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222 research outcomes, page 1 of 23
  • publication . Preprint . 2021
    English
    Authors:
    Marie Alexandre; Romain Marlin; Mélanie Prague; Coleon Severin; Nidhal Kahlaoui; Sylvain Cardinaud; Thibaut Naninck; Benoit Delache; Mathieu Surenaud; Mathilde Galhaut; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Country: France

    AbstractThe definition of correlates of protection is critical for the development of next generation SARS-CoV-2 vaccine platforms. Here, we propose a new framework for identifying mechanistic correlates of protection based on mathematical modelling of viral dynamics an...

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  • publication . Article . 2021
    Open Access
    Authors:
    Marina Sánchez-Rico; Frédéric Limosin; Raphaël Vernet; Nathanaël Beeker; Antoine Neuraz; Carlos Blanco; Mark Olfson; Cédric Lemogne; Pierre Meneton; Christel Daniel; ...
    Persistent Identifiers
    Publisher: MDPI AG
    Country: France

    International audience; Background: Based on its antiviral activity, anti-inflammatory properties, and functional inhibition effects on the acid sphingomyelinase/ceramide system (FIASMA), we sought to examine the potential usefulness of the H1 antihistamine hydroxyzine ...

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  • publication . Preprint . 2021
    Authors:
    Rinchai, Darawan; Deola, Sara; Zoppoli, Gabriele; Ahamed Kabeer, Basirudeen Syed; Taleb, Sara; Pavlovski, Igor; Maacha, Selma; Gentilcore, Giusy; Toufiq, Mohammed; Mathew, Lisa; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Country: France

    ABSTRACTKnowledge of the factors contributing to the development of protective immunity after vaccination with COVID-19 mRNA vaccines is fragmentary. Thus we employed high- temporal-resolution transcriptome profiling and in-depth characterization of antibody production ...

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  • publication . Conference object . Preprint . 2021
    Open Access English
    Authors:
    Muhammad Umar B Niazi; Alain Kibangou; Carlos Canudas de Wit; Denis Nikitin; Liudmila Tumash; Pierre-Alexandre Bliman;
    Publisher: HAL CCSD
    Country: France
    Project: EC | Scale-FreeBack (694209)

    Testing is a crucial control mechanism for an epidemic outbreak because it enables the health authority to detect and isolate the infected cases, thereby limiting the disease transmission to susceptible people, when no effective treatment or vaccine is available. In thi...

  • publication . Preprint . 2021
    English
    Authors:
    Annabelle Collin; Boris P. Hejblum; Carole Vignals; Laurent Lehot; Rodolphe Thiébaut; Philippe Moireau; Mélanie Prague;
    Persistent Identifiers
    Publisher: HAL CCSD
    Country: France

    In response to the ongoing COVID-19 pandemic caused by SARS-CoV-2, governments are taking a wide range of non-pharmaceutical interventions (NPI). These measures include interventions as stringent as strict lockdown but also school closure, bar and restaurant closure, cu...

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  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Marine Gauthier; Denis Agniel; Rodolphe Thiébaut; Boris P. Hejblum;
    Publisher: HAL CCSD
    Country: France

    SummaryState-of-the-art methods for single-cell RNA sequencing (scRNA-seq) Differential Expression Analysis (DEA) often rely on strong distributional assumptions that are difficult to verify in practice. Furthermore, while the increasing complexity of clinical and biolo...

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  • publication . Part of book or chapter of book . 2021
    Closed Access
    Authors:
    Emiris, Ioannis Z.; Chalkis, Apostolos; Christoforou, Emmanouil; Dalamagas, Theodore;
    Persistent Identifiers
    Publisher: Springer International Publishing
    Country: France

    International audience; We exploit a recent computational framework to model and detect financial crises in stock markets, as well as shock events in cryptocurrency markets, which are characterized by a sudden or severe drop in prices. Our method manages to detect all p...

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  • publication . Conference object . Article . 2021
    Open Access English
    Authors:
    Kibangou, Alain; Moyo, Thembani; Musakwa, Walter;
    Persistent Identifiers
    Publisher: HAL CCSD
    Country: France

    International audience; Congestion is a phenomenon that impacts most cities in the world. Due to car emissions, it is a significant source of pollution. Even though mobility restrictions can reduce congestion and emissions, essential activities still need cars. With loc...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Wallin, Rosanne; van Iersel, L.J.J.; Kelk, Steven; Stougie, Leen;
    Countries: Netherlands, France, France, France

    Abstract Background Rooted phylogenetic networks are used to display complex evolutionary history involving so-called reticulation events, such as genetic recombination. Various methods have been developed to construct such networks, using for example a multiple sequenc...

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  • publication . Doctoral thesis . 2021
    French
    Authors:
    Gauthier, Marine;
    Publisher: HAL CCSD
    Country: France

    RNA-seq technology is the new standard for measuring gene expression. Its variations can be linked to many pathologies or phenotypes and can be detected by statistical methods called differential analysis. The purpose of differential analysis is to identify genes whose ...

222 research outcomes, page 1 of 23