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  • English
    Authors: 
    Chen, Dongxuan; Lau, Yiu-Chung; Xu, Xiao-Ke; Wang, Lin; Du, Zhanwei; Tsang, Tim K.; Wu, Peng; Lau, Eric H. Y.; Wallinga, Jacco; Cowling, Benjamin J.; +1 more
    Publisher: Nature Publishing Group UK
    Country: United Kingdom
  • French
    Authors: 
    Benezech, Ludovic;
    Publisher: HAL CCSD
    Country: France

    Le Dossier "La motivation de la peine", Actes du colloque de Clermont-Ferrand du 20 mai 2022, F. Safi (dir.) ; Le Commentaire "Les risques contractuels face au Covid-19 : le maintien de l’obligation de régler les loyers des baux commerciaux. Commentaire des arrêts du 30 juin 2022, n°21-19.889 – n°21-20.127 – n°21-20.190", par E. Roumeau ; Les Chroniques "Un an de droit de l’environnement (2021)", avec le Master 2 Droit public approfondi, Ecole de droit-UCA, sous la direction de Ch-A. Dubreuil - "Chronique de jurisprudence de droit notarial", avec le Master 2 Droit notarial 2021-2022, Faculté de droit de Dijon-Université de Bourgogne, sous la direction de V. Bonnet

  • French
    Authors: 
    Fourmont Giustiniani, Eve; Gebeil, Sophie;
    Publisher: HAL CCSD
    Country: France

    Exposition numérique 'Quatre Pandémies à la Une en 80 documents. Informations et crises sanitaires (France-Espagne, 1720-2021)', site web 80 Documents à la Une, https://80docsalaune.nakalona.fr; Constituée dans le cadre de l’exposition numérique 'Quatre Pandémies à la Une en 80 documents. Informations et crises sanitaires (France-Espagne, 1720-2021)', cette collection de documents aborde la question de l’émission, de la transmission et de la réception de l’information liée à la pandémie de Covid-19, en France, en Espagne et plus largement dans l’espace sud-européen et méditerranéen, sur la période qui s’étend de janvier à décembre 2020. Elle entend montrer comment, à travers les différents canaux d’information et de communication actuels, majoritairement numériques —quatrième pouvoir que sont les médias, source d’information alternative que constitue le web, mais aussi vecteur de fake news que peuvent devenir les réseaux sociaux numériques—, ont été construites et véhiculées à la fois les réponses à ces mesures restrictives inédites et les représentations collectives de la maladie. Elle réunit une sélection de 20 documents autour de six axes thématiques : la pandémie dans les médias et la communication des gouvernements ; la crise de l’hôpital et le statut de l’expertise scientifique dans l’information ; la réception de l’information sur la pandémie dans l’opinion populaire et la culture numérique ; les pratiques d’information et de documentation scolaires et universitaires en temps de confinement ; les enjeux de l’archivage d’une mémoire numérique de la pandémie ; et enfin les imaginaires visuels de la pandémie tels que les véhiculent l’art urbain et numérique. Ce document rassemble ainsi les textes écrits en 2022 pour la salle 4 de cette exposition virtuelle : une introduction générale, et les notices de chacun des documents présentés dans la galerie.

  • Open Access English
    Authors: 
    Torres, Catalina; Garcia, Jenny; Meslé, France; Barbieri, Magali; Bonnet, Florian; Camarda, Carlo Giovanni; Cambois, Emmanuelle; Caporali, Arianna; Couppié, Etienne; Poniakina, Svitlana; +1 more
    Country: France

    Objective The COVID-19 pandemic is characterized by successive waves that each developed differently over time and through space. We aim to provide an in-depth analysis of the evolution of COVID-19 mortality during 2020 and 2021 in a selection of countries. Methods We focus on five European countries and the United States. Using standardised and age-specific mortality rates, we address variations in COVID-19 mortality within and between countries, as well as demographic characteristics and seasonality patterns. Results Our results highlight periods of acceleration and deceleration in the pace of COVID-19 mortality, with substantial differences across countries. Periods of stabilization were identified during summer (especially in 2020) among the European countries analysed, but not in the United States. The latter stands out as the study population with the highest COVID-19 mortality at young ages. In general, COVID-19 mortality is highest at old ages, particularly during winter. Compared to women, men have higher COVID-19 mortality rates at most ages and in most seasons. Conclusions There is seasonality in COVID-19 mortality for both sexes at all ages, characterized by higher rates during winter. In 2021, the highest COVID-19 mortality rates continued to be observed at ages 75+, despite vaccinations having specifically targeted those ages.

  • English
    Authors: 
    Göndör, Gabor; Ksiazek, Sara H; Regele, Heinz; Kronbichler, Andreas; Knechtelsdorfer, Maarten; Säemann, Marcus D;
    Publisher: Oxford University Press (OUP)
    Country: United Kingdom

    Membranoproliferative glomerulonephritis (MPGN) comprises a histologic pattern of glomerular injury with different underlying diseases. Here we report on a 47-year-old female with rapidly progressive glomerulonephritis (RPGN) on top of a previously diagnosed idiopathic MPGN after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) mRNA vaccine. After aggressive immunosuppression her serum creatinine returned to normal values, along with reduction of proteinuria. Recently, numerous publications have reported an association of glomerular diseases with COVID-19 vaccination. Our case presents to the best of our knowledge the first occurrence of possible association of COVID-19 mRNA vaccination with a crescentic form of MPGN.

  • Open Access French
    Authors: 
    Astruc, Lisa; Lemaire, Emilie; Golaz, Valérie; Gastineau, Bénédicte;
    Country: France

    Comme lors de la première vague épidémique de Covid-19 en 2020, les communications du Ministère de la santé et la presse nous alertent sur le fait que les hôpitaux de France sont saturés ou sur le point de l’être. Dans plusieurs régions françaises, des opérations chirurgicales sont déprogrammées. Les soignants, remobilisés même lorsqu’ils sont malades, montrent des signes d’épuisement, voire se mettent en grève. Que savons-nous de la tension hospitalière ? L’objectif de cette note est de clarifier la manière dont elle est mesurée, de clarifier comment l’indicateur de tension hospitalière est construit, à partir de l’analyse de ses tendances nationales et régionales. Cela nous amène à mettre en lumière le rôle de cet indicateur dans les politiques mises en place en période épidémique. Pour cela, nous allons aborder quatre questions. Comment a évolué la tension hospitalière depuis le début de la pandémie ? Connait-elle de grandes disparités régionales ? Comment la tension hospitalière est-elle calculée ? Que ne dit pas cet indicateur de tension hospitalière ?

  • Authors: 
    McCorkindale, William; Ahel, Ivan; Barr, Haim; Correy, Galen; Fraser, James; London, Nir; Schuller, Marion; Shurrush, Khriesto; Lee, Alpha;
    Country: United Kingdom

    The process of finding molecules that bind to a target protein is a challenging first step in drug discovery. Crystallographic fragment screening is a strategy based on elucidating binding modes of small polar compounds and then building potency by expanding or merging them. Recent advances in high-throughput crystallography enable screening of large fragment libraries, reading out dense ensembles of fragments spanning the binding site. However, fragments typically have low affinity thus the road to potency is often long and fraught with false starts. Here, we take advantage of high-throughput crystallography to reframe fragment-based hit discovery as a denoising problem – identifying significant pharmacophore distributions from a fragment ensemble amid noise due to weak binders – and employ an unsupervised machine learning method to tackle this problem. Our method screens potential molecules by evaluating whether they recapitulate those fragment-derived pharmacophore distributions. We retrospectively validated our approach on an open science campaign against SARS-CoV-2 main protease (Mpro), showing that our method can distinguish active compounds from inactive ones using only structural data of fragment-protein complexes, without any activity data. Further, we prospectively found novel hits for Mpro and the Mac1 domain of SARS-CoV-2 non-structural protein 3. More broadly, our results demonstrate how unsupervised machine learning helps interpret high throughput crystallography data to rapidly discover of potent chemical modulators of protein function.

  • Open Access English
    Authors: 
    Sikarwar, Ankit; Rani, Ritu; Duthé, Géraldine; Golaz, Valérie;
    Country: France

    Background The world has witnessed a colossal death toll due to the novel coronavirus disease-2019 (COVID-19). A few environmental epidemiology studies have identified association of environmental factors (air pollution, greenness, temperature, etc.) with COVID-19 incidence and mortality, particularly in developed countries. India, being one of the most severely affected countries by the pandemic, still has a dearth of research exploring the linkages of environment and COVID-19 pandemic. Objectives We evaluate whether district-level greenness exposure is associated with a reduced risk of COVID-19 deaths in India. Methods We used average normalized difference vegetation index (NDVI) from January to March 2019, derived by Oceansat-2 satellite, to represent district-level greenness exposure. COVID-19 death counts were obtained through May 1, 2021 (around the peak of the second wave) from an open portal: covid19india.org. We used hierarchical generalized negative binomial regressions to check the associations of greenness with COVID-19 death counts. Analyses were adjusted for air pollution (PM2.5), temperature, rainfall, population density, proportion of older adults (50 years and above), sex ratio over age 50, proportions of rural population, household overcrowding, materially deprived households, health facilities, and secondary school education. Results Our analyses found a significant association between greenness and reduced risk of COVID-19 deaths. Compared to the districts with the lowest NDVI (quintile 1), districts within quintiles 3, 4, and 5 have respectively, around 32% [MRR = 0.68 (95% CI: 0.51, 0.88)], 39% [MRR = 0.61 (95% CI: 0.46, 0.80)], and 47% [MRR = 0.53 (95% CI: 0.40, 0.71)] reduced risk of COVID-19 deaths. The association remains consistent for analyses restricted to districts with a rather good overall death registration (>80%). Conclusion Though cause-of-death statistics are limited, we confirm that exposure to greenness was associated with reduced district-level COVID-19 deaths in India. However, material deprivation and air pollution modify this association.

  • Open Access English
    Authors: 
    Moulin, Léonard;
    Country: France

    This article investigates the effect of a decrease in the speed limit for motor vehicles on bicycle commuting in French cities. I use a difference-in-differences event study design to measure a possible causal effect of motor vehicle speed limits on changes in bicycle traffic. I do not find any effect of the reduction of the speed limit from 50 km/h to 30 km/h on bicycle commuting. This result is important for public policy design, since increasing the number of bicycles is one of the benefits that politicians expect from decreasing the speed limit for motor vehicles.

  • English
    Authors: 
    Kohler, Katharina; Morris, Andrew Conway;
    Publisher: The European respiratory journal
    Country: United Kingdom
Advanced search in
Research products
arrow_drop_down
Searching FieldsTerms
Any field
arrow_drop_down
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Include:
1,914 Research products, page 1 of 192
  • English
    Authors: 
    Chen, Dongxuan; Lau, Yiu-Chung; Xu, Xiao-Ke; Wang, Lin; Du, Zhanwei; Tsang, Tim K.; Wu, Peng; Lau, Eric H. Y.; Wallinga, Jacco; Cowling, Benjamin J.; +1 more
    Publisher: Nature Publishing Group UK
    Country: United Kingdom
  • French
    Authors: 
    Benezech, Ludovic;
    Publisher: HAL CCSD
    Country: France

    Le Dossier "La motivation de la peine", Actes du colloque de Clermont-Ferrand du 20 mai 2022, F. Safi (dir.) ; Le Commentaire "Les risques contractuels face au Covid-19 : le maintien de l’obligation de régler les loyers des baux commerciaux. Commentaire des arrêts du 30 juin 2022, n°21-19.889 – n°21-20.127 – n°21-20.190", par E. Roumeau ; Les Chroniques "Un an de droit de l’environnement (2021)", avec le Master 2 Droit public approfondi, Ecole de droit-UCA, sous la direction de Ch-A. Dubreuil - "Chronique de jurisprudence de droit notarial", avec le Master 2 Droit notarial 2021-2022, Faculté de droit de Dijon-Université de Bourgogne, sous la direction de V. Bonnet

  • French
    Authors: 
    Fourmont Giustiniani, Eve; Gebeil, Sophie;
    Publisher: HAL CCSD
    Country: France

    Exposition numérique 'Quatre Pandémies à la Une en 80 documents. Informations et crises sanitaires (France-Espagne, 1720-2021)', site web 80 Documents à la Une, https://80docsalaune.nakalona.fr; Constituée dans le cadre de l’exposition numérique 'Quatre Pandémies à la Une en 80 documents. Informations et crises sanitaires (France-Espagne, 1720-2021)', cette collection de documents aborde la question de l’émission, de la transmission et de la réception de l’information liée à la pandémie de Covid-19, en France, en Espagne et plus largement dans l’espace sud-européen et méditerranéen, sur la période qui s’étend de janvier à décembre 2020. Elle entend montrer comment, à travers les différents canaux d’information et de communication actuels, majoritairement numériques —quatrième pouvoir que sont les médias, source d’information alternative que constitue le web, mais aussi vecteur de fake news que peuvent devenir les réseaux sociaux numériques—, ont été construites et véhiculées à la fois les réponses à ces mesures restrictives inédites et les représentations collectives de la maladie. Elle réunit une sélection de 20 documents autour de six axes thématiques : la pandémie dans les médias et la communication des gouvernements ; la crise de l’hôpital et le statut de l’expertise scientifique dans l’information ; la réception de l’information sur la pandémie dans l’opinion populaire et la culture numérique ; les pratiques d’information et de documentation scolaires et universitaires en temps de confinement ; les enjeux de l’archivage d’une mémoire numérique de la pandémie ; et enfin les imaginaires visuels de la pandémie tels que les véhiculent l’art urbain et numérique. Ce document rassemble ainsi les textes écrits en 2022 pour la salle 4 de cette exposition virtuelle : une introduction générale, et les notices de chacun des documents présentés dans la galerie.

  • Open Access English
    Authors: 
    Torres, Catalina; Garcia, Jenny; Meslé, France; Barbieri, Magali; Bonnet, Florian; Camarda, Carlo Giovanni; Cambois, Emmanuelle; Caporali, Arianna; Couppié, Etienne; Poniakina, Svitlana; +1 more
    Country: France

    Objective The COVID-19 pandemic is characterized by successive waves that each developed differently over time and through space. We aim to provide an in-depth analysis of the evolution of COVID-19 mortality during 2020 and 2021 in a selection of countries. Methods We focus on five European countries and the United States. Using standardised and age-specific mortality rates, we address variations in COVID-19 mortality within and between countries, as well as demographic characteristics and seasonality patterns. Results Our results highlight periods of acceleration and deceleration in the pace of COVID-19 mortality, with substantial differences across countries. Periods of stabilization were identified during summer (especially in 2020) among the European countries analysed, but not in the United States. The latter stands out as the study population with the highest COVID-19 mortality at young ages. In general, COVID-19 mortality is highest at old ages, particularly during winter. Compared to women, men have higher COVID-19 mortality rates at most ages and in most seasons. Conclusions There is seasonality in COVID-19 mortality for both sexes at all ages, characterized by higher rates during winter. In 2021, the highest COVID-19 mortality rates continued to be observed at ages 75+, despite vaccinations having specifically targeted those ages.

  • English
    Authors: 
    Göndör, Gabor; Ksiazek, Sara H; Regele, Heinz; Kronbichler, Andreas; Knechtelsdorfer, Maarten; Säemann, Marcus D;
    Publisher: Oxford University Press (OUP)
    Country: United Kingdom

    Membranoproliferative glomerulonephritis (MPGN) comprises a histologic pattern of glomerular injury with different underlying diseases. Here we report on a 47-year-old female with rapidly progressive glomerulonephritis (RPGN) on top of a previously diagnosed idiopathic MPGN after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) mRNA vaccine. After aggressive immunosuppression her serum creatinine returned to normal values, along with reduction of proteinuria. Recently, numerous publications have reported an association of glomerular diseases with COVID-19 vaccination. Our case presents to the best of our knowledge the first occurrence of possible association of COVID-19 mRNA vaccination with a crescentic form of MPGN.

  • Open Access French
    Authors: 
    Astruc, Lisa; Lemaire, Emilie; Golaz, Valérie; Gastineau, Bénédicte;
    Country: France

    Comme lors de la première vague épidémique de Covid-19 en 2020, les communications du Ministère de la santé et la presse nous alertent sur le fait que les hôpitaux de France sont saturés ou sur le point de l’être. Dans plusieurs régions françaises, des opérations chirurgicales sont déprogrammées. Les soignants, remobilisés même lorsqu’ils sont malades, montrent des signes d’épuisement, voire se mettent en grève. Que savons-nous de la tension hospitalière ? L’objectif de cette note est de clarifier la manière dont elle est mesurée, de clarifier comment l’indicateur de tension hospitalière est construit, à partir de l’analyse de ses tendances nationales et régionales. Cela nous amène à mettre en lumière le rôle de cet indicateur dans les politiques mises en place en période épidémique. Pour cela, nous allons aborder quatre questions. Comment a évolué la tension hospitalière depuis le début de la pandémie ? Connait-elle de grandes disparités régionales ? Comment la tension hospitalière est-elle calculée ? Que ne dit pas cet indicateur de tension hospitalière ?

  • Authors: 
    McCorkindale, William; Ahel, Ivan; Barr, Haim; Correy, Galen; Fraser, James; London, Nir; Schuller, Marion; Shurrush, Khriesto; Lee, Alpha;
    Country: United Kingdom

    The process of finding molecules that bind to a target protein is a challenging first step in drug discovery. Crystallographic fragment screening is a strategy based on elucidating binding modes of small polar compounds and then building potency by expanding or merging them. Recent advances in high-throughput crystallography enable screening of large fragment libraries, reading out dense ensembles of fragments spanning the binding site. However, fragments typically have low affinity thus the road to potency is often long and fraught with false starts. Here, we take advantage of high-throughput crystallography to reframe fragment-based hit discovery as a denoising problem – identifying significant pharmacophore distributions from a fragment ensemble amid noise due to weak binders – and employ an unsupervised machine learning method to tackle this problem. Our method screens potential molecules by evaluating whether they recapitulate those fragment-derived pharmacophore distributions. We retrospectively validated our approach on an open science campaign against SARS-CoV-2 main protease (Mpro), showing that our method can distinguish active compounds from inactive ones using only structural data of fragment-protein complexes, without any activity data. Further, we prospectively found novel hits for Mpro and the Mac1 domain of SARS-CoV-2 non-structural protein 3. More broadly, our results demonstrate how unsupervised machine learning helps interpret high throughput crystallography data to rapidly discover of potent chemical modulators of protein function.

  • Open Access English
    Authors: 
    Sikarwar, Ankit; Rani, Ritu; Duthé, Géraldine; Golaz, Valérie;
    Country: France

    Background The world has witnessed a colossal death toll due to the novel coronavirus disease-2019 (COVID-19). A few environmental epidemiology studies have identified association of environmental factors (air pollution, greenness, temperature, etc.) with COVID-19 incidence and mortality, particularly in developed countries. India, being one of the most severely affected countries by the pandemic, still has a dearth of research exploring the linkages of environment and COVID-19 pandemic. Objectives We evaluate whether district-level greenness exposure is associated with a reduced risk of COVID-19 deaths in India. Methods We used average normalized difference vegetation index (NDVI) from January to March 2019, derived by Oceansat-2 satellite, to represent district-level greenness exposure. COVID-19 death counts were obtained through May 1, 2021 (around the peak of the second wave) from an open portal: covid19india.org. We used hierarchical generalized negative binomial regressions to check the associations of greenness with COVID-19 death counts. Analyses were adjusted for air pollution (PM2.5), temperature, rainfall, population density, proportion of older adults (50 years and above), sex ratio over age 50, proportions of rural population, household overcrowding, materially deprived households, health facilities, and secondary school education. Results Our analyses found a significant association between greenness and reduced risk of COVID-19 deaths. Compared to the districts with the lowest NDVI (quintile 1), districts within quintiles 3, 4, and 5 have respectively, around 32% [MRR = 0.68 (95% CI: 0.51, 0.88)], 39% [MRR = 0.61 (95% CI: 0.46, 0.80)], and 47% [MRR = 0.53 (95% CI: 0.40, 0.71)] reduced risk of COVID-19 deaths. The association remains consistent for analyses restricted to districts with a rather good overall death registration (>80%). Conclusion Though cause-of-death statistics are limited, we confirm that exposure to greenness was associated with reduced district-level COVID-19 deaths in India. However, material deprivation and air pollution modify this association.

  • Open Access English
    Authors: 
    Moulin, Léonard;
    Country: France

    This article investigates the effect of a decrease in the speed limit for motor vehicles on bicycle commuting in French cities. I use a difference-in-differences event study design to measure a possible causal effect of motor vehicle speed limits on changes in bicycle traffic. I do not find any effect of the reduction of the speed limit from 50 km/h to 30 km/h on bicycle commuting. This result is important for public policy design, since increasing the number of bicycles is one of the benefits that politicians expect from decreasing the speed limit for motor vehicles.

  • English
    Authors: 
    Kohler, Katharina; Morris, Andrew Conway;
    Publisher: The European respiratory journal
    Country: United Kingdom
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