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117 research outcomes, page 1 of 12
  • publication . Article . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Maryam Alqabandi; N. de Franceschi; Nolwenn Miguet; Sourav Maity; Marta Bally; Wouter H. Roos; Winfried Weissenhorn; Patricia Bassereau; Stéphanie Mangenot;
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | INTERACT (751404), ANR | ESCRTfission (ANR-14-CE09-0003), ANR | PSL (ANR-10-IDEX-0001), EC | ESCRT model (751715)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Article . 2021
    Open Access
    Authors:
    Michel P.M. Vierboom; Karin Dijkman; Claudia C. Sombroek; Sam O. Hofman; Charelle Boot; Richard A.W. Vervenne; Krista G. Haanstra; Maarten van der Sande; Liesbeth van Emst; Jorge Domínguez-Andrés; ...
    Persistent Identifiers
    Project: EC | TRANSVAC2 (730964), EC | TBVAC2020 (643381)

    Graphical Abstract

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  • publication . Article . Preprint . Other literature type . 2020
    Open Access
    Authors:
    Alexander F Schubert; Justine V Nguyen; Tyler G Franklin; Paul P. Geurink; Cameron G Roberts; Daniel J. Sanderson; Lauren N. Miller; Huib Ovaa; Kay Hofmann; Jonathan N. Pruneda; ...
    Publisher: EMBO
    Project: NIH | Program in Molecular and ... (5T32GM071338-10), EC | UbiArchitect (724804), NWO | Covalent Enzyme Capture (2300182105), EC | BIOSTRUCT-X (283570)

    Prediction and validation of pathogenic bacterial DUBs and insights into their structures and (poly)ubiquitin linkage specificities allows for first cross‐kingdom comparison of the OTU deubiquitination enzyme fold.

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  • publication . Article . 2020
    Open Access
    Authors:
    Rhythm Shukla; João Medeiros-Silva; Anish Parmar; Bram J. A. Vermeulen; Sanjit Das; Alessandra Lucini Paioni; Shehrazade Jekhmane; Joseph H. Lorent; Alexandre M. J. J. Bonvin; Marc Baldus; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: EC | BioExcel-2 (823830), NWO | An ultra-high field NMR f... (2300171444), NWO | Membrane proteins at work... (2300154435), NWO | Towards in-situ structura... (2300163571), EC | BioExcel (675728), EC | iNEXT (653706)

    The natural antibiotic teixobactin kills pathogenic bacteria without detectable resistance. The difficult synthesis and unfavourable solubility of teixobactin require modifications, yet insufficient knowledge on its binding mode impedes the hunt for superior analogues. ...

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  • publication . Article . 2020
    Open Access
    Authors:
    Ditmer T. Talsma; Felix Poppelaars; Wendy Dam; Anita H. Meter-Arkema; Romain R. Vivès; Peter Gál; Geert-Jan Boons; Geert-Jan Boons; Pradeep Chopra; Annamaria Naggi; ...
    Publisher: Frontiers Media SA

    It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system. Therefore, we evaluated a libra...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Pascal Albanese; Sem Tamara; Guido Saracco; Richard A. Scheltema; Cristina Pagliano;
    Persistent Identifiers
    Project: EC | EPIC-XS (823839), NWO | Proteins@Work; A large-sc... (2300171290)

    Grana are a characteristic feature of higher plants’ thylakoid membranes, consisting of stacks of appressed membranes enriched in Photosystem II (PSII) and associated light-harvesting complex II (LHCII) proteins, together forming the PSII-LHCII supercomplex. Grana stack...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Ila van Kruijsbergen; Monique P. C. Mulder; Michael Uckelmann; Tibor van Welsem; John de Widt; Aldo Spanjaard; Heinz Jacobs; Farid El Oualid; Huib Ovaa; Fred van Leeuwen;
    Persistent Identifiers
    Project: NWO | Commercial development of... (2300180757)

    Protein ubiquitination is a key post-translational modification regulating a wide range of biological processes. Ubiquitination involves the covalent attachment of the small protein ubiquitin to a lysine of a protein substrate. In addition to its well-established role i...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Frank Møller Aarestrup; A. Albeyatti; W. J. Armitage; Charles Auffray; L. Augello; Rudi Balling; N. Benhabiles; G. Bertolini; Jan G. Bjaalie; Michaela Black; ...
    Project: EC | B-CAST (633784), EC | SYSCOL (258236), EC | INSTRUCT-ULTRA (731005), EC | CONNECARE (689802), EC | SYSCID (733100), EC | EMIF (115372), EC | ERA PerMed (779282), EC | E-COMPARED (603098), EC | SYSCLAD (305457), EC | EuroPOND (666992),...

    The European Union (EU) initiative on the Digital Transformation of Health and Care (Digicare) aims to provide the conditions necessary for building a secure, flexible, and decentralized digital health infrastructure. Creating a European Health Research and Innovation C...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Abulikemu Abudukelimu; Abulikemu Abudukelimu; Matteo Barberis; Matteo Barberis; Matteo Barberis; Frank Redegeld; Nilgun Sahin; Raju P. Sharma; Hans V. Westerhoff; Hans V. Westerhoff; ...
    Project: EC | EOSC-Life (824087), EC | SYNPOL (311815), EC | EpiPredict (642691), EC | CORBEL (654248), UKRI | China & the UK: super... (BB/J020060/1)

    We here apply a control analysis and various types of stability analysis to an in silico model of innate immunity that addresses the management of inflammation by a therapeutic peptide. Motivation is the observation, both in silico and in experiments, that this therapy ...

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  • publication . Article . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Mona Seifert; Pauline van Nies; Flavia Stal Papini; Jamie J. Arnold; Minna M. Poranen; Craig E. Cameron; Martin Depken; David Dulin;

    Abstract RNA virus survival depends on efficient viral genome replication, which is performed by the viral RNA dependent RNA polymerase (RdRp). The recent development of high throughput magnetic tweezers has enabled the simultaneous observation of dozens of viral RdRp e...

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117 research outcomes, page 1 of 12