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  • Publications
  • 2021-2021
  • CA
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  • English
  • COVID-19

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  • Open Access English
    Authors: 
    Subha Dahal; Ran Cheng; Peter K. Cheung; Terek Been; Ramy Malty; Melissa Geng; Sarah Manianis; Lulzim Shkreta; Shahrazad Jahanshahi; Johanne Toutant; +13 more
    Publisher: Multidisciplinary Digital Publishing Institute
    Project: CIHR

    Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the identification of the thiazole-5-carboxamide derivative (GPS491), which retained potent anti-HIV-1 activity with reduced toxicity. In this report, we demonstrate that the block of HIV-1 replication by GPS491 is accompanied by a drastic inhibition of viral gene expression (IC50 ~ 0.25 µM), and alterations in the production of unspliced, singly spliced, and multiply spliced HIV-1 RNAs. GPS491 also inhibited the replication of adenovirus and multiple coronaviruses. Low µM doses of GPS491 reduced adenovirus infectious yield ~1000 fold, altered virus early gene expression/viral E1A RNA processing, blocked viral DNA amplification, and inhibited late (hexon) gene expression. Loss of replication of multiple coronaviruses (229E, OC43, SARS-CoV2) upon GPS491 addition was associated with the inhibition of viral structural protein expression and the formation of virus particles. Consistent with the observed changes in viral RNA processing, GPS491 treatment induced selective alterations in the accumulation/phosphorylation/function of splicing regulatory SR proteins. Our study establishes that a compound that impacts the activity of cellular factors involved in RNA processing can prevent the replication of several viruses with minimal effect on cell viability.

  • Publication . Part of book or chapter of book . 2021
    Open Access English
    Authors: 
    Kennan, Danielle; Dolan, Pat; Anderson, Ella; Garrett, Kalem;
    Publisher: Routledge Taylor and Francis
    Country: Ireland

    This chapter reflects on how youth, through the medium of youth-led research, can seek to influence public policy by bringing a more democratic and informed youth perspective into the policy-making arena. The chapter details the Youth as Researchers Programme Model. It outlines how the programme has supported youth, in Ireland and internationally, to undertake social research projects with their peers on issues of concern, to collectively inform policy dialogue. The chapter documents the development of the programme, including a case study of one of the early youth-led research projects set up in Ireland in response to Ireland¿s National Child and Family Agency seeking to better understand how young people facing adversity can be heard and helped. It traces the programme¿s development from its inception to the present day, when the programme is now central to UNESCO¿s global response to inform policy on supporting youth during COVID-19. Not peer reviewed 2023-06-24

  • Open Access English
    Authors: 
    Linke Yu; Mariah Lecompte; Weiguo Zhang; Peizhong Wang; Lixia Yang;
    Publisher: MDPI
    Project: CIHR

    The current study investigates the mental health condition of Mainland Chinese in Canada and identifies the associated sociodemographic and COVID-19-related predictors. A sample of 471 Mainland Chinese aged 18 or older completed an online survey that collected information on demographics, experience, cognition, and behaviours related to the COVID-19 pandemic and mental health condition. Mental health condition was assessed with the Depression, Anxiety, and Stress Scale-21 (DASS-21) for the depression, anxiety, and stress levels of Mainland Chinese during the pandemic. Moderate to severe depression, anxiety, and stress levels were respectively reported by 11.30%, 10.83%, and 5.10% of respondents. Univariate analysis of variance models (ANOVAs) were conducted to assess mental health condition variance as stratified by independent sociodemographic- or COVID-19-related explanatory variables, to identify possible predictors to be entered into the subsequent regression models. The regression models identified age, income level, health status, and perceived discrimination as significant sociodemographic predictors (absolute value of βs = 1.19–7.11, ps < 0.05), whereas self-infection worry, attitude towards Canadian measures, information confusion, food/goods stocking, and room cleaning/sanitizing were identified as significant COVID-19-reltaed predictors (absolute value of βs = 1.33–3.45, ps < 0.05) for mental health outcomes. The results shed light on our understanding of the major factors associated with the mental health condition of Mainland Chinese in Canada during the COVID-19 pandemic.

  • Open Access English
    Authors: 
    Jamie L. Benham; Omid Atabati; Robert J. Oxoby; Mehdi Mourali; Blake Shaffer; Hasan Sheikh; Jean-Christophe Boucher; Cora Constantinescu; Jeanna Parsons Leigh; Noah Ivers; +7 more
    Publisher: JMIR Publications

    Background There are concerns that vaccine hesitancy may impede COVID-19 vaccine rollout and prevent the achievement of herd immunity. Vaccine hesitancy is a delay in acceptance or refusal of vaccines despite their availability. Objective We aimed to identify which people are more and less likely to take a COVID-19 vaccine and factors associated with vaccine hesitancy to inform public health messaging. Methods A Canadian cross-sectional survey was conducted in Canada in October and November 2020, prior to the regulatory approval of the COVID-19 vaccines. Vaccine hesitancy was measured by respondents answering the question “what would you do if a COVID-19 vaccine were available to you?” Negative binomial regression was used to identify the factors associated with vaccine hesitancy. Cluster analysis was performed to identify distinct clusters based on intention to take a COVID-19 vaccine, beliefs about COVID-19 and COVID-19 vaccines, and adherence to nonpharmaceutical interventions. Results Of 4498 participants, 2876 (63.9%) reported COVID-19 vaccine hesitancy. Vaccine hesitancy was significantly associated with (1) younger age (18-39 years), (2) lower education, and (3) non-Liberal political leaning. Participants that reported vaccine hesitancy were less likely to believe that a COVID-19 vaccine would end the pandemic or that the benefits of a COVID-19 vaccine outweighed the risks. Individuals with vaccine hesitancy had higher prevalence of being concerned about vaccine side effects, lower prevalence of being influenced by peers or health care professionals, and lower prevalence of trust in government institutions. Conclusions These findings can be used to inform targeted public health messaging to combat vaccine hesitancy as COVID-19 vaccine administration continues. Messaging related to preventing COVID among friends and family, highlighting the benefits, emphasizing safety and efficacy of COVID-19 vaccination, and ensuring that health care workers are knowledgeable and supported in their vaccination counselling may be effective for vaccine-hesitant populations.

  • Open Access English
    Authors: 
    Noof Aloufi; Zahraa Haidar; Jun Ding; Parameswaran Nair; Andrea Benedetti; David H. Eidelman; Imed-Eddine Gallouzi; Sergio Di Marco; Sabah N. Hussain; Carolyn J. Baglole;
    Publisher: MDPI AG
    Project: CIHR

    Patients with COPD may be at an increased risk for severe illness from COVID-19 because of ACE2 upregulation, the entry receptor for SARS-CoV-2. Chronic exposure to cigarette smoke, the main risk factor for COPD, increases pulmonary ACE2. How ACE2 expression is controlled is not known but may involve HuR, an RNA binding protein that increases protein expression by stabilizing mRNA. We hypothesized that HuR would increase ACE2 protein expression. We analyzed scRNA-seq data to profile ELAVL1 expression in distinct respiratory cell populations in COVID-19 and COPD patients. HuR expression and cellular localization was evaluated in COPD lung tissue by multiplex immunohistochemistry and in human lung cells by imaging flow cytometry. The regulation of ACE2 expression was evaluated using siRNA-mediated knockdown of HuR. There is a significant positive correlation between ELAVL1 and ACE2 in COPD cells. HuR cytoplasmic localization is higher in smoker and COPD lung tissue; there were also higher levels of cleaved HuR (CP-1). HuR binds to ACE2 mRNA but knockdown of HuR does not change ACE2 protein levels in primary human lung fibroblasts (HLFs). Our work is the first to investigate the association between ACE2 and HuR. Further investigation is needed to understand the mechanistic underpinning behind the regulation of ACE2 expression.

  • Open Access English
    Authors: 
    Rebecca Carlson;
    Publisher: University of Alberta
    Country: Canada

    Bien que la vie biologique et la complexité sociale humaine soient fondamentalement interdépendantes, les chercheurs en biologie et en sciences sociales continuent de se percevoir à travers les clivages du scepticisme théorique, méthodologique et institutionnel. Cet article considère le travail de frontière conversationnel entre les scientifiques qualitatifs et quantitatifs comme une performance rhétorique institutionnalisée qui limite leur coopération, même face à la pandémie de COVID-19 lorsque cela est le plus urgent. À titre d’exemple, j’examine la manière dont des conflits épistémologiques familiers ont émergé de la collaboration entre moi-même et un bioscientifique au printemps 2020, lorsque j’ai participé au Massive Microscopic Sensemaking Project, un projet internationale d’écriture auto-ethnographique de 21 jours. Although biological life and human social complexity are fundamentally interdependent, biological and social researchers continue to perceive each other from across divides of theoretical, methodological, and institutional skepticism. This paper considers conversational boundary work between qualitative and quantitative scientists as an institutionalized rhetorical performance which throttles their cooperation, even in the face of the COVID-19 pandemic when it is most urgently needed. As an example, I look at the way familiar epistemological conflicts emerged out of collaboration between myself and a bioscientist during the spring of 2020, when co-participating in the Massive Microscopic Sensemaking Project, a 21-day international auto-ethnographic writing experiment.

  • Open Access English
    Authors: 
    Veronica Mitchell;
    Publisher: University of Alberta
    Country: Canada

    Cet article s’appuie sur mon lien avec les fils à coudre et explore comment le défi en ligne 2020 Massive Microscopic Sensemaking (MMS) a contribué à un enchevêtrement émergent de l’espace-temps lié à COVID-19, à l’enseignement et à la recherche sur l’apprentissage médical en obstétrique, et à la réflexion plus approfondie de mon doctorat . Il explore les processus affirmatifs mis en œuvre pendant les périodes d’anxiété, lorsque mes pensées se frayaient un chemin à travers des espaces intermédiaires avec des moments et des matériaux différents qui étaient génératifs et productifs. J’explique mes mouvements rhizomatiques qui saignent à travers les séparations conventionnelles et les hypothèses de délimitation. Je m’appuie sur le réalisme agential de Karen Barad pour théoriser l’émergence de relations créatives avec des artefacts astucieux mis en scène avec des étudiants de premier cycle en médecine, avec des participants au projet MMS et avec mon propre doctorat en période de tension. This article draws on my connection with sewing threads, and explores how the 2020 Massive Microscopic Sensemaking (MMS) online challenge contributed to an emergent entanglement of timespacemattering related to COVID-19, teaching and researching medical learning in obstetrics, and thinking further with my PhD. It explores affirmative processes enacted during times of anxiety, when my thoughts needled through in-between spaces with different times and materials that were generative and productive. I explain my rhizomatic movements that bleed through conventional separations and boundary-making assumptions. I draw on Karen Barad’s agential realism to theorize the emergence of creative relationalities with artful artifacts enacted with medical undergraduate students, with participants in the MMS project, and with my own PhD during times of tension.

  • Publication . Article . Other literature type . 2021
    Open Access English
    Authors: 
    Kim Snepvangers;
    Publisher: University of Alberta
    Country: Canada

    Ce projet, qui a débuté avec Prompt #2 du Massive Micro Sensemaking (MMS) dirigé par Annette Markham et Anne Harris de mai à juin 2020, m’a aidé à faire face à l’anxiété causée par le confinement de la COVID-19. J’ai mis en place quatre représentations visuelles - une série de photographies qui, à travers un processus de déploiement, établissent des liens avec des questionnements plus larges au cours de mes recherches d’archives dans le contexte de la colonisation de Sydney, en Australie. Explorer l’expérience vécue à travers la photographie prévoit un objectif a/r/tographique créatif, axé sur la représentation des objets afin qu’ils prennent un aspect plus que représentatif, touchant la matérialité des objets en tant que données. Adapter la superposition des rendus va au-delà de l’aspect dimensionnel en tant que simple capture d’un phénomène observé. Cette première photographie a ici une couche d’ombre supplémentaire pour créer du volume et recréer des semblants du monde figuratif à travers le reflet. This project, starting with Prompt 2 from the Massive Micro Sensemaking (MMS) led by Annette Markham and Anne Harris in May through June 2020, assisted me to move through the anxiety of COVID-19 lockdown. I set up four visual renderings—a series of photographs that, through a process of unfolding, make links to broader issues in my archival research in the context of settler colonial Sydney, Australia. Exploring lived experience through photography anticipates a creative a/r/tographic lens, focusing on rendering objects so that they take on a more-than-representational aspect, touching the materiality of objects as data. Adaptively layering the renderings moves beyond one dimensionality as a strict capturing of an observed phenomena. Here, an initial photograph has a latent, additional layer of shadow to build volume and re-cast semblances of the representational world through reflection.

  • Open Access English
    Authors: 
    Annette Markham;
    Publisher: York University
    Country: Canada

    Comment donner un sens à ce qui est à la fois global et granulaire ? Cet essai visuel explore la relation entre le macro et le micro à travers les pratiques quotidiennes de création, de recadrage et de partage d'images. Il pose la question de savoir si de nouveaux modes de connaissance émergent ou si des modèles de création de sens préexistent, un équivalent psychologique ou social des formes fractales dans la nature. Cela est particulièrement pertinent si l'on considère que c'est précisément dans les détails banals et les actions quotidiennes de création de sens que naissent les structures d'interprétation futures. Alors que l'on traverse une période traumatique à l'échelle du globe, l'essai s'interroge sur la façon dont ces micro-pratiques pourraient contribuer à renforcer ou à résister aux relations existantes entre les humains, les technologies et la planète. How do we make sense of the global and granular at the same time? This visual essay explores the relationship of the macro and micro through everyday practices of image making, cropping, and sharing. It asks whether new ways of knowing emerge or if perhaps patterns of sensemaking pre-exist, a psychological or social equivalent to fractals in nature. This becomes relevant when we consider that it is precisely within the mundane details of everyday actions of sensemaking that future structures are born. In wonders about how, in times of global trauma, might these micro practices reinforce or resist existing relations among humans, technologies, and the planet.

  • Open Access English
    Authors: 
    Rebecca Carlson; Polina Golovátina-Mora; Corinna Peterken; Kim Snepvangers; Anne Soronen; Karoliina Talvitie-Lamberg;
    Publisher: University of Alberta Press
    Countries: Canada, Finland

    Dans le contexte de l’épidémie de COVID-19, les auteurs de ce numéro spécial se sont réunis autour du projet de rédaction Massive Microscopic Sensemaking (MMS) au printemps 2020. Les articles de ce numéro viennent collectivement se confronter aux répercussions de la pandémie prolongée. Chaque article relate des expériences d’isolement social, d’adaptation et d’ouverture technologique en temps de crise sanitaire. Cette introduction décrit le raisonnement de ce numéro à la composition « patchwork » qui illustre une tentative de rupture avec les traditions académiques qui souvent ne réussissent pas à reconnaître la valeur émergente, et par conséquent incertaine, des travaux transdisciplinaires et collectifs. In the context of the COVID-19 outbreak, the authors in this special issue came together within the Massive Microscopic Sensemaking (MMS) writing project in the spring of 2020. Collectively grappling with the impact of the extended pandemic, each paper in this issue touches on experiences of social isolation, making do, and a technological reaching out under conditions of a public health crisis. This introduction describes the issue’s ‘patchwork’ development which reflects an attempt to break from traditions of academic scholarship that often fail to recognize the value of emergent, and therefore uncertain, cross-disciplinary and collective work.

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3,178 Research products, page 1 of 318
  • Open Access English
    Authors: 
    Subha Dahal; Ran Cheng; Peter K. Cheung; Terek Been; Ramy Malty; Melissa Geng; Sarah Manianis; Lulzim Shkreta; Shahrazad Jahanshahi; Johanne Toutant; +13 more
    Publisher: Multidisciplinary Digital Publishing Institute
    Project: CIHR

    Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the identification of the thiazole-5-carboxamide derivative (GPS491), which retained potent anti-HIV-1 activity with reduced toxicity. In this report, we demonstrate that the block of HIV-1 replication by GPS491 is accompanied by a drastic inhibition of viral gene expression (IC50 ~ 0.25 µM), and alterations in the production of unspliced, singly spliced, and multiply spliced HIV-1 RNAs. GPS491 also inhibited the replication of adenovirus and multiple coronaviruses. Low µM doses of GPS491 reduced adenovirus infectious yield ~1000 fold, altered virus early gene expression/viral E1A RNA processing, blocked viral DNA amplification, and inhibited late (hexon) gene expression. Loss of replication of multiple coronaviruses (229E, OC43, SARS-CoV2) upon GPS491 addition was associated with the inhibition of viral structural protein expression and the formation of virus particles. Consistent with the observed changes in viral RNA processing, GPS491 treatment induced selective alterations in the accumulation/phosphorylation/function of splicing regulatory SR proteins. Our study establishes that a compound that impacts the activity of cellular factors involved in RNA processing can prevent the replication of several viruses with minimal effect on cell viability.

  • Publication . Part of book or chapter of book . 2021
    Open Access English
    Authors: 
    Kennan, Danielle; Dolan, Pat; Anderson, Ella; Garrett, Kalem;
    Publisher: Routledge Taylor and Francis
    Country: Ireland

    This chapter reflects on how youth, through the medium of youth-led research, can seek to influence public policy by bringing a more democratic and informed youth perspective into the policy-making arena. The chapter details the Youth as Researchers Programme Model. It outlines how the programme has supported youth, in Ireland and internationally, to undertake social research projects with their peers on issues of concern, to collectively inform policy dialogue. The chapter documents the development of the programme, including a case study of one of the early youth-led research projects set up in Ireland in response to Ireland¿s National Child and Family Agency seeking to better understand how young people facing adversity can be heard and helped. It traces the programme¿s development from its inception to the present day, when the programme is now central to UNESCO¿s global response to inform policy on supporting youth during COVID-19. Not peer reviewed 2023-06-24

  • Open Access English
    Authors: 
    Linke Yu; Mariah Lecompte; Weiguo Zhang; Peizhong Wang; Lixia Yang;
    Publisher: MDPI
    Project: CIHR

    The current study investigates the mental health condition of Mainland Chinese in Canada and identifies the associated sociodemographic and COVID-19-related predictors. A sample of 471 Mainland Chinese aged 18 or older completed an online survey that collected information on demographics, experience, cognition, and behaviours related to the COVID-19 pandemic and mental health condition. Mental health condition was assessed with the Depression, Anxiety, and Stress Scale-21 (DASS-21) for the depression, anxiety, and stress levels of Mainland Chinese during the pandemic. Moderate to severe depression, anxiety, and stress levels were respectively reported by 11.30%, 10.83%, and 5.10% of respondents. Univariate analysis of variance models (ANOVAs) were conducted to assess mental health condition variance as stratified by independent sociodemographic- or COVID-19-related explanatory variables, to identify possible predictors to be entered into the subsequent regression models. The regression models identified age, income level, health status, and perceived discrimination as significant sociodemographic predictors (absolute value of βs = 1.19–7.11, ps < 0.05), whereas self-infection worry, attitude towards Canadian measures, information confusion, food/goods stocking, and room cleaning/sanitizing were identified as significant COVID-19-reltaed predictors (absolute value of βs = 1.33–3.45, ps < 0.05) for mental health outcomes. The results shed light on our understanding of the major factors associated with the mental health condition of Mainland Chinese in Canada during the COVID-19 pandemic.

  • Open Access English
    Authors: 
    Jamie L. Benham; Omid Atabati; Robert J. Oxoby; Mehdi Mourali; Blake Shaffer; Hasan Sheikh; Jean-Christophe Boucher; Cora Constantinescu; Jeanna Parsons Leigh; Noah Ivers; +7 more
    Publisher: JMIR Publications

    Background There are concerns that vaccine hesitancy may impede COVID-19 vaccine rollout and prevent the achievement of herd immunity. Vaccine hesitancy is a delay in acceptance or refusal of vaccines despite their availability. Objective We aimed to identify which people are more and less likely to take a COVID-19 vaccine and factors associated with vaccine hesitancy to inform public health messaging. Methods A Canadian cross-sectional survey was conducted in Canada in October and November 2020, prior to the regulatory approval of the COVID-19 vaccines. Vaccine hesitancy was measured by respondents answering the question “what would you do if a COVID-19 vaccine were available to you?” Negative binomial regression was used to identify the factors associated with vaccine hesitancy. Cluster analysis was performed to identify distinct clusters based on intention to take a COVID-19 vaccine, beliefs about COVID-19 and COVID-19 vaccines, and adherence to nonpharmaceutical interventions. Results Of 4498 participants, 2876 (63.9%) reported COVID-19 vaccine hesitancy. Vaccine hesitancy was significantly associated with (1) younger age (18-39 years), (2) lower education, and (3) non-Liberal political leaning. Participants that reported vaccine hesitancy were less likely to believe that a COVID-19 vaccine would end the pandemic or that the benefits of a COVID-19 vaccine outweighed the risks. Individuals with vaccine hesitancy had higher prevalence of being concerned about vaccine side effects, lower prevalence of being influenced by peers or health care professionals, and lower prevalence of trust in government institutions. Conclusions These findings can be used to inform targeted public health messaging to combat vaccine hesitancy as COVID-19 vaccine administration continues. Messaging related to preventing COVID among friends and family, highlighting the benefits, emphasizing safety and efficacy of COVID-19 vaccination, and ensuring that health care workers are knowledgeable and supported in their vaccination counselling may be effective for vaccine-hesitant populations.

  • Open Access English
    Authors: 
    Noof Aloufi; Zahraa Haidar; Jun Ding; Parameswaran Nair; Andrea Benedetti; David H. Eidelman; Imed-Eddine Gallouzi; Sergio Di Marco; Sabah N. Hussain; Carolyn J. Baglole;
    Publisher: MDPI AG
    Project: CIHR

    Patients with COPD may be at an increased risk for severe illness from COVID-19 because of ACE2 upregulation, the entry receptor for SARS-CoV-2. Chronic exposure to cigarette smoke, the main risk factor for COPD, increases pulmonary ACE2. How ACE2 expression is controlled is not known but may involve HuR, an RNA binding protein that increases protein expression by stabilizing mRNA. We hypothesized that HuR would increase ACE2 protein expression. We analyzed scRNA-seq data to profile ELAVL1 expression in distinct respiratory cell populations in COVID-19 and COPD patients. HuR expression and cellular localization was evaluated in COPD lung tissue by multiplex immunohistochemistry and in human lung cells by imaging flow cytometry. The regulation of ACE2 expression was evaluated using siRNA-mediated knockdown of HuR. There is a significant positive correlation between ELAVL1 and ACE2 in COPD cells. HuR cytoplasmic localization is higher in smoker and COPD lung tissue; there were also higher levels of cleaved HuR (CP-1). HuR binds to ACE2 mRNA but knockdown of HuR does not change ACE2 protein levels in primary human lung fibroblasts (HLFs). Our work is the first to investigate the association between ACE2 and HuR. Further investigation is needed to understand the mechanistic underpinning behind the regulation of ACE2 expression.

  • Open Access English
    Authors: 
    Rebecca Carlson;
    Publisher: University of Alberta
    Country: Canada

    Bien que la vie biologique et la complexité sociale humaine soient fondamentalement interdépendantes, les chercheurs en biologie et en sciences sociales continuent de se percevoir à travers les clivages du scepticisme théorique, méthodologique et institutionnel. Cet article considère le travail de frontière conversationnel entre les scientifiques qualitatifs et quantitatifs comme une performance rhétorique institutionnalisée qui limite leur coopération, même face à la pandémie de COVID-19 lorsque cela est le plus urgent. À titre d’exemple, j’examine la manière dont des conflits épistémologiques familiers ont émergé de la collaboration entre moi-même et un bioscientifique au printemps 2020, lorsque j’ai participé au Massive Microscopic Sensemaking Project, un projet internationale d’écriture auto-ethnographique de 21 jours. Although biological life and human social complexity are fundamentally interdependent, biological and social researchers continue to perceive each other from across divides of theoretical, methodological, and institutional skepticism. This paper considers conversational boundary work between qualitative and quantitative scientists as an institutionalized rhetorical performance which throttles their cooperation, even in the face of the COVID-19 pandemic when it is most urgently needed. As an example, I look at the way familiar epistemological conflicts emerged out of collaboration between myself and a bioscientist during the spring of 2020, when co-participating in the Massive Microscopic Sensemaking Project, a 21-day international auto-ethnographic writing experiment.

  • Open Access English
    Authors: 
    Veronica Mitchell;
    Publisher: University of Alberta
    Country: Canada

    Cet article s’appuie sur mon lien avec les fils à coudre et explore comment le défi en ligne 2020 Massive Microscopic Sensemaking (MMS) a contribué à un enchevêtrement émergent de l’espace-temps lié à COVID-19, à l’enseignement et à la recherche sur l’apprentissage médical en obstétrique, et à la réflexion plus approfondie de mon doctorat . Il explore les processus affirmatifs mis en œuvre pendant les périodes d’anxiété, lorsque mes pensées se frayaient un chemin à travers des espaces intermédiaires avec des moments et des matériaux différents qui étaient génératifs et productifs. J’explique mes mouvements rhizomatiques qui saignent à travers les séparations conventionnelles et les hypothèses de délimitation. Je m’appuie sur le réalisme agential de Karen Barad pour théoriser l’émergence de relations créatives avec des artefacts astucieux mis en scène avec des étudiants de premier cycle en médecine, avec des participants au projet MMS et avec mon propre doctorat en période de tension. This article draws on my connection with sewing threads, and explores how the 2020 Massive Microscopic Sensemaking (MMS) online challenge contributed to an emergent entanglement of timespacemattering related to COVID-19, teaching and researching medical learning in obstetrics, and thinking further with my PhD. It explores affirmative processes enacted during times of anxiety, when my thoughts needled through in-between spaces with different times and materials that were generative and productive. I explain my rhizomatic movements that bleed through conventional separations and boundary-making assumptions. I draw on Karen Barad’s agential realism to theorize the emergence of creative relationalities with artful artifacts enacted with medical undergraduate students, with participants in the MMS project, and with my own PhD during times of tension.

  • Publication . Article . Other literature type . 2021
    Open Access English
    Authors: 
    Kim Snepvangers;
    Publisher: University of Alberta
    Country: Canada

    Ce projet, qui a débuté avec Prompt #2 du Massive Micro Sensemaking (MMS) dirigé par Annette Markham et Anne Harris de mai à juin 2020, m’a aidé à faire face à l’anxiété causée par le confinement de la COVID-19. J’ai mis en place quatre représentations visuelles - une série de photographies qui, à travers un processus de déploiement, établissent des liens avec des questionnements plus larges au cours de mes recherches d’archives dans le contexte de la colonisation de Sydney, en Australie. Explorer l’expérience vécue à travers la photographie prévoit un objectif a/r/tographique créatif, axé sur la représentation des objets afin qu’ils prennent un aspect plus que représentatif, touchant la matérialité des objets en tant que données. Adapter la superposition des rendus va au-delà de l’aspect dimensionnel en tant que simple capture d’un phénomène observé. Cette première photographie a ici une couche d’ombre supplémentaire pour créer du volume et recréer des semblants du monde figuratif à travers le reflet. This project, starting with Prompt 2 from the Massive Micro Sensemaking (MMS) led by Annette Markham and Anne Harris in May through June 2020, assisted me to move through the anxiety of COVID-19 lockdown. I set up four visual renderings—a series of photographs that, through a process of unfolding, make links to broader issues in my archival research in the context of settler colonial Sydney, Australia. Exploring lived experience through photography anticipates a creative a/r/tographic lens, focusing on rendering objects so that they take on a more-than-representational aspect, touching the materiality of objects as data. Adaptively layering the renderings moves beyond one dimensionality as a strict capturing of an observed phenomena. Here, an initial photograph has a latent, additional layer of shadow to build volume and re-cast semblances of the representational world through reflection.

  • Open Access English
    Authors: 
    Annette Markham;
    Publisher: York University
    Country: Canada

    Comment donner un sens à ce qui est à la fois global et granulaire ? Cet essai visuel explore la relation entre le macro et le micro à travers les pratiques quotidiennes de création, de recadrage et de partage d'images. Il pose la question de savoir si de nouveaux modes de connaissance émergent ou si des modèles de création de sens préexistent, un équivalent psychologique ou social des formes fractales dans la nature. Cela est particulièrement pertinent si l'on considère que c'est précisément dans les détails banals et les actions quotidiennes de création de sens que naissent les structures d'interprétation futures. Alors que l'on traverse une période traumatique à l'échelle du globe, l'essai s'interroge sur la façon dont ces micro-pratiques pourraient contribuer à renforcer ou à résister aux relations existantes entre les humains, les technologies et la planète. How do we make sense of the global and granular at the same time? This visual essay explores the relationship of the macro and micro through everyday practices of image making, cropping, and sharing. It asks whether new ways of knowing emerge or if perhaps patterns of sensemaking pre-exist, a psychological or social equivalent to fractals in nature. This becomes relevant when we consider that it is precisely within the mundane details of everyday actions of sensemaking that future structures are born. In wonders about how, in times of global trauma, might these micro practices reinforce or resist existing relations among humans, technologies, and the planet.

  • Open Access English
    Authors: 
    Rebecca Carlson; Polina Golovátina-Mora; Corinna Peterken; Kim Snepvangers; Anne Soronen; Karoliina Talvitie-Lamberg;
    Publisher: University of Alberta Press
    Countries: Canada, Finland

    Dans le contexte de l’épidémie de COVID-19, les auteurs de ce numéro spécial se sont réunis autour du projet de rédaction Massive Microscopic Sensemaking (MMS) au printemps 2020. Les articles de ce numéro viennent collectivement se confronter aux répercussions de la pandémie prolongée. Chaque article relate des expériences d’isolement social, d’adaptation et d’ouverture technologique en temps de crise sanitaire. Cette introduction décrit le raisonnement de ce numéro à la composition « patchwork » qui illustre une tentative de rupture avec les traditions académiques qui souvent ne réussissent pas à reconnaître la valeur émergente, et par conséquent incertaine, des travaux transdisciplinaires et collectifs. In the context of the COVID-19 outbreak, the authors in this special issue came together within the Massive Microscopic Sensemaking (MMS) writing project in the spring of 2020. Collectively grappling with the impact of the extended pandemic, each paper in this issue touches on experiences of social isolation, making do, and a technological reaching out under conditions of a public health crisis. This introduction describes the issue’s ‘patchwork’ development which reflects an attempt to break from traditions of academic scholarship that often fail to recognize the value of emergent, and therefore uncertain, cross-disciplinary and collective work.

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