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C-arm systems with digital flat-panel detectors are used in interventional radiology and hybrid operating rooms for visualizing and performing interventions on three-dimensional structures. Advances in C-arm technology have enabled intraoperative quantitative perfusion imaging with these scanners. This systematic review provides an overview of flat-panel detector C-arm techniques for quantifying perfusion, their clinical applications, and their validation. A systematic search was performed for articles published between January 2000 and October 2022 in which a flat-panel detector C-arm technique for quantifying perfusion was compared with a reference technique. Nine articles were retrieved describing two techniques: two-dimensional perfusion angiography (n = 5) and dual-phase cone beam computed tomography perfusion (n = 4). A quality assessment revealed no concerns about the applicability of the studies. The risk of bias was relatively high for the index and reference tests. Both techniques demonstrated potential for clinical application; however, weak-to-moderate correlations were reported between them and the reference techniques. In conclusion, both techniques could add new possibilities to treatment planning and follow-up; however, the available literature is relatively scarce and heterogeneous. Larger-scale randomized prospective studies focusing on clinical outcomes and standardization are required for the full understanding and clinical implementation of these techniques.

Systemic peripheral T cell lymphomas (PTCL) are a rare and clinically and biologically heterogeneous group of disorders with scarce and generally low-quality evidence guiding their management. In this manuscript, we tackle the current controversies in the front-line treatment of systemic PTCL including (1) whether CNS prophylaxis should be administered; (2) whether CHOEP should be preferred over CHOP; (3) what role brentuximab vedotin should have; (4) whether stem cell transplant (SCT) consolidation should be used and whether autologous or allogeneic; (5) how should molecular subtypes (including DUSP22 or TP63-rearranged ALCL or GATA3 or TBX21 PTCL, NOS) impact therapeutic decisions; and (6) whether there is a role for targeted agents beyond brentuximab vedotin.

An understanding of traditional ecological knowledge systems is increasingly acknowledged as a means of helping to develop global, regional and national, but locally relevant policies. Pastoralists often use lands that are unsuitable for crops due to biophysical and climatic extremities and variabilities. Forage plants of pastures are utilized by herding communities by applying locally relevant multigenerational knowledge. We analyzed the forage-related knowledge of pastoralists and herders by reviewing scientific papers and video documentaries on forage plants and indicators, their use in land management, and plant-livestock interactions. Semi-structured interviews were also conducted with key knowledge holders in Iran, Mongolia, Kenya, Poland and Hungary. We found 35 indicators used by herders to describe forage species. The indicators described botanical features, livestock behavior during grazing, and the impact of plants on livestock condition and health. The indicators were used in context-specific management decisions, with a variety of objectives to optimize grazing. We identified ten global principles, including, among others, a livestock-centered perspective, close monitoring and targeted pasturing of various (preferred or avoided) forages, and the use of different livestock types and well-planned spatial movements at multiple scales to optimize the utilization of available plant resources. Although pastoralists vary greatly across the globe, the character and use of their traditional forage-related knowledge do seem to follow strikingly similar principles. Understanding these may help the local-to-global-level understanding of these locally specific systems, support bottom-up pastoral initiatives and discussions on sustainable land management, and help to develop locally relevant global and national policies. © 2022 Elsevier Ltd This research was supported partly by the projects of the Hungarian National Research, Development and Innovation Office NKFIH K 131837 (“Fine-scale landscape ecology: linking vegetation change with interacting indirect and direct drivers using traditional ecological knowledge and oral history”) and GINOP-2.3.2-15-2016-00019. This research also relied on the support from IUBS through the GIPP project.

AbstractPlatform chemicals and polymer precursors can be produced via enzymatic pathways starting from lignocellulosic waste materials. The hemicellulose fraction of lignocellulose contains aldopentose sugars, such as d-xylose and l-arabinose, which can be enzymatically converted into various biobased products by microbial non-phosphorylated oxidative pathways. The Weimberg and Dahms pathways convert pentose sugars into α-ketoglutarate, or pyruvate and glycolaldehyde, respectively, which then serve as precursors for further conversion into a wide range of industrial products. In this review, we summarize the known three-dimensional structures of the enzymes involved in oxidative non-phosphorylative pathways of pentose catabolism. Key structural features and reaction mechanisms of a diverse set of enzymes responsible for the catalytic steps in the reactions are analysed and discussed.

The publication of the correspondence between Reinhart Koselleck and Carl Schmitt enables readers to assess the relation between the conceptual historian and his radically conservative mentor, a topic of some longstanding controversy. In this review essay, I discuss their correspondence in relation to Gennaro Imbriano's book on Koselleck, which also relies on the correspondence to argue that Koselleck gradually transcended his earlier Schmittian beliefs. I seek to capture the current state of scholarship regarding this particular issue and anticipate possible future developments in the field. Although they do not offer major revelations about Koselleck and Schmitt's relationship, the recently published letters add welcome nuance to earlier scholarly estimations thereof and show how Koselleck gradually assumed a more equal role in the exchange. The most fertile theoretical points in the letters pertain, first, to Schmitt's observations about the uniqueness of history and the repetition of key questions in history and, second, to Koselleck's remarks on the need for a proper theoretical basis for historiography, including readjusted historicism and criticism on the philosophy of history's ideological ramifications. Imbriano's book characterizes Koselleck as a systematic thinker of history's political aspect who differed from Schmitt in making the distinction between politics (as a regulating process) and "the political" (as a principle in need of containment). As I argue, this distinction is not sufficient to set Koselleck's moderate conservatism apart from Schmitt's radical conservatism because Schmitt also took both aspects into account. I also predict that future scholarship will display a balanced use of archival material that further clarifies the genesis of Koselleck's theorems, in turn directly serving historical theory by examining its emergence out of concrete historical, political, and intellectual contexts. Peer reviewed

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Non peer reviewed