Quick search
Advanced search in
Field to searchTerm
Add rule
Filters (4)
Download Results
26 research outcomes, page 1 of 3
  • publication . Article . Preprint . 2020
    Open Access
    Authors:
    Jiandong Huo; Yuguang Zhao; Jingshan Ren; D. Zhou; Helen Me Duyvesteyn; Helen M. Ginn; L. Carrique; Tomas Malinauskas; R R Ruza; Pranav N.M. Shah; ...
    Publisher: Elsevier BV
    Project: WT | Understanding the genetic... (090532), UKRI | Structural Biology in the... (EP/S025243/1), WT | Studies of immunopathogen... (095541), WT | Improved control of endem... (101122)

    SummaryThere are as yet no licenced therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric Spike whose receptor binding domain (RBD) recognizes angiotensin-converting enzyme 2 (ACE2), initiating conformational changes...

    Add to ORCIDorcid
  • publication . Other literature type . Article . 2019
    Open Access English
    Authors:
    Robert Firth; Francesco Talo; Aravind Venkatesan; Abhik Mukhopadhyay; Johanna McEntyre; Sameer Velankar; Chris Morris;
    Persistent Identifiers
    Publisher: International Union of Crystallography
    Project: EC | ERC-EuropePMC-2015 (699257), WT , EC | West-Life (675858), EC | ELIXIR-EXCELERATE (676559)

    This work presents an annotation tool that automatically locates mentions of particular amino-acid residues in published papers and identifies the protein concerned. These matches can be provided in context or in a searchable format in order for researchers to better us...

    Add to ORCIDorcid
  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Luke R. Lloyd-Jones; Jian Zeng; Julia Sidorenko; Loic Yengo; Gerhard Moser; Kathryn E. Kemper; Huanwei Wang; Zhili Zheng; Reedik Mägi; Tõnu Esko; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | A Genome-Wide Association... (5R01HL086694-05), EC | CORBEL (654248), EC | ADOPT BBMRI-ERIC (676550), NIH | Health and Retirement Stu... (3U01AG009740-24S2), NIH | Creating a National Resou... (5RC2AG036495-02), NIH | Institute for Clinical an... (3UL1RR025005-03S2), NIH | Analysis of Genome-Wide D... (5R01AG042568-03), EC | ENGAGE (201413), NIH | Expanding a National Reso... (3RC4AG039029-01S1), NIH | Genome-Wide Association f... (5R01HL087641-02),...

    Accurate prediction of an individual’s phenotype from their DNA sequence is one of the great promises of genomics and precision medicine. We extend a powerful individual-level data Bayesian multiple regression model (BayesR) to one that utilises summary statistics from ...

    Add to ORCIDorcid
  • publication . Article . Other literature type . Preprint . 2019
    Open Access English
    Authors:
    Adam S. B. Jalal; Cesar L. Pastrana; Ngat T. Tran; Clare E. M. Stevenson; David M. Lawson; Fernando Moreno-Herrero; Tung B. K. Le;
    Publisher: eLife Sciences Publications, Ltd
    Project: EC | BIOSTRUCT-X (283570), UKRI | How does Structural Maint... (BB/P018165/1), UKRI | Investigate the roles of ... (BBS/E/J/000C0683), WT , EC | Mechan-of-Chromo (681299)

    ABSTRACTProper chromosome segregation is essential in all living organisms. The ParA-ParB-parS system is widely employed for chromosome segregation in bacteria. Previously, we showed that Caulobacter crescentus ParB requires cytidine triphosphate to escape the nucleatio...

    Add to ORCIDorcid
  • publication . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Benjamin G Butt; Danielle J Owen; Cy M. Jeffries; Lyudmila Ivanova; Jack W. Houghton; Firoz Ahmed; Robin Antrobus; Dmitri I. Svergun; John J. Welch; Colin M. Crump; ...
    Persistent Identifiers
    Publisher: bioRxiv
    Project: EC | BIOSTRUCT-X (283570), EC | iNEXT (653706), WT | Molecular mechanisms of m... (098406)

    AbstractHerpesviruses are an ancient family of highly-prevalent human and animal pathogens that acquire their membrane envelopes in the cytoplasm of infected cells. While multiple conserved viral proteins are known to be required for efficient herpesvirus production, ma...

    Add to ORCIDorcid
  • publication . Preprint . Other literature type . Article . 2019
    Open Access English
    Authors:
    Maria Shamin; Tomasz H. Benedyk; Stephen C. Graham; Janet E. Deane;
    Publisher: Cold Spring Harbor Laboratory
    Project: WT , WT | Molecular mechanisms of m... (098406), WT | Cambridge - Infection, Im... (203984), EC | BIOSTRUCT-X (283570)

    Background: Lipid antigens are presented on the surface of cells by the CD1 family of glycoproteins, which have structural and functional similarity to MHC class I molecules. The hydrophobic lipid antigens are embedded in membranes and inaccessible to the lumenal lipid-...

    Add to ORCIDorcid
  • publication . Preprint . Article . Other literature type . 2019
    Open Access English
    Authors:
    Iain M Hay; Gareth W. Fearnley; Pablo Rios; Maja Köhn; Hayley J. Sharpe; Janet E. Deane;
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | BIOSTRUCT-X (283570), WT

    Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it may act as a decoy re...

    Add to ORCIDorcid
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Davey, Norman E.; Babu, M. Madan; Blackledge, Martin; Bridge, Alan; Capella-Gutierrez, Salvador; Dosztanyi, Zsuzsanna; Drysdale, Rachel; Edwards, Richard J.; Elofsson, Arne; Felli, Isabella C.; ...
    Publisher: F1000 Research Limited
    Project: WT | Protein Data Bank in Euro... (104948), EC | IDPfun (778247), NIH | UniProt supporting an int... (3U24HG007822-05S1), UKRI | Bioinformatics Resources ... (BB/P024092/1)

    Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELI...

    Add to ORCIDorcid
  • publication . Conference object . Other literature type . Part of book or chapter of book . Preprint . 2019
    Open Access English
    Authors:
    Miriam Baglioni; Alessia Bardi; Argiro Kokogiannaki; Paolo Manghi; Katerina Iatropoulou; Pedro Príncipe; André Vieira; Lars Holm Nielsen; Harry Dimitropoulos; Ioannis Foufoulas; ...
    Publisher: Springer International Publishing, CH-6330 Cham (ZG), CHE
    Project: EC | OpenAIRE-Advance (777541), WT , EC | OpenAIRE-Connect (731011)

    First Online 30 August 2019

    Add to ORCIDorcid
  • publication . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Alister Burt; C. Keith Cassidy; Peter Ames; Maria Bacia-Verloop; Megghane Baulard; Karine Huard; Zaida Luthey-Schulten; Ambroise Desfosses; Phillip J. Stansfeld; William Margolin; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: WT , UKRI | Assembly and Dynamics of ... (BB/S003339/1), ANR | CBH-EUR-GS (ANR-17-EURE-0003), NSF | The Computational Microsc... (1713784), EC | iNEXT (653706), EC | Chap4Resp (647784), NSF | PFC: Center for the Physi... (1430124), NIH | CENTER FOR MACROMOLECULAR... (9P41GM104601-23), NSF | Sustained-Petascale In Ac... (1238993), NSF | Leadership Class Scientif... (0725070)

    Motile bacteria sense chemical gradients with transmembrane receptors organised in supramolecular signalling arrays.1,2Understanding stimulus detection and transmission at the molecular level requires precise structural characterisation of the array building block known...

    Add to ORCIDorcid
26 research outcomes, page 1 of 3