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17 research outcomes, page 1 of 2
  • publication . Article . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Maryam Alqabandi; N. de Franceschi; Nolwenn Miguet; Sourav Maity; Marta Bally; Wouter H. Roos; Winfried Weissenhorn; Patricia Bassereau; Stéphanie Mangenot;
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | INTERACT (751404), ANR | ESCRTfission (ANR-14-CE09-0003), ANR | PSL (ANR-10-IDEX-0001), EC | ESCRT model (751715)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Article . 2020
    Open Access
    Authors:
    Ditmer T. Talsma; Felix Poppelaars; Wendy Dam; Anita H. Meter-Arkema; Romain R. Vivès; Peter Gál; Geert-Jan Boons; Geert-Jan Boons; Pradeep Chopra; Annamaria Naggi; ...
    Publisher: Frontiers Media SA

    It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system. Therefore, we evaluated a libra...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Rui Jun Eveline Li; Tim P. Hogervorst; Silvia Achilli; Sven C. M. Bruijns; Tim Arnoldus; Corinne Vivès; Chung C. Wong; Michel Thépaut; Nico J. Meeuwenoord; Hans van den Elst; ...
    Persistent Identifiers
    Publisher: Frontiers Media SA
    Project: EC | IMMUNOSHAPE (642870)

    International audience; Dendritic cells (DCs) are important initiators of adaptive immunity, and they possess a multitude of Pattern Recognition Receptors (PRR) to generate an adequate T cell mediated immunity against invading pathogens. PRR ligands are frequently conju...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Ambroise Desfosses; Hariprasad Venugopal; Tapan Joshi; Jan Felix; Matthew Jessop; Hyengseop Jeong; Jaekyung Hyun; J. Bernard Heymann; Mark R. H. Hurst; Irina Gutsche; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706), EC | Chap4Resp (647784), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    International audience; Contractile injection systems are sophisticated multiprotein nanomachines that puncture target cell membranes. Although the number of atomic-resolution insights into contractile bacteriophage tails, bacterial type six secretion systems and R-pyoc...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Nika M. Strokappe; Miriam Hock; Lucy Rutten; Laura E. McCoy; Jaap W. Back; Christophe Caillat; Matthias Haffke; Robin A Weiss; Winfried Weissenhorn; Theo Verrips;
    Persistent Identifiers
    Publisher: HAL CCSD

    Broad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization. Here we describe the epitopes of three additional VHH groups selected from phage libraries. The...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Carlos Silvestre-Roig; Quinte Braster; Kanin Wichapong; Ernest Y. Lee; Jean Marie Teulon; Nihel Berrebeh; Janine Winter; José M. Adrover; Giancarlo Santiago Santos; Alexander Froese; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | PROVASC (692511), NIH | Medical Scientist Trainin... (5T32GM008042-27), NIH | Dermatology Scientist Tra... (1T32AR071307-01), NIH | NIGMS SYSTEMS AND INTEGRA... (5T32GM008185-05), NIH | Bacterial amyloids: inter... (1R56AI125429-01A1)

    International audience; The perpetuation of inflammation is an important pathophysiological contributor to the global medical burden. Chronic inflammation is promoted by non-programmed cell death1,2; however, how inflammation is instigated, its cellular and molecular me...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Sourav Maity; Christophe Caillat; Nolwenn Miguet; Guidenn Sulbarán; Gregory Effantin; Guy Schoehn; Wouter H. Roos; Winfried Weissenhorn;
    Publisher: HAL CCSD
    Project: EC | INTERACT (751404), ANR | ESCRTfission (ANR-14-CE09-0003)

    VPS4 constricts ESCRT-III CHMP2A-CHMP3.

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  • publication . Article . 2019
    Open Access English
    Authors:
    Johan Decelle; Hryhoriy Stryhanyuk; Benoit Gallet; Giulia Veronesi; Matthias Schmidt; Sergio Balzano; Sophie Marro; Clarisse Uwizeye; Pierre-Henri Jouneau; Josselin Lupette; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | OCEANOMICS (ANR-11-BTBR-0008), EC | MINOTAUR (658442)

    International audience; Photosymbiosis between single-celled hosts and microalgae is common in oceanic plankton, especially in oligotrophic surface waters. However, the functioning of this ecologically important cell-cell interaction and the subcellular mechanisms allow...

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  • publication . Article . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Anne Laure Favier; Olivier Reynard; Evelyne Gout; Martin van Eijk; Henk P. Haagsman; Erika C. Crouch; Viktor E. Volchkov; Christophe N. Peyrefitte; Nicole M. Thielens;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | EBODISREG (ANR-14-EBOL-0002)

    International audience; Since the largest 2014⁻2016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators. Amongst them, collectins are important players in the antiviral inna...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Simona V. Antonova; Matthias Haffke; Eleonora Corradini; Mykolas Mikuciunas; Teck Yew Low; Luca Signor; Robert M. van Es; Kapil Gupta; Elisabeth Scheer; Harmjan R. Vos; ...
    Project: ANR | INRT (ANR-10-LABX-0030), EC | BIRTOACTION (340551), ANR | UNISTRA (ANR-10-IDEX-0002), WT | Unlocking the structure, ... (106115), NWO | Bijvoet Graduate Research... (2300175297), UKRI | BrisSynBio: Bristol Centr... (BB/L01386X/1), NWO | Proteins@Work; A large-sc... (2300171290)

    TFIID is a cornerstone of eukaryotic gene regulation. Distinct TFIID complexes with unique subunit compositions exist and several TFIID subunits are shared with other complexes, thereby conveying precise cellular control of subunit allocation and functional assembly of ...

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17 research outcomes, page 1 of 2