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11 Research products, page 1 of 2

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  • Open Access English
    Authors: 
    Flechard, Chris R.; Ibrom, Andreas; Skiba, Ute M.; Vries, Wim; Oijen, Marcel; Cameron, David R.; Dise, Nancy B.; Korhonen, Janne F. J.; Buchmann, Nina; Legout, Arnaud; +62 more
    Project: NWO | EFFECT Exploiting Filtere... (2300149327), EC | ECLAIRE (282910), UKRI | UK Status, Change and Pro... (NE/R016429/1)

    The impact of atmospheric reactive nitrogen (Nr) deposition on carbon (C) sequestration in soils and biomass of unfertilized, natural, semi-natural and forest ecosystems has been much debated. Many previous results of this dC∕dN response were based on changes in carbon ...

  • Other research product . Other ORP type . 2018
    Open Access English
    Authors: 
    Doestzada, Marwah; Vich Vila, Arnau; Zhernakova, Alexandra; Koonen, Debby P Y; Weersma, Rinse K; Touw, Daan J; Kuipers, Folkert; Wijmenga, Cisca; Fu, Jingyuan;
    Project: EC | BabyVir (715772), NWO | Understanding the causal ... (2300184638), EC | CD-LINK (322698)

    Inter-individual heterogeneity in drug response is a serious problem that affects the patient's wellbeing and poses enormous clinical and financial burdens on a societal level. Pharmacogenomics has been at the forefront of research into the impact of individual genetic ...

  • Other research product . Other ORP type . 2018
    Open Access English
    Authors: 
    van Beek, Nienke; Klionsky, Daniel J; Reggiori, Fulvio;
    Project: EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771), EC | DRIVE (765912)

    The catabolic process of macroautophagy, through the rapid degradation of unwanted cellular components, is involved in a multitude of cellular and organismal functions that are essential to maintain homeostasis. Those functions include adaptation to starvation, cell dev...

  • Open Access English
    Authors: 
    Cao, Fangyuan; Zwinderman, Martijn R H; Dekker, Frank J;
    Project: EC | FWGDEKKER (309782), NWO | Expanding the molecular t... (2300172468)

    Histone deacetylases (HDACs) are epigenetic drug targets that have gained major scientific attention. Inhibition of these important regulatory enzymes is used to treat cancer, and has the potential to treat a host of other diseases. However, currently marketed HDAC inhi...

  • Other research product . Other ORP type . 2018
    Open Access English
    Authors: 
    Weiden, J.; Tel, J.; Figdor, C.G.;
    Project: NWO | The Institute for Chemica... (2300181608), EC | PATHFINDER (269019)

    Cancer immunotherapy can successfully promote long-term anticancer immune responses, although there is still only a limited number of patients who benefit from such treatment, and it can sometimes have severe treatment-associated adverse events. Compared with systemic i...

  • Other research product . Other ORP type . 2018
    Open Access English
    Authors: 
    Aloi, Antonio; Voets, Ilja K.;
    Project: EC | PRISM (635928), NWO | Research Centre for Funct... (2300176518)

    Super-resolution microscopy (SRM), also known as nanoscopy, has gained ground in the past decade as a valuable imaging and characterization tool to investigate sub-μm architectures. Widespread is its usage in cell biology and biophysics, while visualization of the inner...

  • Other research product . Other ORP type . 2017
    Open Access English
    Authors: 
    Bernstein, D.J.; Lange, T.;
    Project: NSF | TWC: Option: Medium: Coll... (1314919), NWO | Computational number theo... (2300163763), EC | PQCRYPTO (645622)

    Cryptography is essential for the security of online communication, cars and implanted medical devices. However, many commonly used cryptosystems will be completely broken once large quantum computers exist. Post-quantum cryptography is cryptography under the assumption...

  • Open Access English
    Authors: 
    Gribling, Sander; Laat, David; Laurent, Monique;
    Project: NWO | Approximation Algorithms,... (2300181725), EC | QPROGRESS (615307)

    We use techniques from (tracial noncommutative) polynomial optimization to formulate hierarchies of semidefinite programming lower bounds on matrix factorization ranks. In particular, we consider the nonnegative rank, the completely positive rank, and their symmetric an...

  • Other research product . Other ORP type . 2017
    Open Access English
    Authors: 
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Project: SNSF | ER-phagy mechanisms to ma... (CRSII3_154421), EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

  • Open Access English
    Authors: 
    van den Bosch, Thea; Kwiatkowski, Marcel; Bischoff, Rainer; Dekker, Frank J;
    Project: NWO | Expanding the molecular t... (2300172468), EC | FWGDEKKER (309782)

    Asthma and chronic obstructive pulmonary disease are inflammatory airway diseases for which alternative therapeutic strategies are urgently needed. Interestingly, HDAC inhibitors show anti-inflammatory effects in mouse models for these diseases. Here we explore underlyi...