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188 research outcomes, page 1 of 19
  • publication . Article . Part of book or chapter of book . 2021
    Restricted English
    Authors:
    Lionel Imbert; Rachel Lenoir-Capello; Elodie Crublet; Alicia Vallet; Rida Awad; Isabel Ayala; Celine Juillan-Binard; Hubert Mayerhofer; Rime Kerfah; Pierre Gans; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | INSTRUCT-ULTRA (731005)

    International audience; The cell-free synthesis is an efficient strategy to produce in large scale protein samples for structural investigations. In vitro synthesis allows for significant reduction of production time, simplification of purification steps and enables pro...

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  • publication . Other literature type . 2021
    Open Access
    Authors:
    Ziegler, Jule Anna; Stevanovic, Uros; Groep, David Leo; Neilson, Ian; Kelsey, David P.; Kremers, Maarten;
    Publisher: Zenodo
    Project: EC | AARC2 (730941)

    Submitted for publication to the Proceedings of the ISGC Conference 2021 (under review).

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  • publication . Other literature type . Article . Preprint . 2021
    Open Access
    Authors:
    Juraszek, Jarek; Rutten, Lucy; Blokland, Sven; Bouchier, Pascale; Voorzaat, Richard; Ritschel, Tina; Bakkers, Mark J. G.; Renault, Ludovic L. R.; Langedijk, Johannes P. M.;
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | INSTRUCT-ULTRA (731005)

    SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominan...

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  • publication . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Eleftherios Zarkadas; Hong Zhang; Wensheng Cai; Gregory Effantin; Jonathan Perot; Jacques Neyton; Christophe Chipot; Guy Schoehn; François Dehez; Hugues Nury;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | PentaBrain (637733)

    Inaccurately perceived as niche drugs, antiemetics are key elements of cancer treatment alleviating the most dreaded side effect of chemotherapy. Serotonin 5-HT3 receptor antagonists are the most commonly prescribed class of drugs to control chemotherapy-induced nausea ...

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Marion Lechable; Alexandre Jan; Axel Duchene; Julie Uveira; Brandon Weissbourd; Loann Gissat; Sophie Collet; Laurent Gilletta; Sandra Chevalier; Lucas Leclère; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | CORBEL (654248), ANR | i-MMEJ (ANR-17-CE13-0016), EC | ASSEMBLE Plus (730984)

    ABSTRACT The jellyfish species Clytia hemisphaerica (Cnidaria, Hydrozoa) has emerged as a new experimental model animal in the last decade. Favorable characteristics include a fully transparent body suitable for microscopy, daily gamete production and a relatively short...

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  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Roberto Melero; Carlos Oscar S. Sorzano; Brent Foster; José Luis Vilas; Marta Martínez; Roberto Marabini; Erney Ramírez-Aportela; Rubén J. Sánchez-García; D. Herreros; Laura del Cano; ...
    Publisher: International Union of Crystallography (IUCr)
    Project: EC | INSTRUCT-ULTRA (731005), EC | IMpaCT (857203), EC | HighResCells (810057), EC | EOSC-Life (824087), EC | CORBEL (654248), EC | EOSC-synergy (857647)

    AbstractWith the help of novel processing workflows and algorithms, we have obtained a better understanding of the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state. We have re-analyzed previous cryo-EM data combining 3D clustering a...

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    K.K. Rasmussen; Andrés Palencia; Anders K. Varming; Habiba El-Wali; Elisabetta Boeri Erba; Martin Blackledge; Karin Hammer; Torsten Herrmann; Mogens Kilstrup; Leila Lo Leggio; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706), EC | ERCSC-CHAIRS-SUP2013 (341400), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Temperate bacteriophages can enter one of two life cycles following infection of a sensitive host: the lysogenic or the lytic life cycle. The choice between the two alternative life cycles is dependent upon a tight regulation of promoters and their cognate regulatory pr...

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  • publication . Article . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Aldo R. Camacho-Zarco; Sissy Kalayil; Damien Maurin; Nicola Salvi; Elise Delaforge; Sigrid Milles; Malene Ringkjøbing Jensen; Darren J. Hart; Stephen Cusack; Martin Blackledge;
    Publisher: Nature Publishing Group
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | AvINFLUENZA (796490)

    Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. Here, the authors use NMR spectroscopy and quantitative ensemble modelling to describe the highly dynamic assemblies formed by the human-adapted or avian-adapted C-ter...

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  • publication . Preprint . Article . Other literature type . 2020
    Open Access English
    Authors:
    carlos oscar Sorzano; Enrique Crisman; Jose Maria Carazo; rafael leon;
    Project: EC | CORBEL (654248), EC | INSTRUCT-ULTRA (731005), EC | HighResCells (810057), EC | IMpaCT (857203), EC | iNEXT-Discovery (871037), EC | EOSC-Life (824087), EC | EOSC-synergy (857647)

    No

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  • publication . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Daniel Scholl; Maud Sigoillot; Marie Overtus; Rafael Colomer Martinez; Chloe Martens; Yiting Wang; Els Pardon; Toon Laeremans; Abel Garcia-Pino; Jan Steyaert; ...
    Persistent Identifiers
    Project: EC | INSTRUCT-ULTRA (731005)

    AbstractCystic Fibrosis (CF) is a common lethal genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Misfolding and degradation of CFTR are the hallmarks of the predominant mutation, F508del, located in th...

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188 research outcomes, page 1 of 19