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376 research outcomes, page 1 of 38
  • publication . Article . Other literature type . Preprint . 2021
    Open Access English
    Authors:
    Maryam Alqabandi; N. de Franceschi; Nolwenn Miguet; Sourav Maity; Marta Bally; Wouter H. Roos; Winfried Weissenhorn; Patricia Bassereau; Stéphanie Mangenot;
    Project: ANR | PSL (ANR-10-IDEX-0001), EC | ESCRT model (751715), ANR | ESCRTfission (ANR-14-CE09-0003), EC | INTERACT (751404), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Article . Other literature type . 2021
    Open Access English
    Authors:
    Sergi López-Serrano; Lorena Cordoba; Mónica Pérez-Maillo; Patricia Pleguezuelos; Edmond J. Remarque; Thomas Ebensen; Carlos A. Guzmán; Dennis Christensen; Joaquim Segalés; Ayub Darji;
    Persistent Identifiers
    Publisher: MDPI
    Project: EC | TRANSVAC2 (730964)

    This study aimed to evaluate the immune response and protection correlates against influenza virus (IV) infection in pigs vaccinated with the novel NG34 HA1 vaccine candidate adjuvanted with either CAF®01 or CDA/αGalCerMPEG (αGCM). Two groups of six pigs each were vacci...

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  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Uwizeye Clarisse; Mars Brisbin Margaret; Gallet Benoit; Chevalier Fabien; LeKieffre Charlotte; Schieber L. Nicole; Falconet Denis; Wangpraseurt Daniel; Schertel Lukas; Stryhanyuk Hryhoriy; ...
    Publisher: HAL CCSD
    Project: EC | CORBEL (654248), EC | ChloroMito (833184)

    Endosymbioses have shaped the evolutionary trajectory of life and remain ecologically important. Investigating oceanic photosymbioses can illuminate how algal endosymbionts are energetically exploited by their heterotrophic hosts and inform on putative initial steps of ...

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  • publication . Preprint . 2021
    Open Access English
    Authors:
    Zullino, Sara; Paglialonga, Alessandro; Dastrù, Walter; Longo, Dario Livio; Aime, Silvio;
    Project: EC | CORBEL (654248), EC | GLINT (667510), EC | EOSC-Life (824087)

    Molecular imaging generates large volumes of heterogeneous biomedical imagery with an impelling need of guidelines for handling image data. Although several successful solutions have been implemented for human epidemiologic studies, few and limited approaches have been ...

  • publication . Article . Other literature type . 2021
    Open Access English
    Authors:
    Begoña Alburquerque-González; Ángel Bernabé-García; Manuel Bernabé-García; Javier Ruiz-Sanz; Fernando Feliciano López-Calderón; Leonardo Gonnelli; Lucia Banci; Jorge Peña-García; Irene Luque; Francisco José Nicolás; ...
    Persistent Identifiers
    Publisher: MDPI AG
    Project: EC | CORBEL (654248)

    Fundación Seneca 20988/PI/18 20646/JLI/18

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  • publication . Article . Preprint . 2021
    Open Access
    Authors:
    Golovinas, Edvardas; Rutkauskas, Danielis; Manakova, Elena; Jankunec, Marija; Silanskas, Arunas; Sasnauskas, Giedrius; Zaremba, Mindaugas;
    Publisher: Springer Science and Business Media LLC
    Project: EC | iNEXT (653706)

    ABSTRACTBackgroundArgonaute (Ago) proteins are found in all three domains of life. The best characterized group is eukaryotic Argonautes (eAgos), which are the core of RNA interference. The best understood prokaryotic Ago (pAgo) proteins are full-length pAgos. They are ...

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  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Jarek Juraszek; Lucy Rutten; Sven Blokland; Pascale Bouchier; Richard Voorzaat; Tina Ritschel; Mark J G Bakkers; Ludovic Renault; Johannes P. M. Langedijk;
    Publisher: Nature Publishing Group UK
    Project: EC | INSTRUCT-ULTRA (731005)

    SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominan...

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  • publication . Preprint . 2021
    Open Access English
    Authors:
    Eleftherios Zarkadas; Hong Zhang; Wensheng Cai; Gregory Effantin; Jonathan Perot; Jacques Neyton; Christophe Chipot; Guy Schoehn; François Dehez; Hugues Nury;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | PentaBrain (637733), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Inaccurately perceived as niche drugs, antiemetics are key elements of cancer treatment alleviating the most dreaded side effect of chemotherapy. Serotonin 5-HT3 receptor antagonists are the most commonly prescribed class of drugs to control chemotherapy-induced nausea ...

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  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Christophe Caillat; Guilligay D; Torralba J; Nikolas Friedrich; Nieva Jl; Alexandra Trkola; Chris Chipot; François Dehez; Winfried Weissenhorn;
    Publisher: eLife Sciences
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | EAVI2020 (681137)

    The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate state by an MPER-specific neutralizing antib...

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  • publication . Preprint . Article . 2021
    Open Access
    Authors:
    Erik I. Hallin; Sigurbjorn Markusson; Lev Bottger; Andrew E. Torda; Clive R. Bramham; Petri Kursula;
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | iNEXT (653706), EC | CALIPSOplus (730872)

    Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated protein (Arc). Mammalian Arc forms virus-like capsid structures in a process requi...

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376 research outcomes, page 1 of 38