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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yibrah Gebreyesus; Damian Dalton; Sebastian Nixon; Davide De Chiara; +1 Authors

    The need for artificial intelligence (AI) and machine learning (ML) models to optimize data center (DC) operations increases as the volume of operations management data upsurges tremendously. These strategies can assist operators in better understanding their DC operations and help them make informed decisions upfront to maintain service reliability and availability. The strategies include developing models that optimize energy efficiency, identifying inefficient resource utilization and scheduling policies, and predicting outages. In addition to model hyperparameter tuning, feature subset selection (FSS) is critical for identifying relevant features for effectively modeling DC operations to provide insight into the data, optimize model performance, and reduce computational expenses. Hence, this paper introduces the Shapley Additive exPlanation (SHAP) values method, a class of additive feature attribution values for identifying relevant features that is rarely discussed in the literature. We compared its effectiveness with several commonly used, importance-based feature selection methods. The methods were tested on real DC operations data streams obtained from the ENEA CRESCO6 cluster with 20,832 cores. To demonstrate the effectiveness of SHAP compared to other methods, we selected the top ten most important features from each method, retrained the predictive models, and evaluated their performance using the MAE, RMSE, and MPAE evaluation criteria. The results presented in this paper demonstrate that the predictive models trained using features selected with the SHAP-assisted method performed well, with a lower error and a reasonable execution time compared to other methods.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Future Internet; ENE...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Future Internet
    Article . 2023
    Data sources: DOAJ
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    https://doi.org/10.20944/prepr...
    Preprint . 2022
    License: CC BY
    Data sources: Crossref
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Future Internet; ENE...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Future Internet
      Article . 2023
      Data sources: DOAJ
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      https://doi.org/10.20944/prepr...
      Preprint . 2022
      License: CC BY
      Data sources: Crossref
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Agosta G.; Aldinucci M.; Alvarez C.; Ammendola R.; +52 Authors

    Article signat per 56 autors/es: Giovanni Agosta (a) , Marco Aldinucci (f) , Carlos Alvarez (h) , Roberto Ammendola (n) , Yasir Arfat (f) , Olivier Beaumont (g) , Massimo Bernaschi (c) , Andrea Biagioni (j) , Tommaso Boccali (l) , Berenger Bramas (g) , Carlo Brandolese (a) , Barbara Cantalupo (f) , Mauro Carrozzo (c) , Daniele Cattaneo (a) , Alessandro Celestini (c) , Massimo Celino (b) , Iacopo Colonnelli (f) , Paolo Cretaro (j) , Pasqua D’Ambra (d) , Marco Danelutto (e) , Roberto Esposito (f) , Lionel Eyraud-Dubois (g) , Antonio Filgueras (h) , William Fornaciari (a) , Ottorino Frezza (j) , Andrea Galimberti (a) , Francesco Giacomini (k) , Brice Goglin (g) , Daniele Gregori (o) , Abdou Guermouche (g) , Francesco Iannone (b) , Michal Kulczewski (i) , Francesca Lo Cicero (j) , Alessandro Lonardo (j) , Alberto R. Martinelli (f) , Michele Martinelli (j) , Xavier Martorell (h) , Giuseppe Massari (a) , Simone Montangero (m), Gianluca Mittone (f) , Raymond Namyst (g) , Ariel Oleksiak (i) , Paolo Palazzari (b) , Pier Stanislao Paolucci (j) , Federico Reghenzani (a)∗ , Cristian Rossi (j) , Sergio Saponara (e) , Francesco Simula (j) , Federico Terraneo (a) , Samuel Thibault (g) , Massimo Torquati (e) , Matteo Turisini (j) , Piero Vicini (j) , Miquel Vidal (h) , Davide Zoni (a) , Giuseppe Zummo (b) // (a) Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, Italy; (b) ENEA, Agenzia nazionale per le nuove tecnologie, l’energia e lo sviluppo economico sostenibile, Italy; (c) Istituto per le Applicazioni del Calcolo (IAC), Consiglio Nazionale delle Ricerche, Rome, Italy; (d) Istituto per le Applicazioni del Calcolo (IAC), Consiglio Nazionale delle Ricerche, Naples, Italy; (e) University of Pisa, Italy; (f) University of Torino, Italy; (g) Institut national de recherche en informatique et en automatique (Inria), France; (h) Barcelona Supercomputing Center, Spain; (i) Poznan Supercomputing and Networking Center, Poland; (j) Istituto Nazionale di Fisica Nucleare, Sezione di Roma, Italy; (k) Istituto Nazionale di Fisica Nucleare, CNAF, Italy; (l) Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, Italy; (m) University of Padova and Istituto Nazionale di Fisica Nucleare Sezione di Padova, Italy; (n) Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata, Italy; (o) E4 Computer Engineering Spa, Italy In the near future, Exascale systems will need to bridge three technology gaps to achieve high performance while remaining under tight power constraints: energy efficiency and thermal control; extreme computation efficiency via HW acceleration and new arithmetic; methods and tools for seamless integration of reconfigurable accelerators in heterogeneous HPC multi-node platforms. TEXTAROSSA addresses these gaps through a co-design approach to heterogeneous HPC solutions, supported by the integration and extension of HW and SW IPs, programming models, and tools derived from European research. This work is supported by the TEXTAROSSA project (G.A. n. 956831), as part of the EuroHPC initiative. Peer Reviewed

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Archivio Istituziona...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    ENEA Open Archive
    Article . 2022
    Data sources: ENEA Open Archive
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Vincenzo Bonaiuto; Andrea Zanela;

    This paper focuses on integrating a laser rangefinder system with an anthropomorphic robot (NAO6—Aldebaran, United Robotics Group) to improve its sensory and operational capabilities, as part of a larger project concerning the use of these systems in “assisted living” activities. This additional sensor enables the robot to reconstruct its surroundings by integrating new information with that identified by the on-board sensors. Thus, it can identify more objects in a scene and detect any obstacles along its navigation path. This feature will improve the efficiency of navigation algorithms, increasing movement competence in environments where people live and work. Indeed, these environments are characterized by details and specificities within a range of distances that best suit the new robot design. The paper presents a laser finder integration project that consists of two different parts, which are as follows: the former, the mechanical part, provided the NAO robot’s head; the latter, the software, provided the robot with proper software drivers to enable integration of the new sensor with its acquisition system. Some experimental results in an actual environment are presented.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Applied System Innov...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Applied System Innovation
    Article . 2022
    Data sources: DOAJ
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Applied System Innov...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Applied System Innovation
      Article . 2022
      Data sources: DOAJ
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Barbara Tanno; Flavia Novelli; Simona Leonardi; Caterina Merla; +12 Authors

    A causal association between radiation exposure and various types of non-malignant diseases, especially cardiovascular diseases, has been extensively reported [1,2]. The risks of radiation-induced heart disease (RIHD) were described in therapeutically exposed cohorts of patients with thoracic tumors in which a high incidence of long-term complications (i.e., pericarditis, cardiomyopathy, coronary artery disease, valvular heart disease, conduction abnormalities and myocardial fibrosis) increased the risk of heart-disease-related mortality [3]. Patients who received post-mastectomy radiotherapy for left-sided breast cancer were at a 2–3-time higher risk of developing cardiovascular disease, due to the apex and anterior wall of the heart being exposed to doses of radiation between 1 and 5 Gy on average [4]. Nevertheless, at a median follow-up of 8 years, the risk of RIHD was not associated with the laterality of the irradiated breast [5]. An increased risk for cardiovascular diseases, especially stroke and heart attack, also resulted from epidemiological studies of A-bomb survivors [6] as well as occupationally exposed workers [7]. At these moderate doses (0.5–5 Gy), the mechanisms of action seem to especially involve atherosclerosis or vascular injury. Many animal studies support such evidence, indicating increased oxidative stress and the promotion of inflammation as possible mechanisms by which radiation promotes atherogenesis [8]. Cardiac fibrosis and hypertrophy were also observed after the irradiation of mice with 0.5 Gy of protons or 0.15 Gy of 56Fe ions, at late time points.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Cancersarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Cancers
    Other literature type . Article . 2022 . Peer-reviewed
    License: CC BY
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Arrow@TU Dublin
    Article . 2022
    Data sources: Arrow@TU Dublin
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Cancers
    Article . 2022
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Cancers
    Article . 2022
    Data sources: DOAJ
    ENEA Open Archive
    Article . 2022
    Data sources: ENEA Open Archive
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Cancersarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Cancers
      Other literature type . Article . 2022 . Peer-reviewed
      License: CC BY
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Arrow@TU Dublin
      Article . 2022
      Data sources: Arrow@TU Dublin
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Cancers
      Article . 2022
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Cancers
      Article . 2022
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      ENEA Open Archive
      Article . 2022
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Simonetta Pazzaglia; Barbara Tanno; Ilaria De Stefano; Paola Giardullo; +13 Authors

    Cell communication via exosomes is capable of influencing cell fate in stress situations such as exposure to ionizing radiation. In vitro and in vivo studies have shown that exosomes might play a role in out-of-target radiation effects by carrying molecular signaling mediators of radiation damage, as well as opposite protective functions resulting in resistance to radiotherapy. However, a global understanding of exosomes and their radiation-induced regulation, especially within the context of an intact mammalian organism, has been lacking. In this in vivo study, we demonstrate that, compared to sham-irradiated (SI) mice, a distinct pattern of proteins and miRNAs is found packaged into circulating plasma exosomes after whole-body and partial-body irradiation (WBI and PBI) with 2 Gy X-rays. A high number of deregulated proteins (59% of WBI and 67% of PBI) was found in the exosomes of irradiated mice. In total, 57 and 13 miRNAs were deregulated in WBI and PBI groups, respectively, suggesting that the miRNA cargo is influenced by the tissue volume exposed to radiation. In addition, five miRNAs (miR-99b-3p, miR-200a-3p, miR-200a, miR-182-5p, miR-182) were commonly overexpressed in the exosomes from the WBI and PBI groups. In this study, particular emphasis was also given to the determination of the in vivo effect of exosome transfer by intracranial injection in the highly radiosensitive neonatal cerebellum at postnatal day 3. In accordance with a major overall anti-apoptotic function of the commonly deregulated miRNAs, here, we report that exosomes from the plasma of irradiated mice, especially in the case of WBI, prevent radiation-induced apoptosis, thus holding promise for exosome-based future therapeutic applications against radiation injury.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ International Journa...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Arrow@TU Dublin
    Article . 2022
    Data sources: Arrow@TU Dublin
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      Article . 2022
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    Authors: X Litaudon; F Jenko; D Borba; D V Borodin; +32 Authors

    Abstract This paper is a written summary of an overview oral presentation given at the 1st Spanish Fusion High Performance Computer (HPC) Workshop that took place on the 27 November 2020 as an online event. Given that over the next few years ITER 24 24 ITER (‘The Way’ in Latin) is the world’s largest tokamak under construction in the south of France: a magnetic fusion device that has been designed to prove the feasibility of fusion as a large-scale and carbon-free source of energy ( https://www.iter.org/ ). will move to its operation phase and the European-DEMO design will be significantly advanced, the EUROfusion consortium has initiated a coordination effort in theory and advanced simulation to address some of the challenges of the fusion research in Horizon EUROPE (2021–2027), i.e. the next EU Framework Programme for Research and Technological Development. This initiative has been called E-TASC, which stands for EUROfusion-Theory and Advanced Simulation Coordination. The general and guiding principles of E-TASC are summarized in this paper. In addition, an overview of the scientific results obtained in the pilot phase (2019–2020) of E-TASC are provided while highlighting the importance of the required progress in computational methods and HPC techniques. In the initial phase, five pilot theory and simulation tasks were initiated: towards a validated predictive capability of the low to high transition and pedestal physics; runaway electrons in tokamak disruptions in the presence of massive material injection; fast code for the calculation of neoclassical toroidal viscosity in stellarators and tokamaks; development of a neutral gas kinetics modular code; European edge and boundary code for reactor-relevant devices. In this paper, we report on recent progress made by each of these projects. International audience

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    DIFFER: Publications; ENEA Open Archive; Plasma Physics and Controlled Fusion
    Other literature type . Article . Conference object . 2022 . Peer-reviewed
    License: IOP Copyright Policies
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    Authors: You, J; Mazzone, G; Visca, E; Greuner, H; +45 Authors

    In a power plant scale fusion reactor, a huge amount of thermal power produced by the fusion reaction and external heating must be exhausted through the narrow area of the divertor targets. The targets must withstand the intense bombardment of the diverted particles where high heat fluxes are generated and erosion takes place on the surface. A considerable amount of volumetric nuclear heating power must also be exhausted. To cope with such an unprecedented power exhaust challenge, a highly efficient cooling capacity is required. Furthermore, the divertor must fulfill other critical functions such as nuclear shielding and channeling (and compression) of exhaust gas for pumping. Assuring the structural integrity of the neutron-irradiated (thus embrittled) components is a crucial prerequisite for a reliable operation over the lifetime. Safety, maintainability, availability, waste and costs are another points of consideration.In late 2020, the Pre-Conceptual Design activities to develop the divertor of the European demonstration fusion reactor were officially concluded. On this occasion, the baseline design and the key technology options were identified and verified by the project team (EUROfusion Work Package Divertor) based on seven years of R&D efforts and endorsed by Gate Review Panel.In this paper, an overview of the load specifications, brief descriptions of the design and the highlights of the technology R&D work are presented together with the further work still needed. International audience

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    https://doi.org/10.5445/ir/100...
    Article . 2022
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    Authors: Alessandro Anav; Alessandra De Marco; Alessio Collalti; Lisa Emberson; +7 Authors

    Surface ozone (O3) is a threat to forests by decreasing photosynthesis and, consequently, influencing the strength of land carbon sink. However, due to the lack of continuous surface O3 measurements, observational-based assessments of O3 impacts on forests are largely missing at hemispheric to global scales. Currently, some metrics are used for regulatory purposes by governments or national agencies to protect forests against the negative impacts of ozone: in particular, both Europe and United States (US) makes use of two different exposure-based metrics, i.e. AOT40 and W126, respectively. However, because of some limitations in these metrics, a new standard is under consideration by the European Union (EU) to replace the current exposure metric. We analyse here the different air quality standards set or proposed for use in Europe and in the US to protect forests from O3 and to evaluate their spatial and temporal consistency while assessing their effectiveness in protecting northern-hemisphere forests. Then, we compare their results with the information obtained from a complex land surface model (ORCHIDEE). We find that present O3 uptake decreases gross primary production (GPP) in 37.7% of the NH forested area of northern hemisphere with a mean loss of 2.4% year-1. We show how the proposed US (W126) and the currently used European (AOT40) air quality standards substantially overestimate the extension of potential vulnerable regions, predicting that 46% and 61% of the Northern Hemisphere (NH) forested area are at risk of O3 pollution. Conversely, the new proposed European standard (POD1) identifies lower extension of vulnerability regions (39.6%).

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    Authors: Bachmann, C.; Ciupinski, L.; Gliss, C.; Franke, T.; +11 Authors

    This article describes the DEMO cryostat, the vacuum vessel, and the tokamak building as well as the system configurations to integrate the main in-vessel components and auxiliary systems developed during the Pre-Conceptual Design Phase. The vacuum vessel is the primary component for radiation shielding and containment of tritium and other radioactive material. Various systems required to operate the plasma are integrated in its ports. The vessel together with the external magnetic coils is located inside the even larger cryostat that has the primary function to provide a vacuum to enable the operation of the superconducting coils in cryogenic condition. The cryostat is surrounded by a thick concrete structure: the bioshield. It protects the external areas from neutron and gamma radiation emitted from the tokamak. The tokamak building layout is aligned with the VV ports implementing floors and separate rooms, so-called port cells, that can be sealed to provide a secondary confinement when a port is opened during in-vessel maintenance. The ports of the torus-shaped VV have to allow for the replacement of in-vessel components but also incorporate plasma limiters and auxiliary heating and diagnostic systems. The divertor is replaced through horizontal ports at the lower level, the breeding blanket (BB) through upper vertical ports. The pipe work of these in-vessel components is also routed through these ports. To facilitate the vertical replacement of the BB, it is divided into large vertical segments. Their mechanical support during operation relies on vertically clamping them inside the vacuum vessel by a combination of obstructed thermal expansion and radial pre-compression due to the ferromagnetic force acting on the breeding blanket structural material in the toroidal magnetic field.

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    KITopen
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    https://doi.org/10.5445/ir/100...
    Article . 2022
    License: CC BY
    Data sources: Datacite
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    Fusion Engineering and Design
    Other literature type . Article . Conference object . 2022 . Peer-reviewed
    License: CC BY
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    ENEA Open Archive
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    MPG.PuRe
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ENEA Open Archivearrow_drop_down
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      KITopen
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      https://doi.org/10.5445/ir/100...
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      Fusion Engineering and Design
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      ENEA Open Archive
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Acharya, Shreyasi; Adamova, Dagmar; Adler, Alexander; Aglieri Rinella, Gianluca; +366 Authors

    A measurement of the inclusive b-jet production cross section is presented in pp and p-Pb collisions at $\sqrt{s_{\rm NN}} = 5.02$ TeV, using data collected with the ALICE detector at the LHC. The jets were reconstructed in the central rapidity region $|\eta|<0.5$ from charged particles using the anti-$k_{\rm T}$ algorithm with resolution parameter $R=0.4$. Identification of b jets exploits the long lifetime of b-hadrons, using the properties of secondary vertices and impact parameter distributions. %The production yields of tagged jets were corrected for tagging efficiency, purity, detector effects, and contribution from the underlying event background. The $p_{\rm T}$-differential inclusive production cross section of b jets, as well as the corresponding inclusive b-jet fraction, are reported for pp and p-Pb collisions in the jet transverse momentum range $10 \le p_{\text{T, ch jet}} \le 100$ GeV/$c$, together with the nuclear modification factor, $R_{\rm pPb}^{\text{b-jet}}$. The analysis thus extends the lower $p_{\rm T}$ limit of b-jet measurements at the LHC. The nuclear modification factor is found to be consistent with unity, indicating that the production of b jets in p-Pb at $\sqrt{s_{\rm NN}} = 5.02$ TeV is not affected by cold nuclear matter effects within the current precision. The measurements are well reproduced by POWHEG NLO pQCD calculations with PYTHIA fragmentation. A measurement of the inclusive b-jet production cross section is presented in pp and p-Pb collisions at $ \sqrt{s_{\mathrm{NN}}} $ = 5.02 TeV, using data collected with the ALICE detector at the LHC. The jets were reconstructed in the central rapidity region |η| < 0.5 from charged particles using the anti-k$_{T}$ algorithm with resolution parameter R = 0.4. Identification of b jets exploits the long lifetime of b hadrons, using the properties of secondary vertices and impact parameter distributions. The p$_{T}$-differential inclusive production cross section of b jets, as well as the corresponding inclusive b-jet fraction, are reported for pp and p-Pb collisions in the jet transverse momentum range 10 ≤ p$_{T,ch jet}$≤ 100 GeV/c, together with the nuclear modification factor, $ {R}_{\mathrm{pPb}}^{\mathrm{b}-\mathrm{jet}} $. The analysis thus extends the lower p$_{T}$ limit of b-jet measurements at the LHC. The nuclear modification factor is found to be consistent with unity, indicating that the production of b jets in p-Pb at $ \sqrt{s_{\mathrm{NN}}} $ = 5.02 TeV is not affected by cold nuclear matter effects within the current precision. The measurements are well reproduced by POWHEG NLO pQCD calculations with PYTHIA fragmentation.[graphic not available: see fulltext] A measurement of the inclusive b-jet production cross section is presented in pp and p-Pb collisions at $\sqrt{s_{\rm NN}} = 5.02$ TeV, using data collected with the ALICE detector at the LHC. The jets were reconstructed in the central rapidity region $|\eta|<0.5$ from charged particles using the anti-$k_{\rm T}$ algorithm with resolution parameter $R=0.4$. Identification of b jets exploits the long lifetime of b hadrons, using the properties of secondary vertices and impact parameter distributions. The $p_{\rm T}$-differential inclusive production cross section of b jets, as well as the corresponding inclusive b-jet fraction, are reported for pp and p-Pb collisions in the jet transverse momentum range $10 \le p_{\text{T, ch jet}} \le 100$ GeV/$c$, together with the nuclear modification factor, $R_{\rm pPb}^{\text{b-jet}}$. The analysis thus extends the lower $p_{\rm T}$ limit of b-jet measurements at the LHC. The nuclear modification factor is found to be consistent with unity, indicating that the production of b jets in p-Pb at $\sqrt{s_{\rm NN}} = 5.02$ TeV is not affected by cold nuclear matter effects within the current precision. The measurements are well reproduced by POWHEG NLO pQCD calculations with PYTHIA fragmentation.

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