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93 research outcomes, page 1 of 10
  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Alqabandi, Maryam; de Franceschi, Nicola; Miguet, Nolwenn; Maity, Sourav; Bally, Marta; Roos, Wouter H.; Weissenhorn, Winfried; Bassereau, Patricia; Mangenot, Stéphanie;
    Publisher: Cold Spring Harbor Laboratory
    Project: ANR | ESCRTfission (ANR-14-CE09-0003), EC | INTERACT (751404), EC | ESCRT model (751715), ANR | PSL (ANR-10-IDEX-0001), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Bertin, Aurélie; de Franceschi, Nicola; de la Mora, Eugenio; Maiti, Sourav; Alqabandi, Maryam; Miguet, Nolwen; di Cicco, Aurélie; Roos, Wouter H.; Mangenot, Stéphanie; Weissenhorn, Winfried; ...
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706), ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | ESCRT model (751715), ANR | SwingBridge (ANR-15-CE11-0027), ANR | ESCRTfission (ANR-14-CE09-0003)

    ESCRT-III complexes assemble in vivo inside membrane structures with a negative Gaussian curvature, but how membrane shape influences ESCRT-III polymerization remains unclear. Here authors use structural and biophysical methods to show how human ESCRT-III polymers assem...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Talsma, Ditmer T; Poppelaars, Felix; Dam, Wendy; Meter-Arkema, Anita H; Vivès, Romain R; Gál, Peter; Boons, Geert-Jan; Chopra, Pradeep; Naggi, Annamaria; Seelen, Marc A; ...
    Publisher: HAL CCSD

    It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system. Therefore, we evaluated a libra...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Christine Orengo; Sameer Velankar; Shoshana Wodak; Vincent Zoete; Alexandre M.J.J. Bonvin; Arne Elofsson; K. Anton Feenstra; Dietland L. Gerloff; Thomas Hamelryck; John M. Hancock; ...
    Publisher: HAL CCSD
    Project: EC | BioExcel-2 (823830)

    Structural bioinformatics provides the scientific methods and tools to analyse, archive, validate, and present the biomolecular structure data generated by the structural biology community. It also provides an important link with the genomics community, as structural bi...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Leemans, Margaux; Galicia, Christian; Deyaert, Egon; Daems, Elise; Krause, Linda; Paesmans, Jone; Pardon, Els; Steyaert, Jan; Kortholt, Arjan; Sobott, Frank; ...
    Project: EC | BIOSTRUCT-X (283570)

    Abstract: Mutations in the Parkinson's disease (PD)-associated protein leucine-rich repeat kinase 2 (LRRK2) commonly lead to a reduction of GTPase activity and increase in kinase activity. Therefore, strategies for drug development have mainly been focusing on the desig...

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  • publication . Preprint . Article . Other literature type . 2020
    Open Access English
    Authors:
    Alexander F Schubert; Justine V Nguyen; Tyler G Franklin; Paul P. Geurink; Cameron G Roberts; Daniel J. Sanderson; Lauren N. Miller; Huib Ovaa; Kay Hofmann; Jonathan N. Pruneda; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | BIOSTRUCT-X (283570), NWO | Covalent Enzyme Capture (2300182105), NIH | Program in Molecular and ... (5T32GM071338-10)

    Prediction and validation of pathogenic bacterial DUBs and insights into their structures and (poly)ubiquitin linkage specificities allows for first cross‐kingdom comparison of the OTU deubiquitination enzyme fold.

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  • publication . Article . 2020
    Open Access
    Authors:
    Pascal Albanese; Sem Tamara; Guido Saracco; Richard A. Scheltema; Cristina Pagliano;
    Persistent Identifiers
    Publisher: Nature Publishing Group
    Project: EC | EPIC-XS (823839), NWO | Proteins@Work; A large-sc... (2300171290)

    Grana are a characteristic feature of higher plants’ thylakoid membranes, consisting of stacks of appressed membranes enriched in Photosystem II (PSII) and associated light-harvesting complex II (LHCII) proteins, together forming the PSII-LHCII supercomplex. Grana stack...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Frank Møller Aarestrup; A. Albeyatti; W. J. Armitage; Charles Auffray; L. Augello; Rudi Balling; N. Benhabiles; G. Bertolini; Jan G. Bjaalie; Michaela Black; ...
    Publisher: BMC
    Project: EC | SYSCID (733100), EC | ERA PerMed (779282), EC | DEFORM (710246), EC | ETRIKS (115446), EC | EHR4CR (115189), EC | MedBioinformatics (634143), EC | PANCARESURFUP (257505), EC | ICT4DEPRESSION (248778), EC | COMPARE (643476), EC | INSTRUCT-ULTRA (731005),...

    The European Union (EU) initiative on the Digital Transformation of Health and Care (Digicare) aims to provide the conditions necessary for building a secure, flexible, and decentralized digital health infrastructure. Creating a European Health Research and Innovation C...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Abudukelimu, Abulikemu; Barberis, Matteo; Redegeld, Frank; Sahin, Nilgun; Sharma, Raju P.; Westerhoff, Hans V.;
    Publisher: Frontiers Media SA
    Project: EC | CORBEL (654248), EC | EpiPredict (642691), UKRI | China & the UK: super... (BB/J020060/1), EC | SYNPOL (311815), EC | EOSC-Life (824087)

    We here apply a control analysis and various types of stability analysis to an in silico model of innate immunity that addresses the management of inflammation by a therapeutic peptide. Motivation is the observation, both in silico and in experiments, that this therapy ...

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  • publication . Other literature type . Article . Preprint . 2020
    Open Access
    Authors:
    Mona Seifert; Pauline van Nies; Flavia Stal Papini; Jamie J. Arnold; Minna M. Poranen; Craig E. Cameron; Martin Depken; David Dulin;
    Publisher: bioRxiv

    Abstract RNA virus survival depends on efficient viral genome replication, which is performed by the viral RNA dependent RNA polymerase (RdRp). The recent development of high throughput magnetic tweezers has enabled the simultaneous observation of dozens of viral RdRp e...

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93 research outcomes, page 1 of 10