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121 research outcomes, page 1 of 13
  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Alqabandi, Maryam; de Franceschi, Nicola; Miguet, Nolwenn; Maity, Sourav; Bally, Marta; Roos, Wouter H.; Weissenhorn, Winfried; Bassereau, Patricia; Mangenot, Stéphanie;
    Publisher: Cold Spring Harbor Laboratory
    Project: ANR | ESCRTfission (ANR-14-CE09-0003), EC | INTERACT (751404), EC | ESCRT model (751715), ANR | PSL (ANR-10-IDEX-0001), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Preprint . 2021
    Open Access English
    Authors:
    Zullino, Sara; Paglialonga, Alessandro; Dastrù, Walter; Longo, Dario Livio; Aime, Silvio;
    Project: EC | CORBEL (654248), EC | GLINT (667510), EC | EOSC-Life (824087)

    Molecular imaging generates large volumes of heterogeneous biomedical imagery with an impelling need of guidelines for handling image data. Although several successful solutions have been implemented for human epidemiologic studies, few and limited approaches have been ...

  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Edvardas Golovinas; Danielis Rutkauskas; Elena Manakova; Marija Jankunec; Arunas Silanskas; Giedrius Sasnauskas; Mindaugas Zaremba;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | iNEXT (653706)

    AbstractArgonaute (Ago) proteins are found in all three domains of life. The best-characterized group is eukaryotic Argonautes (eAgos), which are the core of RNA interference. The best understood prokaryotic Ago (pAgo) proteins are full-length pAgos. They are composed o...

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  • publication . Other literature type . Article . Preprint . 2021
    Open Access
    Authors:
    Juraszek, Jarek; Rutten, Lucy; Blokland, Sven; Bouchier, Pascale; Voorzaat, Richard; Ritschel, Tina; Bakkers, Mark J. G.; Renault, Ludovic L. R.; Langedijk, Johannes P. M.;
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | INSTRUCT-ULTRA (731005)

    SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominan...

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  • publication . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Eleftherios Zarkadas; Hong Zhang; Wensheng Cai; Gregory Effantin; Jonathan Perot; Jacques Neyton; Christophe Chipot; Guy Schoehn; François Dehez; Hugues Nury;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | PentaBrain (637733)

    Inaccurately perceived as niche drugs, antiemetics are key elements of cancer treatment alleviating the most dreaded side effect of chemotherapy. Serotonin 5-HT3 receptor antagonists are the most commonly prescribed class of drugs to control chemotherapy-induced nausea ...

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  • publication . Article . Preprint . 2021
    Open Access
    Authors:
    Christophe Caillat; Delphine Guilligay; Johana Torralba; Nikolas Friedrich; Jose L Nieva; Alexandra Trkola; Christophe J Chipot; François L Dehez; Winfried Weissenhorn;
    Persistent Identifiers
    Publisher: eLife Sciences Publications, Ltd
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | EAVI2020 (681137)

    The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate state by an MPER-specific neutralizing antib...

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  • publication . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Lynda Djerbal; Romain R. Vivès; Chrystel Lopin-Bon; Ralf P. Richter; Jessica C. F. Kwok; Hugues Lortat-Jacob;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    ABSTRACTSemaphorin 3A (Sema3A) is a secreted protein that signals to cells through binding to neuropilin and plexin receptors and provides neurons with guidance cues key for axon pathfinding, and also controls cell migration in several other biological systems. Sema3A i...

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  • publication . Contribution for newspaper or weekly magazine . Preprint . Conference object . 2020
    Open Access English
    Authors:
    Arne Köhn; Julia Wichlacz; Álvaro Torralba; Daniel Höller; Jörg Hoffmann; Alexander Koller;
    Persistent Identifiers
    Publisher: International Committee on Computational Linguistics

    Comment: Accepted COLING 2020 long paper

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Melero, Roberto; Sorzano, Carlos Oscar S.; Foster, Brent; Vilas, José-Luis; Martínez, Marta; Marabini, Roberto; Ramírez-Aportela, Erney; Sanchez-Garcia, Ruben; Herreros, David; del Caño, Laura; ...
    Project: EC | IMpaCT (857203), EC | INSTRUCT-ULTRA (731005), EC | HighResCells (810057), EC | CORBEL (654248), EC | EOSC-Life (824087), EC | EOSC-synergy (857647)

    Peer reviewed

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Sorzano, C.O.S.; de Isidro-Gómez, F.; Fernández-Giménez, E.; Herreros, D.; Marco, S.; Carazo, J.M.; Messaoudi, C.;
    Persistent Identifiers
    Publisher: Elsevier
    Project: EC | iNEXT-Discovery (871037), EC | INSTRUCT-ULTRA (731005), EC | HighResCells (810057), EC | IMpaCT (857203), EC | CORBEL (654248), EC | EOSC-Life (824087), EC | EOSC-synergy (857647)

    We thank financial support from the Spanish Ministry of Economy and Competitiveness through Grants BIO2016-76400-R(AEI/FEDER, UE), the “Comunidad Autónoma de Madrid” through Grant: S2017/BMD-3817, Instituto de Salud Carlos III, PT17/0009/0010 (ISCIII-SGEFI/ERDF), Europe...

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121 research outcomes, page 1 of 13