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347 research outcomes, page 1 of 35
  • publication . Article . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Maryam Alqabandi; N. de Franceschi; Nolwenn Miguet; Sourav Maity; Marta Bally; Wouter H. Roos; Winfried Weissenhorn; Patricia Bassereau; Stéphanie Mangenot;
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | INTERACT (751404), ANR | ESCRTfission (ANR-14-CE09-0003), ANR | PSL (ANR-10-IDEX-0001), EC | ESCRT model (751715)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Nicola L Harman; Adrian Sanz-Moreno; Stamatia Papoutsopoulou; Katie A. Lloyd; Kamar E. Ameen-Ali; Malcolm R. Macleod; Paula R Williamson;
    Publisher: BMC
    Project: EC | CORBEL (654248)

    Abstract Background In pre-clinical research, systematic reviews have the potential to mitigate translational challenges by facilitating understanding of how pre-clinical studies can inform future clinical research. Yet their conduct is encumbered by heterogeneity in th...

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  • publication . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Lynda Djerbal; Romain R. Vivès; Chrystel Lopin-Bon; Ralf P. Richter; Jessica C. F. Kwok; Hugues Lortat-Jacob;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    ABSTRACTSemaphorin 3A (Sema3A) is a secreted protein that signals to cells through binding to neuropilin and plexin receptors and provides neurons with guidance cues key for axon pathfinding, and also controls cell migration in several other biological systems. Sema3A i...

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  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Marion Lechable; Alexandre Jan; Axel Duchene; Julie Uveira; Brandon Weissbourd; Loann Gissat; Sophie Collet; Laurent Gilletta; Sandra Chevalier; Lucas Leclère; ...
    Persistent Identifiers
    Publisher: The Company of Biologists
    Project: EC | ASSEMBLE Plus (730984), ANR | i-MMEJ (ANR-17-CE13-0016), EC | CORBEL (654248)

    ABSTRACT The jellyfish species Clytia hemisphaerica (Cnidaria, Hydrozoa) has emerged as a new experimental model animal in the last decade. Favorable characteristics include a fully transparent body suitable for microscopy, daily gamete production and a relatively short...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Gabriella T. Heller; Francesco A. Aprile; Thomas C. T. Michaels; Ryan Limbocker; Michele Perni; Francesco Simone Ruggeri; Benedetta Mannini; Thomas Löhr; Massimiliano Bonomi; Carlo Camilloni; ...
    Persistent Identifiers
    Publisher: American Association for the Advancement of Science
    Project: EC | iNEXT (653706), UKRI | Peta-5: A National Facili... (EP/P020259/1), ANR | INCEPTION (ANR-16-CONV-0005), SNSF | Correlating biophysical p... (P300P2_171219), SNSF | Bringing Together Nanosca... (P2ELP2_162116), UKRI | Probing Post-Translationa... (MR/S033947/1)

    A small molecule binds to a disordered protein in its monomeric form, preventing its aggregation linked to Alzheimer’s disease.

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  • publication . Article . 2020
    Open Access English
    Authors:
    Nicholas D. Holland; Ildiko M. L. Somorjai;
    Persistent Identifiers
    Publisher: BioMed Central
    Project: EC | CORBEL (654248)

    Abstract Background The cellular basis of adult growth in cephalochordates (lancelets or amphioxus) has received little attention. Lancelets and their constituent organs grow slowly but continuously during adult life. Here, we consider whether this slow organ growth in...

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  • publication . Article . 2020
    Open Access
    Authors:
    Alejandra Zárate-Potes; Wentao Yang; Barbara Pees; Rebecca Schalkowski; Philipp Segler; Bentje Andresen; Daniela Haase; Rania Nakad; Philip Rosenstiel; Guillaume Tetreau; ...
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01), ANR | X-in-vivo (ANR-17-CE11-0018)

    Author summary Although invertebrates possess a comparatively simple immune system, research over the past decades revealed that a complexity of different signaling processes interact to produce fine-tuned defense responses to various pathogenic challenges. To date, how...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Judit Osz; Alastair G. McEwen; Maxime Bourguet; Frédéric Przybilla; Carole Peluso-Iltis; Pierre Poussin-Courmontagne; Yves Mély; Sarah Cianférani; Cy M. Jeffries; Dmitri I. Svergun; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706), ANR | INRT (ANR-10-LABX-0030), ANR | UNISTRA (ANR-10-IDEX-0002), EC | BIOSTRUCT-X (283570)

    AbstractRetinoic acid receptors (RARs) as a functional heterodimer with retinoid X receptors (RXRs), bind a diverse series of RA-response elements (RAREs) in regulated genes. Among them, the non-canonical DR0 elements are bound by RXR–RAR with comparable affinities to D...

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Herimela Solomon-Degefa; Jan M. Gebauer; Cy M. Jeffries; Carolin D. Freiburg; Patrick Meckelburg; Louise E. Bird; Ulrich Baumann; Dmitri I. Svergun; Raymond J. Owens; Jörn M. Werner; ...
    Publisher: Deutsches Elektronen-Synchrotron, DESY, Hamburg
    Project: EC | iNEXT (653706)

    Published by American Soc. for Biochemistry and Molecular Biology8772, Bethesda, MD.

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  • publication . Article . Preprint . Other literature type . 2020
    Open Access
    Authors:
    Alexander F Schubert; Justine V Nguyen; Tyler G Franklin; Paul P. Geurink; Cameron G Roberts; Daniel J. Sanderson; Lauren N. Miller; Huib Ovaa; Kay Hofmann; Jonathan N. Pruneda; ...
    Publisher: EMBO
    Project: NIH | Program in Molecular and ... (5T32GM071338-10), EC | UbiArchitect (724804), NWO | Covalent Enzyme Capture (2300182105), EC | BIOSTRUCT-X (283570)

    Prediction and validation of pathogenic bacterial DUBs and insights into their structures and (poly)ubiquitin linkage specificities allows for first cross‐kingdom comparison of the OTU deubiquitination enzyme fold.

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347 research outcomes, page 1 of 35