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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Mishra, Aniket; Malik, Rainer; He, Yunye; Rosand, Jonathan; +256 Authors

    Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries. Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.

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    Apollo
    Other literature type . 2022
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    Nature
    Article . 2022
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    Nature
    Article . 2022
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    Apollo
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    Lille Open Archive
    Review . 2022
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    Serveur académique lausannois
    Article . 2022
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    Radboud Repository
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    Apollo
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    Lille Open Archive
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    NTNU Open
    Article . 2022
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Apollo
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    NARCIS
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    Nature
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    Apollo
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    Apollo
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    Apollo
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      Nature
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      Lille Open Archive
      Review . 2022
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      Serveur académique lausannois
      Article . 2022
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      NTNU Open
      Article . 2022
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      Apollo
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      Nature
      Article . 2021
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    Authors: Åström Elmersjö, Henrik;

    Review (English): Johan Samuelsson, Läroverken och progressivismen: Perspektiv på historieundervisningens praktik och policy 1920–1950, Lund: Nordic Academic Press, 2021, 290pp.

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    Authors: Gilhus, Ingvild Sælid; Kraft, Siv Ellen; Sundström, Olle;

    Konsta Kaikkonens avhandling er en kildekritisk studie av noen av de historiske kildene til det forfatteren kaller noaidevuohta, dvs. funksjoner, tradisjoner og fenomener knyttet til de sentrale rituelle spesialistene (noaidit) i det nordsamiske området. Målet er å utføre «an autopsy on the concept of Saami shamanism», gjennom kontekstualisering av kilder og forfatterposisjoner i forhold til noaidevuohta, til det samiske, til andre tekster om samme anliggender, og til diskurser, paradigmer, idehistoriske strømninger og samfunnsmessige forhold Presentasjon av ny ph.d.-avhandling: Konsta Kaikkonen, 2020, Contextualising Descriptions of Noaidevuohta: Saami Ritual Specialists in Texts Written until 1871, Bergen: Universitetet i Bergen.

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    Authors: Fairbrother, Malcolm;

    Review of: From the Inside Out: The Fight for Environmental Justice within Government Agencies, by Jill Lindsey Harrison. Cambridge, MA: MITPress, 2019. 328 pp. ISBN: 9780262537742.

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    Authors: Proctor, Helen;

    Review: Christian Ydesen (ed.). The OECD’s historical rise in education: the formation of a global governing complex. London: Palgrave Macmillan, 2019, 308 pp.

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    Authors: Skundberg, Øystein;

    Review: Björn Norlin. Skolagans historia och pedagogik: Sedlighetsfostran, disciplinering och våldsbruk i den tidigmoderna skolan, 1560–1820. Lund: Nordic Academic Press, 2021, 267 pp.

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    Authors: Parfa Koskinen, Katarina;

    This is a book review of an anthropological anthology, Indigenous Efflorescence. Beyond revitalisation in Sápmi and Ainu Mosiredited by Gerhard Roche, Hiroshi Maruyama and Åsa Virdi Kråik (2018). The volume acknowledge ongoing efforts around the globe to revitalise languages and cultures, defining Indigenous efflorescence as a slow revolution occurring almost unnoticeably. Examples from two Indigenous peoples are provided, Sámi and Ainu, giving voice to thirty contributors who describe contexts and practices of 'Indigenous efflorescence' in a broad variety of settings. The review focusses on the merits of the concept of Indigenous efflorescence with a special emphasis on three of the chapters where digital contexts are provided. (Indigenous) efflorescence is an interesting theoretical concept to investigate in relation to theory and practice in remote teaching, online learning, and distance education for K-12 schools as it stresses the aim with any educational practice, which is the growth and flourishing of those involved. It also offers leverage against simplistic narratives of both decline and progress. This volume does what it sets out to do: offer hope and stimulate projects for supporting Indigenous efflorescence.

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    Authors: Almqvist, Louise;

    Recension: B. J. Epstein & Elizabeth L. Chapman (red.). International LGBTQ+ literature for children and young adults. London & New York: Anthem Press, 2021 (341 s.)

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    Authors: Theresa Rambaran; Romana Schirhagl;

    Nanotechnology holds great promise and is hyped by many as the next industrial evolution. Medicine, food and cosmetics, agriculture and environmental health, and technology industries already profit from nanotechnology innovations and their influence is expected to increase drastically in the near future. However, there are also many challenges that need to be overcome to bring a nanotechnological product or business to the market. In this article we discuss current examples of nanotechnology that have been successfully introduced in the market and their relevance and geographical spread. We then discuss different partners for scientists and their role in the commercialization process. Finally, we review the different steps it takes to bring a nanotechnology to the market, highlight the many difficulties related to these steps, and provide a roadmap for the journey from lab to industry which can be beneficial to researchers.

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    Nanoscale Advances
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    Authors: Graham, Brandon;

    Review: Nell Musgrove and Deidre Michell. The Slow Evolution of Foster Care in Australia: Just Like a Family? Cham: Palgrave Macmillan, 2018, 314 pp.

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    Authors: Mishra, Aniket; Malik, Rainer; He, Yunye; Rosand, Jonathan; +256 Authors

    Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries. Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      Other literature type . 2022
      Data sources: Apollo
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      NARCIS
      Article . 2022
      Data sources: NARCIS
      Nature
      Article . 2021
      Apollo
      Article . 2022
      Data sources: Datacite
      Apollo
      Article . 2022
      License: CC BY
      Data sources: Datacite
      Apollo
      Article . 2022
      Data sources: Datacite