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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Barthé, Marion; Lefebvre, Flora; Langlois, Emilie; Lefebvre, Florence; +6 Authors

    Membrane proteins are present in both cardiac T-tubule (TTM) and outer surface membrane (OSM), although at a different density. Classical pharmacology does not allow to explore the function of a membrane protein separately in OSM vs. TTM. Here, we developed a technology based on size exclusion to explore the function of β-adrenergic receptors (β-ARs) located in the OSM. We synthetized a PEG-Iso molecule by covalent linking between isoprenaline (Iso) and a 5000 Da PolyEthylene-Glycol (PEG). Using confocal microscopy, we show that PEGylation constrains molecules outside the T-tubule network. PEG-Iso produced similar effects as Iso on I ca,L , sarcomere shortening and Ca 2+ transients. However, PEG-Iso increased [cAMP] i with a lower efficacy than Iso, produced a much lower stimulation of nuclear PKA activity than Iso but a larger stimulation of cytosolic PKA at equivalent levels of [cAMP] i . Our results show that activation of OSM β-ARs is sufficient to activate cytosolic PKA and excitation-contraction coupling, but insufficient to activate nuclear PKA or nuclear protein phosphorylation for which additional activation of TTM β-ARs is needed.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ HAL CY Cergy Paris U...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    HAL-Inserm
    Other literature type . Preprint . 2022
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ HAL CY Cergy Paris U...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      Other literature type . Preprint . 2022
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  • Authors: Kamionka, Thierry; Leveneur, Pauline;

    We investigate interactions between individual's position in the labor market and health status. We jointly model health, employment and working hours using a dynamic model. We estimate a dynamic multivariate model with random effects for the period going from 1991 to 2009 and using data from the British Household Panel Survey (BHPS). Instrumental variables are used. We consider interactions of the error terms of the model using a vector autoregressive process of the order 1. A shock on one component of the error term can have an impact on the distribution of the error term the next period of time. Individual effects-one for each equation-can be correlated. The model is estimated using simulated maximum likelihood estimator. We consider the initial conditions problem. We find that joint dynamics of health and employment is determined by the interactions of their past realizations as well as by the individual's socioeconomic characteristics.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Ruda, Aurélia; Louf, François; Boucard, Pierre-Alain; Mininger, Xavier;

    International audience; In this work, a mixed domain decomposition method (LATIN) is proposed to improve the efficiency of magnetostatic simulation of rotating machines. This strategy relies on a decomposed formulation of the problem considering both primal and dual fields on the interfaces. From this formulation, the LATIN solver method gives a powerful iterative scheme to build a solution. A first implementation using the magnetic vector potential formulation in 2D is developed and is illustrated on two test cases: a ferromagnetic 2D bar and a switched reluctance motor.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Hyper Article en Lig...arrow_drop_down
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    Hyper Article en Ligne; Hal-Diderot
    Other literature type . Conference object . 2021
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  • Authors: Urso, Riccardo Giovanni; Vuitton, Veronique; Le Sergeant d’Hendecourt, L.; Flandinet, Laurene; +7 Authors

    International audience; Context. Near-and mid-infrared observations have revealed the presence of organic refractory materials in the solar system, in cometary nuclei and on the surface of centaurs, Kuiper-belt and trans-neptunian objects. In these astrophysical environments, organic materials can be formed because of the interaction of frozen volatile compounds with cosmic rays, stellar/solar particles, and favoured by thermal processing. The analysis of laboratory analogues of such materials gives information on their properties, complementary to observations. Aims. We present new experiments to contribute in the understanding of the chemical composition of organic refractory materials in space. Methods. We bombard frozen water, methanol and ammonia mixtures with 40 keV H + and we warm the by-products up to 300 K. The experiments allow the production of organic residues that we analyse by means of infrared spectroscopy and by Very High Resolution Mass Spectrometry to study their chemical composition and their high molecular diversity, including the presence of hexamethylenetetramine and its derivatives. Results. We find that the accumulated irradiation dose plays a role in determining the residue's composition. Conclusions. Based on the laboratory doses, we estimate the astrophysical timescales to be short enough to induce an efficient formation of organic refractory materials at the surface of icy bodies in the outer solar system.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Fawaz, Hassan; Khawam, Kinda; Lahoud, Samer; Adjih, Cédric; +1 Authors

    International audience; LoRaWAN is a popular internet of things (IoT) solution over the unlicensed radio band. It sustains low-cost, durable, and long range IoT wireless communications. Nonetheless, with over 24 billion connected IoT devices being expected by the end of the year, and over 50 billion by 2025, the concurrent and legacy approaches to spreading factor and channel assignment in LoRaWAN networks can no longer keep up. This is exacerbated with the growing densification of IoT device deployments and, with the increasing requirements for better throughput and packet delivery ratios. In this paper, we propose a proportional fair-based joint optimal formulation for spreading factor and channel assignment in multi-operator LoRaWAN deployments. The objective of this problem is to maximize the total sum of the logarithmic normalized throughput. We split the problem into two subproblems, and propose a game theoretic approach to solving them. We prove that our games converge towards a pure Nash equilibrium and, afterwards, solve the optimization problems using both semi-distributed and completely distributed algorithms. Via simulations, we show that our algorithms greatly improve the total normalized throughput for LoRaWAN as well as the packet success rate, in comparison to the legacy approaches.

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    Sensors
    Other literature type . 2020
    License: CC BY
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    Europe PubMed Central
    Article . 2020
    Data sources: PubMed Central
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    Sensors
    Article . 2021
    Data sources: DOAJ-Articles
    Hal-Diderot
    Article . 2020
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      Sensors
      Other literature type . 2020
      License: CC BY
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Europe PubMed Central
      Article . 2020
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      Sensors
      Article . 2021
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      Hal-Diderot
      Article . 2020
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Crisci, Elisa; Moroldo, Marco; Vu Manh, Thien-Phong; Mohammad, Ammara; +12 Authors

    International audience; Porcine reproductive and respiratory syndrome (PRRS) has an extensive impact on pig production. The causative virus (PRRSV) is divided into two species, PRRSV-1 (European origin) and PRRSV-2 (North American origin). Within PRRSV-1, PRRSV-1.3 strains, such as Lena, are more pathogenic than PRRSV-1.1 strains, such as Flanders 13 (FL13). To date, the molecular interactions of PRRSV with primary lung mononuclear phagocyte (MNP) subtypes, including conventional dendritic cells types 1 (cDC1) and 2 (cDC2), monocyte-derived DCs (moDC), and pulmonary intravascular macrophages (PIM), have not been thoroughly investigated. Here, we analyze the transcriptome profiles of in vivo FL13-infected parenchymal MNP subpopulations and of in vitro FL13- and Lena-infected parenchymal MNP. The cell-specific expression profiles of in vivo sorted cells correlated with their murine counterparts (AM, cDC1, cDC2, moDC) with the exception of PIM. Both in vivo and in vitro, FL13 infection altered the expression of a low number of host genes, and in vitro infection with Lena confirmed the higher ability of this strain to modulate host response. Machine learning (ML) and gene set enrichment analysis (GSEA) unraveled additional relevant genes and pathways modulated by FL13 infection that were not identified by conventional analyses. GSEA increased the cellular pathways enriched in the FL13 data set, but ML allowed a more complete comprehension of functional profiles during FL13 in vitro infection. Data indicates that cellular reprogramming differs upon Lena and FL13 infection and that the latter might keep antiviral and inflammatory macrophage/DC functions silent. Although the slow replication kinetics of FL13 likely contribute to differences in cellular gene expression, the data suggest distinct mechanisms of interaction of the two viruses with the innate immune system during early infection.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    Europe PubMed Central
    Article . 2020
    Data sources: PubMed Central
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    Frontiers in Immunology
    Article . 2020
    Data sources: DOAJ-Articles
    HAL-Inserm
    Other literature type . 2020
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Camille Ingargiola; Gustavo Turqueto Duarte; Christophe Robaglia; Anne-Sophie Leprince; +1 Authors

    International audience; Living organisms possess many mechanisms to sense nutrients and favorable conditions, which allow them to grow and develop. Photosynthetic organisms are very diverse, from green unicellular algae to multicellular flowering plants, but most of them are sessile and thus unable to escape from the biotic and abiotic stresses they experience. The Target of Rapamycin (TOR) signaling pathway is conserved in all eukaryotes and acts as a central regulatory hub between growth and extrinsic factors, such as nutrients or stress. However, relatively little is known about the regulations and roles of this pathway in plants and algae. Although some features of the TOR pathway seem to have been highly conserved throughout evolution, others clearly differ in plants, perhaps reflecting adaptations to different lifestyles and the rewiring of this primordial signaling module to adapt to specific requirements. Indeed, TOR is involved in plant responses to a vast array of signals including nutrients, hormones, light, stresses or pathogens. In this review, we will summarize recent studies that address the regulations of TOR by nutrients in photosynthetic organisms, and the roles of TOR in controlling important metabolic pathways, highlighting similarities and differences with the other eukaryotes.

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    Europe PubMed Central
    Article . 2020
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    Genes
    Article . 2020
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  • Authors: Berger, Loïc; Berger, Nicolas; Bosetti, Valentina; Gilboa, Itzhak; +4 Authors

    Policymaking during a pandemic can be extremely challenging. As COVID-19 is a new disease and its global impacts are unprecedented, decisions need to be made in a highly uncertain, complex and rapidly changing environment. In such a context, in which human lives and the economy are at stake, we argue that using ideas and constructs from modern decision theory, even informally, will make policymaking more a responsible and transparent process.

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  • Authors: Boyer, Pierre, C; Gerschel, Elie; Raj, Anasuya;

    Summary:The European economic union is incomplete, which makes it vulnerable to macroeconomic shocks. The opportunity to move forward in the integration process was highly debated even before the Covid-19 crisis.Yet the diverging views among countries and political groups are often considered as an obstacle on the path to required agreements for completing the Economic and Monetary Union (EMU). We present the results of a survey conducted in 2018 among members of national parliaments (MPs) in France, Germany and Italy on European integration in policy fields related to risk-sharing and budgetary institutions, asking for their opinion on proposals such as the creation of a European Unemployment Insurance (EUI), Eurobonds, or an EU tax. We find that nationality and political groups are key determinants of support for such proposals, the latter being the strongest. We describe how opinions are divided and try to identify policy proposals which could gather enough political support. The agreement reached on July 21st, 2020 at the last European summit includes financial transfers between States and the creation of Eurobonds, thus representing an important institutional move and an application of some of the reforms suggested by our survey. Yet what has been decided upon is only temporary and leaves open the question of the future of European integration.Key points: At first glance, the answers show diverging opinions on most questions between countries with Italy supporting more integration, and Germany opposing it for most proposals. France has an intermediate position, leaning towards Italy. A breakdown of the results by party affiliation shows a more nuanced picture. For cross-country comparisons, we build a party indicator using the affiliation of national parties to European political groups. National MPs associated with the group of Socialists and Democrats (S&D) at the European level show strong support for the creation of new fiscal institutions and a new EU tax, and for risk sharing institutions (European Unemployment Insurance, Eurobonds). On the contrary, MPs associated with the European People’s Party (EPP) are mildly positive or against risk-sharing and fiscal institutions. National MPs affiliated to Renew Europe hold similar views to S&D MPs, but are less supportive of risk-sharing mechanisms. There is a substantial diversity of positions between the German AfD, the Italian Lega and the 5-star movement: the three parties have diverging views on the future of integration. Our econometric analysis shows that party affiliations have more explanatory power than nationality for all questions. This clearly shows that outcomes of national parliamentary elections could change the overall support for any issue.; Summary:The European economic union is incomplete, which makes it vulnerable to macroeconomic shocks. The opportunity to move forward in the integration process was highly debated even before the Covid-19 crisis.Yet the diverging views among countries and political groups are often considered as an obstacle on the path to required agreements for completing the Economic and Monetary Union (EMU). We present the results of a survey conducted in 2018 among members of national parliaments (MPs) in France, Germany and Italy on European integration in policy fields related to risk-sharing and budgetary institutions, asking for their opinion on proposals such as the creation of a European Unemployment Insurance (EUI), Eurobonds, or an EU tax. We find that nationality and political groups are key determinants of support for such proposals, the latter being the strongest. We describe how opinions are divided and try to identify policy proposals which could gather enough political support. The agreement reached on July 21st, 2020 at the last European summit includes financial transfers between States and the creation of Eurobonds, thus representing an important institutional move and an application of some of the reforms suggested by our survey. Yet what has been decided upon is only temporary and leaves open the question of the future of European integration.Key points: At first glance, the answers show diverging opinions on most questions between countries with Italy supporting more integration, and Germany opposing it for most proposals. France has an intermediate position, leaning towards Italy. A breakdown of the results by party affiliation shows a more nuanced picture. For cross-country comparisons, we build a party indicator using the affiliation of national parties to European political groups. National MPs associated with the group of Socialists and Democrats (S&D) at the European level show strong support for the creation of new fiscal institutions and a new EU tax, and for risk sharing institutions (European Unemployment Insurance, Eurobonds). On the contrary, MPs associated with the European People’s Party (EPP) are mildly positive or against risk-sharing and fiscal institutions. National MPs affiliated to Renew Europe hold similar views to S&D MPs, but are less supportive of risk-sharing mechanisms. There is a substantial diversity of positions between the German AfD, the Italian Lega and the 5-star movement: the three parties have diverging views on the future of integration. Our econometric analysis shows that party affiliations have more explanatory power than nationality for all questions. This clearly shows that outcomes of national parliamentary elections could change the overall support for any issue.

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    Authors: Nedder, Margaux; Boland, Sonja; Devineau, Stephanie; Zerrad-Saadi, Amal; +10 Authors

    72 h), to assess trophoblast uptake, toxicity and impact on trophoblast differentiation and endocrine function. We have shown the capacity of both cytotrophoblasts and syncytiotrophoblasts to internalize CeO2 NPs. CeO2 NPs affected trophoblast metabolic activity in a dose and time dependency, induced caspase activation and a LDH release in the absence of oxidative stress. CeO2 NPs decreased the fusion capacity of cytotrophoblasts to form a syncytiotrophoblast and disturbed secretion of the pregnancy hormones hCG, hPL, PlGF, P4 and E2, in accordance with NPs concentration. This is the first study on the impact of CeO2 NPs using human primary trophoblasts that decrypts their toxicity and impact on placental formation and functions The human placenta is at the interface between maternal and fetal circulations, and is crucial for fetal development. The nanoparticles of cerium dioxide (CeO2 NPs) from air pollution are an unevaluated risk during pregnancy. Assessing the consequences of placenta exposure to CeO2 NPs could contribute to a better understanding of NPs&rsquo effect on the development and functions of the placenta and pregnancy outcome. We used primary villous cytotrophoblasts purified from term human placenta, with a wide range of CeO2 NPs concentrations (0.1&ndash g/cm2) and exposure time (24&ndash 101 &mu

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    Europe PubMed Central
    Article . 2020
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    Nanomaterials
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    Nanomaterials
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    Article . 2020
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    Article . 2020
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Barthé, Marion; Lefebvre, Flora; Langlois, Emilie; Lefebvre, Florence; +6 Authors

    Membrane proteins are present in both cardiac T-tubule (TTM) and outer surface membrane (OSM), although at a different density. Classical pharmacology does not allow to explore the function of a membrane protein separately in OSM vs. TTM. Here, we developed a technology based on size exclusion to explore the function of β-adrenergic receptors (β-ARs) located in the OSM. We synthetized a PEG-Iso molecule by covalent linking between isoprenaline (Iso) and a 5000 Da PolyEthylene-Glycol (PEG). Using confocal microscopy, we show that PEGylation constrains molecules outside the T-tubule network. PEG-Iso produced similar effects as Iso on I ca,L , sarcomere shortening and Ca 2+ transients. However, PEG-Iso increased [cAMP] i with a lower efficacy than Iso, produced a much lower stimulation of nuclear PKA activity than Iso but a larger stimulation of cytosolic PKA at equivalent levels of [cAMP] i . Our results show that activation of OSM β-ARs is sufficient to activate cytosolic PKA and excitation-contraction coupling, but insufficient to activate nuclear PKA or nuclear protein phosphorylation for which additional activation of TTM β-ARs is needed.

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    HAL-Inserm
    Other literature type . Preprint . 2022
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  • Authors: Kamionka, Thierry; Leveneur, Pauline;

    We investigate interactions between individual's position in the labor market and health status. We jointly model health, employment and working hours using a dynamic model. We estimate a dynamic multivariate model with random effects for the period going from 1991 to 2009 and using data from the British Household Panel Survey (BHPS). Instrumental variables are used. We consider interactions of the error terms of the model using a vector autoregressive process of the order 1. A shock on one component of the error term can have an impact on the distribution of the error term the next period of time. Individual effects-one for each equation-can be correlated. The model is estimated using simulated maximum likelihood estimator. We consider the initial conditions problem. We find that joint dynamics of health and employment is determined by the interactions of their past realizations as well as by the individual's socioeconomic characteristics.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Ruda, Aurélia; Louf, François; Boucard, Pierre-Alain; Mininger, Xavier;

    International audience; In this work, a mixed domain decomposition method (LATIN) is proposed to improve the efficiency of magnetostatic simulation of rotating machines. This strategy relies on a decomposed formulation of the problem considering both primal and dual fields on the interfaces. From this formulation, the LATIN solver method gives a powerful iterative scheme to build a solution. A first implementation using the magnetic vector potential formulation in 2D is developed and is illustrated on two test cases: a ferromagnetic 2D bar and a switched reluctance motor.

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    Hyper Article en Ligne; Hal-Diderot
    Other literature type . Conference object . 2021
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  • Authors: Urso, Riccardo Giovanni; Vuitton, Veronique; Le Sergeant d’Hendecourt, L.; Flandinet, Laurene; +7 Authors

    International audience; Context. Near-and mid-infrared observations have revealed the presence of organic refractory materials in the solar system, in cometary nuclei and on the surface of centaurs, Kuiper-belt and trans-neptunian objects. In these astrophysical environments, organic materials can be formed because of the interaction of frozen volatile compounds with cosmic rays, stellar/solar particles, and favoured by thermal processing. The analysis of laboratory analogues of such materials gives information on their properties, complementary to observations. Aims. We present new experiments to contribute in the understanding of the chemical composition of organic refractory materials in space. Methods. We bombard frozen water, methanol and ammonia mixtures with 40 keV H + and we warm the by-products up to 300 K. The experiments allow the production of organic residues that we analyse by means of infrared spectroscopy and by Very High Resolution Mass Spectrometry to study their chemical composition and their high molecular diversity, including the presence of hexamethylenetetramine and its derivatives. Results. We find that the accumulated irradiation dose plays a role in determining the residue's composition. Conclusions. Based on the laboratory doses, we estimate the astrophysical timescales to be short enough to induce an efficient formation of organic refractory materials at the surface of icy bodies in the outer solar system.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Fawaz, Hassan; Khawam, Kinda; Lahoud, Samer; Adjih, Cédric; +1 Authors

    International audience; LoRaWAN is a popular internet of things (IoT) solution over the unlicensed radio band. It sustains low-cost, durable, and long range IoT wireless communications. Nonetheless, with over 24 billion connected IoT devices being expected by the end of the year, and over 50 billion by 2025, the concurrent and legacy approaches to spreading factor and channel assignment in LoRaWAN networks can no longer keep up. This is exacerbated with the growing densification of IoT device deployments and, with the increasing requirements for better throughput and packet delivery ratios. In this paper, we propose a proportional fair-based joint optimal formulation for spreading factor and channel assignment in multi-operator LoRaWAN deployments. The objective of this problem is to maximize the total sum of the logarithmic normalized throughput. We split the problem into two subproblems, and propose a game theoretic approach to solving them. We prove that our games converge towards a pure Nash equilibrium and, afterwards, solve the optimization problems using both semi-distributed and completely distributed algorithms. Via simulations, we show that our algorithms greatly improve the total normalized throughput for LoRaWAN as well as the packet success rate, in comparison to the legacy approaches.

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    Sensors
    Other literature type . 2020
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    Europe PubMed Central
    Article . 2020
    Data sources: PubMed Central
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    Article . 2021
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    Article . 2020
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      Article . 2020
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      Article . 2020
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