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34 research outcomes, page 1 of 4
  • publication . Article . 2020
    Open Access English
    Authors:
    Antonio Schirò; Azzurra Carlon; Giacomo Parigi; Garib N. Murshudov; Vito Calderone; Enrico Ravera; Claudio Luchinat;
    Persistent Identifiers
    Publisher: Elsevier
    Project: EC | INSTRUCT-ULTRA (731005)

    Graphical abstract

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  • publication . Article . Other literature type . Preprint . 2019
    Open Access English
    Authors:
    Lukáš Slavata; Josef Chmelík; Daniel Kavan; Růžena Filandrová; Jan Fiala; Michal Rosůlek; Hynek Mrázek; Zdeněk Kukačka; Karel Valis; Petr Man; ...
    Publisher: MDPI AG
    Project: EC | EPIC-XS (823839), EC | WENMR (261572), EC | EU_FT-ICR_MS (731077), EC | West-Life (675858), NIH | Characterization of ncRNA... (1R01GM121844-01A1)

    The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level. We implemented a concerted structu...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Benoît Arragain; Juan Reguera; Ambroise Desfosses; Irina Gutsche; Guy Schoehn; Hélène Malet;
    Persistent Identifiers
    Publisher: HAL CCSD

    [u'Rats and mice sometimes transmit hantaviruses, a family of microbes that can cause deadly human diseases. For example, the Hantaan virus leads to haemorrhagic fevers that are potentially fatal. There are no vaccine or even drugs against these infections.', u'To multi...

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  • publication . Article . 2019
    Open Access
    Authors:
    Linda Cerofolini; Stefano Giuntini; Azzurra Carlon; Enrico Ravera; Vito Calderone; Marco Fragai; Giacomo Parigi; Claudio Luchinat;
    Persistent Identifiers
    Publisher: Wiley
    Project: EC | West-Life (675858), EC | iNEXT (653706), EC | WENMR (261572)

    Resonance assignment and structural characterization of pharmacologically relevant proteins promise to improve understanding and safety of these proteins by rational design. However, the PEG coating that is used to evade the immune system also causes these molecules to ...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Linda Cerofolini; Stefano Giuntini; Letizia Barbieri; Matteo Pennestri; Anna Codina; Marco Fragai; Lucia Banci; Enrico Luchinat; Enrico Ravera;
    Persistent Identifiers
    Project: EC | INSTRUCT-ULTRA (731005), EC | West-Life (675858), EC | iNEXT (653706)

    Abstract FlowNMR has the aim of continuously monitoring processes that occur in conditions that are not compatible with being carried out within a closed tube. However, it is sample intensive and not suitable for samples, such as proteins or living cells, that are often...

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  • publication . Other literature type . Project deliverable . Report . 2018
    Open Access English
    Authors:
    Bonvin, Alexandre M.J.J.;
    Publisher: Zenodo
    Project: EC | West-Life (675858)

    West-Life has brought complex data analysis in Structural Biology to a simple Web browser-based Virtual Research Environment (VRE). Capitalizing on European and National projects, such as Instruct, WeNMR, and CCP4, as well as other projects, like EGI-Engage, through the...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Carlon, Azzurra; Ravera, Enrico; Parigi, Giacomo; Murshudov, Garib N.; Luchinat, Claudio;
    Persistent Identifiers
    Project: UKRI | Computational Crystallogr... (MC_UP_A025_1012), EC | iNEXT (653706), EC | West-Life (675858)

    Data integration in structural biology has become a paradigm for the characterization of biomolecular systems, and it is now accepted that combining different techniques can fill the gaps in each other’s blind spots. In this frame, one of the combinations, which we have...

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  • publication . Article . 2018
    Open Access
    Authors:
    Claudia Andreini; Valeria Putignano; Antonio Rosato; Lucia Banci;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: EC | West-Life (675858)

    In this work we compiled a comprehensive list of all human iron-proteins based on bioinformatics predictions and analyzed their functional roles, distribution within cell compartments and involvement in disease.

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  • publication . Article . 2018
    Open Access English
    Authors:
    Nelly Morellet; Xianghong Li; Silke Andrea Wieninger; Jennifer L Taylor; Julien Bischerour; Séverine Moriau; Ewen Lescop; Benjamin Bardiaux; Nathalie Mathy; Nadine Assrir; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | WENMR (261572), EC | BAYCELLS (294809), EC | West-Life (675858), ANR | PIGGYPACK (ANR-14-CE10-0005)

    International audience; The piggyBac transposase (PB) is distinguished by its activity and utility in genome engineering, especially in humans where it has highly promising therapeutic potential. Little is known, however, about the structure-function relationships of th...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Kovalevskiy, Oleg; Nicholls, Robert A.; Long, Fei; Carlon, Azzurra; Murshudov, Garib N.;
    Persistent Identifiers
    Publisher: International Union of Crystallography
    Project: EC | West-Life (675858)

    Here, a macromolecule-centred approach to three-dimensional structure determination as implemented in REFMAC5 is considered. The use of restraints to transfer chemical and structural information during macromolecular refinement, and how different sources of information ...

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34 research outcomes, page 1 of 4