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The use of temozolomide in paediatric metastatic phaeochromocytoma/paraganglioma: A case report and literature review.
appsOther research productkeyboard_double_arrow_right Other ORP type 2022Embargo end date: 23 Nov 2022 United Kingdom English Publisher:Frontiers Media SA
Authors: Urquhart, Calum; Fleming, Ben; Harper, Ines; Aloj, Luigi; +11 Authors
Urquhart, Calum; Fleming, Ben; Harper, Ines; Aloj, Luigi; Armstrong, Ruth; Hook, Liz; Long, Anna-May; Jackson, Claire; Gallagher, Ferdia A; McLean, Mary A; Tarpey, Patrick; Kosmoliaptsis, Vasilis; Nicholson, James; Hendriks, A Emile J; Casey, Ruth T;
doi: 10.17863/cam.91003
doi: 10.17863/cam.91003
There is increasing evidence to support the use of temozolomide therapy for the treatment of metastatic phaeochromocytoma/paraganglioma (PPGL) in adults, particularly in patients with SDHx mutations. In children however, very little data is available. In this report, we present the case of a 12-year-old female with a SDHB-related metastatic paraganglioma treated with surgery followed by temozolomide therapy. The patient presented with symptoms of palpitations, sweating, flushing and hypertension and was diagnosed with a paraganglioma. The primary mass was surgically resected six weeks later after appropriate alpha- and beta-blockade. During the surgery extensive nodal disease was identified that had been masked by the larger paraganglioma. Histological review confirmed a diagnosis of a metastatic SDHB-deficient paraganglioma with nodal involvement. Post-operatively, these nodal lesions demonstrated tracer uptake on 18F-FDG PET-CT. Due to poor tumour tracer uptake on 68Ga-DOTATATE and 123I-MIBG functional imaging studies radionuclide therapy was not undertaken as a potential therapeutic option for this patient. Due to the low tumour burden and lack of clinical symptoms, the multi-disciplinary team opted for close surveillance for the first year, during which time the patient continued to thrive and progress through puberty. 13 months after surgery, evidence of radiological and biochemical progression prompted the decision to start systemic monotherapy using temozolomide. The patient has now completed ten cycles of therapy with limited adverse effects and has benefited from a partial radiological and biochemical response. Peer reviewed: True
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Apollo
Other ORP type . 2022
License: CC BY
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Apollo
Other ORP type . 2022
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Apollo
Other ORP type . 2022
License: CC BY
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Apollo
Other ORP type . 2022
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Green-function Method for Nonlinear Interactions of Elastic Waves
appsOther research productkeyboard_double_arrow_right Other ORP type 2019 United Kingdom Funded by:EC | BIO-PHONONICS, UKRI | Advanced Diagnostics usin...
EC| BIO-PHONONICS ,
UKRI| Advanced Diagnostics using Phononics
Authors: Demcenko, A; Mazilu, M; Reboud, J; Cooper, JM;
UCL Discoveryarrow_drop_down
UCL Discovery
Other ORP type . 2019
Data sources: UCL Discovery
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UCL Discovery
Other ORP type . 2019
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The British press and the end of empire in Africa: to engage with issues of colonial reparation, Britain must address the enduring significance of its media history
appsOther research productkeyboard_double_arrow_right Other ORP type 2022 United Kingdom
Authors: Coffey, Rosalind;
LSE Research Onlinearrow_drop_down
LSE Research Online
Other ORP type . 2022
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LSE Research Online
Other ORP type . 2022
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Concurrent Data Structures Linked in Time
appsOther research productkeyboard_double_arrow_right Other ORP type 2017 United Kingdom Funded by:UKRI | Program Logics for Compos..., EC | Mathador
UKRI| Program Logics for Compositional Specification and Verification of Distributed Systems ,
EC| Mathador
Authors: Delbianco, GA; Sergey, I; Nanevski, A; Banerjee, A;
UCL Discoveryarrow_drop_down
UCL Discovery
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UCL Discoveryarrow_drop_down
UCL Discovery
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3D Pioneers Challenge 2018
appsOther research productkeyboard_double_arrow_right Other ORP type 2018 United Kingdom
Authors: Jimenez Garcia, M; Retsin, G;
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UCL Discovery
Other ORP type . 2018
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Epithelioid haemangioendothelioma—a rare cause of right pleural effusion and multiple primary nodules: Case report & review of the literature
appsOther research productkeyboard_double_arrow_right Other ORP type 2023 United Kingdom Publisher:SAGE Publications
Authors: Bashir Mohamed, Ryan; orcid: 0000-0002-1005-6433; email: r.mohamed4@rbht.nhs.uk; Shehata, Monica; Gorman, William; orcid: 0000-0003-3509-7650; AlShammari, Abdullah; +2 Authors
Bashir Mohamed, Ryan; orcid: 0000-0002-1005-6433; email: r.mohamed4@rbht.nhs.uk; Shehata, Monica; Gorman, William; orcid: 0000-0003-3509-7650; AlShammari, Abdullah; Buderi, Silviu; Jordan, Simon;
Pulmonary epithelioid haemangioendothelioma (PEH) is a rare vascular neoplasm. The thoracic manifestation of this disorder is identified via three major imaging patterns, namely multiple primary nodules, diffuse infiltrative pleural thickening, and multiple pulmonary reticulonodular opacities. The commonest pattern of presentation is bilateral multiple nodules. Diagnosis is based on histopathological findings and verified by positive immunochemistry staining. Patients with PEH are usually asymptomatic. We report the case of a 51-year-old female who presented to our facility with a five-month history of cough, pleural nodularity, and pleural effusion. She underwent surgical washout with right pleural biopsies that showed a malignant epithelioid tumor with features of epithelioid haemangioendothelioma (EH). A CXR after treatment did not demonstrate a residual pleural effusion.
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Other ORP type . 2023
Data sources: Apollo
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Lessons for 2016 from the smashup of the Second Party System and the War of the Whig succession.
appsOther research productkeyboard_double_arrow_right Other ORP type 2016 United Kingdom
Authors: Burnham, Walter Dean;
LSE Research Onlinearrow_drop_down
LSE Research Online
Other ORP type . 2016
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LSE Research Online
Other ORP type . 2016
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Distributive politics inside the city? The political economy of Spain's Plan E
appsOther research productkeyboard_double_arrow_right Other ORP type 2017 United Kingdom
Authors: Carozzi, Felipe; Repetto, Luca;
LSE Research Onlinearrow_drop_down
LSE Research Online
Other ORP type . 2017
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King Edward Point Observatory Monthly Magnetic Bulletin: October 2016
appsOther research productkeyboard_double_arrow_right Other ORP type 2016 United Kingdom
Authors: British Geological Survey;
NERC Open Research A...arrow_drop_down
NERC Open Research Archive
Other ORP type . 2016
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India’s Afghanistan policy needs to look beyond the great game to be effective
appsOther research productkeyboard_double_arrow_right Other ORP type 2022 United Kingdom
Authors: Singh, Shweta;
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50,793 Research products

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The use of temozolomide in paediatric metastatic phaeochromocytoma/paraganglioma: A case report and literature review.
appsOther research productkeyboard_double_arrow_right Other ORP type 2022Embargo end date: 23 Nov 2022 United Kingdom English Publisher:Frontiers Media SA
Authors: Urquhart, Calum; Fleming, Ben; Harper, Ines; Aloj, Luigi; +11 Authors
Urquhart, Calum; Fleming, Ben; Harper, Ines; Aloj, Luigi; Armstrong, Ruth; Hook, Liz; Long, Anna-May; Jackson, Claire; Gallagher, Ferdia A; McLean, Mary A; Tarpey, Patrick; Kosmoliaptsis, Vasilis; Nicholson, James; Hendriks, A Emile J; Casey, Ruth T;
doi: 10.17863/cam.91003
doi: 10.17863/cam.91003
There is increasing evidence to support the use of temozolomide therapy for the treatment of metastatic phaeochromocytoma/paraganglioma (PPGL) in adults, particularly in patients with SDHx mutations. In children however, very little data is available. In this report, we present the case of a 12-year-old female with a SDHB-related metastatic paraganglioma treated with surgery followed by temozolomide therapy. The patient presented with symptoms of palpitations, sweating, flushing and hypertension and was diagnosed with a paraganglioma. The primary mass was surgically resected six weeks later after appropriate alpha- and beta-blockade. During the surgery extensive nodal disease was identified that had been masked by the larger paraganglioma. Histological review confirmed a diagnosis of a metastatic SDHB-deficient paraganglioma with nodal involvement. Post-operatively, these nodal lesions demonstrated tracer uptake on 18F-FDG PET-CT. Due to poor tumour tracer uptake on 68Ga-DOTATATE and 123I-MIBG functional imaging studies radionuclide therapy was not undertaken as a potential therapeutic option for this patient. Due to the low tumour burden and lack of clinical symptoms, the multi-disciplinary team opted for close surveillance for the first year, during which time the patient continued to thrive and progress through puberty. 13 months after surgery, evidence of radiological and biochemical progression prompted the decision to start systemic monotherapy using temozolomide. The patient has now completed ten cycles of therapy with limited adverse effects and has benefited from a partial radiological and biochemical response. Peer reviewed: True
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Green-function Method for Nonlinear Interactions of Elastic Waves
appsOther research productkeyboard_double_arrow_right Other ORP type 2019 United Kingdom Funded by:EC | BIO-PHONONICS, UKRI | Advanced Diagnostics usin...
EC| BIO-PHONONICS ,
UKRI| Advanced Diagnostics using Phononics
Authors: Demcenko, A; Mazilu, M; Reboud, J; Cooper, JM;
UCL Discoveryarrow_drop_down
UCL Discovery
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The British press and the end of empire in Africa: to engage with issues of colonial reparation, Britain must address the enduring significance of its media history
appsOther research productkeyboard_double_arrow_right Other ORP type 2022 United Kingdom
Authors: Coffey, Rosalind;
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Concurrent Data Structures Linked in Time
appsOther research productkeyboard_double_arrow_right Other ORP type 2017 United Kingdom Funded by:UKRI | Program Logics for Compos..., EC | Mathador
UKRI| Program Logics for Compositional Specification and Verification of Distributed Systems ,
EC| Mathador
Authors: Delbianco, GA; Sergey, I; Nanevski, A; Banerjee, A;
UCL Discoveryarrow_drop_down
UCL Discovery
Other ORP type . 2017
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UCL Discovery
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3D Pioneers Challenge 2018
appsOther research productkeyboard_double_arrow_right Other ORP type 2018 United Kingdom
Authors: Jimenez Garcia, M; Retsin, G;
UCL Discoveryarrow_drop_down
UCL Discovery
Other ORP type . 2018
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UCL Discovery
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Epithelioid haemangioendothelioma—a rare cause of right pleural effusion and multiple primary nodules: Case report & review of the literature
appsOther research productkeyboard_double_arrow_right Other ORP type 2023 United Kingdom Publisher:SAGE Publications
Authors: Bashir Mohamed, Ryan; orcid: 0000-0002-1005-6433; email: r.mohamed4@rbht.nhs.uk; Shehata, Monica; Gorman, William; orcid: 0000-0003-3509-7650; AlShammari, Abdullah; +2 Authors
Bashir Mohamed, Ryan; orcid: 0000-0002-1005-6433; email: r.mohamed4@rbht.nhs.uk; Shehata, Monica; Gorman, William; orcid: 0000-0003-3509-7650; AlShammari, Abdullah; Buderi, Silviu; Jordan, Simon;
Pulmonary epithelioid haemangioendothelioma (PEH) is a rare vascular neoplasm. The thoracic manifestation of this disorder is identified via three major imaging patterns, namely multiple primary nodules, diffuse infiltrative pleural thickening, and multiple pulmonary reticulonodular opacities. The commonest pattern of presentation is bilateral multiple nodules. Diagnosis is based on histopathological findings and verified by positive immunochemistry staining. Patients with PEH are usually asymptomatic. We report the case of a 51-year-old female who presented to our facility with a five-month history of cough, pleural nodularity, and pleural effusion. She underwent surgical washout with right pleural biopsies that showed a malignant epithelioid tumor with features of epithelioid haemangioendothelioma (EH). A CXR after treatment did not demonstrate a residual pleural effusion.
Apolloarrow_drop_down
Apollo
Other ORP type . 2023
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Apollo
Other ORP type . 2023
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Lessons for 2016 from the smashup of the Second Party System and the War of the Whig succession.
appsOther research productkeyboard_double_arrow_right Other ORP type 2016 United Kingdom
Authors: Burnham, Walter Dean;
LSE Research Onlinearrow_drop_down
LSE Research Online
Other ORP type . 2016
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LSE Research Online
Other ORP type . 2016
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Distributive politics inside the city? The political economy of Spain's Plan E
appsOther research productkeyboard_double_arrow_right Other ORP type 2017 United Kingdom
Authors: Carozzi, Felipe; Repetto, Luca;
LSE Research Onlinearrow_drop_down
LSE Research Online
Other ORP type . 2017
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LSE Research Online
Other ORP type . 2017
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King Edward Point Observatory Monthly Magnetic Bulletin: October 2016
appsOther research productkeyboard_double_arrow_right Other ORP type 2016 United Kingdom
Authors: British Geological Survey;
NERC Open Research A...arrow_drop_down
NERC Open Research Archive
Other ORP type . 2016
Data sources: NERC Open Research Archive
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NERC Open Research Archive
Other ORP type . 2016
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India’s Afghanistan policy needs to look beyond the great game to be effective
appsOther research productkeyboard_double_arrow_right Other ORP type 2022 United Kingdom
Authors: Singh, Shweta;
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LSE Research Online
Other ORP type . 2022
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LSE Research Online
Other ORP type . 2022
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The use of temozolomide in paediatric metastatic phaeochromocytoma/paraganglioma: A case report and literature review.

Green-function Method for Nonlinear Interactions of Elastic Waves

The British press and the end of empire in Africa: to engage with issues of colonial reparation, Britain must address the enduring significance of its media history

Concurrent Data Structures Linked in Time

3D Pioneers Challenge 2018

Epithelioid haemangioendothelioma—a rare cause of right pleural effusion and multiple primary nodules: Case report & review of the literature

Lessons for 2016 from the smashup of the Second Party System and the War of the Whig succession.

Distributive politics inside the city? The political economy of Spain's Plan E

King Edward Point Observatory Monthly Magnetic Bulletin: October 2016

India’s Afghanistan policy needs to look beyond the great game to be effective

The use of temozolomide in paediatric metastatic phaeochromocytoma/paraganglioma: A case report and literature review.

Green-function Method for Nonlinear Interactions of Elastic Waves

The British press and the end of empire in Africa: to engage with issues of colonial reparation, Britain must address the enduring significance of its media history

Concurrent Data Structures Linked in Time

3D Pioneers Challenge 2018

Epithelioid haemangioendothelioma—a rare cause of right pleural effusion and multiple primary nodules: Case report & review of the literature

Lessons for 2016 from the smashup of the Second Party System and the War of the Whig succession.

Distributive politics inside the city? The political economy of Spain's Plan E

King Edward Point Observatory Monthly Magnetic Bulletin: October 2016

India’s Afghanistan policy needs to look beyond the great game to be effective

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