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133 research outcomes, page 1 of 14
  • publication . Article . Other literature type . Preprint . 2021
    Open Access English
    Authors:
    Alqabandi, Maryam; de Franceschi, Nicola; Miguet, Nolwenn; Maity, Sourav; Bally, Marta; Roos, Wouter H.; Weissenhorn, Winfried; Bassereau, Patricia; Mangenot, Stéphanie;
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), ANR | PSL (ANR-10-IDEX-0001), ANR | ESCRTfission (ANR-14-CE09-0003), EC | ESCRT model (751715), EC | INTERACT (751404)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Preprint . 2021
    Open Access
    Authors:
    Laure Coutos-Thévenot; Syrine Beji; Hélène Neyret-Kahn; Quentin Pippo; Jacqueline Fontugne; J. Osz; Clémentine Krucker; Clarice Dos Santos Groeneveld; Florent Dufour; Aurélie Kamoun; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: ANR | INRT (ANR-10-LABX-0030), ANR | UNISTRA (ANR-10-IDEX-0002)

    AbstractPPARγ activation is a critical event in luminal muscle-invasive bladder cancer (MIBC) tumorigenesis, favoring both tumor cell growth and microenvironment modulation toward tumor immune escape. Conversely, the down-regulation of PPARγ activity in basal MIBC sugge...

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  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Uwizeye Clarisse; Mars Brisbin Margaret; Gallet Benoit; Chevalier Fabien; LeKieffre Charlotte; Schieber L. Nicole; Falconet Denis; Wangpraseurt Daniel; Schertel Lukas; Stryhanyuk Hryhoriy; ...
    Publisher: HAL CCSD
    Project: EC | ChloroMito (833184), EC | CORBEL (654248)

    Endosymbioses have shaped the evolutionary trajectory of life and remain ecologically important. Investigating oceanic photosymbioses can illuminate how algal endosymbionts are energetically exploited by their heterotrophic hosts and inform on putative initial steps of ...

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  • publication . Preprint . 2021
    Open Access English
    Authors:
    Zullino, Sara; Paglialonga, Alessandro; Dastrù, Walter; Longo, Dario Livio; Aime, Silvio;
    Project: EC | GLINT (667510), EC | EOSC-Life (824087), EC | CORBEL (654248)

    Molecular imaging generates large volumes of heterogeneous biomedical imagery with an impelling need of guidelines for handling image data. Although several successful solutions have been implemented for human epidemiologic studies, few and limited approaches have been ...

  • publication . Preprint . Article . 2021
    Open Access
    Authors:
    Edvardas Golovinas; Danielis Rutkauskas; Elena Manakova; Marija Jankunec; Arunas Silanskas; Giedrius Sasnauskas; Mindaugas Zaremba;
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | iNEXT (653706)

    Argonaute (Ago) proteins are found in all three domains of life. The best-characterized group is eukaryotic Argonautes (eAgos), which are the core of RNA interference. The best understood prokaryotic Ago (pAgo) proteins are full-length pAgos. They are composed of four m...

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  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Juraszek, Jarek; Rutten, Lucy; Blokland, Sven; Bouchier, Pascale; Voorzaat, Richard; Ritschel, Tina; Bakkers, Mark J. G.; Renault, Ludovic L. R.; Langedijk, Johannes P. M.;
    Project: EC | INSTRUCT-ULTRA (731005)

    SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominan...

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  • publication . Preprint . 2021
    Open Access English
    Authors:
    Eleftherios Zarkadas; Hong Zhang; Wensheng Cai; Gregory Effantin; Jonathan Perot; Jacques Neyton; Christophe Chipot; Guy Schoehn; François Dehez; Hugues Nury;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | PentaBrain (637733), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Inaccurately perceived as niche drugs, antiemetics are key elements of cancer treatment alleviating the most dreaded side effect of chemotherapy. Serotonin 5-HT3 receptor antagonists are the most commonly prescribed class of drugs to control chemotherapy-induced nausea ...

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  • publication . Article . Preprint . 2021
    Open Access
    Authors:
    Christophe Caillat; Guilligay D; Torralba J; Nikolas Friedrich; Nieva Jl; Alexandra Trkola; Chris Chipot; François Dehez; Winfried Weissenhorn;
    Publisher: eLife Sciences Publications, Ltd
    Project: EC | EAVI2020 (681137), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate state by an MPER-specific neutralizing antib...

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  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Erik I. Hallin; Sigurbjorn Markusson; Lev Bottger; Andrew E. Torda; Clive R. Bramham; Petri Kursula;
    Publisher: Public Library of Science
    Project: EC | iNEXT (653706), EC | CALIPSOplus (730872)

    Published by PLOS, San Francisco, California, US

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  • publication . Article . Preprint . 2021
    Open Access
    Authors:
    Abdul Rehman; Armstrong; Lange; Kristariyanto; Grawert; Knebel; Svergun; Kulathu;
    Publisher: Elsevier BV

    Summary Of the eight distinct polyubiquitin (polyUb) linkages that can be assembled, the roles of K48-linked polyUb (K48-polyUb) are the most established, with K48-polyUb modified proteins being targeted for degradation. MINDY1 and MINDY2 are members of the MINDY family...

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133 research outcomes, page 1 of 14