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1,551 research outcomes, page 1 of 156
  • publication . Article . Other literature type . Preprint . 2021
    Open Access English
    Authors:
    Maryam Alqabandi; N. de Franceschi; Nolwenn Miguet; Sourav Maity; Marta Bally; Wouter H. Roos; Winfried Weissenhorn; Patricia Bassereau; Stéphanie Mangenot;
    Project: ANR | PSL (ANR-10-IDEX-0001), EC | ESCRT model (751715), ANR | ESCRTfission (ANR-14-CE09-0003), EC | INTERACT (751404), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Clarisse Uwizeye; Johan Decelle; Pierre-Henri Jouneau; Serena Flori; Benoit Gallet; Jean-Baptiste Keck; Davide Dal Bo; Christine Moriscot; Claire Seydoux; Fabien Chevalier; ...
    Publisher: HAL CCSD
    Project: EC | ChloroMito (833184), ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | CORBEL (654248), ANR | MoMix (ANR-17-CE05-0029)

    Nature Communications, 12 (1)

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  • publication . Article . 2021
    Open Access
    Authors:
    Enrico Luchinat; Letizia Barbieri; Matteo Cremonini; Matteo Pennestri; Alessio Nocentini; Claudiu T. Supuran; Lucia Banci;
    Persistent Identifiers
    Publisher: International Union of Crystallography (IUCr)
    Project: EC | iNEXT-Discovery (871037), EC | INSTRUCT-ULTRA (731005)

    Structure-based drug development suffers from high attrition rates due to the poor activity of lead compounds in cellular and animal models caused by low cell penetrance, off-target binding or changes in the conformation of the target protein in the cellular environment...

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  • publication . Article . 2021
    Open Access
    Authors:
    F. Helfrich; Axel J. Scheidig;
    Persistent Identifiers
    Publisher: International Union of Crystallography (IUCr)
    Project: EC | iNEXT (653706)

    Polyamines influence medically relevant processes in the opportunistic pathogen Pseudomonas aeruginosa, including virulence, biofilm formation and susceptibility to antibiotics. Although homospermidine synthase (HSS) is part of the polyamine metabolism in various strain...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Ohmann, Christian; Moher, David; Siebert, Maximilian; Motschall, Edith; Naudet, Florian;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | CORBEL (654248)

    ObjectivesTo explore the impact of data-sharing initiatives on the intent to share data, on actual data sharing, on the use of shared data and on research output and impact of shared data.Eligibility criteriaAll studies investigating data-sharing practices for individua...

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  • publication . Article . 2021
    Open Access English
    Authors:
    D. Xu; J. van der Voet; J.H. Waarsing; E.H. Oei; S. Klein; M. Englund; F. Zhang; S. Bierma-Zeinstra; J. Runhaar;
    Persistent Identifiers
    Publisher: Elsevier
    Project: EC | CORBEL (654248)

    OBJECTIVE: To explore the interplay between (changes in) medial meniscus volume, meniscus extrusion and radiographic knee osteoarthritis (OA) development over 30 months follow-up (FU). METHODS: Data from the PRevention of knee Osteoarthritis in Overweight Females study ...

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  • publication . Article . 2021
    Open Access
    Authors:
    Wouter Elings; Aleksandra Chikunova; Danny B. van Zanten; Ralphe Drenth; Misbha Ud Din Ahmad; Anneloes J. Blok; Monika Timmer; Anastassis Perrakis; Marcellus Ubbink;
    Persistent Identifiers
    Publisher: American Society for Microbiology
    Project: EC | iNEXT (653706)

    The β-lactamase of Mycobacterium tuberculosis , BlaC, is susceptible to inhibition by clavulanic acid. The ability of this enzyme to escape inhibition through mutation was probed using error-prone PCR combined with functional screening in Escherichia coli .

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  • publication . Article . 2021
    Open Access
    Authors:
    Francesco Torricella; Alessio Bonucci; Panagis Polykretis; Francesca Cencetti; Lucia Banci;
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: EC | INSTRUCT-ULTRA (731005), EC | iNEXT-Discovery (871037)
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  • publication . Article . Other literature type . 2021
    Open Access English
    Authors:
    Sergi López-Serrano; Lorena Cordoba; Mónica Pérez-Maillo; Patricia Pleguezuelos; Edmond J. Remarque; Thomas Ebensen; Carlos A. Guzmán; Dennis Christensen; Joaquim Segalés; Ayub Darji;
    Persistent Identifiers
    Publisher: MDPI
    Project: EC | TRANSVAC2 (730964)

    This study aimed to evaluate the immune response and protection correlates against influenza virus (IV) infection in pigs vaccinated with the novel NG34 HA1 vaccine candidate adjuvanted with either CAF®01 or CDA/αGalCerMPEG (αGCM). Two groups of six pigs each were vacci...

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  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Uwizeye Clarisse; Mars Brisbin Margaret; Gallet Benoit; Chevalier Fabien; LeKieffre Charlotte; Schieber L. Nicole; Falconet Denis; Wangpraseurt Daniel; Schertel Lukas; Stryhanyuk Hryhoriy; ...
    Publisher: HAL CCSD
    Project: EC | CORBEL (654248), EC | ChloroMito (833184)

    Endosymbioses have shaped the evolutionary trajectory of life and remain ecologically important. Investigating oceanic photosymbioses can illuminate how algal endosymbionts are energetically exploited by their heterotrophic hosts and inform on putative initial steps of ...

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1,551 research outcomes, page 1 of 156