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37 research outcomes, page 1 of 4
  • publication . Article . 2020
    Open Access English
    Authors:
    Frank Møller Aarestrup; A. Albeyatti; W. J. Armitage; Charles Auffray; L. Augello; Rudi Balling; N. Benhabiles; G. Bertolini; Jan G. Bjaalie; Michaela Black; ...
    Publisher: BioMed Central
    Project: EC | PANCARESURFUP (257505), EC | SYSCOL (258236), EC | OpenAIRE-Advance (777541), EC | CENTER-TBI (602150), EC | U-BIOPRED (115010), EC | SYSCID (733100), EC | INSTRUCT-ULTRA (731005), EC | ELIXIR-EXCELERATE (676559), EC | PREPARE (602525), EC | MIDAS (727721),...

    The European Union (EU) initiative on the Digital Transformation of Health and Care (Digicare) aims to provide the conditions necessary for building a secure, flexible, and decentralized digital health infrastructure. Creating a European Health Research and Innovation C...

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  • publication . Preprint . 2020
    Open Access English
    Authors:
    Trindade, Inês; Invernici, Michele; Cantini, Francesca; Louro, Ricardo O; Piccioli, Mario;
    Project: EC | TIMB3 (810856)

    The current paradigm for protein structure determination by NMR spectroscopy has thus far been based on collecting distance restrains between pairs of nuclei in the form of nuclear Overhauser enhancements (NOE). These, have in some circumstances been supplemented with o...

  • publication . Preprint . Article . Other literature type . 2019
    Open Access English
    Authors:
    Yannick Blum; Jan Mikelson; Maciej Dobrzyński; Hyunryul Ryu; Marc-Antoine Jacques; Noo Li Jeon; Mustafa Khammash; Olivier Pertz;
    Publisher: Cold Spring Harbor Laboratory
    Project: SNSF | Understanding single cell... (IZKSZ3_162195), EC | TRANSVAC2 (730964)

    Abstract Stimulation of PC‐12 cells with epidermal (EGF) versus nerve (NGF) growth factors (GFs) biases the distribution between transient and sustained single‐cell ERK activity states, and between proliferation and differentiation fates within a cell population. We rep...

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  • publication . Preprint . Article . Other literature type . 2019
    Open Access English
    Authors:
    Iain M Hay; Gareth W. Fearnley; Pablo Rios; Maja Köhn; Hayley J. Sharpe; Janet E. Deane;
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | BIOSTRUCT-X (283570), WT

    Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it may act as a decoy re...

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  • publication . Conference object . Other literature type . Part of book or chapter of book . Preprint . 2019
    Open Access English
    Authors:
    Miriam Baglioni; Alessia Bardi; Argiro Kokogiannaki; Paolo Manghi; Katerina Iatropoulou; Pedro Príncipe; André Vieira; Lars Holm Nielsen; Harry Dimitropoulos; Ioannis Foufoulas; ...
    Publisher: Springer International Publishing, CH-6330 Cham (ZG), CHE
    Project: EC | OpenAIRE-Advance (777541), WT , EC | OpenAIRE-Connect (731011)

    First Online 30 August 2019

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  • publication . Article . Preprint . 2019
    Open Access English
    Authors:
    Jan Felix; Katharina Weinhäupl; Christophe Chipot; François Dehez; Audrey Hessel; Diego F. Gauto; Cecile Morlot; Olga Abian; Irina Gutsche; Adrián Velázquez-Campoy; ...
    Publisher: HAL CCSD
    Project: EC | PROTDYN2FUNCTION (311318)

    18 pags., 6 figs., 1 tab. -- Open Access funded by Creative Commons Atribution Licence 4.0

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  • publication . Article . Preprint . 2019
    Open Access English
    Authors:
    Tiago N. Cordeiro; Nathalie Sibille; Pierre Germain; Philippe Barthe; Abdel Boulahtouf; Frédéric Allemand; Rémy Bailly; Valérie Vivat; Christine Ebel; Alessandro Barducci; ...
    Persistent Identifiers
    Publisher: HAL CCSD

    AbstractThe retinoic acid receptors (RARs) form heterodimers with retinoid X receptors (RXRs) and control gene transcription in response to ligand binding and via allosteric activation of the C-termini helix (helix H12) of its ligand-binding domain. Herein we show that ...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Karin H. Müller; Robert Hayward; Rakesh Rajan; Meredith Whitehead; Andrew M. Cobb; Sadia Ahmad; Mengxi Sun; Ieva Goldberga; Rui Li; Uliana Bashtanova; ...
    Project: EC | iNEXT (653706), UKRI | Nano-Optics to controlled... (EP/L027151/1), UKRI | Cambridge NanoScience thr... (EP/G037221/1)

    Müller et al. investigate the physicochemical process of extracellular matrix calcification in both physiological (bone) and pathological (vascular calcification) contexts. They find that oxidative stress-induced poly(ADP-ribose) nucleates calcium phosphate mineral crys...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Joao Ramos; Jayaraman Muthukumaran; Filipe Freire; João Paquete-Ferreira; Ana Rita Otrelo-Cardoso; Dmitri I. Svergun; Alejandro Panjkovich; Teresa Santos-Silva;
    Project: EC | iNEXT (653706)

    International journal of molecular sciences 20(4), 860 - (2019). doi:10.3390/ijms20040860

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  • publication . Article . 2018
    Open Access English
    Authors:
    Cécile Morlot; Daniel Straume; Katharina Peters; Olav Aaseth Hegnar; Nolwenn Simon; Anne-Maria Villard; Carlos Contreras-Martel; Francisco Leisico; Eefjan Breukink; Christine Gravier-Pelletier; ...
    Project: WT | Bacterial Cell Wall Synth... (101824)

    The universality of peptidoglycan in bacteria underlies the broad spectrum of many successful antibiotics. However, in our times of widespread resistance, the diversity of peptidoglycan modifications offers a variety of new antibacterials targets. In some Gram-positive ...

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37 research outcomes, page 1 of 4