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81 research outcomes, page 1 of 9
  • publication . Article . Other literature type . Preprint . 2021
    Open Access English
    Authors:
    Maryam Alqabandi; N. de Franceschi; Nolwenn Miguet; Sourav Maity; Marta Bally; Wouter H. Roos; Winfried Weissenhorn; Patricia Bassereau; Stéphanie Mangenot;
    Project: ANR | PSL (ANR-10-IDEX-0001), EC | ESCRT model (751715), ANR | ESCRTfission (ANR-14-CE09-0003), EC | INTERACT (751404), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Uwizeye Clarisse; Mars Brisbin Margaret; Gallet Benoit; Chevalier Fabien; LeKieffre Charlotte; Schieber L. Nicole; Falconet Denis; Wangpraseurt Daniel; Schertel Lukas; Stryhanyuk Hryhoriy; ...
    Publisher: HAL CCSD
    Project: EC | CORBEL (654248), EC | ChloroMito (833184)

    Endosymbioses have shaped the evolutionary trajectory of life and remain ecologically important. Investigating oceanic photosymbioses can illuminate how algal endosymbionts are energetically exploited by their heterotrophic hosts and inform on putative initial steps of ...

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  • publication . Preprint . 2021
    Open Access English
    Authors:
    Zullino, Sara; Paglialonga, Alessandro; Dastrù, Walter; Longo, Dario Livio; Aime, Silvio;
    Project: EC | CORBEL (654248), EC | GLINT (667510), EC | EOSC-Life (824087)

    Molecular imaging generates large volumes of heterogeneous biomedical imagery with an impelling need of guidelines for handling image data. Although several successful solutions have been implemented for human epidemiologic studies, few and limited approaches have been ...

  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Jarek Juraszek; Lucy Rutten; Sven Blokland; Pascale Bouchier; Richard Voorzaat; Tina Ritschel; Mark J G Bakkers; Ludovic Renault; Johannes P. M. Langedijk;
    Publisher: Nature Publishing Group UK
    Project: EC | INSTRUCT-ULTRA (731005)

    SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominan...

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  • publication . Preprint . 2021
    Open Access English
    Authors:
    Eleftherios Zarkadas; Hong Zhang; Wensheng Cai; Gregory Effantin; Jonathan Perot; Jacques Neyton; Christophe Chipot; Guy Schoehn; François Dehez; Hugues Nury;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | PentaBrain (637733), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Inaccurately perceived as niche drugs, antiemetics are key elements of cancer treatment alleviating the most dreaded side effect of chemotherapy. Serotonin 5-HT3 receptor antagonists are the most commonly prescribed class of drugs to control chemotherapy-induced nausea ...

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  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Christophe Caillat; Guilligay D; Torralba J; Nikolas Friedrich; Nieva Jl; Alexandra Trkola; Chris Chipot; François Dehez; Winfried Weissenhorn;
    Publisher: eLife Sciences
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | EAVI2020 (681137)

    The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate state by an MPER-specific neutralizing antib...

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  • publication . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Lynda Djerbal; Romain R. Vivès; Chrystel Lopin-Bon; Ralf P. Richter; Jessica C. F. Kwok; Hugues Lortat-Jacob;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    ABSTRACTSemaphorin 3A (Sema3A) is a secreted protein that signals to cells through binding to neuropilin and plexin receptors and provides neurons with guidance cues key for axon pathfinding, and also controls cell migration in several other biological systems. Sema3A i...

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  • publication . Contribution for newspaper or weekly magazine . Preprint . Conference object . 2020
    Open Access English
    Authors:
    Arne Köhn; Julia Wichlacz; Álvaro Torralba; Daniel Höller; Jörg Hoffmann; Alexander Koller;
    Persistent Identifiers
    Publisher: International Committee on Computational Linguistics

    Comment: Accepted COLING 2020 long paper

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Roberto Melero; Carlos Oscar S. Sorzano; Brent Foster; José Luis Vilas; Marta Martínez; Roberto Marabini; Erney Ramírez-Aportela; Rubén J. Sánchez-García; D. Herreros; Laura del Cano; ...
    Publisher: International Union of Crystallography
    Project: EC | INSTRUCT-ULTRA (731005), EC | IMpaCT (857203), EC | EOSC-synergy (857647), EC | HighResCells (810057), EC | CORBEL (654248), EC | EOSC-Life (824087)

    Peer reviewed

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Aldo R. Camacho-Zarco; Sissy Kalayil; Damien Maurin; Nicola Salvi; Elise Delaforge; Sigrid Milles; Malene Ringkjøbing Jensen; Darren J. Hart; Stephen Cusack; Martin Blackledge;
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | AvINFLUENZA (796490)

    Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. Here, the authors use NMR spectroscopy and quantitative ensemble modelling to describe the highly dynamic assemblies formed by the human-adapted or avian-adapted C-ter...

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81 research outcomes, page 1 of 9