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5 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Katherine V. Houser; Lisa M. Gretebeck; Tianlei Ying; Yanping Wang; Leatrice Vogel; Elaine W. Lamirande; Kevin W. Bock; Ian N. Moore; Dimiter S. Dimitrov; Kanta Subbarao;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclon...

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  • publication . Article . 2012
    Open Access English
    Authors:
    Silke Niemann; Christina Ehrhardt; Eva Medina; Kathrin Warnking; Lorena Tuchscherr; Vanessa Heitmann; Stephan Ludwig; Georg Peters; Bettina Löffler;
    Persistent Identifiers
    Publisher: Oxford University Press

    Staphylococcus aureus necrotizing pneumonia is a life-threatening disease that is frequently preceded by influenza infection. The S. aureus toxin Panton–Valentine leukocidin (PVL) is most likely causative for necrotizing diseases, but the precise pathogenic mechanisms o...

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  • publication . Article . Other literature type . 2011
    Open Access
    Authors:
    Mike Bray; James V. Lawler; Jason Paragas; Peter B. Jahrling; Daniel J. Mollura;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Research on the pathogenesis and therapy of influenza and other emerging respiratory viral infections would be aided by methods that directly visualize pathophysiologic processes in patients and laboratory animals. At present, imaging of diseases, such as swine-origin H...

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  • publication . Article . 2007
    Open Access English
    Authors:
    Miriam E. R. Darnell; Ewan P. Plant; Hisayoshi Watanabe; Russ Byrum; Marisa St. Claire; Jerrold M. Ward; Deborah R. Taylor;
    Persistent Identifiers
    Publisher: The University of Chicago Press

    Abstract Background. Development of vaccines to prevent severe acute respiratory syndrome (SARS) is limited by the lack of well-characterized animal models. Previous vaccine reports have noted robust neutralizing antibody and inflammatory responses in ferrets, resulting...

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  • publication . Article . 2006
    Open Access
    Authors:
    Zhaochun Chen; Mahtab Moayeri; Yi-Hua Zhou; Stephen H. Leppla; Suzanne U. Emerson; Andrew Sebrell; Fujuan Yu; Juraj Svitel; Peter Schuck; Marisa St. Claire; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: NIH | CARE AND HOUSING OF HEPAT... (N01AO002733-002)

    Abstract Four single-chain variable fragments (scFvs) against protective antigen (PA) and 2 scFvs against lethal factor (LF) of anthrax were isolated from a phage display library generated from immunized chimpanzees. Only 2 scFvs recognizing PA (W1 and W2) neutralized t...

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5 research outcomes, page 1 of 1