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International audience; A recommendation – based on reviews by Lei Zhao, Yaniv Brandvain and one anonymous reviewer – of the article: Awad DA, Waller D (2022) Conditions for maintaining and eroding pseudo-overdominance and its contribution to inbreeding depression. bioRxiv, 2021.12.16.473022, ver. 3 peer-reviewed and recommended by Peer Community in Evolutionary Biology. https://doi.org/10.1101/2021.12.16.473022

This chapter of the Gaia DR3 documentation describes the Gaia DR3 data model.

The data collected during the first 34 months of the Gaia mission have been processed by the Gaia Data Processing and Analysis Consortium (DPAC), resulting in Gaia's third data release, Gaia DR3. Gaia DR3 contains the astrometry and broad-band photometry already published as part of Gaia EDR3 and introduces a large variety of new data products. A summary of the release properties is provided in Gaia Collaboration et al. (2022). The overall scientific validation of the data is described in Babusiaux et al. (2022) and Fabricius et al. (2021) (astrometry and broad-band photometry). Background information on the Gaia mission and the spacecraft can be found in Gaia Collaboration et al. (2016). In addition, Gaia DR3 is accompanied by dedicated processing papers, all part of a Special Issue of A&A, that describe the processing and validation of the various data products. The data release documentation provides complementary information to the processing papers. Finally, nine performance verification papers accompanying Gaia DR3 co-authored by the Gaia Collaboration provide an impression on the immense scientific potential of this release.

International audience; Dear editors, we read with a great interest the Brief Communication entitled “Acoustic stimulation time-locked to the beginning of sleep apnea events reduces oxygen desaturations: a pilot-study”, by Waeber et al.

Blog - Le club des juristes

White paper co-published by JPI Cultural Heritage and JPI Climate; Collaboration between the two Joint Programming Initiatives “Cultural Heritage and Global Change” (JPI CH), and “Connecting Climate Knowledge for Europe” (JPI Climate) began in 2019 and led to the organisation of a joint workshop a year later. Following the recommendations in the workshop report, an expert working group was set up to scope research gaps and opportunities at the interface of cultural heritage and climate change, culminating in the publication of this White Paper. This strategic document is expected to support the two JPIs to generate policy-relevant research outcomes. Four key messages are brought forth reviewing the state of the art in the field of cultural heritage and climate change research:• Research on individual geopolitical regions, or a few in immediate vicinity of one another, remains prevalent: there is an opportunity to stimulate research and knowledge exchange that crosscuts several regions which - although geographically disparate - present common challenges and opportunities.• Quantitative and qualitative methods remain siloed in their applications; mixed methods, which reflect a cross-disciplinary approach, are more likely to be found in pre-policy publications.• There is a need for further understanding of culture and heritage as embedded in their socio-environmental contexts to inform policy, including the role of traditional and local knowledge, as well as learning from the past.• The ecological and social impacts related to losses and opportunities for cultural assets and values from adaptation and mitigation need to be researched more intensively.Based on this comprehensive literature review, key research gaps and priorities have been identified for the European region and beyond that require more advanced knowledge in the coming years and that should be addressed by researchers to support climate adaptation and mitigation measures. To address the research gaps and priorities, both JPIs propose three types of instrument that could be used in supporting collaborative efforts between and beyond the two initiatives:

European genetic ancestry originates from three main ancestral populations - Western hunter-gatherers, early European farmers and Yamnaya Eurasian herders - whose edges geographically met in present-day France. Despite its central role to our understanding of how the ancestral populations interacted and gave rise to modern population structure, the population history of France has remained largely understudied. Here, we analysed 856 high-coverage whole-genome sequences along with genome-wide genotyping data of 3,234 present-day individuals from the northern half of France and merged them with publicly available present-day and ancient Europe-wide genotype datasets. We also analysed, for the first time, the whole-genome sequences of six medieval individuals (300-1100 CE) from Western France to gain insights into the genetic impact of what is commonly known as the Migration Period in Europe. We found extensive fine-scale population structure across Brittany and the downstream Loire basin, emphasizing the need for investigating local populations to better understand the distribution of rare and putatively deleterious variants across space. Overall, we observed an increased population differentiation between the northern and southern sides of the river Loire, which are characterised by different proportions of steppe vs. Neolithic-related ancestry. Samples from Western Brittany carry the largest levels of steppe ancestry and show high levels of allele sharing with individuals associated with the Bell Beaker complex, levels that are only comparable with those found in populations lying on the northwestern edges of Europe. Together, our results imply that present-day individuals from Western Brittany retain substantial legacy of the genetic changes that occurred in Northwestern Europe following the arrival of the Bell Beaker people c. 2500 BCE. Such genetic legacy may explain the sharing of disease-related alleles with other present-day populations from Western Britain and Ireland.

INTRODUCTION - Cold environments are a potential risk factor for stroke. The aim of this study was to investigate the association between performing work tasks in cold environments and the occurrence of a first stroke event. METHODS - From the French population-based cohort CONSTANCES, we collected data from baseline questionnaires along with medical interviews on cardiovascular risk factors and reported exposure to cold temperatures (<10°C) at work. Exposures were categorized as rare (<2 h/day), often (≥2 and <4 h/day), and almost always (≥4 h/day). Incidence of stroke was retrieved from the French National Health database. Bivariate and multivariable logistic regression models were used to assess the association between working in cold environments and the incidence of stroke. Stratified analysis on stroke types were also conducted. RESULTS - There were 160 782 participants and 224 strokes (168 ischemic, 76 hemorrhagic) included in our study. No significant increase of stroke was found for working in cold environments; the adjusted odds ratio (OR) for often or almost always exposed was 1.14 (95% CI, 0.46–2.82). CONCLUSIONS - This study did not reveal a significant excess risk of stroke for occupational exposures to low temperatures. Further studies are needed to better assess the effect of preventive measures and very low temperature on the occurrence of cardiovascular diseases.

Flash report sur le site de l'European social policy network, European commission

Flash report de l'European social policynetwork sur le site de la commission européenne