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3,541 research outcomes, page 1 of 355
  • publication . Doctoral thesis . 2021
    French
    Authors:
    Troupinon, Maud;
    Publisher: HAL CCSD
    Country: France

    Aneuploidy is a hallmark of cancer cells, characterized by a chromosome’s number which is not a multiple of the haploid complement12,15. Aneuploidy is characterized by an unbalanced genomic content. Aneuploidy as a therapeutic target is promising because it is a hallmar...

  • publication . Doctoral thesis . 2021
    French
    Authors:
    Aouache, Rajaa;
    Publisher: HAL CCSD
    Country: France

    In France, 380,000 new cancer diagnoses are made each year and 60% of these cancers are treated by radiotherapy, which uses ionizing radiation to destroy tumor cells. Radiation therapy causes undesirable radiotoxic effects on healthy tissues located in the radiation fie...

  • publication . Doctoral thesis . 2021
    French
    Authors:
    Pallares Lupon, Néstor;
    Publisher: HAL CCSD
    Country: France

    Sudden cardiac death is responsible for 50000 deaths every year in France. A loss of the electrical control of the heart, known as ventricular fibrillation leads to an inability of the heart to pump blood. Between 5 and 10 % of patients do not show any apparent electric...

  • publication . Doctoral thesis . 2021
    French
    Authors:
    GUYON, Joris;
    Publisher: HAL CCSD
    Country: France

    Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. It can be recognized by its angiogenic and invasive growth, in addition to its altered metabolism.To study GBM, we developed three-dimensional models to better mimic its complex architect...

  • publication . Doctoral thesis . 2021
    French
    Authors:
    Varangot, Alexandre;
    Publisher: HAL CCSD
    Country: France

    The discovery of the neuronal expression of the serine protease tissue type plasminogen activator (tPA) has opened new avenues of research, with important functions of tPA in the physiopathology of the central nervous system. For example, its interactions with synaptic ...

  • publication . Doctoral thesis . 2021
    French
    Authors:
    Mercier, Julia;
    Publisher: HAL CCSD
    Country: France

    Cystic fibrosis (CF) is due to CFTR gene pathogenic variants and has no curative treatment to date. The main cause of morbidity and mortality in CF patients is respiratory failure, due to cycles of infection and inflammation responsible for progressive lung tissue degra...

  • publication . Doctoral thesis . 2021
    French
    Authors:
    Baron, Chloé;
    Publisher: HAL CCSD
    Country: France

    The transfer of a competent embryo into a uterine cavity during the implantion window is a major objective to ensure success in in vitro fertilization (IVF). My thesis work contributes to (i) the identification of new biomarkers for the evaluation of endometrial recepti...

  • publication . Doctoral thesis . 2021
    French
    Authors:
    El Haddad, Chadia;
    Publisher: HAL CCSD
    Country: France

    Cognitive deficits is a fundamental characteristic of schizophrenia where the most affected function are particularly memory, attention, motor skills, executive functions and social cognition. Cognitive assessment is one of the best indicators of the functional and soci...

  • publication . Doctoral thesis . 2021
    French
    Authors:
    Kharouf, Naji;
    Publisher: HAL CCSD
    Country: France

    The guideline of this thesis is to add polyphenols to the liquid used for the setting of dental root canal repair cements with the assumption that this family of molecules, known for their ability to adsorb on the surface of all types of materials, promote interparticle...

  • publication . Doctoral thesis . 2021
    French
    Authors:
    Viailly, Pierre-Julien;
    Publisher: HAL CCSD
    Country: France

    Lymphoma is the sixth most common cancer in France with 15,000 new cases diagnosed and 4,500 deaths each year. Lymphomas are very heterogeneous diseases both in clinical and phenotypic aspects. The development of immunohistochemistry, cytogenetics and more recently next...

3,541 research outcomes, page 1 of 355