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59 research outcomes, page 1 of 6
  • publication . Article . 2021
    Open Access English
    Authors:
    Clarisse Uwizeye; Johan Decelle; Pierre-Henri Jouneau; Serena Flori; Benoit Gallet; Jean-Baptiste Keck; Davide Dal Bo; Christine Moriscot; Claire Seydoux; Fabien Chevalier; ...
    Publisher: HAL CCSD
    Project: EC | ChloroMito (833184), ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | CORBEL (654248), ANR | MoMix (ANR-17-CE05-0029)

    Nature Communications, 12 (1)

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  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Uwizeye Clarisse; Mars Brisbin Margaret; Gallet Benoit; Chevalier Fabien; LeKieffre Charlotte; Schieber L. Nicole; Falconet Denis; Wangpraseurt Daniel; Schertel Lukas; Stryhanyuk Hryhoriy; ...
    Publisher: HAL CCSD
    Project: EC | CORBEL (654248), EC | ChloroMito (833184)

    Endosymbioses have shaped the evolutionary trajectory of life and remain ecologically important. Investigating oceanic photosymbioses can illuminate how algal endosymbionts are energetically exploited by their heterotrophic hosts and inform on putative initial steps of ...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Agathe Marcelot; Ambre Petitalot; Virginie Ropars; Marie-Hélène Le Du; Camille Samson; Stevens Dubois; Guillaume Hoffmann; Simona Miron; Philippe Cuniasse; Jose Antonio Marquez; ...
    Publisher: HAL CCSD
    Project: EC | iNEXT-Discovery (871037), EC | iNEXT (653706)

    Barrier-to-autointegration factor (BAF), encoded by the BANF1 gene, is an abundant and ubiquitously expressed metazoan protein that has multiple functions during the cell cycle. Through its ability to cross-bridge two double-stranded DNA (dsDNA), it favours chromosome c...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Matthew Jessop; Clarissa Liesche; Jan Felix; Ambroise Desfosses; Megghane Baulard; Virgile Adam; Angélique Fraudeau; Karine Huard; Gregory Effantin; Jean-Philippe Kleman; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | Chap4Resp (647784), EC | RespViRALI (789385)

    Pathogenic and commensal bacteria often have to resist the harsh acidity of the host stomach. The inducible lysine decarboxylase LdcI buffers the cytosol and the local extracellular environment to ensure enterobacterial survival at low pH. Here, we investigate the acid ...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Marco Schiavina; Edoardo Salladini; Maria Grazia Murrali; Giancarlo Tria; Isabella C. Felli; Roberta Pierattelli; Sonia Longhi;
    Persistent Identifiers
    Publisher: Nature Publishing Group UK
    Project: EC | iNEXT (653706)

    International audience; Using SAXS and NMR spectroscopy, we herein provide a high-resolution description of the intrinsically disordered N-terminal domain (PNT, aa 1-406) shared by the Nipah virus (NiV) phosphoprotein (P) and V protein, two key players in viral genome r...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Pauline Maisonnasse; Jeremie Guedj; Vanessa Contreras; Sylvie Behillil; Caroline Solas; Romain Marlin; Thibaut Naninck; Andrés Pizzorno; Julien Lemaitre; Antonio Gonçalves; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | IDMIT (ANR-11-INBS-0008), EC | Fight-nCoV (101003555), EC | EVAg (653316), EC | TRANSVAC2 (730964)

    International audience; Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic and no antiviral drug or vaccine is yet available for the treatment of this disease1-3. Several clinical studies are ongoing to evaluate the efficacy of repurposed drugs tha...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Simon G. P. Funnell; W. E. Dowling; César Muñoz-Fontela; Pierre Stéphane Gsell; Donald E. Ingber; G. A. Hamilton; Leen Delang; Joana Rocha-Pereira; Suzanne J. F. Kaptein; K. H. Dallmeier; ...
    Persistent Identifiers
    Publisher: Nature Publishing Group UK
    Project: EC | EVAg (653316), ANR | IDMIT (ANR-11-INBS-0008), NIH | Lung-on-a-Chip Disease Mo... (1UG3HL141797-01), EC | TRANSVAC2 (730964)

    International audience; There is an urgent need for drugs, therapies and vaccines to be available to protect the human population against COVID-19. One of the first approaches taken in the COVID-19 global response was to consider repurposing licensed drugs. This comment...

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Aldo R. Camacho-Zarco; Sissy Kalayil; Damien Maurin; Nicola Salvi; Elise Delaforge; Sigrid Milles; Malene Ringkjøbing Jensen; Darren J. Hart; Stephen Cusack; Martin Blackledge;
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | AvINFLUENZA (796490)

    Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. Here, the authors use NMR spectroscopy and quantitative ensemble modelling to describe the highly dynamic assemblies formed by the human-adapted or avian-adapted C-ter...

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Nicolas Flaugnatti; Chiara Rapisarda; Martial Rey; Solène G Beauvois; Viet Anh Nguyen; Stéphane Canaan; Eric Durand; Julia Chamot-Rooke; Eric Cascales; Rémi Fronzes; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706)

    International audience; The bacterial type VI secretion system (T6SS) is a macromolecular machine that injects effectors into prokaryotic and eukaryotic cells. The mode of action of the T6SS is similar to contractile phages: the contraction of a sheath structure pushes ...

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  • publication . Article . 2020
    English
    Authors:
    Swale, Christopher; Da Costa, Bruno; Sedano, Laura; Garzoni, Frederic; McCarthy, Andrew; Berger, Imre; Bieniossek, Christoph; Ruigrok, Rob W H; Delmas, Bernard; Crépin, Thibaut;
    Publisher: HAL CCSD
    Project: EC | COMPLEXINC (279039)

    International audience; Here, we describe the crystal structures of two distinct isoforms of ligand-free human karyopherin RanBP5 and investigate its global propensity to interact with influenza A virus polymerase. Our results confirm the general architecture and mechan...

59 research outcomes, page 1 of 6