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77 research outcomes, page 1 of 8
  • publication . Book . 2021
    Open Access English
    Authors:
    Wierenga, Klaas; Johansson, Leif; Kanellopoulos, Christos; Groep, David; Vaghetti, Davide; Liampotis, Nicolas; van de Sanden, Mark; Reetz, Johannes; Alam, Sadaf; Linden, Mikael; ...
    Persistent Identifiers
    Publisher: European Commission (EU)
    Country: Germany
    Project: EC | AARC2 (730941)

    The EOSC Architecture Working Group has assigned the AAI Task Force (AAI TF) the task to establish a common global ecosystem for identity and access control infrastructures for the European Open Science Cloud (EOSC). Since the EOSC is part of an international environmen...

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Roberto Melero; C.O.S. Sorzano; Brent Foster; José Luis Vilas; Marta Martínez; Roberto Marabini; Erney Ramírez-Aportela; Rubén J. Sánchez-García; David Herreros; Laura del Cano; ...
    Country: Spain
    Project: EC | CORBEL (654248), EC | INSTRUCT-ULTRA (731005), EC | EOSC-synergy (857647), EC | IMpaCT (857203), EC | EOSC-Life (824087), EC | HighResCells (810057)

    Using a new consensus-based image-processing approach together with principal component analysis, the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state have been analysed. These studies revealed concerted motions involving the recept...

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  • publication . Report . Other literature type . Research . 2020
    Open Access English
    Authors:
    Stevanovic, Uros; Short, Hannah; Kesley, David; Neilsson, Ian; Gietz, Peter;
    Publisher: Zenodo
    Country: Germany
    Project: EC | AARC2 (730941)

    Authored by: the FIM4R Community The European Open Science Cloud (EOSC) will soon enter the next phase of integration and consolidation with the establishment of a common service portal listing underpinning services that enable distributed resources in the areas of comp...

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  • publication . Article . 2020
    Open Access English
    Authors:
    C.O.S. Sorzano; F. de Isidro-Gomez; E. Fernández-Giménez; David Herreros; Sergio Marco; José María Carazo; C. Messaoudi;
    Project: EC | INSTRUCT-ULTRA (731005), EC | iNEXT-Discovery (871037), EC | EOSC-synergy (857647), EC | IMpaCT (857203), EC | EOSC-Life (824087), EC | HighResCells (810057), EC | CORBEL (654248)

    Electron tomography is a technique to obtain three-dimensional structural information of samples. However, the technique is limited by shifts occurring during acquisition that need to be corrected before the reconstruction process. In 2009, we proposed an approach for p...

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  • publication . Article . Other literature type . Preprint . 2020
    Open Access English
    Authors:
    Brian Bockelman; Andrea Ceccanti; Ian Collier; Linda Cornwall; Thomas Dack; Jaroslav Guenther; Mario Lassnig; Maarten Litmaath; Paul Millar; Mischa Sallé; ...
    Persistent Identifiers
    Project: NSF | S2I2: Institute for Resea... (1836650), EC | EOSC-hub (777536), EC | AARC2 (730941), EC | EOSCpilot (739563)

    The WLCG Authorisation Working Group was formed in July 2017 with the objective to understand and meet the needs of a future-looking Authentication and Authorisation Infrastructure (AAI) for WLCG experiments. Much has changed since the early 2000s when X.509 certificate...

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  • publication . Other literature type . 2019
    Open Access English
    Authors:
    AARC Community members; AppInt members;
    Publisher: Zenodo
    Project: EC | AARC2 (730941)

    The AARC Blueprint Architecture (BPA) provides a set of building blocks for software architects and technical decision makers who are designing and implementing access management solutions for international research collaborations. This document describes the evolution ...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Rimbault, Charlotte; Maruthi, Kashyap; Breillat, Christelle; Genuer, Camille; Crespillo, Sara; Puente-Muñoz, Virginia; Chamma, Ingrid; Gauthereau, Isabel; Antoine, Ségolène; Thibaut, Coraline; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Country: France
    Project: ANR | ChemMoPPI (ANR-13-BS07-0019), EC | NEUROCHEMBIOTOOLS (273817), EC | Dyn-Syn-Mem (787340), EC | West-Life (675858), EC | ADOS (339541), EC | WENMR (261572), EC | EOSC-hub (777536), EC | NANO-DYN-SYN (232942)

    Designing highly specific modulators of protein-protein interactions (PPIs) is especially challenging in the context of multiple paralogs and conserved interaction surfaces. In this case, direct generation of selective and competitive inhibitors is hindered by high simi...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Kosol, Simone; Gallo, Angelo; Griffiths, Daniel; Valentic, Timothy R.; Masschelein, Joleen; Jenner, Matthew; de los Santos, Emmanuel L. C.; Manzi, Lucio; Sydor, Paulina K.; Rea, Dean; ...
    Persistent Identifiers
    Publisher: Nature Publishing Group
    Countries: Belgium, United States, United Kingdom
    Project: NIH | Resource for Biocomputing... (5P41GM103311-36), UKRI | 100 kHz magic angle spinn... (EP/L025906/1), EC | NOVENA (656067), UKRI | Exploiting natural produc... (BB/K002341/1), UKRI | Elucidating and exploitin... (BB/R010218/1), UKRI | Biophysical basis for the... (BB/L022761/1), UKRI | Warwick Integrative Synth... (BB/M017982/1), EC | complexNMR (639907), EC | West-Life (675858), UKRI | Cross-scale prediction of... (EP/M027503/1),...

    Modular polyketide synthases and non-ribosomal peptide synthetases are molecular assembly lines that consist of several multienzyme subunits that undergo dynamic self-assembly to form a functional megacomplex. N- and C-terminal docking domains are usually responsible fo...

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  • publication . Article . Conference object . 2019
    Open Access English
    Authors:
    Maluenda, D.; Majtner, T.; Horvath, P.; Vilas, J. L.; Jiménez-Moreno, A.; Mota, J.; Ramírez-Aportela, E.; Sánchez-García, R.; Conesa, P.; del Caño, L.; ...
    Publisher: International Union of Crystallography
    Country: Spain
    Project: EC | ELIXIR-EXCELERATE (676559), EC | EOSCpilot (739563), EC | INSTRUCT-ULTRA (731005), EC | CORBEL (654248), EC | INPhINIT (713673), EC | iNEXT (653706)

    Electron microscopy of macromolecular structures is an approach that is in increasing demand in the field of structural biology. The automation of image acquisition has greatly increased the potential throughput of electron microscopy. Here, the focus is on the possibil...

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  • publication . Article . Preprint . 2019
    Open Access English
    Authors:
    Lukáš Slavata; Josef Chmelík; Daniel Kavan; Růžena Filandrová; Jan Fiala; Michal Rosůlek; Hynek Mrázek; Zdeněk Kukačka; Karel Valis; Petr Man; ...
    Publisher: Multidisciplinary Digital Publishing Institute
    Country: Czech Republic
    Project: EC | West-Life (675858), EC | WENMR (261572), EC | EU_FT-ICR_MS (731077), EC | EPIC-XS (823839), NIH | Characterization of ncRNA... (1R01GM121844-01A1)

    The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level. We implemented a concerted structu...

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77 research outcomes, page 1 of 8