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47 research outcomes, page 1 of 5
  • publication . Preprint . Part of book or chapter of book . 2020
    Open Access English
    Authors:
    Mikael Trellet; Gydo C. P. van Zundert; Alexandre M. J. J. Bonvin;
    Persistent Identifiers
    Project: EC | West-Life (675858), EC | BioExcel-2 (823830), EC | BioExcel (675728)

    Comment: 28 pages including 7 figures

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  • publication . Article . 2020
    Open Access English
    Authors:
    Pascal Albanese; Sem Tamara; Guido Saracco; Richard A. Scheltema; Cristina Pagliano;
    Persistent Identifiers
    Publisher: Nature Publishing Group
    Project: EC | EPIC-XS (823839), NWO | Proteins@Work; A large-sc... (2300171290)

    Grana are a characteristic feature of higher plants’ thylakoid membranes, consisting of stacks of appressed membranes enriched in Photosystem II (PSII) and associated light-harvesting complex II (LHCII) proteins, together forming the PSII-LHCII supercomplex. Grana stack...

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  • publication . Article . 2020
    Open Access
    Authors:
    Abulikemu Abudukelimu; Abulikemu Abudukelimu; Matteo Barberis; Matteo Barberis; Matteo Barberis; Frank Redegeld; Nilgun Sahin; Raju P. Sharma; Hans V. Westerhoff; Hans V. Westerhoff; ...
    Project: UKRI | China & the UK: super... (BB/J020060/1), EC | EpiPredict (642691), EC | SYNPOL (311815), EC | CORBEL (654248), EC | EOSC-Life (824087)

    We here apply a control analysis and various types of stability analysis to an in silico model of innate immunity that addresses the management of inflammation by a therapeutic peptide. Motivation is the observation, both in silico and in experiments, that this therapy ...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Reinier Damman; Stefan Schütz; Yanzhang Luo; Markus Weingarth; Remco Sprangers; Marc Baldus;
    Persistent Identifiers
    Publisher: Nature Publishing Group UK
    Project: NWO | Towards in-situ structura... (2300163571), EC | iNEXT (653706), NWO | An ultra-high field NMR f... (2300171444), EC | MRNA-DECAY (616052), NWO | Membrane proteins at work... (2300154435)

    Liquid–liquid phase separation is increasingly recognized as a process involved in cellular organization. Thus far, a detailed structural characterization of this intrinsically heterogeneous process has been challenging. Here we combine solid- and solution-state NMR spe...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Narasimhan, Siddarth; Scherpe, Stephan; Lucini Paioni, Alessandra; van der Zwan, Johan; Folkers, Gert E.; Ovaa, Huib; Baldus, Marc;
    Project: NWO | Towards in-situ structura... (2300163571), EC | iNEXT (653706), NWO | Netherlands' MAgnetic Res... (2300181106), NWO | Membrane proteins at work... (2300154435)

    Abstract Elucidating at atomic level how proteins interact and are chemically modified in cells represents a leading frontier in structural biology. We have developed a tailored solid‐state NMR spectroscopic approach that allows studying protein structure inside human c...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Jakub Barylski; François Enault; Bas E. Dutilh; Margo B.P. Schuller; Robert Edwards; Annika Gillis; Jochen Klumpp; Petar Knezevic; Mart Krupovic; Jens H. Kuhn; ...
    Publisher: HAL CCSD
    Project: EC | Virus-X (685778), NSF | Experimental and Computat... (1330800)

    Systematic Biology, 69 (1)

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  • publication . Article . 2019
    Open Access
    Authors:
    Marjoleine F. Broekema; Maarten P.G. Massink; Cinzia Donato; Joep de Ligt; Joerg Schaarschmidt; Anouska Borgman; Marieke G. Schooneman; Diana Melchers; Martin N. Gerding; René Houtman; ...
    Publisher: Elsevier BV
    Project: WT , EC | West-Life (675858), EC | BioExcel-2 (823830)

    Objective The nuclear receptor PPARγ is the master regulator of adipocyte differentiation, distribution, and function. In addition, PPARγ induces terminal differentiation of several epithelial cell lineages, including colon epithelia. Loss-of-function mutations in PPARG...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Chris Morris; Paolo Andreetto; Lucia Banci; Alexandre M. J. J. Bonvin; Grzegorz Chojnowski; Laura del Cano; José María Carazo; Pablo Conesa; Susan Daenke; George Damaskos; ...
    Publisher: Elsevier
    Project: EC | EOSC-hub (777536), EC | West-Life (675858), EC | BioExcel-2 (823830)

    Graphical abstract

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  • publication . Article . 2018
    Open Access English
    Authors:
    Maryam Faridounnia; Gert E. Folkers; Rolf Boelens;
    Persistent Identifiers
    Project: EC | INSTRUCT-ULTRA (731005), EC | BIO-NMR (261863), EC | iNEXT (653706)

    Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterod...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Simona V. Antonova; Matthias Haffke; Eleonora Corradini; Mykolas Mikuciunas; Teck Yew Low; Luca Signor; Robert M. van Es; Kapil Gupta; Elisabeth Scheer; Harmjan R. Vos; ...
    Project: ANR | INRT (ANR-10-LABX-0030), ANR | UNISTRA (ANR-10-IDEX-0002), UKRI | BrisSynBio: Bristol Centr... (BB/L01386X/1), WT | Unlocking the structure, ... (106115), NWO | Bijvoet Graduate Research... (2300175297), EC | BIRTOACTION (340551), NWO | Proteins@Work; A large-sc... (2300171290)

    TFIID is a cornerstone of eukaryotic gene regulation. Distinct TFIID complexes with unique subunit compositions exist and several TFIID subunits are shared with other complexes, thereby conveying precise cellular control of subunit allocation and functional assembly of ...

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47 research outcomes, page 1 of 5