft tube (0.021 m I.D.) was employed to obtain fundamental data for the design of a spouted bed coal gasifier. Air was used as the carrier gas. Three kinds of glass particles were used as the circulating medium. The effects of gas feed rate, tube-cone clearance, cone angle, particle diameter, and particles loading on the behavior of the semi-cylindrical spouted bed were investigated. The gas velocity in draft tube only depended on the gas feed rate. The gas velocity in the annulus increased with increasing the tube-cone clearance, with increasing the cone angle, with increasing particle diameter, and with decreasing the particles loading. The solids circulation rate increased with increasing the tube-cone clearance. Correlations to describe the annulus gas velocity and solids circulation rate were proposed. departmental bulletin paper

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    This study aimed to reveal the short- and long-term changes in nutrient cycling after whole tree clearcutting of forested watershed developed on volcanic immature soil where soil organic matter contents is quite low. There were no clear differences in the parameters concerning nitrogen cycling such as net primary production, soil nitrogen mineralization and nitrogen uptake by plant between this study site and other regions. In contrast, nitrate discharge was significantly lower than other regions probably due to the unique soil properties and hydrological process of this study site. 本研究は、土壌中の有機物含量が非常に小さい火山灰性未熟土壌に成立する森林の皆伐後の短期的・長期的な養分循環の変化を明らかにすることを目的として行った。樹木の一次生産量、土壌窒素無機化速度、樹木の窒素吸収量など窒素循環に関わるパラメーターは、人工林と常緑広葉樹林ともに未熟土以外の同一気候帯の森林と大差ないことが明らかとなった。一方で伐採に伴う硝酸流出量は、他の同一気候帯での結果に比べて小さく、このことは本調査地の特徴的な土壌特性や水文特性などを反映しているものと考えられた。 2008-2010年度科学研究費補助金(若手研究(B))研究成果報告書 課題番号:20780120 研究代表者:舘野隆之輔 (鹿児島大学農学部准教授)

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