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99 Research products

  • 2019-2023
  • Publications
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  • European Commission
  • Digital Humanities and Cultural Heritage
  • Neuroinformatics

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Lukasz Piszczek; Joanna Kaczanowska; Wulf Haubensak;

    Abstract Retracing human cognitive origins started out at the systems level with the top-down interpretation of archaeological records spanning from man-made artifacts to endocasts of ancient skulls. With emerging evolutionary genetics and organoid technologies, it is now possible to deconstruct evolutionary processes on a molecular/cellular level from the bottom-up by functionally testing archaic alleles in experimental models. The current challenge is to complement these approaches with novel strategies that allow a holistic reconstruction of evolutionary patterns across human cognitive domains. We argue that computational neuroarcheology can provide such a critical mesoscale framework at the brain network-level, linking molecular/cellular (bottom-up) to systems (top-down) level data for the correlative archeology of the human mind.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Biological Chemistryarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Biological Chemistry
    Article . 2023
    License: CC BY
    Data sources: Crossref
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Biological Chemistryarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Biological Chemistry
      Article . 2023
      License: CC BY
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Alexandra A. de Sousa; Amélie Beaudet; Tanya Calvey; Ameline Bardo; +17 Authors

    AbstractFossil endocasts record features of brains from the past: size, shape, vasculature, and gyrification. These data, alongside experimental and comparative evidence, are needed to resolve questions about brain energetics, cognitive specializations, and developmental plasticity. Through the application of interdisciplinary techniques to the fossil record, paleoneurology has been leading major innovations. Neuroimaging is shedding light on fossil brain organization and behaviors. Inferences about the development and physiology of the brains of extinct species can be experimentally investigated through brain organoids and transgenic models based on ancient DNA. Phylogenetic comparative methods integrate data across species and associate genotypes to phenotypes, and brains to behaviors. Meanwhile, fossil and archeological discoveries continuously contribute new knowledge. Through cooperation, the scientific community can accelerate knowledge acquisition. Sharing digitized museum collections improves the availability of rare fossils and artifacts. Comparative neuroanatomical data are available through online databases, along with tools for their measurement and analysis. In the context of these advances, the paleoneurological record provides ample opportunity for future research. Biomedical and ecological sciences can benefit from paleoneurology’s approach to understanding the mind as well as its novel research pipelines that establish connections between neuroanatomy, genes and behavior.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Amsterdam UMC (VU Am...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Apollo
    Other literature type . 2023
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    MPG.PuRe
    Article . 2023
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Apollo
    Other literature type . 2023
    License: CC BY
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Communications Biology
    Article . 2023
    License: CC BY
    Data sources: Crossref
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Amsterdam UMC (VU Am...arrow_drop_down
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      Apollo
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      MPG.PuRe
      Article . 2023
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      Apollo
      Other literature type . 2023
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      Communications Biology
      Article . 2023
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Demnitz, N; Hulme, OJ; Siebner, HR; Kjaer, M; +3 Authors

    Modifiable lifestyle factors have been shown to promote healthy brain ageing. However, studies have typically focused on a single factor at a time. Given that lifestyle factors do not occur in isolation, multivariable analyses provide a more realistic model of the lifestyle-brain relationship. Here, canonical correlation analyses (CCA) examined the relationship between nine lifestyle factors and seven MRI-derived indices of brain structure. The resulting covariance pattern was further explored with Bayesian regressions. CCA analyses were first conducted on a Danish cohort of older adults (n = 251) and then replicated in a British cohort (n = 668). In both cohorts, the latent factors of lifestyle and brain structure were positively correlated (UK: r = .37, p < 0.001; Denmark: r = .27, p < 0.001). In the cross-validation study, the correlation between lifestyle-brain latent factors was r = .10, p = 0.008. However, the pattern of associations differed between datasets. These findings suggest that baseline characterisation and tailoring towards the study sample may be beneficial for achieving targeted lifestyle interventions. Modifiable lifestyle factors have been shown to promote healthy brain ageing. However, studies have typically focused on a single factor at a time. Given that lifestyle factors do not occur in isolation, multivariable analyses provide a more realistic model of the lifestyle-brain relationship. Here, canonical correlation analyses (CCA) examined the relationship between nine lifestyle factors and seven MRI-derived indices of brain structure. The resulting covariance pattern was further explored with Bayesian regressions. CCA analyses were first conducted on a Danish cohort of older adults (n = 251) and then replicated in a British cohort (n = 668). In both cohorts, the latent factors of lifestyle and brain structure were positively correlated (UK: r =.37, p < 0.001; Denmark: r =.27, p < 0.001). In the cross-validation study, the correlation between lifestyle-brain latent factors was r =.10, p = 0.008. However, the pattern of associations differed between datasets. These findings suggest that baseline characterisation and tailoring towards the study sample may be beneficial for achieving targeted lifestyle interventions.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Oxford University Re...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Neurobiology of Aging; Oxford University Research Archive
    Other literature type . Article . 2023
    License: CC BY NC ND
    SSRN Electronic Journal
    Article . 2023
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Oxford University Re...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Neurobiology of Aging; Oxford University Research Archive
      Other literature type . Article . 2023
      License: CC BY NC ND
      SSRN Electronic Journal
      Article . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Jimenez Morales, Fabricio;

    A highly granular silicon-tungsten electromagnetic calorimeter (SiW-ECAL) is the reference design of the ECAL for International Large Detector concept, one of the two detector concepts for the future International Linear Collider. Prototypes for this type of detector are developed within the CALICE Collaboration. The technological prototype addresses technical challenges such as integrated front-end electronics or compact layer and readout design. A stack of 7 layers was compiled and tested at DESY test beam facilities in 2017. We present preliminary results on the properties of the electromagnetic showers. An outline on the next steps is given. Finally, we illustrate the first steps of the digitization concept on simulations of the prototype. Comment: 6 pages, 3 figures. Talk presented at the International Conference on Technology and Instrumentation in Particle Physics (TIPP 2021), May 24-28 2021. Submitted to Journal of Physics: Conference Series

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Journal of Physics :...arrow_drop_down
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    Journal of Physics : Conference Series
    Article . 2022
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    CERN Document Server
    Other literature type . 2022
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    Hyper Article en Ligne; Hal-Diderot
    Other literature type . Conference object . 2021
    https://doi.org/10.48550/arxiv...
    Article . 2021
    License: CC BY
    Data sources: Datacite
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      Journal of Physics : Conference Series
      Article . 2022
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      CERN Document Server
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      Hyper Article en Ligne; Hal-Diderot
      Other literature type . Conference object . 2021
      https://doi.org/10.48550/arxiv...
      Article . 2021
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Sharif Islam; Andreas Weber; Erzsébet Tóth-Czifra;

    This talk outlines a vision for Common European Data Spaces, proposed by the European Commission, where FAIR principles (Wilkinson et al. 2016) and FAIR Digital Objects (FDOs) (De Smedt et al. 2020, Schwardmann 2020) can play a role in bringing together research infrastructures, data aggregators and other stakeholders working with curated objects in museums, herbaria, libraries and archives. The organisations and stakeholders involved represent a wide range of disciplines and data types including biodiversity, ecology, anthropology, archaeology, cultural history, digital storytelling, art conservation, and history of science among others (ICEDIG 2020, Ortolja-Baird and Nyhan 2021). The context and the history of the curated objects also span the natural sciences and cultural heritage domains (Nadim 2021, Weber 2021). Despite this heterogeneity, various common themes in the area of digital curation, open access, and data usage (Tasovac et al. 2020) appear where FDOs and Common European Data Spaces can be a useful venue for supporting the European Strategy for Data. In particular, FDOs, as an abstraction mechanism to structure and describe digital artefacts from a specific domain yet at the same time provide interoperability (De Smedt et al. 2020), can help realise the vision behind a common data space to “bring together relevant data infrastructures and governance frameworks in order to facilitate data pooling and sharing” (European Commission 2022:2). A May 2022 report on the challenges and opportunities of European Common Data Spaces highlights the following points: Open data holders have extensive experience in data publishing, metadata management, data quality, dataset discovery, data federation, as well as tried-and-tested standards (e.g. DCAT) and technologies. There seems to be very little knowledge/technology transfer from the open data community to the data spaces community, which is a missed opportunity. Data space implementations should not reinvent wheels that the open data community has already developed, tested, and used extensively. Whether the data is private, shared, or open, using data from multiple sources requires interoperability at several levels, from identifiers to vocabularies. The question of which data intermediaries will act as neutral agents to ensure interoperability is underexplored in the data space context. Public administrations, building on their experience of publishing open data, are best placed to take on such roles Open data holders have extensive experience in data publishing, metadata management, data quality, dataset discovery, data federation, as well as tried-and-tested standards (e.g. DCAT) and technologies. There seems to be very little knowledge/technology transfer from the open data community to the data spaces community, which is a missed opportunity. Data space implementations should not reinvent wheels that the open data community has already developed, tested, and used extensively. Whether the data is private, shared, or open, using data from multiple sources requires interoperability at several levels, from identifiers to vocabularies. The question of which data intermediaries will act as neutral agents to ensure interoperability is underexplored in the data space context. Public administrations, building on their experience of publishing open data, are best placed to take on such roles Building on previous conversations facilitated by DiSSCo, DARIAH, Europeana, and Archives Portal Europe Foundation, (Europeana Conference 2021, DARIAH Annual Event 2022), this talk will address the above points from the perspective of bringing together the domains of natural history museums, cultural heritage, and digital humanities. Within our collaboration, we have identified several common areas such as data discoverability, linking, and providing contextual information, which align with the goal of FDO implementation. DiSSCo and DARIAH as European infrastructures, on the one hand, and Europeana and Archives Portal as data aggregators, on the other hand, are involved in improving access to data and the researchers' capacity to work with heterogeneous data sources. One of the biggest shared challenges across the diverse workflows in the arts and humanities and natural history domains is that the data curation processes form a natural continuum between a range of different actors working either in cultural heritage institutions or in academia. In reality, these different layers of curation, enrichment and analysis are separated by legal, institutional, infrastructural and even funding silos (as in many countries, these institutions belong to different ministries, and fall under different legislative frameworks). How can this continuum, from a scholarly point of view, be supported within common data space and FDO framework? At the same time, implementing a common data space requires not just interoperability but stewardship and strategy for sharing resources (Keller 2021). The data infrastructure and FAIR related activities explored in our collaboration are of strategic importance to help Europe and the rest of the world deal with important societal issues. Therefore, bringing this collaboration within the context of FDO provides an ideal avenue to explore potential data, policy, and implementation matters, in order to address the two gaps outlined above for Common Data Spaces. Furthermore, the ideas expressed in Common European Data Space for Cultural Heritage (with Europeana as the core stakeholder) and Green Deal Data Spaces need further clarification concerning implementation planning and most importantly, how multiple commons would work together. With DARIAH coming from the humanities and DiSSCo from the natural sciences side, such collaborations and synergy should align with the Common Data Spaces vision. The philosophy and ideas behind data and digital commons are not new (Fuchs 2020, Kashwan et al. 2021). However, it is crucial to contextualise the implementation strategy and benefits within data intensive, multidisciplinary research and FAIR principles. Given that curated objects are informational resources for the researchers, but can also provide contexts, and make visible the relationships between artefacts, people, publications, organisations, provenance, and events, it is important to think of them as much more than just records in a database. Additionally, FDOs as the digital representations of the curated objects have the potential of fostering cross-disciplinary collaborations (such as between biology, history, art or anthropology) and of providing a wider lens for understanding materiality and the role of data (Ribes 2019). As interdisciplinarity and data-driven foci are gaining traction via applications of artificial intelligence and machine learning, it is vital to understand what FDO adoption and implementation can contribute to common data spaces. We believe FDOs can be a successful foundation for Common European Data Spaces because they can can connect multiple commons -- from Green Deal to Cultural Heritage -- in order to drive forward the vision for interdisciplinary collaboration.

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    Authors: Schottenhamml, Helen; Anciaux-Sedrakian, Ani; Blondel, Frédéric; Borras-Nadal, Adria; +2 Authors

    Abstract Due to the cost and difficulty to precisely measure aerodynamic quantities in onshore and offshore wind farms, researchers often rely on high-fidelity large eddy simulation, based on Navier-Stokes flow solvers. However, the cost of such simulation is very high and does not allow, in practice, extensive parametric studies for large wind farms. Among others, the lattice Boltzmann method is a good candidate for much faster, ExaScale wind farm flow simulations. The present paper aims to assess the validity of a lattice Boltzmann-based actuator line model and highlights its strengths and potential weaknesses. With this intent, comparisons against a Navier-Stokes approach commonly used in the wind energy community are performed. We assess the potential of the lattice Boltzmann method to reduce the computational cost of such simulations by analyzing the performance of the different solvers and their scalability. The lattice Boltzmann-based waLBerla solver reduces the computational costs significantly compared to SOWFA while maintaining the same accuracy as the Navier-Stokes-based method. Furthermore, we show that a multi-GPU implementation leads to an even more drastic reduction of the computational time, achieving faster-than-real-time simulations. This performance will allow extensive parametric studies over large wind farms in future studies.

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    Journal of Physics : Conference Series
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    Authors: Albers, Thilo N. H.; Bartels, Charlotte; Schularick, Moritz;

    German history over the past 125 years has been turbulent. Marked by two world wars, revolutions and major regime changes, as well as a hyperinflation and three currency reforms, expropriations and territorial divisions, it provides unique insights into the role of country-specific shocks in shaping long-run wealth dynamics. This paper presents the first comprehensive study of wealth and its distribution in Germany since the 19th century. We combine tax and archival data, household surveys, historical national accounts, and rich lists to analyze the evolution of the German wealth distribution over the long run. We show that the top 1% wealth share has fallen by half, from close to 50% in 1895 to 27% today. Nearly all of this decline was the result of changes that occurred between 1914 and 1952. The interwar period and the wealth taxation in the aftermath of World War II stand out as the great equalizers in 20th century German history. After unification in 1990, two trends have left their mark on the German wealth distribution. Households at the top made substantial capital gains from rising business wealth while the middle-class had large capital gains in the housing market. The wealth share of the bottom 50% halved since 1990. Our findings speak to the importance of historical shocks to the distribution and valuations of existing wealth in explaining the evolution of the wealth distribution over the long run. (Stone Center on Socio-Economic Inequality Working Paper)

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    Authors: Schading, Simon; David, Gergely; Max Emmenegger, Tim; Achim, Cristian; +4 Authors

    BackgroundFollowing spinal cord injury (SCI), disease processes spread gradually along the spinal cord forming a spatial gradient with most pronounced changes located at the lesion site. However, the dynamics of this gradient in sub-acute SCI patients is not established.ObjectiveThis study tracks the spatiotemporal dynamics of remote anterograde and retrograde spinal tract degeneration in the upper cervical cord following SCI over two years utilizing quantitative MRI.MethodsTwenty-three acute SCI patients (11 paraplegics, 12 tetraplegics) and 21 healthy controls were scanned with a T1-weighted sequence for volumetry and a FLASH sequence for myelin-sensitive magnetization transfer saturation (MTsat) map of the upper cervical cord. We estimated myelin content from MTsat maps within the corticospinal tracts (CST) and dorsal columns (DC) and measured spinal cord atrophy by means of left-right width (LRW) and anterior-posterior width (APW) on the T1-weighted images across cervical levels C1-C3. MTsat in the CST and LRW were considered proxies for retrograde degeneration, while MTsat in the DC and APW provided evidence for anterograde degeneration, respectively. Using regression models, we compared the temporal and spatial trajectories of these MRI readouts between tetraplegics, paraplegics, and controls over a 2-year period and assessed their associations with clinical improvement.ResultsLinear rates and absolute differences in myelin-sensitive MTsat indicated retrograde and anterograde neurodegeneration in the CST and DC, respectively. Changes in MTsat within the CST (change per cervical level: -0.247 p.u./level, p=0.034) and LRW (change per level: -0.323 mm/level, p=0.024) progressively developed over time with a strong gradient towards lower cervical segments specifically in tetraplegics. Within the DC, MTsat was already decreased at all cervical levels at baseline and linear rates in APW were similar across all cervical levels showing no spatial gradient in para- and tetraplegics. The relative improvement in light touch score was correlated with MTsat within the DC at baseline (1.5 months) (rs=0.575, p=0.014).ConclusionRostral and remote to the injury, the CST and DC showed ongoing structural changes, indicative of myelin reductions and atrophy within 2 years after SCI. While anterograde degeneration in the DC was already detectable uniformly at C1-C3 early following SCI, retrograde degeneration in the CST developed over time revealing specific spatial and temporal neurodegenerative gradients. Disentangling and quantifying such dynamic pathological processes may provide biomarkers for regenerative and remyelinating therapies, where antero- and retrograde spinal pathways become specifically affected.

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    NeuroImage: Clinical
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      NeuroImage: Clinical
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    Authors: Baichen Li; Marta Poyo Solanas; Giuseppe Marrazzo; Rajani Raman; +4 Authors

    This ultrahigh field 7 T fMRI study addressed the question of whether there exists a core network of brain areas at the service of different aspects of body perception. Participants viewed naturalistic videos of monkey and human faces, bodies, and objects along with mosaic-scrambled videos for control of low-level features. Independent component analysis (ICA) based network analysis was conducted to find body and species modulations at both the voxel and the network levels. Among the body areas, the highest species selectivity was found in the middle frontal gyrus and amygdala. Two large-scale networks were highly selective to bodies, dominated by the lateral occipital cortex and right superior temporal sulcus (STS) respectively. The right STS network showed high species selectivity, and its significant human body-induced node connectivity was focused around the extrastriate body area (EBA), STS, temporoparietal junction (TPJ), premotor cortex, and inferior frontal gyrus (IFG). The human body-specific network discovered here may serve as a brain-wide internal model of the human body serving as an entry point for a variety of processes relying on body descriptions as part of their more specific categorization, action, or expression recognition functions. ispartof: PROGRESS IN NEUROBIOLOGY vol:221 ispartof: location:England status: published

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    Progress in Neurobiology
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      Lirias
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      Progress in Neurobiology
      Article . 2023
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      Article . 2022
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  • Authors: Dimoula, Anastasia; Tsirtsoni, Zoï; Yiouni, Paraskevi; Chohadzhiev, Alexander; +16 Authors

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Lukasz Piszczek; Joanna Kaczanowska; Wulf Haubensak;

    Abstract Retracing human cognitive origins started out at the systems level with the top-down interpretation of archaeological records spanning from man-made artifacts to endocasts of ancient skulls. With emerging evolutionary genetics and organoid technologies, it is now possible to deconstruct evolutionary processes on a molecular/cellular level from the bottom-up by functionally testing archaic alleles in experimental models. The current challenge is to complement these approaches with novel strategies that allow a holistic reconstruction of evolutionary patterns across human cognitive domains. We argue that computational neuroarcheology can provide such a critical mesoscale framework at the brain network-level, linking molecular/cellular (bottom-up) to systems (top-down) level data for the correlative archeology of the human mind.

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    Biological Chemistry
    Article . 2023
    License: CC BY
    Data sources: Crossref
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      Biological Chemistry
      Article . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Alexandra A. de Sousa; Amélie Beaudet; Tanya Calvey; Ameline Bardo; +17 Authors

    AbstractFossil endocasts record features of brains from the past: size, shape, vasculature, and gyrification. These data, alongside experimental and comparative evidence, are needed to resolve questions about brain energetics, cognitive specializations, and developmental plasticity. Through the application of interdisciplinary techniques to the fossil record, paleoneurology has been leading major innovations. Neuroimaging is shedding light on fossil brain organization and behaviors. Inferences about the development and physiology of the brains of extinct species can be experimentally investigated through brain organoids and transgenic models based on ancient DNA. Phylogenetic comparative methods integrate data across species and associate genotypes to phenotypes, and brains to behaviors. Meanwhile, fossil and archeological discoveries continuously contribute new knowledge. Through cooperation, the scientific community can accelerate knowledge acquisition. Sharing digitized museum collections improves the availability of rare fossils and artifacts. Comparative neuroanatomical data are available through online databases, along with tools for their measurement and analysis. In the context of these advances, the paleoneurological record provides ample opportunity for future research. Biomedical and ecological sciences can benefit from paleoneurology’s approach to understanding the mind as well as its novel research pipelines that establish connections between neuroanatomy, genes and behavior.

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    Apollo
    Other literature type . 2023
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    MPG.PuRe
    Article . 2023
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    Apollo
    Other literature type . 2023
    License: CC BY
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    Communications Biology
    Article . 2023
    License: CC BY
    Data sources: Crossref
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