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16,478 research outcomes, page 1 of 1,648
  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Vinh-Loc Dao; Cécile Bothorel; Philippe Lenca;
    Persistent Identifiers

    Community detection emerges as an important task in the discovery of network mesoscopic structures. However, the concept of a "good" community is very context-dependent and it is relatively complicated to deduce community characteristics using available community detect...

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  • publication . Preprint . 2021
    Open Access English
    Authors:
    Warrier, Varun; Zhang, Xinhe; Reed, Patrick; Havdahl, Alexandra; Moore, Tyler; Cliquet, Freddy; Leblond, Claire; Rolland, Thomas; Rosengren, Anders; Rowitch, David; ...
    Persistent Identifiers
    Publisher: HAL CCSD

    Importance Schizophrenia, educational attainment, and intelligence are all genetically correlated with autism. However, autism is a complex condition, with several different core (such as social communication difficulties and repetitive and restricted behaviour) and ass...

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  • publication . Preprint . 2021
    English
    Authors:
    Clara A. Moreau; Kuldeep Kumar; Annabelle Harvey; Guillaume Huguet; Sebastian Urchs; Elise A. Douard; Laura M. Schultz; Hanad Sharmarke; Khadije Jizi; Charles-Olivier Martin; ...
    Persistent Identifiers
    Publisher: HAL CCSD

    AbstractPolygenicity and pleiotropy are key properties of the genomic architecture of psychiatric disorders. An optimistic interpretation of polygenicity is that genomic variants converge on a limited set of mechanisms at some level from genes to behavior. Alternatively...

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  • publication . Preprint . 2021
    Open Access English
    Authors:
    Aurèle Piazza; Hélène Bordelet; Agnès Dumont; Agnès Thierry; Jérôme Savocco; Fabien Girard; Romain Koszul;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | SynarchiC (771813)

    SummaryHomologous recombination (HR) is a ubiquitous DNA double-strand break (DSB) repair mechanism that promotes cell survival. It entails a potentially genome-wide homology search step, carried out along a conserved RecA/Rad51-ssDNA nucleoprotein filament (NPF) assemb...

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  • publication . Preprint . 2021
    English
    Authors:
    Khalife, Sammy; Malliavin, Thérèse,; Liberti, Leo;
    Publisher: HAL CCSD

    The structure of proteins is organized in a hierarchy among which the secondary structure elements, α-helix, β-strand and loop, are the basic bricks. The determination of secondary structure elements usually requires the knowledge of the whole structure. Nevertheless, i...

  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Alice Lepelley; Erika Della Mina; Erika Van Nieuwenhove; Lise Waumans; Sylvie Fraitag; Gillian I. Rice; Ashish Dhir; Marie-Louise Frémond; Mathieu P. Rodero; Luis Seabra; ...
    Publisher: HAL CCSD
    Project: EC | E-T1IFNs (786142), EC | MitoFeron (892311)

    AbstractMitochondrial DNA (mtDNA) has been suggested to drive immune system activation, but the induction of interferon signaling by mtDNA has not been demonstrated in a Mendelian mitochondrial disease. We initially ascertained two patients, one with a purely neurologic...

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  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Etore , Pierre; Martinez , Miguel;
    Persistent Identifiers
    Publisher: HAL CCSD

    International audience; In this paper we consider multi-dimensional partial differential equations of parabolic type involving divergence form operators that possess a discontinuous coefficient matrix along some smooth interface. The solution of the equation is assumed ...

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  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Léonard Guetta;
    Persistent Identifiers
    Publisher: HAL CCSD

    International audience; In this paper, we extend a result of Lafont and Métayer and prove that the polygraphic homology of a small category, defined in terms of polygraphic resolutions in the category ωCat of strict ω-categories, is naturally isomorphic to the homology ...

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  • publication . Preprint . 2021
    English
    Authors:
    Philipp Trepte; Christopher Secker; Soon Gang Choi; Julien Olivet; Eduardo Silva Ramos; Patricia Cassonnet; Sabrina Golusik; Martina Zenkner; Stephanie Beetz; Marcel Sperling; ...
    Persistent Identifiers
    Publisher: HAL CCSD

    ABSTRACTComplementary methods are required to fully characterize all protein complexes, or the complexome, of a cell. Affinity purification coupled to mass-spectrometry (AP-MS) can identify the composition of complexes at proteome-scale. However, information on direct c...

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  • publication . Conference object . Preprint . 2021
    English
    Authors:
    Wan, Y; Koromyslov, Maxime; Wu, F; Zhu, H;
    Publisher: HAL CCSD

    International audience

16,478 research outcomes, page 1 of 1,648