The EOSC Architecture Working Group has assigned the AAI Task Force (AAI TF) the task to establish a common global ecosystem for identity and access control infrastructures for the European Open Science Cloud (EOSC). Since the EOSC is part of an international environmen...

Using a new consensus-based image-processing approach together with principal component analysis, the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state have been analysed. These studies revealed concerted motions involving the recept...

Authored by: the FIM4R Community The European Open Science Cloud (EOSC) will soon enter the next phase of integration and consolidation with the establishment of a common service portal listing underpinning services that enable distributed resources in the areas of comp...

Electron tomography is a technique to obtain three-dimensional structural information of samples. However, the technique is limited by shifts occurring during acquisition that need to be corrected before the reconstruction process. In 2009, we proposed an approach for p...

The WLCG Authorisation Working Group was formed in July 2017 with the objective to understand and meet the needs of a future-looking Authentication and Authorisation Infrastructure (AAI) for WLCG experiments. Much has changed since the early 2000s when X.509 certificate...

The AARC Blueprint Architecture (BPA) provides a set of building blocks for software architects and technical decision makers who are designing and implementing access management solutions for international research collaborations. This document describes the evolution ...

Designing highly specific modulators of protein-protein interactions (PPIs) is especially challenging in the context of multiple paralogs and conserved interaction surfaces. In this case, direct generation of selective and competitive inhibitors is hindered by high simi...

Modular polyketide synthases and non-ribosomal peptide synthetases are molecular assembly lines that consist of several multienzyme subunits that undergo dynamic self-assembly to form a functional megacomplex. N- and C-terminal docking domains are usually responsible fo...

Electron microscopy of macromolecular structures is an approach that is in increasing demand in the field of structural biology. The automation of image acquisition has greatly increased the potential throughput of electron microscopy. Here, the focus is on the possibil...

The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level. We implemented a concerted structu...