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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Dunn, Harriet;

    Negotiated Development Agreements (NDvAs) are a tool of public-sector deal-making in Sweden where land-use and transport initiatives are integrated via contracts between national, regional and local actors. Negotiations involve the direct quid pro quo trading of public transport financing in direct exchange for local housing commitments. The article contributes to ongoing conversations regarding public-sector deal-making by demonstrating how contractualism plays out in contexts where land-use planning is strongly decentralised and infrastructure planning highly centralised. The article sheds light on the core rationales underpinning deal-based governance, as well as demonstrating how negotiations play out in practise. The aims are addressed through a case study of the most recent batch of agreements: the New Towns inquiry. NDvAs are conceptualized as a mechanism by which the central state attempts to both affect local land-use decisions and metagovern the complex actor networks characterizing integrated planning. Rapid quid pro quo deals, made behind closed doors, allow for the maximisation of municipal housing commitments and minimisation of critique, bypassing existing statutory decision-making processes. This has consequences for the relations between central-local planning actors and for the democratic legitimacy of decisions made, and thus the potential actualisation of housing commitments. The findings elucidate the role of nation states in setting the conditions for integrated transport and land-use governance, as well as the tensions that arise when this is orchestrated through informal, deal-based instruments. QC 20240115

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    Publikationer från KTH
    Article . 2023 . Peer-reviewed
    Nordic Journal of Urban Studies
    Article . 2023 . Peer-reviewed
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      Publikationer från KTH
      Article . 2023 . Peer-reviewed
      Nordic Journal of Urban Studies
      Article . 2023 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Tzu‐Yin Chen; Eileen Shyur; Tzu‐Hsuan Ma; Lakshmi Wijeyewickrema; +7 Authors

    Hirudins, natural sulfo(glyco)proteins, are clinical anticoagulants that directly inhibit thrombin, a key coagulation factor. Their potent thrombin inhibition primarily results from antagonistic interactions with both the catalytic and non-catalytic sites of thrombin. Hirudins often feature sulfate moieties on Tyr residues in their anionic C-terminus region, enabling strong interactions with thrombin exosite-I and effectively blocking its engagement with fibrinogen. Although sulfotyrosines have been identified in various hirudin variants, the precise relationship between sulfotyrosine and the number of negatively charged amino acids within the anionic-rich C-terminus peptide domain for the binding of thrombin has remained elusive. By using Fmoc-SPPS, hirudin dodecapeptides homologous to the C-terminus of hirudin variants from various leech species were successfully synthesized, and the effect of sulfotyrosine and the number of negatively charged amino acids on hirudin-thrombin interactions was investigated. Our findings did not reveal any synergistic effect between an increasing number of sulfotyrosines or negatively charged amino acids and their inhibitory activity on thrombin or fibrinolysis in the assays, despite a higher binding level toward thrombin in the sulfated dodecapeptide Hnip_Hirudin was observed in SPR analysis. QC 20240209

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    ChemBioChem
    Article . 2023 . Peer-reviewed
    License: CC BY
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    https://doi.org/10.26181/25272...
    Other literature type . 2024
    License: CC BY
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    https://doi.org/10.26181/25272...
    Other literature type . 2024
    License: CC BY
    Data sources: Datacite
    ChemBioChem
    Article . 2023
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      ChemBioChem
      Article . 2023 . Peer-reviewed
      License: CC BY
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      https://doi.org/10.26181/25272...
      Other literature type . 2024
      License: CC BY
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      https://doi.org/10.26181/25272...
      Other literature type . 2024
      License: CC BY
      Data sources: Datacite
      ChemBioChem
      Article . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Susanne Engström; Johanna Blom;

    This study aims to understand how students manage higher technical education and contribute to research on institutional culture, STEM education, and students’ educational strategies by identifying patterns of how students navigate within one university’s engineering education. To achieve this, we define and use the concept of technical science capital and habitus reconstruction. We collected data through a survey sent to engineering students who have followed an engineering program’s intended linear progression and those who have taken a ‘detour’ within the same cohort at one specific Swedish university. The survey had a high number of qualitative questions, including free text answers that captured students’ narratives. The results indicate that having a large amount of technical science capital alone is not enough for students to be successful in their studies. The university culture has its own structure, which can be intolerant. Within this culture, specific social skills and experiences are desirable, which provides students from a particular background with a greater opportunity for success. Despite possessing high technical science capital, students from other social groups or cultures face challenges. We discuss various measures that could make higher technical education more engaging. This study is limited to one Swedish university, and future studies could include a broader sample that represents several universities. QC 20240212

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    International Journal of Technology and Design Education
    Article . 2023 . Peer-reviewed
    License: CC BY
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Publikationer från K...arrow_drop_down
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      International Journal of Technology and Design Education
      Article . 2023 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Mehdifar, Farhad; Lindemann, Lars; Bechlioulis, Charalampos P; Dimarogonas, Dimos V.;

    This paper proposes a novel control framework for handling (potentially coupled) multiple time-varying output constraints for uncertain nonlinear systems. First, it is shown that the satisfaction of multiple output constraints boils down to ensuring the positiveness of a scalar variable (the signed distance from the time-varying output-constrained set's boundary). Next, a single funnel constraint is designed properly, whose satisfaction ensures convergence to and invariance of the time-varying output-constrained set. Then a robust and low-complexity funnel-based feedback controller is designed employing the prescribed performance control method. Finally, a simulation example clarifies and verifies the proposed approach. Comment: 9 pages, 2 figures, submitted to 2023 IEEE 62nd Conference on Decision and Control (CDC)

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ arXiv.org e-Print Ar...arrow_drop_down
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    arXiv.org e-Print Archive
    Other literature type . Preprint . 2023
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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    https://doi.org/10.1109/cdc497...
    Conference object . 2023 . Peer-reviewed
    License: STM Policy #29
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    https://doi.org/10.48550/arxiv...
    Article . 2023
    License: arXiv Non-Exclusive Distribution
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      arXiv.org e-Print Archive
      Other literature type . Preprint . 2023
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      https://doi.org/10.1109/cdc497...
      Conference object . 2023 . Peer-reviewed
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      https://doi.org/10.48550/arxiv...
      Article . 2023
      License: arXiv Non-Exclusive Distribution
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Marchesini, Gregorio; Roque, Pedro; Dimarogonas, Dimos V.;

    In this work, we propose an extension of the previously introduced Corridor Model Predictive Control scheme for high-order and distributed systems, with an application for on-orbit inspection. To this end, we leverage high order control barrier function (HOCBF) constraints as a suitable control approach to maintain each agent in the formation within a safe corridor from its reference trajectory. The recursive feasibility of the designed MPC scheme is tested numerically, while suitable modifications of the classical HOCBF constraint definition are introduced such that safety is guaranteed both in sampled and continuous time. The designed controller is validated through computer simulation in a realistic inspection scenario of the International Space Station. Comment: Paper accepted at Conference on Decision and Control 2023 (CDC)

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    https://doi.org/10.1109/cdc497...
    Conference object . 2023 . Peer-reviewed
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    Article . 2024
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    Authors: Zhang, Qi; Ma, Zhenliang; Zhang, Pengfei; Jenelius, Erik;

    Understanding human mobility in urban areas is crucial for transportation planning, operations, and online control. The availability of large-scale and diverse mobility data (e.g., smart card data, GPS data), provides valuable insights into human mobility patterns. However, organizing and analyzing such data pose significant challenges. Knowledge graph (KG), a graph-based knowledge representation method, has been successfully applied in various domains but has limited applications in urban mobility. This paper aims to address this gap by reviewing existing KG studies, introducing the concept of a mobility knowledge graph (MKG), and proposing a general learning framework to construct MKG from smart card data. The MKG represents hidden travel activities between public transport stations, with stations as nodes and their relations as edges. Two decomposition approaches, rule-based and neural network-based models, are developed to extract MKG relations from smart card data, capturing latent spatiotemporal travel dependencies. The case study is conducted using smart card data from a heavily used urban railway system to validate the effectiveness of MKG in predicting individual trip destinations. The results demonstrate the significance of establishing an MKG database, as it assists in a typical problem of predicting individual trip destinations for public transport systems with only tap-in records. Additionally, the MKG framework offers potential for efficient data management and applications such as individual mobility prediction and personalized travel recommendations. QC 20231211

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    Transportation
    Article . 2023 . Peer-reviewed
    License: CC BY
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      Transportation
      Article . 2023 . Peer-reviewed
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    Authors: Lena Gumaelius; Inga-Britt Skogh; Ásrún Matthíasdóttir; Panagiotis Pantzos;

    This study investigates the question of how Engineering education in the Nordic region responds to the challenge of educating future engineers who are ready for professional practice in a digital world. Particular interest is put on identifying who is responsible for the implementation of digital knowledge and what and how subject content is addressed. Our study draws on Bernstein’s pedagogical device model (Bernstein, B. 2002. “Editorial: Basil Bernstein’s Theory of Social Class, Educational Codes and Social Control.” British Journal of Sociology of Education 23 (4): 525–526). The study focuses on the questions of if/how digital transformation leads to change of engineering education content and/or pedagogical approaches. Narratives of 20 university teachers have been collected and analysed. Findings reveal three areas of consideration; there is a connection between how digital knowledge is valued and how the subject is introduced in engineering education, differences in digital knowledge can be linked to the generation gap and, universities are seldom seen as the driving force for digital innovation. It is concluded that education must reflect on the purpose for which digitalisation takes place, continuous training targeting digital transformation should be offered to senior teachers and, universities need to provide increased focus and dedicated time for educational development. QC 20231215

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    European Journal of Engineering Education
    Article . 2023 . Peer-reviewed
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      European Journal of Engineering Education
      Article . 2023 . Peer-reviewed
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    Authors: Mathias Fridahl; Felix Schenuit; Liv Lundberg; Kenneth Möllersten; +3 Authors

    In comparison to its emissions reductions policy, the European Union’s (EU) policy for achieving carbon dioxide (CO2) removals is underdeveloped. Only in forestry and land usemanagement does current EU law allow its Member States to use removals to comply with their climate policy commitments. This excludes the potential role that novel removals could play for effectively and efficiently addressing climate policy objectives. Novel removals with significantEuropean potential include bioenergy with carbon capture and storage, biochar, enhanced weathering, marine removal options like alkalinity enhancement, and direct air carbon captureand storage.Emissions reductions are crucial to mitigating climate change. However, in the past decade, the world community’s failure to reduce emissions at a sufficient speed to avoid dangerous climate change has become obvious. This reality acutely necessitates the development of innovative sets of policies to spur the deployment of novel CO2 removals, an urgency that is further underlined by the long lead time for many novel removal methods. Disregarding the potential of novel removals is incommensurate with the scale of the challenge of achieving EU’s commitment to reach net-zero greenhouse gas emissions by 2050. We argue that the current policy framework neither provides Union-wide economic incentives for novel CO2 removals, nor does it encourage EU Member States to develop national policy incentives. Our proposed solutions includes incentivizing removals through a conditional integration into the EU Emissions Trading System (ETS), expanding the portfolio of removal methods in the Land-Use, Land-Use Change and Forestry (LULUCF) Regulation, and to manage anticipations regarding which residual emissions that need to be counterbalanced by removals. QC 20231211

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    EconStor
    Article . 2023
    License: CC BY
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    Article . 2023
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      EconStor
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    Authors: Andrea de Giorgio; Fabio Marco Monetti; Antonio Maffei; Mario Romero; +1 Authors

    The training of future experts and operators in manufacturing engineering relies on understanding procedural processes that require applied practice. Yet, current manufacturing education and training overwhelmingly continues to depend on traditional pedagogical methods that segregate theoretical studies and practical training. While educational institutes have generally improved theoretical studies, they often lack facilities and labs to properly reproduce the working environments necessary for practice. Even in industrial settings, it is difficult, if not impossible, to halt the actual production lines to train new operators. Recently, applications with extended reality (XR) technologies, such as virtual, augmented, or mixed reality, reached a mature technology readiness level. With this technological advancement, we can envision a transition to a new teaching paradigm that exploits simulated learning environments. Thus, it becomes possible to bridge the gap between theory and practice for both students and industrial trainees. This article presents a systematic literature review of the main applications of XR technologies in manufacturing education, their goals and technology readiness levels, and a comprehensive overview of the development tools and experimental strategies deployed. This review contributes: (1) a state-of-the-art description of current research in XR education for manufacturing systems, and (2) a comprehensive analysis of the technological platforms, the experimental procedures and the analytical methodologies deployed in the body of literature examined. It serves as a guide for setting up and executing experimental designs for evaluating interventions of XR in manufacturing education and training. QC 20231215

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    Journal of Manufacturing Systems
    Article . 2023 . Peer-reviewed
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      Journal of Manufacturing Systems
      Article . 2023 . Peer-reviewed
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    Authors: Vania Ceccato; Chloé Martin;

    Virtual reality (VR) has become an important resource in light research and an ultimate tool for participatory approaches in sustainable urban planning. This article reviews the research design of VR light research focusing on the profile of participants. A search for peer-reviewed articles using a systematic literature review in Scopus (2000-2023) resulted in 56 articles that show that a quarter of the studies integrate the participants' characteristics into the results but the nature of the samples may put into doubt the external validity of the results. The article discusses the implications of these findings for research and practice. QC 20231027

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    Sustainable Futures
    Article . 2023
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    Sustainable Futures
    Article . 2023 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Dunn, Harriet;

    Negotiated Development Agreements (NDvAs) are a tool of public-sector deal-making in Sweden where land-use and transport initiatives are integrated via contracts between national, regional and local actors. Negotiations involve the direct quid pro quo trading of public transport financing in direct exchange for local housing commitments. The article contributes to ongoing conversations regarding public-sector deal-making by demonstrating how contractualism plays out in contexts where land-use planning is strongly decentralised and infrastructure planning highly centralised. The article sheds light on the core rationales underpinning deal-based governance, as well as demonstrating how negotiations play out in practise. The aims are addressed through a case study of the most recent batch of agreements: the New Towns inquiry. NDvAs are conceptualized as a mechanism by which the central state attempts to both affect local land-use decisions and metagovern the complex actor networks characterizing integrated planning. Rapid quid pro quo deals, made behind closed doors, allow for the maximisation of municipal housing commitments and minimisation of critique, bypassing existing statutory decision-making processes. This has consequences for the relations between central-local planning actors and for the democratic legitimacy of decisions made, and thus the potential actualisation of housing commitments. The findings elucidate the role of nation states in setting the conditions for integrated transport and land-use governance, as well as the tensions that arise when this is orchestrated through informal, deal-based instruments. QC 20240115

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    Publikationer från KTH
    Article . 2023 . Peer-reviewed
    Nordic Journal of Urban Studies
    Article . 2023 . Peer-reviewed
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      Publikationer från KTH
      Article . 2023 . Peer-reviewed
      Nordic Journal of Urban Studies
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    Authors: Tzu‐Yin Chen; Eileen Shyur; Tzu‐Hsuan Ma; Lakshmi Wijeyewickrema; +7 Authors

    Hirudins, natural sulfo(glyco)proteins, are clinical anticoagulants that directly inhibit thrombin, a key coagulation factor. Their potent thrombin inhibition primarily results from antagonistic interactions with both the catalytic and non-catalytic sites of thrombin. Hirudins often feature sulfate moieties on Tyr residues in their anionic C-terminus region, enabling strong interactions with thrombin exosite-I and effectively blocking its engagement with fibrinogen. Although sulfotyrosines have been identified in various hirudin variants, the precise relationship between sulfotyrosine and the number of negatively charged amino acids within the anionic-rich C-terminus peptide domain for the binding of thrombin has remained elusive. By using Fmoc-SPPS, hirudin dodecapeptides homologous to the C-terminus of hirudin variants from various leech species were successfully synthesized, and the effect of sulfotyrosine and the number of negatively charged amino acids on hirudin-thrombin interactions was investigated. Our findings did not reveal any synergistic effect between an increasing number of sulfotyrosines or negatively charged amino acids and their inhibitory activity on thrombin or fibrinolysis in the assays, despite a higher binding level toward thrombin in the sulfated dodecapeptide Hnip_Hirudin was observed in SPR analysis. QC 20240209

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    ChemBioChem
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    ChemBioChem
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      ChemBioChem
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      ChemBioChem
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    Authors: Susanne Engström; Johanna Blom;

    This study aims to understand how students manage higher technical education and contribute to research on institutional culture, STEM education, and students’ educational strategies by identifying patterns of how students navigate within one university’s engineering education. To achieve this, we define and use the concept of technical science capital and habitus reconstruction. We collected data through a survey sent to engineering students who have followed an engineering program’s intended linear progression and those who have taken a ‘detour’ within the same cohort at one specific Swedish university. The survey had a high number of qualitative questions, including free text answers that captured students’ narratives. The results indicate that having a large amount of technical science capital alone is not enough for students to be successful in their studies. The university culture has its own structure, which can be intolerant. Within this culture, specific social skills and experiences are desirable, which provides students from a particular background with a greater opportunity for success. Despite possessing high technical science capital, students from other social groups or cultures face challenges. We discuss various measures that could make higher technical education more engaging. This study is limited to one Swedish university, and future studies could include a broader sample that represents several universities. QC 20240212

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    International Journal of Technology and Design Education
    Article . 2023 . Peer-reviewed
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