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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Nørremark, Michael; Hansen, Michael Jørgen; Børsting, Christian Friis; Ottosen, Carl-Otto; +1 Authors
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Theses@asb; PURE Aar...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Theses@asb; PURE Aar...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Larsen, T. G.; Ethelberg, S.; Zangenberg, M.; Stensvold, C. R.; +7 Authors
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Brodersen, Jakob; Andersen, Camilla Vaskjær Aakjær;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Aalborg University R...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Aalborg University R...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Bo, Yao;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Hansen, Carsten Jahn; Aaen, Maria; Halkier, Henrik; James, Laura;

    Baggrundsnotat

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: McIlvenny, Paul; Davidsen, Jacob Gorm; Stein, Alexander; Kovács, Artúr Barnabás;

    DOTE is a new type of transcription software developed by the BigSoftVideo team at Aalborg University. It has been designed to support a specific standard of transcription practices common in conversation analysis. It has some of the features commonly found in other software -- such as video playback, a timeline and a visual waveform -- but these features are streamlined and easier to use in DOTE. Moreover, DOTE has enhanced features that do not exist in any legacy software so far, such as auto-completion, intellisense, 360 video support, viewcodes and version control. Our motto is make transcription fun again!

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Rasmussen, John;

    Et mekanisk skelet spændt uden på kroppen kan gøre dig stærkere og sundere – eller give endnu flere arbejdsskader. Exoskeletter i science fiction-stil er nu virkelighed – viden og teknologi afgør, om de bliver drøm eller mareridt.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Jess, Tine;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Heinsen, Laurits;

    Denne PhD-afhandling er baseret på tre originale manuskrifter. Studierne er gennemført på den Kardiologiske Forskningsenhed, OUH Svendborg Hospital.Baggrund Type 2 diabetes mellitus er en betydelig risikofaktor for iskæmisk hjertesygdom. Patienter med type 2diabetes har en høj byrde af traditionelle risikofaktorer, og behandlingen af disse medfører en betydeligreduktion i dødelighed og risikoen for blodprop i hjertet. Til trods for god risikofaktor-kontrol og normalisering af LDL med kolesterolsænkende medicin er disse patienter fortsat i øget risiko for blodprop i hjertet. Dette fænomen betegnes residualrisiko og har været i fokus i de seneste år. Hovedformålet med denne afhandling var at undersøge og beskrive åreforkalkning i asymptomatiske patienter med type 2diabetes som ikke er kendt med iskæmisk hjertesygdom. Delformål 1) At beskrive forekomsten af høj risiko plaque (HRP) og sammenhængen med risikofaktorer samt den koronare kalk score (CACS). 2) At undersøge sammenhængen mellem ændringer i kolesterol, triglycerider, og langtidsblodsukker i forhold til sammensætning og progression af koronar åreforkalkning 3) At evaluere sammenhængen mellem GLP-1 antagonisten liraglutide og ændringer i det totale plaque volumen samt plaque komposition ved opfølgning efter et år. Metode Dette studie var det prospektivt observationsstudie og patienterne blev rekrutteret og undersøgt i perioden fra marts 2016 til september 2017. Patienter med type 2 diabetes uden symptomer og historik mediskæmisk hjertesygdom blev inviteret til at deltage i studiet. Hjerte-CT blev udført ved studiets start og efter et års opfølgning. Det totale plaque-volumen samt plaque sammensætning og højrisiko plaque-morfologi(HRP) blev estimeret ved studiets start og ved opfølgning efter et år. Kliniske data som blodtryk, hjertekardiogram, medicinsk behandling, diabetiske komplikationer, samt blodprøver blev indsamlet ved studietsstart og ved opfølgning efter et år. Opsummering af afhandlingens hovedfund:1) HRP blev observeret hos 37% af patienterne og var associeret med højere langtidsblodsukker, større tobaks-eksponering og mandligt køn. HRP blev identificeret i alle CACS grupper inklusiv CACS på nul.2) Stigende triglycerider var associeret med progression af både høj-risiko plaque og det total plaque volumen. Stigningen i triglycerider var tæt associeret med stigning i vægt, stagnerende HbA1c, samtfaldende lever attenuation. Ydermere var der en klar sammenhængen mellem stigende triglycerider og rest-partikel kolesterol.3) Ændringer i det totale plaque volumen var ikke associeret med liraglutid behandling. Analysen af plaque kompositionen viste, at liraglutide behandling var associeret med øget progression af fibrøst plaque.KonklusionKonklusionen på dette studie er at hjerte-CT er noninvasiv metode som muliggør at karakterisere typen af åreforkalkning samt ændringer over tid. Høj-risiko plaque morfologi blev identificeret hos 37% af patienterne og var associeret med risikofaktorerne langtidsblodsukker, tobaks-eksponering, og mandligt køn, men kunne ikke udelukkes ved fraværet af koronar kalk. En stigning i triglycerider var associeret med plaque progression af høj risiko plaque og en en forværring af den glukometaboliske kontrol samt stigende rest-partikel kolesterol. Liraglutide behandling var associeret med øget progression af fibrøst plaque og er en mulig mekanisme som kan forklare den kardiovaskulære risikoreduktion associeret med liraglutid behandling. This PhD thesis is based on three original manuscripts, and the studies were carried out at the Cardiovascular Research Unit at OUH Svendborg.BackgroundIschemic heart disease remains the leading cause of mortality in type 2 diabetes mellitus (T2D). Despite a significant risk reduction in the last decades, T2D remains associated with twice the risk of all-cause mortality, mainly due to coronary artery disease (CAD). Coronary computed tomography angiography(CCTA) allows the characterization of coronary artery plaque and disease progression, and several studies have demonstrated that high-risk plaque (HRP) is associated with acute coronary syndrome (ACS). Risk stratification of asymptomatic diabetes is challenging and a better understanding of the extent and progression of coronary atherosclerosis in relation to patient characteristics and risk factors is of interest. The overall aim of this PhD study was to assess plaque characteristics and predictions of plaque progression in a cohort of asymptomatic patients with diabetes without CAD. Study objective:1) To assess the prevalence of HRP in asymptomatic T2D and the relationship between HRP and cardiovascular disease (CVD) risk factors, diabetes profile, and the coronary artery calcium score(CACS).2) To assess the association of changes in lipoproteins and glycated hemoglobin (HbA1c) in relation to changes in HRP volumes.3) To assess changes in the total atheroma (TAV) and composition from baseline to follow-up stratified by liraglutide treatmentMethods This PhD thesis is based on data from a prospective observational study performed between March 2016and September 2017 at Odense University Hospital Svendborg. Patients were asymptomatic and without a history of CAD. Serial CCTA was performed to assess total atheroma volume (TAV) and plaque composition at baseline and one-year follow-up. In addition, CACS was assessed from non-enhanced images. A clinical assessment including blood pressure, electrocardiogram, current medication, diabetic complications, and blood test was performed at baseline and at follow-up. The main findings of this PhD thesis were:1) HRP was identified in 37% of patients and was associated with higher HbA1c, greater tobacco exposure, and male gender. HRP was detected in all groups of CACS, and the absence of coronary artery calcium (CACS = 0) could not rule out HRP.2) An increase in triglycerides was associated with the progression of HRP as well as an overall plaque progression. Changes in triglycerides were closely associated with weight gain, stagnant HbA1c, and evidence of increased hepatic fat accumulation. Furthermore, there was a strong association between the increase in triglyceride and the increase in remnant cholesterol.3) We found no association between changes in TAV and liraglutide treatment. The secondary endpoint, changes in plaque composition stratified by liraglutide treatment was positive, and a significant increase in the fibrous plaque volume was detected in the liraglutide treated patients.ConclusionsIn conclusion, CCTA is a non-invasive examination that allows the characterization of plaque composition and changes over time. HRP was detected in 37% of the patients and was associated with higher HbA1c,tobacco exposure, and male gender. Our results warrant caution for use of calcium scoring in this patient group as the absence of coronary artery calcium could not rule out CAD. We found a significant association between an increase in triglyceride levels and HRP progression. The data suggested that this finding was mediated by an increase in remnant cholesterol driven by a worsening in glucometabolic control. Finally, liraglutide was associated with an increase in fibrous plaque which could indicate plaque stabilization. To the best of our knowledge, this study is the first study to assess the association between liraglutide treatment and coronary atherosclerosis in humans.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Zhang, Rui;

    Tekst og netværk er to almindelige former for data. De kan altid bruges samme til at beskrive forskellige applikationer, såsom kommentarsystemer, sociale netværk, og akademiske netværk. Dataanalyse bliver vigtig nu. Det er et afgørende spørgsmålat præsentere tekst- og netværksdata på en effektiv måde. Mange repræsentation læringsmodeller er blevet foreslået til dette problem. Men de fleste metoder har brug for dataetiketter, komplekse systemer og/eller højdimensionelle vektorer forat opnå de gode repræsentationer, og dette er ofte udfordrende for beregning og lagring af både upstream og downstream applikationer. Derfor adresserer denne afhandling ovenstående udfordringer og yder bidrag til repræsentationslæring på tekst- og tekstbaserede netværksdata.Til tekstrepræsentation læring foreslås en multi-label-læringsmodel baseret på semantisk etiketlæring for at kategorisere tekstbaserede publikationer med hierarkiskkategoristruktur. Denne model lærer først repræsentationer af publikationer og kategorier. Derefter genkender og videregiver modellen den matchende information hierarkisk. Endelig opnår denne model bedre forudsigelser i hierarkisk kategori af publikationer.Til tekstbaserede netværksdata foreslås først en metapath-baseret repræsentationsmodel. Denne model kan lære lavdimensionelle repræsentationer for målknuder fra deres tekstattributter og topologiske strukturer ved hjælp af en kaskadestyret selvovervåget læring mekanisme. For at overvinde begrænsningen af metapath og reducere de ekstra omkostninger, foreslår vi også en selvovervåget metapath-fri algoritme med relationsbaseret nabo-graf kontrastlæring. Denne model kan producere globale repræsentationer ved at lære alle knudepunkter og links. Repræsentationerne kan bruges til mange downstream-opgaver. Modellen udkonkurrerer de nyeste metoder.Samlet set giver afhandlingen en omfattende gennemgang af eksisterende repræsentation læringsmetoder og foreslår nye metoder baseret på dyb læring for at producere meget mere effektive og effektive repræsentationer til tekst og netværk. Bidragene er empirisk valideret på adskillige datasæt og opgaver i den virkelige verden. Text and networks, as two common forms of data, always appear cooperatively in describing diverse applications in the real world, such as review systems, social networks, and citation networks. As the demand of data analytics continues to grow, how to effectively and efficiently represent text and network data has become a critical research issue. To resolve this problem, various machine learning models have been proposed for text and network representation learning, but most of them mainly rely on tons of manually labeled training samples, complex systems, and/or high-dimensional vectors to improve the accuracy and precision of representations, which often bring new challenges to computation and storage costs in both upstream and downstream applications. Thus, this thesis addresses the above challengesand makes contributions to representation learning on the text and text-attributed network data.For text representation learning, a label-semantic augmented multi-label-learning model is proposed to categorize text-based publications with hierarchical category structure, which creatively learns representations of publications and categories, recognizes and passes their matching information hierarchically, and as a result, achieves better hierarchical-category predictions.For text-attributed network representation learning, a meta-path-based embedding method is first developed, which is able to learn low-dimensional representations for target-typed nodes from their text attributes and topological structures by a cascaded self-supervised mechanism. Moreover, in order to overcome the limitation of preset meta-paths and reduce the extra learning cost, we also propose a selfsupervised meta-path-free algorithm with relation-based neighbor-graph contrast learning, which could produce global node representations by encoding all-typednodes and relations. These representations can be used for a variety of downstream tasks and outperform state-of-the-art baselines.Overall, this thesis provides a comprehensive review of existing representation learning methods and proposes several novel approaches based on deep learning to produce much more effective and efficient representations for text and networks.The contributions are empirically validated on several real-world datasets and tasks.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Nørremark, Michael; Hansen, Michael Jørgen; Børsting, Christian Friis; Ottosen, Carl-Otto; +1 Authors
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Theses@asb; PURE Aar...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Theses@asb; PURE Aar...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Larsen, T. G.; Ethelberg, S.; Zangenberg, M.; Stensvold, C. R.; +7 Authors
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Brodersen, Jakob; Andersen, Camilla Vaskjær Aakjær;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Aalborg University R...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Aalborg University R...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Bo, Yao;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Hansen, Carsten Jahn; Aaen, Maria; Halkier, Henrik; James, Laura;

    Baggrundsnotat

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: McIlvenny, Paul; Davidsen, Jacob Gorm; Stein, Alexander; Kovács, Artúr Barnabás;

    DOTE is a new type of transcription software developed by the BigSoftVideo team at Aalborg University. It has been designed to support a specific standard of transcription practices common in conversation analysis. It has some of the features commonly found in other software -- such as video playback, a timeline and a visual waveform -- but these features are streamlined and easier to use in DOTE. Moreover, DOTE has enhanced features that do not exist in any legacy software so far, such as auto-completion, intellisense, 360 video support, viewcodes and version control. Our motto is make transcription fun again!

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Rasmussen, John;

    Et mekanisk skelet spændt uden på kroppen kan gøre dig stærkere og sundere – eller give endnu flere arbejdsskader. Exoskeletter i science fiction-stil er nu virkelighed – viden og teknologi afgør, om de bliver drøm eller mareridt.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Jess, Tine;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao VBN; Aalborg Univers...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Heinsen, Laurits;

    Denne PhD-afhandling er baseret på tre originale manuskrifter. Studierne er gennemført på den Kardiologiske Forskningsenhed, OUH Svendborg Hospital.Baggrund Type 2 diabetes mellitus er en betydelig risikofaktor for iskæmisk hjertesygdom. Patienter med type 2diabetes har en høj byrde af traditionelle risikofaktorer, og behandlingen af disse medfører en betydeligreduktion i dødelighed og risikoen for blodprop i hjertet. Til trods for god risikofaktor-kontrol og normalisering af LDL med kolesterolsænkende medicin er disse patienter fortsat i øget risiko for blodprop i hjertet. Dette fænomen betegnes residualrisiko og har været i fokus i de seneste år. Hovedformålet med denne afhandling var at undersøge og beskrive åreforkalkning i asymptomatiske patienter med type 2diabetes som ikke er kendt med iskæmisk hjertesygdom. Delformål 1) At beskrive forekomsten af høj risiko plaque (HRP) og sammenhængen med risikofaktorer samt den koronare kalk score (CACS). 2) At undersøge sammenhængen mellem ændringer i kolesterol, triglycerider, og langtidsblodsukker i forhold til sammensætning og progression af koronar åreforkalkning 3) At evaluere sammenhængen mellem GLP-1 antagonisten liraglutide og ændringer i det totale plaque volumen samt plaque komposition ved opfølgning efter et år. Metode Dette studie var det prospektivt observationsstudie og patienterne blev rekrutteret og undersøgt i perioden fra marts 2016 til september 2017. Patienter med type 2 diabetes uden symptomer og historik mediskæmisk hjertesygdom blev inviteret til at deltage i studiet. Hjerte-CT blev udført ved studiets start og efter et års opfølgning. Det totale plaque-volumen samt plaque sammensætning og højrisiko plaque-morfologi(HRP) blev estimeret ved studiets start og ved opfølgning efter et år. Kliniske data som blodtryk, hjertekardiogram, medicinsk behandling, diabetiske komplikationer, samt blodprøver blev indsamlet ved studietsstart og ved opfølgning efter et år. Opsummering af afhandlingens hovedfund:1) HRP blev observeret hos 37% af patienterne og var associeret med højere langtidsblodsukker, større tobaks-eksponering og mandligt køn. HRP blev identificeret i alle CACS grupper inklusiv CACS på nul.2) Stigende triglycerider var associeret med progression af både høj-risiko plaque og det total plaque volumen. Stigningen i triglycerider var tæt associeret med stigning i vægt, stagnerende HbA1c, samtfaldende lever attenuation. Ydermere var der en klar sammenhængen mellem stigende triglycerider og rest-partikel kolesterol.3) Ændringer i det totale plaque volumen var ikke associeret med liraglutid behandling. Analysen af plaque kompositionen viste, at liraglutide behandling var associeret med øget progression af fibrøst plaque.KonklusionKonklusionen på dette studie er at hjerte-CT er noninvasiv metode som muliggør at karakterisere typen af åreforkalkning samt ændringer over tid. Høj-risiko plaque morfologi blev identificeret hos 37% af patienterne og var associeret med risikofaktorerne langtidsblodsukker, tobaks-eksponering, og mandligt køn, men kunne ikke udelukkes ved fraværet af koronar kalk. En stigning i triglycerider var associeret med plaque progression af høj risiko plaque og en en forværring af den glukometaboliske kontrol samt stigende rest-partikel kolesterol. Liraglutide behandling var associeret med øget progression af fibrøst plaque og er en mulig mekanisme som kan forklare den kardiovaskulære risikoreduktion associeret med liraglutid behandling. This PhD thesis is based on three original manuscripts, and the studies were carried out at the Cardiovascular Research Unit at OUH Svendborg.BackgroundIschemic heart disease remains the leading cause of mortality in type 2 diabetes mellitus (T2D). Despite a significant risk reduction in the last decades, T2D remains associated with twice the risk of all-cause mortality, mainly due to coronary artery disease (CAD). Coronary computed tomography angiography(CCTA) allows the characterization of coronary artery plaque and disease progression, and several studies have demonstrated that high-risk plaque (HRP) is associated with acute coronary syndrome (ACS). Risk stratification of asymptomatic diabetes is challenging and a better understanding of the extent and progression of coronary atherosclerosis in relation to patient characteristics and risk factors is of interest. The overall aim of this PhD study was to assess plaque characteristics and predictions of plaque progression in a cohort of asymptomatic patients with diabetes without CAD. Study objective:1) To assess the prevalence of HRP in asymptomatic T2D and the relationship between HRP and cardiovascular disease (CVD) risk factors, diabetes profile, and the coronary artery calcium score(CACS).2) To assess the association of changes in lipoproteins and glycated hemoglobin (HbA1c) in relation to changes in HRP volumes.3) To assess changes in the total atheroma (TAV) and composition from baseline to follow-up stratified by liraglutide treatmentMethods This PhD thesis is based on data from a prospective observational study performed between March 2016and September 2017 at Odense University Hospital Svendborg. Patients were asymptomatic and without a history of CAD. Serial CCTA was performed to assess total atheroma volume (TAV) and plaque composition at baseline and one-year follow-up. In addition, CACS was assessed from non-enhanced images. A clinical assessment including blood pressure, electrocardiogram, current medication, diabetic complications, and blood test was performed at baseline and at follow-up. The main findings of this PhD thesis were:1) HRP was identified in 37% of patients and was associated with higher HbA1c, greater tobacco exposure, and male gender. HRP was detected in all groups of CACS, and the absence of coronary artery calcium (CACS = 0) could not rule out HRP.2) An increase in triglycerides was associated with the progression of HRP as well as an overall plaque progression. Changes in triglycerides were closely associated with weight gain, stagnant HbA1c, and evidence of increased hepatic fat accumulation. Furthermore, there was a strong association between the increase in triglyceride and the increase in remnant cholesterol.3) We found no association between changes in TAV and liraglutide treatment. The secondary endpoint, changes in plaque composition stratified by liraglutide treatment was positive, and a significant increase in the fibrous plaque volume was detected in the liraglutide treated patients.ConclusionsIn conclusion, CCTA is a non-invasive examination that allows the characterization of plaque composition and changes over time. HRP was detected in 37% of the patients and was associated with higher HbA1c,tobacco exposure, and male gender. Our results warrant caution for use of calcium scoring in this patient group as the absence of coronary artery calcium could not rule out CAD. We found a significant association between an increase in triglyceride levels and HRP progression. The data suggested that this finding was mediated by an increase in remnant cholesterol driven by a worsening in glucometabolic control. Finally, liraglutide was associated with an increase in fibrous plaque which could indicate plaque stabilization. To the best of our knowledge, this study is the first study to assess the association between liraglutide treatment and coronary atherosclerosis in humans.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao