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International audience; Since the beginning of the COVID-19 pandemic in 2020 caused by SARS-CoV-2, the question of the origin of this virus has been a highly debated issue. Debates have been, and are still, very disputed and often violent between the two main hypotheses: a natural origin through the “spillover” model or a laboratory-leak origin. Tenants of these two options are building arguments often based on the discrepancies of the other theory. The main problem is that it is the initial question of the origin itself which is biased. Charles Darwin demonstrated in 1859 that all species are appearing through a process of evolution, adaptation and selection. There is no determined origin to any animal or plant species, simply an evolutionary and selective process in which chance and environment play a key role. The very same is true for viruses. There is no determined origin to viruses, simply also an evolutionary and selective process in which chance and environment play a key role. However, in the case of viruses the process is slightly more complex because the “environment” is another living organism. Pandemic viruses already circulate in humans prior to the emergence of a disease. They are simply not capable of triggering an epidemic yet. They must evolve in-host, i.e. in-humans, for that. The evolutionary process which gave rise to SARS-CoV-2 is still ongoing with regular emergence of novel variants more adapted than the previous ones. The real relevant question is how these viruses can emerge as pandemic viruses and what the society can do to prevent the future emergence of pandemic viruses.

Abstract Fast, sensitive, high-throughput detection of coronavirus antigens at physiologically relevant levels is essential for population screening that could prevent epidemics such as the current COVID-19 global pandemic. Optical methods based on surface-enhanced Raman scattering (SERS) spectroscopy are promising for this purpose because they ensure quick detection of even single biological molecules in a sample. For achieving such a high sensitivity, it is crucial to design SERS-active systems concentrating incident radiation into small sample volumes. Here, metal-dielectric cavities have been obtained through interaction of protein sulfhydryl groups with a SERS-active silver surface. The concentration of light in these cavities allows the differential detection of spike glycoprotein and nucleocapsid protein of SARS-COV-2, which are its key antigens, at physiologically relevant concentrations. The cavity Q-factor can be increased by additionally covering the dielectric protein film with a silver shell to form an ultrathin cavity, which provides an at least tenfold enhancement of the detection signal. The results could be used to design high-throughput systems for specific and sensitive detection of viral antigens and quick diagnosis of viral infections.

COVID-19 mortality increases markedly with age and is also substantially higher among Black, Indigenous, and People of Color (BIPOC) populations in the United States. These two facts can have conflicting implications because BIPOC populations are younger than white populations. In analyses of California and Minnesota—demographically divergent states—we show that COVID vaccination schedules based solely on age benefit the older white populations at the expense of younger BIPOC populations with higher risk of death from COVID-19. We find that strategies that prioritize high-risk geographic areas for vaccination at all ages better target mortality risk than age-based strategies alone, although they do not always perform as well as direct prioritization of high-risk racial/ethnic groups. Vaccination schemas directly implicate equitability of access, both domestically and globally. Age-based COVID-19 vaccination prioritizes white people above higher-risk others; geographic prioritization improves equity. Description

Abstract The global lockdowns brought on by the COVID-19 pandemic forced an immediate change in the way people moved about;namely, travel was slowed from a turbulent river to a trickle In-person meetings, often involving long-distance flights, were either canceled, postponed, or shifted over to virtual modes People who were unfamiliar with online meetings quickly became acquainted with them

International audience; In honour of the International Year of Sound and for the 1 year memorial of the Notre-Dame cathedral fire, a team of researchers and sound engineers created a virtual reconstruction of a concert in the cathedral, using close-mic recordings made on 24-April-2013 of a performance of La Vierge by Jules Massenet. This reconstruction was carried out during the period of strict COVID-19 confinement. With 83 musicians, 6 singers and a 160person choir spatially distributed throughout the cathedral, the original performance offered a spatial composition highlighting the complex acoustics and interactions between source and listener positions. Individual tracks were convolved with spatial room impulse responses, created from a calibrated geometrical acoustic simulation. Several listening positions were binaurally rendered, along with an artistic mix created by a sound engineer, offering a unique 3d-audio experience approaching the reality of the moment in the past. Distributed on-line, the website presenting this virtual reconstruction has been visited from users around the world. A listener opinion survey was included on the website. This paper presents an overview of the source material, the production workflow, and the challenges of realising such a production during confinement. Finally, an overview of visitor statistics and survey results is presented, providing insight into the reception of the virtual recreation and the interest towards future productions.

Pandemic disease is not merely a biological reality but also a cognitive and socially constructed phenomenon which intensely mobilizes a multiplicity of political frames. Far-right political entrepreneurs are, despite their remoteness from actual decision-making processes, active stakeholders in the current crisis. Existential threats to societies breed a sense of urgency and heightened cultural warfare that is a hotbed for extremism. Our study seeks to map, compare and contrast the symbolic responses to the Coronavirus crisis articulated by various far-right actors in two established democracies in the transatlantic area: The United States and France. We aim to shed light on how entrenched far-right mythologies and tropes—which appear increasingly transatlantic—are channeled into a new synthesis as part of an “alternative” political epistemology. Infused with the mythos of resistance and insurgency, resolutely anti-systemic, this alternative epistemology can better be described, following Michael Barkun, as a form of “stigmatized knowledge”. Our study will employ a Critical Discourse Analysis framework to bring into focus, in the response of the Euro-American far-right to the COVID-19 crisis, the ideological semiotics of the current “infodemic”.

In late 2019, an epidemic of SARS-CoV-2 broke out in central China. Within a few months, this new virus had spread right across the globe, officially being classified as a pandemic on 11 March 2020. In France, which was also being affected by the virus, the government applied specific epidemiological management strategies and introduced unprecedented public health measures. This article describes the outbreak management system that was applied within the French military and, more specifically, analyzes an outbreak of COVID-19 that occurred on board a nuclear aircraft carrier. We applied the AcciMap systemic analysis approach to understand the course of events that led to the outbreak and identify the relevant human and organizational failures. Results highlight causal factors at several levels of the outbreak management system. They reveal problems with the benchmarks used for diagnosis and decision-making, and underscore the importance of good communication between different levels. We discuss ways of improving epidemiological management in military context.

Author(s): Laffoley, Dan; Baxter, John M; Amon, Diva J; Claudet, Joachim; Hall-Spencer, Jason M; Grorud-Colvert, Kirsten; Levin, Lisa A; Reid, P Chris; Rogers, Alex D; Taylor, Michelle L; Woodall, Lucy C; Andersen, Natalie F

International audience

Therapies - Sous presse. Epreuves corrigees par l'auteur. Disponible en ligne depuis le jeudi 10 juin 2021