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description Publicationkeyboard_double_arrow_right Article 2021 SpainUniversidad de Valladolid Authors: Montserrat Prat Moratonas; Yuly Marsela Vanegas Muñoz; Alba Rubio Franco;Montserrat Prat Moratonas; Yuly Marsela Vanegas Muñoz; Alba Rubio Franco;handle: 10459.1/83552 , 2072/354842
Este artículo presenta el diseño y construcción de una herramienta para la caracterización de trayectorias de aprendizaje de la medida de longitud en niños de 6-8 años. El proceso seguido ha permitido configurar y validar un instrumento que permite reconocer, mediante actividades abiertas y manipulativas, niveles de comprensión de la medida de longitud, tales como: reconocimiento de la pre-longitud; reconocimiento de la longitud; comparación directa; comparación indirecta; ordenación serial hasta 6+; medida de extremo a extremo; relación y repetición de unidades de medida. El instrumento posibilita contar con diferentes tipos de evidencias para aproximarnos de mejor forma a las comprensiones de los niños, como son: sus acciones, sus explicaciones y sus preguntas. This paper presents the design and construction of a tool for the characterization of learning trajectories of length measurement in 6-8 years old children. The process followed has allowed us to configure and validate an instrument that permits to recognize, through open and manipulative activities, levels of understanding of the measure of length, such as: pre-length quantity recognizer; length quantity recognizer; length direct comparer; indirect length comparer; serial orderer to 6+; end-to-end length measurer; length unit relater and repeater. The instrument provides different types of evidence for a better approach to children comprehensions, such as their actions, their explanations and their questions. Este trabajo ha contado con el soporte de los proyectos: EDU2015-65378-P y EDU2013-46083-R, MINECO. España.
Funes arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARepositorio Documental de la Universidad de Valladolid; Recolector de Ciencia Abierta, RECOLECTA; Edma 0-6 : Educación Matemática en la InfanciaOther literature type . Article . 2021 . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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more_vert Funes arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARepositorio Documental de la Universidad de Valladolid; Recolector de Ciencia Abierta, RECOLECTA; Edma 0-6 : Educación Matemática en la InfanciaOther literature type . Article . 2021 . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2021 Finland, Italy, Spain, Spain, France, Norway, Spain, Germany, Italy, United States, France, ItalySpringer Science and Business Media LLC AKA | LISA and the electroweak ..., FCT | GRAVITY, FCT | CENTRA +15 projectsAKA| LISA and the electroweak phase transition ,FCT| GRAVITY ,FCT| CENTRA ,EC| MaGRaTh ,FCT| AWAkEN ,EC| B Massive ,NSF| Collaborative Research: Mergers of Massive Black Holes at the Centers of Galaxies ,EC| WASE ,NSF| Binary Black Holes at the Extremes in the Era of Gravitational Wave Astronomy ,EC| DarkGRA ,UKRI| Gravitational wave cosmology for LISA ,NSF| Physics and Astrophysics of Compact Binaries ,AKA| LISA and the electroweak phase transition ,NSF| Collaborative Research: Understanding Compact Binary Formation with the First Gravitational Wave Detections ,NSF| Forming the First Massive Black Holes ,NSF| Exploring Gravitational and Nuclear Physics with Gravitational Wave Astronomy ,EC| GRU ,NSF| Collaborative Research: Wou-MMA: Multi-Messenger Signatures of Massive Black Hole BinariesAuthors: Seoane, Pau Amaro; Sedda, Manuel Arca; Babak, Stanislav; Berry, Christopher P. L.; +38 AuthorsSeoane, Pau Amaro; Sedda, Manuel Arca; Babak, Stanislav; Berry, Christopher P. L.; Berti, Emanuele; Bertone, Gianfranco; Blas Temiño, Diego; Bogdanović, Tamara; Bonetti, Matteo; Breivik, Katelyn; Brito, Richard; Caldwell, Robert; Capelo, Pedro R.; Caprini, Chiara; Cardoso, Vitor; Carson, Zack; Chen, Hsin-Yu; Chua, Alvin J. K.; Dvorkin, Irina; Haiman, Zoltan; Heisenberg, Lavinia; Isi, Maximiliano; Karnesis, Nikolaos; Kavanagh, Bradley J.; Littenberg, Tyson B.; Mangiagli, Alberto; Marcoccia, Paolo; Maselli, Andrea; Nardini, Germano; Pani, Paolo; Peloso, Marco; Pieroni, Mauro; Ricciardone, Angelo; Sesana, Alberto; Tamanini, Nicola; Toubiana, Alexandre; Valiante, Rosa; Vretinaris, Stamatis; Weir, David; Yagi, Kent; Zimmerman, Aaron; Institut de Física d'Altes Energies;C.P.L. Berry is supported by the CIERA Board of Visitors Professorship. E. Berti is supported by NSF Grants No. PHY-1912550 and AST-2006538, NASA ATP Grants No. 17-ATP17-0225 and 19-ATP19-0051, NSF-XSEDE Grant No. PHY-090003, and NSF Grant PHY-20043. D. Blas acknowledges support from the Fundación Jesus Serra and the Instituto de Astrofísica de Canarias under the Visiting Researcher Programme 2021 agreed between both institutions. T. Bogdanović acknowledges the support by the National Aeronautics and Space Administration (NASA) under award No. 80NSSC19K0319 and by the National Science Foundation (NSF) under Award No. 1908042. V. Cardoso acknowledges financial support provided under the European Union’s H2020 ERC Consolidator Grant “Matter and strong-field gravity: New frontiers in Einstein’s theory” Grant Agreement No. MaGRaTh–646597. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 101007855. We thank FCT for financial support through Projects No. UIDB/00099/2020 and through grants PTDC/MAT-APL/30043/2017 and PTDC/FIS-AST/7002/2020. H.-Y. Chen is supported by NASA through NASA Hubble Fellowship Grants No. HST-HF2-51452.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., for NASA, under contract NAS5-26555. Z. Haiman acknowledges support by NASA Grant NNX15AB19G and NSF Grants AST-2006176 and AST-1715661. G. Nardini is partly supported by the ROMFORSK Grant Project. No. 302640 “Gravitational Wave Signals From Early Universe Phase Transitions”. P. Pani acknowledges financial support provided under the European Union’s H2020 ERC, Starting Grant Agreement No. DarkGRA–757480. He also acknowledges support under the MIUR PRIN and FARE programmes (GW-NEXT, CUP: B84I20000100001), and by the Amaldi Research Center funded by the MIUR program “Dipartimento di Eccellenza” (CUP: B81I18001170001). A. Sesana acknowledges financial support provided under the European Union’s H2020 ERC Consolidator Grant “Binary Massive Black Hole Astrophysics” (B Massive, Grant Agreement: 818691). K. Yagi acknowledges support from NSF Grant PHY-1806776, NASA Grant 80NSSC20K0523, a Sloan Foundation Research Fellowship and the Owens Family Foundation. D. J. Weir was supported by a Science and Technology Facilities Council Ernest Rutherford Fellowship, Grant no. ST/R003904/1, and by the Academy of Finland, Grants 324882 and 328958. A. Zimmerman is supported by NSF Grant No. PHY-1912578. The authors would like to acknowledge networking support by the GWverse COST Action CA16104, “Black holes, gravitational waves and fundamental physics.” The Flatiron Institute is supported by the Simons Foundation. This research has made use of data, software and web tools obtained from the Gravitational Wave Open Science Center (www.gw-openscience.org/), a service of LIGO Laboratory, the LIGO Scientific Collaboration and the Virgo Collaboration. LIGO Laboratory and Advanced LIGO are funded by the United States National Science Foundation (NSF) as well as the Science and Technology Facilities Council (STFC) of the United Kingdom, the Max-Planck-Society (MPS), and the State of Niedersachsen/Germany for support of the construction of Advanced LIGO and construction and operation of the GEO600 detector. Additional support for Advanced LIGO was provided by the Australian Research Council. Virgo is funded, through the European Gravitational Observatory (EGO), by the French Centre National de Recherche Scientifique (CNRS), the Italian Istituto Nazionale di Fisica Nucleare (INFN) and the Dutch Nikhef, with contributions by institutions from Belgium, Germany, Greece, Hungary, Ireland, Japan, Monaco, Poland, Portugal, Spain. The science objectives of the LISA mission have been defined under the implicit assumption of a 4-years continuous data stream. Based on the performance of LISA Pathfinder, it is now expected that LISA will have a duty cycle of ≈0.75 , which would reduce the effective span of usable data to 3 years. This paper reports the results of a study by the LISA Science Group, which was charged with assessing the additional science return of increasing the mission lifetime. We explore various observational scenarios to assess the impact of mission duration on the main science objectives of the mission. We find that the science investigations most affected by mission duration concern the search for seed black holes at cosmic dawn, as well as the study of stellar-origin black holes and of their formation channels via multi-band and multi-messenger observations. We conclude that an extension to 6 years of mission operations is recommended. Peer reviewed et al.
CORE (RIOXX-UK Aggre... arrow_drop_down OA@INAF - Istituto Nazionale di AstrofisicaArticle . 2022Data sources: OA@INAF - Istituto Nazionale di AstrofisicaHELDA - Digital Repository of the University of HelsinkiArticle . 2022Data sources: HELDA - Digital Repository of the University of HelsinkiGeneral Relativity and GravitationArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu21 citations 21 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 6visibility views 6 download downloads 7 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down OA@INAF - Istituto Nazionale di AstrofisicaArticle . 2022Data sources: OA@INAF - Istituto Nazionale di AstrofisicaHELDA - Digital Repository of the University of HelsinkiArticle . 2022Data sources: HELDA - Digital Repository of the University of HelsinkiGeneral Relativity and GravitationArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Switzerland, Brazil, Italy, Spain, Netherlands, Belgium, Italy, NorwaySpringer Science and Business Media LLC EC | IMBALANCE-P, EC | BACCARA, NWO | Do mycorrhizal fungi medi... +2 projectsEC| IMBALANCE-P ,EC| BACCARA ,NWO| Do mycorrhizal fungi mediate soil carbon fate? ,EC| BACI ,ARC| Discovery Projects - Grant ID: DP170103410Julia S. Joswig; Christian Wirth; Meredith C. Schuman; Jens Kattge; Björn Reu; Ian J. Wright; Sebastian D. Sippel; Nadja Rüger; Ronny Richter; Michael E. Schaepman; Peter M. van Bodegom; J. H. C. Cornelissen; Sandra Díaz; Wesley N. Hattingh; Koen Kramer; Frederic Lens; Ülo Niinemets; Peter B. Reich; Markus Reichstein; Christine Römermann; Franziska Schrodt; Madhur Anand; Michael Bahn; Chaeho Byun; Giandiego Campetella; Bruno E. L. Cerabolini; Joseph M. Craine; Andres Gonzalez-Melo; Alvaro G. Gutiérrez; Tianhua He; Pedro Higuchi; Hervé Jactel; Nathan J. B. Kraft; Vanessa Minden; Vladimir Onipchenko; Josep Peñuelas; Valério D. Pillar; Ênio Sosinski; Nadejda A. Soudzilovskaia; Evan Weiher; Miguel D. Mahecha;pmid: 34949823
pmc: PMC8752441
Plant functional traits can predict community assembly and ecosystem functioning and are thus widely used in global models of vegetation dynamics and land–climate feedbacks. Still, we lack a global understanding of how land and climate affect plant traits. A previous global analysis of six traits observed two main axes of variation: (1) size variation at the organ and plant level and (2) leaf economics balancing leaf persistence against plant growth potential. The orthogonality of these two axes suggests they are differently influenced by environmental drivers. We find that these axes persist in a global dataset of 17 traits across more than 20,000 species. We find a dominant joint effect of climate and soil on trait variation. Additional independent climate effects are also observed across most traits, whereas independent soil effects are almost exclusively observed for economics traits. Variation in size traits correlates well with a latitudinal gradient related to water or energy limitation. In contrast, variation in economics traits is better explained by interactions of climate with soil fertility. These findings have the potential to improve our understanding of biodiversity patterns and our predictions of climate change impacts on biogeochemical cycles. Nature Ecology & Evolution, 6 (1) ISSN:2397-334X
NARCIS arrow_drop_down NARCIS; Research@WUROther literature type . Article . 2022Recolector de Ciencia Abierta, RECOLECTAArticle . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTANature Ecology & Evolution; NARCISArticle . 2021 . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu64 citations 64 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert NARCIS arrow_drop_down NARCIS; Research@WUROther literature type . Article . 2022Recolector de Ciencia Abierta, RECOLECTAArticle . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTANature Ecology & Evolution; NARCISArticle . 2021 . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Spain, Spain, Denmark, Finland, Netherlands, SpainOxford University Press (OUP) Boenink, Rianne; Astley, Megan E.; Huijben, Jilske A.; Stel, Vianda S.; Kerschbaum, Julia; Ots-Rosenberg, Mai; Åsberg, Anders A.; Lopot, Frantisek; Golan, Eliezer; Castro de la Nuez, Pablo; Rodríguez Camblor, Marta; Trujillo-Alemán, Sara; Ruiz San Millan, Juan Carlos; Ucio Mingo, Pablo; Díaz Gómez, Juan Manuel; Bouzas-Caamaño, M. Encarnación; Artamendi, Marta; Aparicio Madre, Manuel I; Santiuste de Pablos, Carmen; Slon Roblero, María Fernanda; Zurriaga, Oscar; Stendahl, Maria E.; Bell, Samira; Idrizi, Alma; Ioannou, Kyriakos; Debska-Slizien, Alicja; Galvão, Ana A.; De Meester, Johan; Resić, Halima; Hommel, Kristine; Radunovic, Danilo; Pálsson, Runolfur; Lassalle, Mathilde; Finne, Patrik; Garcia Bazaga, María De los Ángeles; Gjorgjievski, Nikola; Seyahi, Nurhan; Bonthuis, Marjolein; Ortiz, Alberto; Jager, Kitty J.; Kramer, Anneke; Universitat Autònoma de Barcelona;Data on renal replacement therapy (RRT) for end-stage renal disease were collected by the European Renal Association (ERA) Registry via national and regional renal registries in Europe and countries bordering the Mediterranean Sea. This article provides a summary of the 2019 ERA Registry Annual Report, including data from 34 countries and additional age comparisons. Methods: Individual patient data for 2019 were provided by 35 registries and aggregated data by 17 registries. Using these data, the incidence and prevalence of RRT, the kidney transplantation activity and the survival probabilities were calculated. In 2019, a general population of 680.8 million people was covered by the ERA Registry. Overall, the incidence of RRT was 132 per million population (p.m.p.). Of these patients, 62% were men, 54% were ≥65 years of age and 21% had diabetes mellitus as primary renal disease (PRD), and 84% had haemodialysis (HD), 11% had peritoneal dialysis (PD) and 5% had pre-emptive kidney transplantation as an initial treatment modality. The overall prevalence of RRT on 31 December 2019 was 893 p.m.p., with 58% of patients on HD, 5% on PD and 37% living with a kidney transplant. The overall kidney transplant rate was 35 p.m.p. and 29% of the kidney grafts were from a living donor. The unadjusted 5-year survival probability was 42.3% for patients commencing dialysis, 86.6% for recipients of deceased donor grafts and 94.4% for recipients of living donor grafts in the period 2010-14. When comparing age categories, there were substantial differences in the distribution of PRD, treatment modality and kidney donor type, and in the survival probabilities The ERA Registry is funded by the ERA. This article was written by R. Boenink et al. on behalf of the ERA Registry, which is an official body of the ERA. In addition, S.B. reports personal fees from AstraZeneca, outside the submitted work; A.D.-S. reports personal fees from Astellas and Fresenius, outside the submitted work; F.L. reports personal fees from MeditesPharma, outside the submitted work; R.P. reports grants from The Iceland Centre for Research, Landspitali University Hospital Research Fund and University of Iceland Research Fund, outside the submitted work; P.F. reports grants from Finska läkaresällskapet and Liv och Hälsa, outside the submitted work; M.F.S.R. reports personal fees from Baxter and Fresenius, outside the submitted work; A.O. reports grants from Sanofi, and personal fees from Astellas, AstraZeneca, Amicus, Bayes, Fresenius Medical Care and Idorsia, outside the submitted work; and K.J.J. reports grants from ERA, during the conduct of the study Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, y los autores pertenecientes a la UAM
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAHELDA - Digital Repository of the University of HelsinkiArticle . 2022Data sources: HELDA - Digital Repository of the University of HelsinkiBiblos-e ArchivoOther literature type . Article . 2022 . 2021Recolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu41 citations 41 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAHELDA - Digital Repository of the University of HelsinkiArticle . 2022Data sources: HELDA - Digital Repository of the University of HelsinkiBiblos-e ArchivoOther literature type . Article . 2022 . 2021Recolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/ckj/sfab273&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 SpainWiley Authors: Marc Barbeta-Viñas; Marina Requena;Marc Barbeta-Viñas; Marina Requena;doi: 10.1111/soru.12357
handle: 10234/196959
Altres ajuts: acords transformatius de la UAB Altres ajuts: Institut de Recerca i Tecnologia Agroalimentàries (IRTA) (CF616633) We want to thank Marta Terra for her contribution to the research. To Miren Etxezarreta and Luis Enrique Alonso for the comments on the text. This work was supported by the Departament d'Agricultura Ramaderia i Pesca de la Generalitat de Catalunya within the framework of an agreement between the Institute of Agrifood Research and Technology (IRTA) and UAB: Project code CF616633 The article analyses the crisis and 'double bind' situation to which Catalan dairy farmers find themselves subjected. Two contradictory commands are being imposed on them: 'act as if nature does not matter and increase production because, otherwise, the abandonment of livestock activity threatens you'; and 'reduce production and protect the environment to avoid an environmental catastrophe'. In the first part of the article, we study the socioeconomic crisis facing cattle farmers. In the second, we analyse farmers' discourse on the matter as a 'double bind'. Our conclusions indicate that in order to escape this paradoxical situation and gain some autonomy with respect to industry, farmers must establish a collective conscience and unite their interests: Although the path of producer cooperativism may be among the most realistic, it is not an easy one to follow.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
visibility 2visibility views 2 download downloads 37 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Spain, Brazil, Croatia, SpainOxford University Press (OUP) Lv, Feng-Hua; Cao, Yin-Hong; Liu, Guang-Jian; Luo, Ling-Yun; Lu, Ran; Liu, Ming-Jun; Li, Wen-Rong; Zhou, Ping; Wang, Xin-Hua; Shen, Min; Gao, Lei; Yang, Jing-Quan; Yang, Hua; Yang, Yong-Lin; Liu, Chang-Bin; Wan, Peng-Cheng; Zhang, Yun-Sheng; Pi, Wen-Hui; Ren, Yan-Ling; Shen, Zhi-Qiang; Wang, Feng; Wang, Yu-Tao; Li, Jin-Quan; Salehian-Dehkordi, Hosein; Hehua, Eer; Liu, Yong-Gang; Chen, Jian-Fei; Wang, Jian-Kui; Deng, Xue-Mei; Esmailizadeh, Ali; Dehghani-Qanatqestani, Mostafa; Charati, Hadi; Nosrati, Maryam; Štěpánek, Ondřej; Rushdi, Hossam E.; Olsaker, Ingrid; Curik, Ino; Gorkhali, Neena A.; Paiva, Samuel R.; Caetano, Alexandre R.; Ciani, Elena; Amills, Marcel; Weimann, Christina; Erhardt, Georg; Amane, Agraw; Mwacharo, Joram M.; Han, Jian-Lin; Hanotte, Olivier; Periasamy, Kathiravan; Johansson, Anna M.; Hallsson, Jón H.; Kantanen, Juha; Coltman, David W.; Bruford, Michael W.; Lenstra, Johannes A.; Li, Meng-Hua; Nowick, Katja;Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but their genome landscapes remain understudied. Here, we present a comprehensive genome resource for wild ovine species, landraces and improved breeds of domestic sheep, comprising high-coverage (∼16.10×) whole genomes of 810 samples from 7 wild species and 158 diverse domestic populations. We detected, in total, ∼121.2 million single nucleotide polymorphisms, ∼61 million of which are novel. Some display significant (P < 0.001) differences in frequency between wild and domestic species, or are private to continent-wide or individual sheep populations. Retained or introgressed wild gene variants in domestic populations have contributed to local adaptation, such as the variation in the HBB associated with plateau adaptation. We identified novel and previously reported targets of selection on morphological and agronomic traits such as stature, horn, tail configuration, and wool fineness. We explored the genetic basis of wool fineness and unveiled a novel mutation (chr25: T7,068,586C) in the 3′-UTR of IRF2BP2 as plausible causal variant for fleece fiber diameter. We reconstructed prehistorical migrations from the Near Eastern domestication center to South-and-Southeast Asia and found two main waves of migrations across the Eurasian Steppe and the Iranian Plateau in the Early and Late Bronze Ages. Our findings refine our understanding of genome variation as shaped by continental migrations, introgression, adaptation, and selection of sheep. This study was financially supported by grants from the National Natural Science Foundation of China (Nos. 32061133010, 31825024, 31661143014, and 31972527), the National Key Research and Development Program-Key Projects of International Innovation Cooperation between Governments (2017YFE0117900), the External Cooperation Program of Chinese Academy of Sciences (152111KYSB20150010), and the Second Tibetan Plateau Scientific Expedition and Research Program (STEP) (No. 2019QZKK0501), and the Special Funds of the State Key Laboratory of Sheep Genetic Improvement and Healthy Production (Nos. 2018CA001, and 2019CA009, 2020CA001). Peer reviewed
CORE (RIOXX-UK Aggre... arrow_drop_down Diposit Digital de Documents de la UABArticle . 2021Data sources: Diposit Digital de Documents de la UABRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022Molecular Biology and Evolution; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu34 citations 34 popularity Top 1% influence Average impulse Top 10% Powered by BIP!
visibility 27visibility views 27 download downloads 112 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Diposit Digital de Documents de la UABArticle . 2021Data sources: Diposit Digital de Documents de la UABRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022Molecular Biology and Evolution; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United Kingdom, NorwayEuropean Respiratory Society (ERS) CIHR, WT | ISARIC, ARC | ARC Centres of Excellence... +4 projectsCIHR ,WT| ISARIC ,ARC| ARC Centres of Excellence - Grant ID: CE170100009 ,EC| RECoVER ,UKRI| ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C) ,EC| ECRAID-Base ,WT| Understanding cross-reactive immunity to Japanese encephalitis virusReyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban; Irvine, Mike; Merson, Laura; Martin-Loeches, Ignacio; Rello, Jordi; Taccone, Fabio S.; Fowler, Robert A.; Docherty, Annemarie B.; Kartsonaki, Christiana; Aragao, Irene; Barrett, Peter W.; Beane, Abigail; Burrell, Aidan J.C.; Cheng, Matthew Pellan; Christian, Michael D.; Cidade, Jose Pedro; Citarella, Barbara Wanjiru; Donnelly, Christl A.; Fernandes, Susana M.; French, Craig; Haniffa, Rashan; Harrison, Ewen M.; Ho, Antonia Ying Wai; Joseph, Mark; Khan, Irfan Ahmad; Kho, Michelle E.; Kildal, Anders Benjamin; Kutsogiannis, Demetrios; Lamontagne, François; Lee, Todd C.; Bassi, Gianluigi Li; Revilla, Jose Wagner Lopez; Marquis, Catherine; Millar, Jonathan; Neto, Raul; Nichol, Alistair; Parke, Rachael; Pereira, Rui; Poli, Sergio; Povoa, Pedro; Ramanathan, Kollengode; Rewa, Oleksa; Riera, Jordi; Shrapnel, Sally; Silva, Maria Joao; Udy, Andrew; Uyeki, Timothy; Webb, Steve A.; Wils, Evert-Jan; Rojek, Amanda; Olliaro, Piero L.;Respiratory infections and tuberculosis Infecciones respiratorias y tuberculosis Infeccions respiratòries i tuberculosi Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained in critical care. The clinical characteristics and the relative impact of caring for severe COVID-19 patients outside the ICU is unknown. This was a multinational, multicentre, prospective cohort study embedded in the International Severe Acute Respiratory and Emerging Infection Consortium World Health Organization COVID-19 platform. Severe COVID-19 patients were identified as those admitted to an ICU and/or those treated with one of the following treatments: invasive or noninvasive mechanical ventilation, high-flow nasal cannula, inotropes or vasopressors. A logistic generalised additive model was used to compare clinical outcomes among patients admitted or not to the ICU. A total of 40 440 patients from 43 countries and six continents were included in this analysis. Severe COVID-19 patients were frequently male (62.9%), older adults (median (interquartile range (IQR), 67 (55–78) years), and with at least one comorbidity (63.2%). The overall median (IQR) length of hospital stay was 10 (5–19) days and was longer in patients admitted to an ICU than in those who were cared for outside the ICU (12 (6–23) days versus 8 (4–15) days, p<0.0001). The 28-day fatality ratio was lower in ICU-admitted patients (30.7% (5797 out of 18 831) versus 39.0% (7532 out of 19 295), p<0.0001). Patients admitted to an ICU had a significantly lower probability of death than those who were not (adjusted OR 0.70, 95% CI 0.65–0.75; p<0.0001). Patients with severe COVID-19 admitted to an ICU had significantly lower 28-day fatality ratio than those cared for outside an ICU. This work was supported by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z), the Bill and Melinda Gates Foundation (OPP1209135), Canadian Institutes of Health Research Coronavirus Rapid Research Funding Opportunity OV2170359, grants from Rapid European COVID-19 Emergency Response Research (Horizon 2020 project 101003589), the European Clinical Research Alliance on Infectious Diseases (965313), The Imperial National Institute for Health Research (NIHR) Biomedical Research Centre, and The Cambridge NIHR Biomedical Research Centre; and endorsed by the Irish Critical Care Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland (CTN-2014-12). Data and Material provision was supported by grants from: the NIHR (award CO-CIN-01), the Medical Research Council (grant MC_PC_19059), the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE) (award 200907), Wellcome Trust (Turtle, Lance-fellowship 205228/Z/16/Z), NIHR HPRU in Respiratory Infections at Imperial College London with PHE (award 200927), Liverpool Experimental Cancer Medicine Centre (grant C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (award IS-BRC-1215-20013), and NIHR Clinical Research Network providing infrastructure support. This work was by Research Council of Norway grant number 312780, and a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner.
ERJ Open Research arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2021Data sources: Spiral - Imperial College Digital RepositoryOxford University Research Archive; ERJ Open ResearchOther literature type . Article . 2021 . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1183/23120541.00552-2021&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu30 citations 30 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
visibility 4visibility views 4 download downloads 10 Powered bymore_vert ERJ Open Research arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2021Data sources: Spiral - Imperial College Digital RepositoryOxford University Research Archive; ERJ Open ResearchOther literature type . Article . 2021 . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1183/23120541.00552-2021&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Italy, Netherlands, Belgium, Netherlands, Spain, Germany, Belgium, Netherlands, NetherlandsWiley Global Brain Health Institute, EC | ADAPTED, CIHR +5 projectsGlobal Brain Health Institute ,EC| ADAPTED ,CIHR ,NHMRC| E-DADS: Early Detection of Alzheimer’s Disease Subtypes ,EC| MEDIT-AGEING ,EC| EMIF ,NHMRC| Imaging, fluid and genetic markers of Alzheimer's disease ,NIH| Alzheimers Disease Neuroimaging InitiativeJanssen, Olin; Jansen, Willemijn J; Epelbaum, Stéphane; Lleó, Alberto; Engelborghs, Sebastiaan; van der Flier, Wiesje M; Landau, Susan; Popp, Julius; Wallin, Anders; Scheltens, Philip; Rikkert, Marcel Olde; Snyder, Peter J; Vos, Stephanie J B; Rowe, Chris; Chételat, Gaël; Ruíz, Agustin; Marquié, Marta; Chipi, Elena; Wolfsgruber, Steffen; Heneka, Michael; Boecker, Henning; Peters, Oliver; Jarholm, Jonas; Boada, Merce; Rami, Lorena; Tort-Merino, Adrià; Binette, Alexa Pichet; Poirier, Judes; Rosa-Neto, Pedro; Cerman, Jiri; Dubois, Bruno; Teichmann, Marc; Alcolea, Daniel; Fortea, Juan; Parnetti, Lucilla; Sánchez-Saudinós, M Belén; Ebenau, Jarith; Pocnet, Cornelia; Eckerström, Marie; Thompson, Louisa; Villemagne, Victor; Buckley, Rachel; Burnham, Samantha; Delarue, Marion; Freund-Levi, Yvonne; Gabryelewicz, Tomasz; Wallin, Åsa K; Ramakers, Inez; Tsolaki, Magda; Soininen, Hilkka; Hampel, Harald; Spiru, Luiza; Initiative, Alzheimer's Disease Neuroimaging; group, FACEHBI study; group, PREVENT-AD research; Tijms, Betty; Fladby, Tormod; Ossenkoppele, Rik; Verhey, Frans R J; Jessen, Frank; Visser, Pieter Jelle; Molinuevo, José Luis; Villeneuve, Sylvia; Hort, Jakub;AbstractIntroductionThe evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited.MethodsIn 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD‐specific characteristics (informant confirmation, domain‐specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity.ResultsBetween cohorts, amyloid positivity in 70‐year‐olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant‐confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages.DiscussionNext to age, setting, and APOE ε4 carriership, SCD‐specific characteristics may facilitate the identification of amyloid‐positive individuals.
NARCIS; Alzheimer s ... arrow_drop_down NARCIS; Alzheimer s & DementiaArticle . 2022Recolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAVrije Universiteit Brussel Research PortalOther literature type . 2022Data sources: Vrije Universiteit Brussel Research PortalDiposit Digital de Documents de la UABArticle . 2022Data sources: Diposit Digital de Documents de la UABadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert NARCIS; Alzheimer s ... arrow_drop_down NARCIS; Alzheimer s & DementiaArticle . 2022Recolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAVrije Universiteit Brussel Research PortalOther literature type . 2022Data sources: Vrije Universiteit Brussel Research PortalDiposit Digital de Documents de la UABArticle . 2022Data sources: Diposit Digital de Documents de la UABadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/alz.12512&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Denmark, SpainElsevier BV Gemma Chiva-Blanch; Vibeke Bratseth; Kristian Laake; Harald Arnesen; Svein Solheim; Erik Berg Schmidt; Lina Badimon; Ingebjørg Seljeflot;pmid: 34742136
Altres ajuts: Stein Erik Hagens Foundation of Clinical Heart Research, Oslo, Norway. Background & aims: Circulating microvesicles (cMV) are both effectors and biomarkers of cardiovascular disease (CVD), and the effects of omega 3 polyunsaturated fatty acids (n3 PUFA) in MV shedding are not yet well known. Therefore, we aimed to investigate the effects of long-term n3 PUFA supplementation on cMV release from cells of the vascular compartment in elderly subjects at very high risk of CVD. Methods: We included 156 elderly patients 2-8 weeks after suffering an acute myocardial infarction from the OMEMI cohort. Subjects were randomly allocated to receive 930 mg EPA + 660 mg DHA (n3 PUFA intervention) or corn oil (56% linoleic acid, 32% oleic acid, 10% palmitic acid) used as placebo daily for two years. At inclusion and after one-year follow-up, prothrombotic [annexin V (AV)] cMV derived from blood and vascular cells were phenotyped by flow cytometry. Results: No differences were observed in the levels of cMV between the randomized groups at inclusion in the study. After one-year follow-up, total AV, platelet-derived CD61/AV, and endothelial-derived CD31/AV and CD31/CD42b/AV cMV increased significantly in both groups. In the n3 PUFA supplemented group, platelet-derived CD62P/AV, CD42b/AV and CD31/CD42b/AV; leukocyte-derived CD62L/AV, CD45/AV, and CD11b/AV, as well as endothelial derived CD146/AV, CD62E/AV, and CD309/AV cMV also increased significantly. No significant differences were however, observed in the changes of cMV levels between groups. Conclusion: In elderly Norwegians who have suffered a recent acute myocardial infarction and treated as per guidelines, long-term supplementation with 1.8 g/day n3 PUFA does not modulate prothrombotic MV release from blood and vascular cells. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01841944.