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769 research outcomes, page 1 of 77
  • publication . Article . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Alqabandi, Maryam; de Franceschi, Nicola; Miguet, Nolwenn; Maity, Sourav; Bally, Marta; Roos, Wouter H.; Weissenhorn, Winfried; Bassereau, Patricia; Mangenot, Stéphanie;
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | ESCRT model (751715), ANR | PSL (ANR-10-IDEX-0001), ANR | ESCRTfission (ANR-14-CE09-0003), EC | INTERACT (751404)

    <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two ...

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  • publication . Article . Other literature type . Preprint . 2021
    Open Access English
    Authors:
    Juraszek, Jarek; Rutten, Lucy; Blokland, Sven; Bouchier, Pascale; Voorzaat, Richard; Ritschel, Tina; Bakkers, Mark J. G.; Renault, Ludovic L. R.; Langedijk, Johannes P. M.;
    Publisher: Springer Science and Business Media LLC
    Project: EC | INSTRUCT-ULTRA (731005)

    SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominan...

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  • publication . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Eleftherios Zarkadas; Hong Zhang; Wensheng Cai; Gregory Effantin; Jonathan Perot; Jacques Neyton; Christophe Chipot; Guy Schoehn; François Dehez; Hugues Nury;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | PentaBrain (637733)

    <jats:p>Inaccurately perceived as niche drugs, antiemetics are key elements of cancer treatment alleviating the most dreaded side effect of chemotherapy. Serotonin 5-HT3 receptor antagonists are the most commonly prescribed class of drugs to control chemotherapy-induced...

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  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Marion Lechable; Alexandre Jan; Axel Duchene; Julie Uveira; Brandon Weissbourd; Loann Gissat; Sophie Collet; Laurent Gilletta; Sandra Chevalier; Lucas Leclère; ...
    Persistent Identifiers
    Publisher: The Company of Biologists
    Project: EC | CORBEL (654248), EC | ASSEMBLE Plus (730984), ANR | i-MMEJ (ANR-17-CE13-0016)

    ABSTRACT The jellyfish species Clytia hemisphaerica (Cnidaria, Hydrozoa) has emerged as a new experimental model animal in the last decade. Favorable characteristics include a fully transparent body suitable for microscopy, daily gamete production and a relatively short...

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  • publication . Other literature type . Project deliverable . Report . 2020
    Open Access English
    Authors:
    Vincenz-Donnelly, Lisa; Pieruschka, Roland; Haley, Natalie;
    Publisher: Zenodo
    Project: EC | RI-VIS (824063)

    With this deliverable, we want to provide a guide that helps research infrastructure managers to develop a communication strategy for their own research infrastructure. We provide recommendations for both developing and implementing a communication strategy for research...

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  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Jan Mikelson; Mustafa Khammash;
    Publisher: Public Library of Science (PLoS)
    Project: EC | TRANSVAC2 (730964)

    The development of mechanistic models of biological systems is a central part of Systems Biology. One major challenge in developing these models is the accurate inference of model parameters. In recent years, nested sampling methods have gained increased attention in th...

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  • publication . Other literature type . Article . 2020
    Open Access
    Authors:
    Roberto Melero; Carlos Oscar S. Sorzano; Brent Foster; José Luis Vilas; Marta Martínez; Roberto Marabini; Erney Ramírez-Aportela; Rubén J. Sánchez-García; D. Herreros; Laura del Cano; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | CORBEL (654248), EC | HighResCells (810057), EC | EOSC-synergy (857647), EC | INSTRUCT-ULTRA (731005), EC | EOSC-Life (824087), EC | IMpaCT (857203)

    <jats:title>Abstract</jats:title><jats:p>With the help of novel processing workflows and algorithms, we have obtained a better understanding of the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state. We have re-analyzed previous cryo-...

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  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    K.K. Rasmussen; Andrés Palencia; Anders K. Varming; Habiba El-Wali; Elisabetta Boeri Erba; Martin Blackledge; Karin Hammer; Torsten Herrmann; Mogens Kilstrup; Leila Lo Leggio; ...
    Persistent Identifiers
    Publisher: Proceedings of the National Academy of Sciences
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | iNEXT (653706), EC | ERCSC-CHAIRS-SUP2013 (341400)

    <jats:p>Temperate bacteriophages can enter one of two life cycles following infection of a sensitive host: the lysogenic or the lytic life cycle. The choice between the two alternative life cycles is dependent upon a tight regulation of promoters and their cognate regul...

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  • publication . Other literature type . Article . 2020
    Open Access
    Authors:
    Lensink, Marc F.; Nadzirin, Nurul; Velankar, Sameer; Wodak, Shoshana J.;
    Persistent Identifiers
    Publisher: Wiley
    Project: EC | West-Life (675858), WT

    We present the seventh report on the performance of methods for predicting the atomic resolution structures of protein complexes offered as targets to the community-wide initiative on the Critical Assessment of Predicted Interactions. Performance was evaluated on the ba...

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  • publication . Article . Other literature type . Preprint . 2020
    Open Access English
    Authors:
    Aldo R. Camacho-Zarco; Sissy Kalayil; Damien Maurin; Nicola Salvi; Elise Delaforge; Sigrid Milles; Malene Ringkjøbing Jensen; Darren J. Hart; Stephen Cusack; Martin Blackledge;
    Publisher: Nature Publishing Group UK
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | AvINFLUENZA (796490)

    Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. Here, the authors use NMR spectroscopy and quantitative ensemble modelling to describe the highly dynamic assemblies formed by the human-adapted or avian-adapted C-ter...

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769 research outcomes, page 1 of 77