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242 research outcomes, page 1 of 25
  • publication . Article . 2021
    Open Access English
    Authors:
    Clarisse Uwizeye; Johan Decelle; Pierre-Henri Jouneau; Serena Flori; Benoit Gallet; Jean-Baptiste Keck; Davide Dal Bo; Christine Moriscot; Claire Seydoux; Fabien Chevalier; ...
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | ChloroMito (833184), EC | CORBEL (654248), ANR | MoMix (ANR-17-CE05-0029)

    Nature Communications, 12 (1)

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  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Alqabandi, Maryam; de Franceschi, Nicola; Miguet, Nolwenn; Maity, Sourav; Bally, Marta; Roos, Wouter H.; Weissenhorn, Winfried; Bassereau, Patricia; Mangenot, Stéphanie;
    Publisher: Cold Spring Harbor Laboratory
    Project: ANR | ESCRTfission (ANR-14-CE09-0003), EC | INTERACT (751404), EC | ESCRT model (751715), ANR | PSL (ANR-10-IDEX-0001), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Marcelot, Agathe; Petitalot, Ambre; Ropars, Virginie; Le Du, Marie-Hélène; Samson, Camille; Dubois, Stevens; Hoffmann, Guillaume; Miron, Simona; Cuniasse, Philippe; Marquez, Jose Antonio; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | iNEXT-Discovery (871037), EC | iNEXT (653706)

    International audience; Barrier-to-autointegration factor (BAF), encoded by the BANF1 gene, is an abundant and ubiquitously expressed metazoan protein that has multiple functions during the cell cycle. Through its ability to cross-bridge two double-stranded DNA (dsDNA),...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Jan Felix; Claire Siebert; Julia Novion Ducassou; Jérôme Nigou; Pierre Garcia; Angélique Fraudeau; Karine Huard; Caroline Mas; Céline Brochier-Armanet; Yohann Couté; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | RespViRALI (789385)

    AbstractFrancisella tularensis is one of the most virulent pathogenic bacteria causing the acute human respiratory disease tularemia. While the mechanisms underlying F. tularensis pathogenesis are largely unknown, previous studies have shown that a F. novicida transposo...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Matthew Jessop; Clarissa Liesche; Jan Felix; Ambroise Desfosses; Megghane Baulard; Virgile Adam; Angélique Fraudeau; Karine Huard; Gregory Effantin; Jean-Philippe Kleman; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | Chap4Resp (647784), EC | RespViRALI (789385)

    Pathogenic and commensal bacteria often have to resist the harsh acidity of the host stomach. The inducible lysine decarboxylase LdcI buffers the cytosol and the local extracellular environment to ensure enterobacterial survival at low pH. Here, we investigate the acid ...

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  • publication . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Eleftherios Zarkadas; Hong Zhang; Wensheng Cai; Gregory Effantin; Jonathan Perot; Jacques Neyton; Christophe Chipot; Guy Schoehn; François Dehez; Hugues Nury;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | PentaBrain (637733)

    Inaccurately perceived as niche drugs, antiemetics are key elements of cancer treatment alleviating the most dreaded side effect of chemotherapy. Serotonin 5-HT3 receptor antagonists are the most commonly prescribed class of drugs to control chemotherapy-induced nausea ...

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  • publication . Article . Preprint . 2021
    Open Access
    Authors:
    Christophe Caillat; Delphine Guilligay; Johana Torralba; Nikolas Friedrich; Jose L Nieva; Alexandra Trkola; Christophe J Chipot; François L Dehez; Winfried Weissenhorn;
    Persistent Identifiers
    Publisher: eLife Sciences Publications, Ltd
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | EAVI2020 (681137)

    The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate state by an MPER-specific neutralizing antib...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Laurissa Ouaguia; Tania Dufeu-Duchesne; Vincent Leroy; Thomas Decaens; J.-B. Reiser; Eleonora Sosa Cuevas; David Durantel; Jenny Valladeau‐Guilemond; Nathalie Bendriss‐Vermare; Laurence Chaperot; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Abstract Objectives C‐type lectin receptors (CLRs) are key receptors used by DCs to orchestrate responses to pathogens. During infections, the glycan–lectin interactions shape the virus–host interplay and viruses can subvert the function of CLRs to escape antiviral immu...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Romain Linares; Charles-Adrien Arnaud; Séraphine Degroux; Guy Schoehn; Cécile Breyton;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), ANR | PerfoBac (ANR-16-CE11-0027)

    International audience; Bacteriophages, viruses that infect bacteria, are the most abundant biological entities on Earth. Siphophages, accounting for ∼60% of known phages, bear a long, flexible tail that allows host recognition and safe delivery of the DNA from the caps...

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  • publication . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Lynda Djerbal; Romain R. Vivès; Chrystel Lopin-Bon; Ralf P. Richter; Jessica C. F. Kwok; Hugues Lortat-Jacob;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    ABSTRACTSemaphorin 3A (Sema3A) is a secreted protein that signals to cells through binding to neuropilin and plexin receptors and provides neurons with guidance cues key for axon pathfinding, and also controls cell migration in several other biological systems. Sema3A i...

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242 research outcomes, page 1 of 25